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21,245 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Beneath the surface: Amino acid variation underlying two decades of dengue virus antigenic dynamics in Bangkok, Thailand

Angkana T. Huang, Henrik Salje, Ana Coello Escoto et al. · 2022 · PLoS Pathogens

Neutralizing antibodies are important correlates of protection against dengue. Yet, determinants of variation in neutralization across strains within the four dengue virus serotypes (DENV1-4) is imperfectly understood. Studies focus on structural DENV proteins, especially the envelope (E), the primary target of anti-DENV antibodies. Although changes in immune recognition (antigenicity) are often attributed to variation in epitope residues, viral processes influencing conformation and epitope accessibility also affect neutralizability, suggesting possible modulating roles of nonstructural prote

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Negative / Null Result ReportOpen accessMedicine

Improving patient identification for advanced cardiac imaging through machine learning-integration of clinical and coronary CT angiography data

Jan Walter Benjamins, Ming Wai Yeung, Teemu Maaniitty et al. · 2021 · International Journal of Cardiology

BACKGROUND: Standard computed tomography angiography (CTA) outputs a myriad of interrelated variables in the evaluation of suspected coronary artery disease (CAD). But an important proportion of obstructive lesions does not cause significant myocardial ischemia. Nowadays, machine learning (ML) allows integration of numerous variables through complex interdependencies that optimize classification and prediction at the individual level. We evaluated ML performance in integrating CTA and clinical variables to identify patients that demonstrate myocardial ischemia through PET and those who ultimat

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Negative / Null Result ReportOpen accessPsychology

A Statewide Randomized Controlled Trial to Compare Three Models for Implementing Parent Child Interaction Therapy

Amy D. Herschell, David J. Kolko, Ashley T. Scudder et al. · 2021 · Journal of Clinical Child & Adolescent Psychology

OBJECTIVE: This study (NIMH RO1 MH095750; ClinicalTrials.gov Identifier: NCT02543359) evaluated the effectiveness of three training models to implement a well-established evidence-based treatment, Parent-Child Interaction Therapy (PCIT).…

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Negative / Null Result ReportEngineering

Laboratory and Field Evaluation of Single Layer and Double Layer High Friction Surface Treatments

Shuo Li, Peiliang Cong, Demei Yu et al. · 2019 · Transportation Research Record Journal of the Transportation Research Board

High friction surface treatment (HFST) has been proactively used as a solution to extreme friction demands at locations such as horizontal curves, ramps, bridge decks, and intersections. Considerable efforts have been made to evaluate the…

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Negative / Null Result ReportOpen accessMedicine

Thyroid Autoimmunity and Behçet’s Disease: Is There a Significant Association?

Filiz Cebeci, Nahide Onsun, Ayşe Pekdemir et al. · 2013 · The Scientific World JOURNAL

BACKGROUND: Behcet's disease (BD) could be regarded as an autoimmune disease in many aspects. Autoimmune thyroid disease (ATD) is frequently accompanied by other various autoimmune diseases. Nevertheless, there is not still enough data showing the association between BD and ATD. In addition, no controlled study is present in the PubMed, which evaluates thyroidal autoimmunity using antithyroid peroxidase antibody in a large series of patients with BD. METHODS: We aimed to investigate the frequency of ATD in patients with BD. The study included 124 patients with BD and 99 age- and sex-matched he

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Negative / Null Result ReportOpen accessEngineering

Predicting Hourly Residential Energy Consumption using Random Forest and Support Vector Regression : An Analysis of the Impact of Household Clustering on the Performance Accuracy

William Hedén · 2016 · KTH Publication Database DiVA (KTH Royal Institute of Technology)

The recent increase of smart meters in the residential sector has lead to large available datasets. The electricity consumption of individual households can be accessed in close to real time, and allows both the demand and supply side to…

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Negative / Null Result Report

Daily Intake of Lemna minor or Spinach as Vegetable Does Not Show Significant Difference on Health Parameters and Taste Preference

Jurriaan J. Mes, Diederik Esser, Dianne Somhorst et al. · 2022 · Plant Foods for Human Nutrition

Abstract The growing world population will increase the demand for new sustainable foods and ingredients. Here we studied the safety and tolerance of Lemna minor, a new sustainable vegetable crop from the duckweed family. Twenty-four…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Fusing metabolomics data sets with heterogeneous measurement errors

Sandra Waaijenborg, Oksana Korobko, Ko Willems van Dijk et al. · 2018 · PLoS ONE

Combining different metabolomics platforms can contribute significantly to the discovery of complementary processes expressed under different conditions. However, analysing the fused data might be hampered by the difference in their quality. In metabolomics data, one often observes that measurement errors increase with increasing measurement level and that different platforms have different measurement error variance. In this paper we compare three different approaches to correct for the measurement error heterogeneity, by transformation of the raw data, by weighted filtering before modelling

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Failed Experiment Report

A note on Nakano generalized difference sequence space

Awad A. Bakery, Afaf R. Abou Elmatty · 2020 · Advances in Difference Equations

Abstract In this paper, we investigate the necessary conditions on any s -type sequence space to form an operator ideal. As a result, we show that the s -type Nakano generalized difference sequence space X fails to generate an operator…

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Negative / Null Result ReportOpen accessMedicine

Plasma proteomics for prediction of subclinical coronary artery calcifications in primary prevention

Patrick Royer, Elias Björnson, Martin Adiels et al. · 2024 · American Heart Journal

BACKGROUND AND AIMS: Recent developments in high-throughput proteomic technologies enable the discovery of novel biomarkers of coronary atherosclerosis. The aims of this study were to test if plasma protein subsets could detect coronary artery calcifications (CAC) in asymptomatic individuals and if they add predictive value beyond traditional risk factors. METHODS: Using proximity extension assays, 1,342 plasma proteins were measured in 1,827 individuals from the Impaired Glucose Tolerance and Microbiota (IGTM) study and 883 individuals from the Swedish Cardiopulmonary BioImage Study (SCAPIS)

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Negative / Null Result ReportOpen accessMedicine

Temporal validation of machine learning models for pre-eclampsia prediction using routinely collected maternal characteristics: A validation study

Sofonyas Abebaw Tiruneh, Daniel L. Rolnik, Helena Teede et al. · 2025 · Computers in Biology and Medicine

BACKGROUND: Pre-eclampsia (PE) contributes to more than one-fourth of all maternal deaths and half a million newborn deaths worldwide every year. Early screening and interventions can reduce PE incidence and related complications. We aim to 1) temporally validate three existing models (two machine learning (ML) and one logistic regression) developed in the same region and 2) compare the performances of the validated ML models with the logistic regression model in PE prediction. This work addresses a gap in the literature by undertaking a comprehensive evaluation of existing risk prediction mod

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Negative / Null Result Report

Significant geometry and charge difference between the E 5 4− bare clusters of group 14 Zintl anions and their coordinated form in [E 5 {M(CO) 3 } 2 ] 4− (E = Si, Ge, Sn, Pb; M = Cr, Mo, W) complexes

Yasin Gholiee, Sadegh Salehzadeh, Shiva Khodaveisi · 2019 · New Journal of Chemistry

It is shown that while none of the E 5 n (E = Si, Ge, Sn, Pb; n = 0, 2−, 4−) bare clusters can be stabilized in planar pentagon ( D 5h ) geometry, E 5 4− ions as a five-membered planar ring form stable complexes with two {M(CO) 3 } (M =…

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Negative / Null Result ReportOpen accessMedicine

Autoimmune thyroid disease and urticarial vasculitis: is there a significant association?

Iván Chérrez-Ojeda, Emanuel Vanegas, Valeria L. Mata et al. · 2019 · Allergy Asthma and Clinical Immunology

Little is known about the association of urticarial vasculitis (UV) with thyroid autoimmunity. The latter has been mostly described in the setting of patients with chronic spontaneous urticaria (CSU). In this letter to the editor, we compare UV and CSU through retrospective analyses, which reveal that 41.7% patients with UV presented antithyroperoxidase (anti-TPO) and/or antithyroglobulin antibody (ATA) above the reference range, while only 4% patients with CSU had these antibodies elevated. There is a moderately strong association assessed by the Phi coefficient (φ = 0.420, p = 0.004). Furthe

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Negative / Null Result ReportOpen accessMedicine

Significant associations between bone mineral density and vascular calcification in patients with different stages of chronic kidney disease

Jana Uhlinova, Anne Kuudeberg, Kaja Metsküla et al. · 2022 · BMC Nephrology

INTRODUCTION: Chronic kidney disease-mineral and bone disorders (CKD-MBD) is characterised by generalised vascular calcification (VC) and impaired bone health. We aimed to investigate the relationship between VC and bone mineral density (BMD) in CKD patients. METHODS: We performed a cross-sectional study of patients with different stages of CKD. For assessment of VC of abdominal aorta lateral lumbar X-rays (Kauppila score), the ankle-brachial index (ABI) and echocardiography were used. Total body densitometry provided BMD. RESULTS: Ninety patients (41% male, median age 64 years (range 29-87))

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Negative / Null Result Report

Human-derived Treg and MSC combination therapy may augment immunosuppressive potency in vitro, but did not improve blood brain barrier integrity in an experimental rat traumatic brain injury model

Henry W. Caplan, Karthik S. Prabhakara, Naama E. Toledano Furman et al. · 2021 · PLOS ONE

Traumatic brain injury (TBI) causes both physical disruption of the blood brain barrier (BBB) and altered immune responses that can lead to significant secondary brain injury and chronic inflammation within the central nervous system…

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Negative / Null Result Report

Did a quality improvement intervention improve quality of maternal health care? Implementation evaluation from a cluster-randomized controlled study

Elysia Larson, Godfrey M Mbaruku, Jessica Cohen et al. · 2019 · International Journal for Quality in Health Care

Abstract Objective To test the success of a maternal healthcare quality improvement intervention in actually improving quality. Design Cluster-randomized controlled study with implementation evaluation; we randomized 12 primary care…

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Negative / Null Result ReportOpen accessNeuroscience

A Psychometric Comparison of Two Carer Quality of Life Questionnaires in Huntington's Disease: Implications for Neurodegenerative Disorders

Peter Hagell, Stephen S. Smith · 2013 · Journal of Huntington s Disease

BACKGROUND: The carer impact of neurodegenerative disorders such as Huntington's disease (HD) is vast. Attempts to measure carer QoL in neurodegenerative disorders include the three-dimensional (Practical aspects of Caregiving, PC;…

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