Imaged-guided focused ultrasound in combination with various formulations of doxorubicin for the treatment of diffuse intrinsic pontine glioma
Rianne Haumann; John Bianco; Piotr Waranecki; Pieter J. Gaillard; Gert Storm; Mario Ries; Dannis G. van Vuurden; Gertjan J.L. Kaspers · 2022 · Translational Medicine Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Diffuse intrinsic pontine glioma (DIPG) is a notoriously difficult tumor to treat, with an overall survival of DIPG patients being only 11 months. One of the major obstacles for the effective treatment of DIPG is the blood–brain barrier (BBB). In order to circumvent the BBB, drug delivery methods are needed that target the pontine area. One such approach is microbubble-mediated focused ultrasound (FUS)—a non-invasive method that can temporarily and locally open the BBB. Previously, it was shown that FUS is safe with minimal side effects and rapid recovery times in preclinic
Abstract by Rianne Haumann; John Bianco; Piotr Waranecki; Pieter J. Gaillard; Gert Storm; Mario Ries; Dannis G. van Vuurden; Gertjan J.L. Kaspers, Translational Medicine Communications (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s41231-022-00115-7