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Browse the failure-mode index

21,245 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportImmunology and Microbiology

Characterization of newly revealed sequences in the infectious myonecrosis virus genome in Litopenaeus vannamei

Duan S. Loy, Bradley J. Blitvich, John Dustin Loy et al. · 2015 · Journal of General Virology

Infectious myonecrosis virus (IMNV) causes significant economic losses in farmed shrimp, where associated mortality in ponds can reach 70 %. To explore host/pathogen interactions, a next-generation sequencing approach using lymphoid organ…

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Negative / Null Result Report

The addition of chemotherapy to radiotherapy did not reduce the rate of distant metastases in low‐risk HPV‐related oropharyngeal cancer in a real‐world setting

Stephen F. Hall, Rebecca J. Griffiths, Brian O'Sullivan et al. · 2019 · Head & Neck

Abstract Background Distant metastases (DM) are a leading cause of death for patients with oropharyngeal cancer (OPSCC). The objective of this study was to compare the rates of DM after chemoradiotherapy (CRT) and radiotherapy alone (RT)…

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Negative / Null Result ReportOpen accessNursing

The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation

Shih‐Wei Huang, Horng‐Chyuan Lin, Yu-Feng Chou et al. · 2022 · Nutrients

Prolonged mechanical ventilation (PMV) is associated with poor outcomes and a high economic cost. The association between protein intake and PMV has rarely been investigated in previous studies. This study aimed to investigate the impact of protein intake on weaning from mechanical ventilation. Patients with the PMV (mechanical ventilation ≥6 h/day for ≥21 days) at our hospital between December 2020 and April 2022 were included in this study. Demographic data, nutrition records, laboratory data, weaning conditions, and survival data were retrieved from the patient’s electronic medical records.

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Negative / Null Result ReportOpen accessMedicine

The impact of fluid resuscitation via colon on patients with severe acute pancreatitis

Tongtian Ni, Ying Chen, Bing Zhao et al. · 2021 · Scientific Reports

Severe acute pancreatitis (SAP) is a life-threatening disease. Fluid Resuscitation Via Colon (FRVC) may be a complementary therapy for early controlled fluid resuscitation. But its clinical application has not been reported. This study aims to explore the impact of FRVC on SAP. All SAP patients with the first onset within 72 h admitted to the hospital were included from January 2014 to December 2018 through electronic databases of Ruijin hospital and were divided into FRVC group (n = 103) and non-FRVC group (n = 78). The clinical differences before and after the therapy between the two groups

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Negative / Null Result ReportOpen accessMedicine

Induction TPF followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locally advanced hypopharyngeal cancer: a preliminary analysis of a randomized phase 2 trial

Xi Luo, Xiaodong Huang, Jingwei Luo et al. · 2022 · BMC Cancer

PURPOSE: Concurrent chemoradiotherapy (CCRT) is a standard treatment choice for locally advanced hypopharyngeal carcinoma. The aim of this study was to investigate whether induction chemotherapy (IC) followed by CCRT is superior to CCRT alone to treat locally advanced hypopharyngeal carcinoma. METHODS AND MATERIALS: Patients (n = 142) were randomized to receive two cycles of paclitaxel/cisplatin/5-fluorouracil (TPF) IC followed by CCRT or CCRT alone. The primary end point was overall survival (OS). The secondary end points included the larynx-preservation rate, progression-free survival (PFS),

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Factors correlating with significant differences between X-ray structures of myoglobin

Alexander A. Rashin, Marcin J. Domagalski, Michael T. Zimmermann et al. · 2014 · Acta Crystallographica Section D Biological Crystallography

Validation of general ideas about the origins of conformational differences in proteins is critical in order to arrive at meaningful functional insights. Here, principal component analysis (PCA) and distance difference matrices are used to…

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Negative / Null Result ReportOpen accessMedicine

Impact of Pancreatic Resection on Survival in Locally Advanced Resectable Gastric Cancer

Shih-Chun Chang, Chi-Ming Tang, Puo‐Hsien Le et al. · 2021 · Cancers

Whether gastric adenocarcinoma (GC) patients with adjacent organ invasion (T4b) benefit from aggressive surgery involving pancreatic resection (PR) remains unclear. This study aimed to clarify the impact of PR on survival in patients with locally advanced resectable GC. Between 1995 and 2017, patients with locally advanced GC undergoing radical-intent gastrectomy with and without PR were enrolled and stratified into four groups: group 1 (G1), pT4b without pancreatic resection (PR); group 2 (G2), pT4b with PR; group 3 (G3), positive duodenal margins without Whipple’s operation; and group 4 (G4)

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Gαqprotein-induced cardiomyopathy

Valeriy Timofeyev, C. A. Porter, Dipika Tuteja et al. · 2010 · American Journal of Physiology-Heart and Circulatory Physiology

Adenylyl cyclase (AC) is the principal effector molecule in the β-adrenergic receptor pathway. AC(V) and AC(VI) are the two predominant isoforms in mammalian cardiac myocytes. The disparate roles among AC isoforms in cardiac hypertrophy…

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Negative / Null Result ReportOpen accessEngineering

Are There Any Significant Differences in Terms of Age and Sex in Pedestrian and Cyclist Accidents?

Christoph Leo, Maria C. Rizzi, N M Bos et al. · 2021 · Frontiers in Bioengineering and Biotechnology

This study has analyzed sex-specific differences in pedestrian and cyclist accidents involving passenger cars. The most frequently injured body regions, types of injuries, which show sex-specific differences and the general accident parameters of females and males were compared. Accident data from three different European countries (Austria, Netherlands, Sweden) were analyzed. The current analysis shows that for both, females and males, pedestrian and cyclist injuries are sustained mainly to the body regions head, thorax, upper extremities and lower extremities. The results show that the odds

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Negative / Null Result ReportOpen accessMedicine

High-sensitivity troponin I with or without ultra-sensitive copeptin for the instant rule-out of acute myocardial infarction

Fabrizio Ricci, Franz–Josef Neumann, Nicole Rübsamen et al. · 2022 · Frontiers in Cardiovascular Medicine

Background The instant, single-sampling rule-out of acute myocardial infarction (AMI) is still an unmet clinical need. We aimed at testing and comparing diagnostic performance and prognostic value of two different single-sampling biomarker strategies for the instant rule-out of AMI. Methods From the Biomarkers in Acute Cardiac Care (BACC) cohort, we recruited consecutive patients with acute chest pain and suspected AMI presenting to the Emergency Department of the University Medical Center Hamburg-Eppendorf, Hamburg, Germany. We compared safety, effectiveness and 12-month incidence of the comp

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Negative / Null Result Report

OXIDIZED LIPIDS DID NOT REDUCE LIFESPAN IN THE FRUIT FLY, Drosophila melanogaster

Oleh V. Lushchak, Dmytro V. Gospodaryov, Ihor S. Yurkevych et al. · 2015 · Archives of Insect Biochemistry and Physiology

Aging is often associated with accumulation of oxidative damage in proteins and lipids. However, some studies do not support this view, raising the question of whether high levels of oxidative damage are associated with lifespan. In the…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Platelet Function Guided Versus Unguided Treatment With P2Y12 Inhibitors in Patients With Acute Myocardial Infarction (from the Hungarian Myocardial Infarction Registry)

András Komócsi, Dániel Aradi, Tibor Szük et al. · 2018 · The American Journal of Cardiology

Evidence is conflicting regarding the clinical benefits of selecting P2Y12 inhibitors based on platelet function testing (PFT). Between March 1, 2013 and March 1, 2014, we collected clinical characteristics and platelet function data in a…

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Negative / Null Result ReportOpen accessMedicine

Ilixadencel, a Cell-based Immune Primer, plus Sunitinib Versus Sunitinib Alone in Metastatic Renal Cell Carcinoma: A Randomized Phase 2 Study

Magnus Lindskog, Anna Laurell, Anders Kjellman et al. · 2022 · European Urology Open Science

Background: The prognosis of patients with synchronous metastatic renal cell carcinoma (mRCC) is poor. Whereas single-agent tyrosine kinase inhibition (TKI) is clearly insufficient, the effects can be enhanced by combinations with immune checkpoint inhibitors. Innovative treatment options combining TKI and other immune-stimulating agents could prove beneficial. Objective: To evaluate the clinical effects on metastatic disease when two doses of allogeneic monocyte-derived dendritic cells (ilixadencel) are administrated intratumorally followed by nephrectomy and treatment with sunitinib compared

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Negative / Null Result ReportOpen accessNeuroscience

Quantitative and Qualitative Exploration of Meaningful Change on the Vineland Adaptive Behavior Scales (Vineland™-II) in Children and Adolescents with Autism Without Intellectual Disability Following Participation in a Clinical Trial

Susanne Clinch, Stacie Hudgens, Elizabeth Gibbons et al. · 2023 · Patient Related Outcome Measures

Purpose: Adaptive Behavior Scale is often used in autism spectrum disorder (ASD) trials. The Adaptive Behavior Composite Score (VABS-ABC) is the standardized overall score (the average of the Socialization, Communication and Daily Living…

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Negative / Null Result ReportOpen accessMedicine

Selective internal radiation therapy (SIRT) for hepatocellular carcinoma (HCC): informing clinical practice for multidisciplinary teams in England

Helen L. Reeves, John Reicher, Georgia Priona et al. · 2022 · Frontline Gastroenterology

Objective: Hepatocellular carcinoma (HCC) deaths are rising alarmingly. Many patients are unsuitable for available therapies. Poor response rates further hamper outcomes for those that are. Selective internal radiation therapy (SIRT) offers hope, although which patients benefit over standard approaches remains unclear. Design/method: As a quality/service improvement, we audited consecutive patients treated with SIRT (2015-2020) by the Newcastle upon Tyne Hospitals National Health Service Foundation Trust HCC multidisciplinary team. Indications, Barcelona clinic liver cancer (BCLC) stage, treat

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Negative / Null Result ReportOpen accessMedicine

Ocular Surface Ion Transport and Dry Eye Disease

Ethan S. Lindgren, Onur Çil, A. S. Verkman et al. · 2022 · Current Ophthalmology Reports

Purpose of Review: To review the role of ocular surface epithelial (corneal and conjunctival) ion transporters in the pathogenesis and treatment of dry eye disease (DED). Recent Findings: Currently, anti-inflammatory agents are the mainstay of DED treatment, though there are several agents in development that target ion transport proteins on the ocular surface, acting by pro-secretory or anti-absorptive mechanisms to increase the tear fluid Film volume. Activation or inhibition of selected ion transporters can alter tear fluid osmolality, driving water transport onto the ocular surface via osm

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Negative / Null Result Report

Routine Diagnostics Confirm Novel Neurodevelopmental Disorders

Robin-Tobias Jauss, Sophia Schließke, Rami Abou Jamra · 2022 · Genes

Routine diagnostics is biased towards genes and variants with satisfactory evidence, but rare disorders with only little confirmation of their pathogenicity might be missed. Many of these genes can, however, be considered relevant,…

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Negative / Null Result Report

Pro-inflammatory response ensured by LPS and Pam3CSK4 in RAW 264.7 cells did not improve a fungistatic effect on Cryptococcus gattii infection

Gabriela Yamazaki de Campos, Raquel Amorim Oliveira, Patrícia Kellen Martins Oliveira-Brito et al. · 2020 · PeerJ

Background The macrophage lineage is characterized by plasticity due to the acquisition of distinct functional phenotypes, and two major subsets are evaluated; classical M1 activation (strong microbicidal activity) and alternative M2…

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Negative / Null Result Report

Significant effects on neonatal morbidity and mortality after regional change in management of post‐term pregnancy

CHARLOTTA GRUNEWALD, STELLAN HÅKANSSON, SISSEL SALTVEDT et al. · 2010 · Acta Obstetricia et Gynecologica Scandinavica

Abstract Objective. To evaluate the effects on neonatal morbidity of a regional change in induction policy for post‐term pregnancy from 43 +0 to 42 +0 gestational weeks (GWs). Design and setting. Nationwide retrospective register study…

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Negative / Null Result ReportOpen accessNeuroscience

Music and Language Processing Share Behavioral and Cerebral Features

Clara E. James · 2012 · Frontiers in Psychology

A commentary on Musical expertise and statistical learning of musical and linguistic structures by Schön, D., and François, C. (2011). Front. Psychology 2:167. doi: 10.3389/ fpsyg.2011.00167 Both language and music consist of discrete elements organized in embedded hierarchical structures. Schön and François nicely expose in this review that musical expertise facilitates learning of both linguistic and musical structures. At the behavioral level, the musicians did not outperform the nonmusicians. However, ERP analyses showed that acquisition of boundary perception (segmentation) between units

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Negative / Null Result ReportOpen accessNeuroscience

Visual Perceptual Load Does Not Affect the Frequency Mismatch Negativity

Stefan Wiens, Erik van Berlekom, Malina Szychowska et al. · 2019 · Frontiers in Psychology

The mismatch negativity (MMN) has been of particular interest in auditory perception because of its sensitivity to auditory change. It is typically measured in an oddball task and is computed as the difference of deviant minus standard tones. Previous studies suggest that the oddball MMN can be reduced by crossmodal attention to a concurrent, difficult visual task. However, more recent studies did not replicate this effect. Because previous findings seem to be biased, we preregistered the present study and used Bayesian hypothesis testing to measure the strength of evidence for or against an e

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