Engineered Novel Brijaluronic Terpesomes for Brain-Targeted Quercetin Delivery: Optimization, Ex Vivo and Radiokinetics
Sadek Ahmed; Khaled M. Attallah; Marwa Eid Sayyed · 2026 · AAPS PharmSciTech
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract This research focuses on creating a novel Brijaluronic-based terpesomal system capable of transporting quercetin (QER) efficiently to the brain. The vesicles were fabricated through an ethanol-injection method and then refined using a structured optimization approach in Design-Expert® software. The influence of three main formulation parameters: terpene-to-drug ratio, surfactant type, and hyaluronic acid amount were evaluated. The optimization process was designed to maximize EE%, minimize VS, and maintain ZP within an acceptable stability range. The optimal formula hit a desirability
Abstract by Sadek Ahmed; Khaled M. Attallah; Marwa Eid Sayyed, AAPS PharmSciTech (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1208/s12249-026-03366-x