Failed Experiment ReportOpen accessMedicine
Weidong Zhao, Gan Zhao, Shuren Zhang et al. · 2018 · Oncotarget
// Weidong Zhao 1 , Gan Zhao 1 , Shuren Zhang 1 , Xianzheng Wang 1 , Xueping Yu 2 and Bin Wang 1 1 Key Laboratory of Medical Molecular Virology of The Ministry of Health and Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China 2 Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China Correspondence to: Bin Wang, email: bwang3@fudan.edu.cn Keywords: GM-CSF; IFN-α; therapeutic vaccine; HBV; Ly6C hi monocyte Received: April 14, 2017 Accepted: October 30, 2017 Epub
View details →Negative / Null Result ReportOpen accessNeuroscience
Charlotte Seijger, Joost Raaphorst, Judith M. Vonk et al. · 2021 · Respiration
BACKGROUND: Non-invasive home mechanical ventilation (HMV) is a complex treatment in myotonic dystrophy type 1 (DM1) patients, due to a presumed poor adherence, variable symptom improvement, and uncertainty regarding survival benefits.…
View details →Negative / Null Result ReportMedicine
Thomas Kubiszyn, Sarah S. Mire, Sonia Dutt et al. · 2012 · School Psychology Quarterly
Some side effects (SEs) of increasingly prescribed psychotropic medications can impact student performance in school. SE risk varies, even among drugs from the same class (e.g., antidepressants). Knowing which SEs occur significantly more…
View details →Negative / Null Result ReportOpen accessMedicine
Dejan Georgiev, Harith Akram, Marjan Jahanshahi · 2021 · Psychoradiology
Following the established application of deep brain stimulation (DBS) in the treatment of movement disorders, new non-neurological indications have emerged, such as for obsessive-compulsive disorders, major depressive disorder, dementia, Gilles de la Tourette Syndrome, anorexia nervosa, and addictions. As DBS is a network modulation surgical treatment, the development of DBS for both neurological and psychiatric disorders has been partly driven by advances in neuroimaging, which has helped explain the brain networks implicated. Advances in magnetic resonance imaging connectivity and electrophy
View details →Negative / Null Result ReportOpen accessMedicine
Aaron Simpson, Renata Krowka, Jennifer Kerrigan et al. · 2013 · BMJ Open
OBJECTIVE: To determine the potential of opportunistic glycated haemoglobin (HbA1c) testing of pathology samples to detect previously unknown diabetes. DESIGN: Pathology samples from participants collected for other reasons and suitable…
View details →Negative / Null Result ReportOpen accessMedicine
Jun Ueda, Norihito Uemura, Tomoyuki Ishimoto et al. · 2023 · Movement Disorders
Abstract Background The intercellular transmission of pathogenic proteins plays a crucial role in the progression of neurodegenerative diseases. Previous research has shown that the neuronal uptake of such proteins is activity‐dependent;…
View details →Negative / Null Result ReportOpen accessMedicine
Xiao Li, Maierhaba Maitiyaer, Qing Tan et al. · 2024 · Frontiers in Pharmacology
Primary Sjögren's Syndrome (pSS) is a complex autoimmune disorder characterized by exocrine gland dysfunction, leading to dry eyes and mouth. Despite growing interest in biologic therapies for pSS, FDA approval has proven challenging due to trial complications. This review addresses the absence of a molecular-target-based approach to biologic therapy development and highlights novel research on drug targets and clinical trials. A literature search identified potential pSS treatment targets and recent advances in molecular understanding. Overlooking extraglandular symptoms like fatigue and depr
View details →Negative / Null Result ReportOpen accessMedicine
Martin Scharffenberg, Thomas G. Weiss, Jakob Wittenstein et al. · 2022 · BMC Anesthesiology
Abstract Background Oxygen is one of the most commonly used drugs by anesthesiologists. The World Health Organization (WHO) gave recommendations regarding perioperative oxygen administration, but the practice of oxygen use in anesthesia, critical emergency, and intensive care medicine remains unclear. Methods We conducted an online survey among members of the European Society of Anaesthesiology and Intensive Care (ESAIC). The questionnaire consisted of 46 queries appraising the perioperative period, emergency medicine and in the intensive care, knowledge about current recommendations by the WH
View details →Negative / Null Result ReportOpen accessEngineering
Rianne Haumann, John Bianco, Piotr Waranecki et al. · 2022 · Translational Medicine Communications
Abstract Background Diffuse intrinsic pontine glioma (DIPG) is a notoriously difficult tumor to treat, with an overall survival of DIPG patients being only 11 months. One of the major obstacles for the effective treatment of DIPG is the blood–brain barrier (BBB). In order to circumvent the BBB, drug delivery methods are needed that target the pontine area. One such approach is microbubble-mediated focused ultrasound (FUS)—a non-invasive method that can temporarily and locally open the BBB. Previously, it was shown that FUS is safe with minimal side effects and rapid recovery times in preclinic
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Courtney Davis, Anita K. Wagner, Maximilian Salcher‐Konrad et al. · 2023 · BMJ
OBJECTIVE: To evaluate the frequency with which relevant and accurate information about the benefits and related uncertainties of anticancer drugs are communicated to patients and clinicians in regulated information sources in Europe. DESIGN: Document content analysis. SETTING: European Medicines Agency. PARTICIPANTS: Anticancer drugs granted a first marketing authorisation by the European Medicines Agency, 2017-19. MAIN OUTCOME MEASURES: Whether written information on a product addressed patients' commonly asked questions about: who and what the drug is used for; how the drug was studied; typ
View details →Negative / Null Result ReportOpen accessMedicine
Olga V. Bocharova, Aidan Fisher, Narayan Pandit et al. · 2022 · Brain Pathology
The possibility that the etiology of late onset Alzheimer's disease is linked to viral infections of the CNS has been actively debated in recent years. According to the antiviral protection hypothesis, viral pathogens trigger aggregation…
View details →Negative / Null Result ReportOpen accessEngineering
Gábor Szabó, András Ágoston, Gábor Csató et al. · 2021 · Sensors
As demonstrated by earlier studies, pre-hospital triage with trans-telephonic electrocardiogram (TTECG) and direct referral for catheter therapy shows great value in the management of out-of-hospital chest pain emergencies. It does not only improve in-hospital mortality in ST-segment elevation myocardial infarction, but it has also been identified as an independent predictor of higher in-hospital survival rate. Since TTECG-facilitated triage shortens both transport time and percutaneous coronary intervention (PCI)-related procedural time intervals, it was hypothesized that even high-risk patie
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Deanna Schmitt, Dawn M. O’Dee, Joseph Horzempa et al. · 2012 · PLoS ONE
Vaccination is a proven strategy to mitigate morbidity and mortality of infectious diseases. The methodology of identifying and testing new vaccine candidates could be improved with rational design and in vitro testing prior to animal experimentation. The tularemia vaccine, Francisella tularensis live vaccine strain (LVS), does not elicit complete protection against lethal challenge with a virulent type A Francisella strain. One factor that may contribute to this poor performance is limited stimulation of antigen-presenting cells. In this study, we examined whether the interaction of genetical
View details →Negative / Null Result ReportOpen accessMedicine
Olivia Ruskin, Alexandra Sanelli, Alan Herschtal et al. · 2016 · Head & Neck
BACKGROUND: Recommended margins for thick cutaneous melanoma (Breslow thickness >4 mm; T4) have decreased over recent decades. Optimal margins and the role of sentinel node biopsy (SNB) in thick head and neck melanoma remain controversial.…
View details →Negative / Null Result Report
A Ovental, R Marom, E Botzer et al. · 2014 · Acta Paediatrica
Abstract Aim The US Food and Drug Administration has said that oral preparations containing benzocaine should only be used in infants under strict medical supervision, due to the rare, but potentially fatal, risk of methemoglobinemia. This…
View details →Negative / Null Result ReportOpen accessMedicine
Tyler Beck, Elena Wilson, Erik Wilkes et al. · 2023 · Itch
Chronic pruritus is a debilitating condition affecting 23-44 million Americans. Recently, kappa opioid agonists (KOAs) have emerged as a novel class of potent antipruritic agents. In 2021, the Food and Drug Administration approved…
View details →Negative / Null Result Report
Daniel R. Principe · 2022 · Scientific Reports
Abstract Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and are now the preferred treatment for several tumor types. Though ICIs have shown remarkable efficacy in several cancer histologies, in many cases providing…
View details →Negative / Null Result ReportOpen accessMedicine
Bai Wei, Se-Yeoun Cha, Min Kang et al. · 2015 · Journal of Ethnic Foods
Chongkukjang is a traditional Korean fermented product prepared from soybeans and reported to have multiple biological functions, including antidiabetic, antiinflammatory, and neuroprotective effects. Influenza is a respiratory disease caused by influenza viruses and continues to be a worldwide threat with a high potential to cause pandemics. Besides vaccination, only two classes of drugs are available for antiviral treatment against these pathogens. We tested the inhibitory activity of an ethyl acetate extract from Chongkukjang toward influenza A virus neuraminidase. All 10 compounds extracte
View details →Negative / Null Result Report
Nikola Vučinić, R. Shane Tubbs, Mirela Erić et al. · 2019 · Clinical Anatomy
The appearance of the face is one of the most important factors influencing our perception of beauty. However, few studies have attempted to quantitate what one perceives as beauty. Therefore, this study was conducted with the goal of…
View details →Negative / Null Result ReportOpen accessMedicine
Tomoyoshi Tamura, Hiromichi Narumiya, Koichiro Homma et al. · 2024 · Critical Care Medicine
OBJECTIVE: The Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID) II trial (jRCTs031180352) suggested that hydrogen inhalation may reduce post-cardiac arrest brain injury…
View details →Negative / Null Result ReportOpen accessMedicine
Nesli Ersoy, İlker Taşçı, Taner Özgürtaş et al. · 2018 · Nutrition Research and Practice
BACKGROUND/OBJECTIVES: Available data suggest that seasonal changes may influence the nutritional status and overall health of elderly individuals. Therefore, this study was conducted to investigate the effects of seasonal changes and…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Carlos Morales, Percy Marquina Feldman · 2013 · Journal of CENTRUM Cathedra (JCC) The Business and Economics Research Journal
An extensive literature review reveals various authors acknowledge skills have an impact on entrepreneurial success. However, a lack of consensus regarding the main skills an entrepreneur needs is apparent. In this study, a contribution is made to the debate with empirical data and analysis, in two steps: by testing mean differences and reducing data with a principal components analysis. A sample of 394 potential entrepreneurs was administered the SAT-ECENT questionnaire, testing four skills: readiness to change, learning capacity, impact on people, and stress tolerance. The questionnaires wer
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Aaron S. Weed · 2010 · Entomologia Experimentalis et Applicata
Abstract Several studies have shown that group feeding by immature insects enhances larval performance through feeding facilitation. However, the benefits of this behavior have not been studied for species that hatch off from their host…
View details →Negative / Null Result ReportMedicine
Alberto Zanchetti · 2016 · Journal of Hypertension
The articles published in the current issue of the Journal of Hypertension focus on risk factors for the development of hypertension and on the relationship of hypertension with cardiovascular disease. Two articles illustrate the role of…
View details →Negative / Null Result ReportPhysics and Astronomy
X. J. Li, Desheng Zhao, Desheng Jiang et al. · 2014 · Journal of Applied Physics
The significant effect of the thickness of Ni film on the performance of the Ohmic contact of Ni/Au to p-GaN is studied. The Ni/Au metal films with thickness of 15/50 nm on p-GaN led to better electrical characteristics, showing a lower…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Yvette A. Girard, Christine K. Johnson, Heather Fritz et al. · 2015 · International Journal for Parasitology Parasites and Wildlife
Tissue-cyst forming coccidia in the family Sarcocystidae are etiologic agents of protozoal encephalitis in marine mammals including the federally listed Southern sea otter (Enhydra lutris). California sea lions (Zalophus californianus),…
View details →Negative / Null Result ReportOpen accessMedicine
Alexander Falkenhagen, Marno Huyzers, Alberdina A. van Dijk et al. · 2021 · Viruses
The rotavirus species A (RVA) capsid contains the spike protein VP4, which interacts with VP6 and VP7 and is involved in cellular receptor binding. The capsid encloses the genome consisting of eleven dsRNA segments. Reassortment events can result in novel strains with changed properties. Using a plasmid-based reverse genetics system based on simian RVA strain SA11, we previously showed that the rescue of viable reassortants containing a heterologous VP4-encoding genome segment was strain-dependent. In order to unravel the reasons for the reassortment restrictions, we designed here a series of
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Jon P. Beckmann, Sarah H. Olson, Renee G. Seidler et al. · 2016 · Global Ecology and Conservation
To meet societal demands for energy, ∼50,000 gas sites are developed annually in North America, among which many are in western less-developed and wildlife rich areas. To evaluate effects of increasing energy infrastructure requires…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Sarah Agmon, Srinivas Kunta, Mery Dafny-Yelin et al. · 2022 · Crop Science
Abstract Stem rot, caused by the Sclerotium rolfsii , imposes severe yield losses in peanuts ( Arachis hypogaea L.) worldwide. Breeding for resistance is challenging because not enough is known about mechanisms for resistance. The goals of…
View details →Abandoned Hypothesis
Nicholas Smith, Darby Vickers · 2021 · Ethics and Information Technology
Abstract As artificial intelligence (AI) becomes ubiquitous, it will be increasingly involved in novel, morally significant situations. Thus, understanding what it means for a machine to be morally responsible is important for machine…
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