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Browse the failure-mode index

21,245 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Underestimating Calorie Content When Healthy Foods Are Present: An Averaging Effect or a Reference-Dependent Anchoring Effect?

Suzanna Forwood, Amy L. Ahern, Gareth J Hollands et al. · 2013 · PLoS ONE

OBJECTIVE: Previous studies have shown that estimations of the calorie content of an unhealthy main meal food tend to be lower when the food is shown alongside a healthy item (e.g. fruit or vegetables) than when shown alone. This effect has been called the negative calorie illusion and has been attributed to averaging the unhealthy (vice) and healthy (virtue) foods leading to increased perceived healthiness and reduced calorie estimates. The current study aimed to replicate and extend these findings to test the hypothesized mediating effect of ratings of healthiness of foods on calorie estimat

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Negative / Null Result ReportSocial Sciences

Career Indecision in China

Meghan Roche, Andrea Carr, In Heok Lee et al. · 2016 · Journal of Career Assessment

This study explored the measurement equivalence of the Career Indecision Profile (CIP) in a Chinese sample with both U.S. and South Korean samples. Past measurement invariance research on the CIP in four international samples (Icelandic…

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Negative / Null Result ReportOpen accessMedicine

Replication of H9 influenza viruses in the human ex vivo respiratory tract, and the influence of neuraminidase on virus release

Renee W. Y. Chan, Louisa Chan, Chris Ka Pun Mok et al. · 2017 · Scientific Reports

H9N2 viruses are the most widespread influenza viruses in poultry in Asia. We evaluated the infection and tropism of human and avian H9 influenza virus in the human respiratory tract using ex vivo respiratory organ culture. H9 viruses infected the upper and lower respiratory tract and the majority of H9 viruses had a decreased ability to release virus from the bronchus rather than the lung. This may be attributed to a weak neuraminidase (NA) cleavage of carbon-6-linked sialic acid (Sia) rather than carbon-3-linked Sia. The modified cleavage of N-acetlylneuraminic acid (Neu5Ac) and N-glycolylne

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Negative / Null Result ReportOpen accessNeuroscience

Psychological mechanisms of offset analgesia: The effect of expectancy manipulation

Tibor M. Szikszay, Wacław M. Adamczyk, Janina Panskus et al. · 2023 · PLoS ONE

A frequently used paradigm to quantify endogenous pain modulation is offset analgesia, which is defined as a disproportionate large reduction in pain following a small decrease in a heat stimulus. The aim of this study was to determine whether suggestion influences the magnitude of offset analgesia in healthy participants. A total of 97 participants were randomized into three groups (hypoalgesic group, hyperalgesic group, control group). All participants received four heat stimuli (two constant trials and two offset trials) to the ventral, non-dominant forearm while they were asked to rate the

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Comparing qPCR and DNA methylation-based measurements of telomere length in a high-risk pediatric cohort

Waylon J. Hastings, Laura Etzel, Christine M. Heim et al. · 2022 · Aging

Various approaches exist to assess population differences in biological aging. Telomere length (TL) is one such measure, and is associated with disease, disability and early mortality. Yet, issues surrounding precision and reproducibility are a concern for TL measurement. An alternative method to estimate TL using DNA methylation (DNAmTL) was recently developed. Although DNAmTL has been characterized in adult and elderly cohorts, its utility in pediatric populations remains unknown. We examined the comparability of leukocyte TL measurements generated using qPCR (absolute TL; aTL) to those esti

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Negative / Null Result ReportNeuroscience

On the usefulness of formal judgment tasks in syntax and in second-language research: The case of resumptive pronouns in English, Turkish, and Mandarin Chinese

John Hitz, Elaine J. Francis · 2016 · Linguistics

Abstract Gibson and Fedorenko (2013, The need for quantitative methods in syntax and semantics research, Language and Cognitive Processes 28(2), 88–124) have argued against the continued use of informally collected acceptability judgments…

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Negative / Null Result ReportBusiness, Management and Accounting

THE EFFECTS OF PERCEIVED SERVICE QUALITY ON PATIENT SATISFACTION AT A PUBLIC HOSPITAL IN STATE OF PAHANG, MALAYSIA

Noor Azlinna Azizan, Bahari Mohamed · 2013 · Asian journal of social sciences & humanities

This study focuses on the effects of perceived service quality on patient satisfaction in a public hospital. Data was collected from 109 respondents that experienced the hospital service. Using a PLS-SEM tool, the hypothesized effects…

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Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Glycomacromolecules to Tailor Crowded and Heteromultivalent Glycocalyx Mimetics

Luca‐Cesare Blawitzki, Nina Bartels, Lorand Bonda et al. · 2024 · Biomacromolecules

The glycocalyx, a complex carbohydrate layer on cell surfaces, plays a crucial role in various biological processes. Understanding native glycocalyces' complexity is challenging due to their intricate and dynamic nature. Simplified mimics…

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Negative / Null Result Report

Statistically-Based Trend Analysis of MTInSAR Displacement Time Series

Fabio Bovenga, Guido Pasquariello, Alberto Refice · 2021 · Remote Sensing

Current multi-temporal interferometric Synthetic Aperture Radar (MTInSAR) datasets cover long time periods with regular temporal sampling. This allows high-rate and non-linear trends to be observed, which typically characterize pre-failure…

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Negative / Null Result ReportSocial Sciences

Temporal shifts in Americans’ risk perceptions of the Zika outbreak

Branden B. Johnson, Marcus Mayorga · 2020 · Human and Ecological Risk Assessment An International Journal

Cross-sectional surveys, despite their value, are unable to probe dynamics of risk perceptions over time. An earlier longitudinal panel study of Americans’ views on Ebola risk inspired this partial replication on Americans’ views of Zika…

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Negative / Null Result ReportOpen accessEngineering

Assessment of Worn Textile Antennas’ Exposure on the Physiological Parameters and Well-Being of Adults

Khuzairi Masrakin, Hasliza A. Rahim, Ping Jack Soh et al. · 2019 · IEEE Access

This paper presents the assessment of short-term wireless body area network (WBAN) exposure, which is operated at the industrial, scientific, and medical (ISM) band (2.45 GHz) in the vicinity of the human body. The experiment utilizes two popular textile antenna topologies, a planar monopole and a patch antenna as the radiating sources. The objective of this experiment is to investigate whether the exposure from WBAN may influence the physiological parameters (body temperature, blood pressure, and heart rate) and the well-being of the wearer. Counter-balanced, crossover, and the single-blind m

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Negative / Null Result ReportOpen accessEnvironmental Science

Resolving a heated debate: The utility of prescribed burning as a management tool for biodiversity on lowland heath

Barbara Smith, Dan Carpenter, J. M. Holland et al. · 2023 · Journal of Applied Ecology

Abstract Lowland heath is a priority habitat for conservation, nowadays largely managed for biodiversity. Historically, prescribed burning has been the principal management tool, but there are increasing calls to substitute burning with cutting to improve biodiversity outcomes. However, poor understanding of potential impacts compromises decision making. Our study was carried out in the New Forest National Park, the largest area of lowland heath in Europe. Using a multi‐trophic approach, we compared the ecological impact of prescribed burning with two types of vegetation cutting (swiping and b

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Negative / Null Result ReportOpen accessNeuroscience

Subthalamic deep brain stimulation in Parkinson׳s disease has no significant effect on perceptual timing in the hundreds of milliseconds range

Thomas Cope, Manon Grube, Arnab Mandal et al. · 2014 · Neuropsychologia

Bilateral, high-frequency stimulation of the basal ganglia (STN-DBS) is in widespread use for the treatment of the motor symptoms of Parkinson׳s disease (PD). We present here the first psychophysical investigation of the effect of STN-DBS upon perceptual timing in the hundreds of milliseconds range, with both duration-based (absolute) and beat-based (relative) tasks; 13 patients with PD were assessed with their STN-DBS 'on', 'off', and then 'on' again. Paired parametric analyses revealed no statistically significant differences for any task according to DBS status. We demonstrate, from the exa

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Null DatasetOpen accessNeuroscience

Data visualization for inference in tomographic brain imaging

Cyril Pernet, Christopher R. Madan · 2019 · European Journal of Neuroscience

Tomographic imaging (i.e. magnetic resonance imaging [MRI], positron emission tomography [PET], X-ray computed tomography [CT]) offers a unique window in understanding structure-function relationships in the living brain. Nowadays, it is standard practice to acquire entire brain volumes and perform statistical analyses at each voxel, an approach known as statistical parametric mapping (Friston, Frith, Liddle, & Frackowiak, 1991). Because it is impossible to report the statistical results in every voxel, summary tables and figures are of importance. The choice made by authors to create such fig

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Negative / Null Result ReportOpen accessImmunology and Microbiology

HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly

Alex B. Kleinpeter, Donna L. Mallery, Nadine Renner et al. · 2024 · Nature Communications

The HIV-1 capsid is composed of capsid (CA) protein hexamers and pentamers (capsomers) that contain a central pore hypothesised to regulate capsid assembly and facilitate nucleotide import early during post-infection. These pore functions are mediated by two positively charged rings created by CA Arg-18 (R18) and Lys-25 (K25). Here we describe the forced evolution of viruses containing mutations in R18 and K25. Whilst R18 mutants fail to replicate, K25A viruses acquire compensating mutations that restore nearly wild-type replication fitness. These compensating mutations, which rescue reverse t

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Replication FailureOpen accessMedicine

Transarterial Chemoembolization Combined with Atezolizumab Plus Bevacizumab versus Transarterial Chemoembolization Alone in Intermediate‐stage Hepatocellular Carcinoma: A Multicenter Retrospective Study

Yitao Zheng, Yan‐Jun Xiang, Hongqi Shi et al. · 2024 · Journal of Hepatocellular Carcinoma

Purpose: Combining transarterial chemoembolization (TACE) with systemic therapy has shown significant efficacy for intermediate-stage hepatocellular carcinoma (HCC) patients. This study aimed to validate the therapeutic efficacy of TACE…

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Negative / Null Result ReportOpen accessPsychology

Examining the reliability and validity of two versions of the Effort-Expenditure for Rewards Task (EEfRT)

Hanno Andreas Ohmann, Niclas Kuper, Jan Wacker · 2022 · PLoS ONE

The Effort-Expenditure for Rewards Task (EEfRT) has gained validity evidence from several studies. However, various modifications have been applied to the original version, which have never been compared systematically. In Study 1, we tested 120 healthy participants to directly compare two versions of the EEfRT. In Study 2, we tested a larger sample of 394 healthy participants to further examine the original EEfRT. We replicated the split-half reliability of both task versions. However, self-reported personality traits (e.g., trait BAS) correlated with only some task performance parameters in

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Negative / Null Result Report

The Fragility Index of Statistically Significant Findings From Randomized Controlled Trials Comparing the Management Strategies of Anterior Shoulder Instability

Martin S. Davey, Eoghan T. Hurley, Tom R. Doyle et al. · 2022 · The American Journal of Sports Medicine

Background: Debate centering on the management of anterior shoulder instability (ASI) in recent years has led to many randomized controlled trials (RCTs) being published on the topic. The fragility index (FI) has subsequently emerged as a…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

PRKCZmethylation is associated with sunlight exposure in a North American but not a Mediterranean population

Stella Aslibekyan, Hassan S. Dashti, Toshiko Tanaka et al. · 2014 · Chronobiology International

Sunlight exposure has been shown to alter DNA methylation patterns across several human cell-types, including T-lymphocytes. Since epigenetic changes establish gene expression profiles, changes in DNA methylation induced by sunlight…

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Negative / Null Result ReportOpen accessNeuroscience

A large-scale genome-wide gene expression analysis in peripheral blood identifies very few differentially expressed genes related to antidepressant treatment and response in patients with major depressive disorder

Anne Krogh Nøhr, Morten Lindow, Annika Forsingdal et al. · 2021 · Neuropsychopharmacology

A better understanding of the biological factors underlying antidepressant treatment in patients with major depressive disorder (MDD) is needed. We perform gene expression analyses and explore sources of variability in peripheral blood related to antidepressant treatment and treatment response in patients suffering from recurrent MDD at baseline and after 8 weeks of treatment. The study includes 281 patients, which were randomized to 8 weeks of treatment with vortioxetine (N = 184) or placebo (N = 97). To our knowledge, this is the largest dataset including both gene expression in blood and pl

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Negative / Null Result ReportOpen accessNeuroscience

Emotion in Chinese Words Could Not Be Extracted in Continuous Flash Suppression

Kaiwen Cheng, Aolin Ding, Lianfang Jiang et al. · 2019 · Frontiers in Human Neuroscience

Previous studies have demonstrated the automatic vigilance effect for faces and pictures and have attributed it to the brain's prioritized unconscious evaluation of early evolutionary stimuli that are critical to survival. Whether this effect exists for evolutionarily more recent stimuli, such as written words, has become the center of much debate. Apparently contradicting results have been reported in different languages, such as Hebrew, English, and Traditional Chinese (TC), with regard to the unconscious processing of emotional words in breaking continuous flash suppression (b-CFS). Our cur

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