Negative / Null Result ReportOpen accessHealth Professions
Claire Henderson, Yasuhiro Kotera, Brynmor Lloyd‐Evans et al. · 2026 · World Psychiatry
Social inclusion means being able to participate in activities valued within one's community or wider society as one would wish. People with severe mental illness (i.e., psychoses, bipolar disorder, and severe depression) experience some…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Isabel O. Gallegos, Chen Shani, Weiyan Shi et al. · 2026 · PNAS Nexus
Abstract As generative AI enables the creation and dissemination of information at massive scale and speed, it is increasingly important to understand how people perceive AI-generated content. One prominent policy proposal requires explicitly labeling AI-generated content to increase transparency and encourage critical thinking about the information, but prior research has not yet tested the effects of such labels. To address this gap, we conducted a survey experiment (N=1,601) on a diverse sample of Americans, presenting participants with an AI-generated message about several public policies
View details →Negative / Null Result ReportOpen accessMedicine
Katherine L. Ford, Michael B. Sawyer, Sunita Ghosh et al. · 2024 · ESMO Open
•Patients were able to increase and sustain dietary protein intake from preintervention levels.•Over one-half of patients in the 2.0 g/kg/day group maintained or gained MM with a 12-week targeted nutrition intervention.•This work…
View details →Negative / Null Result ReportOpen accessNeuroscience
Brian Premchand, Liyuan Liang, Kok Soon Phua et al. · 2024 · NeuroSci
Detecting stress is important for improving human health and potential, because moderate levels of stress may motivate people towards better performance at cognitive tasks, while chronic stress exposure causes impaired performance and health risks. We propose a Brain-Computer Interface (BCI) system to detect stress in the context of high-pressure work environments. The BCI system includes an electroencephalogram (EEG) headband with dry electrodes and an electrocardiogram (ECG) chest belt. We collected EEG and ECG data from 40 participants during two stressful cognitive tasks: the Cognitive Vig
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Aras Fahrettin Korkmaz, Fatih Ekinci, Şehmus Altaş et al. · 2025 · Biology
This study presents a novel approach for classifying Discomycetes species using deep learning and explainable artificial intelligence (XAI) techniques. The EfficientNet-B0 model achieved the highest performance, reaching 97% accuracy, a 97% F1-score, and a 99% AUC, making it the most effective model. MobileNetV3-L followed closely, with 96% accuracy, a 96% F1-score, and a 99% AUC, while ShuffleNet also showed strong results, reaching 95% accuracy and a 95% F1-score. In contrast, the EfficientNet-B4 model exhibited lower performance, achieving 89% accuracy, an 89% F1-score, and a 93% AUC. These
View details →Negative / Null Result ReportOpen accessMedicine
Peter A. Merkel, Michael George, Huibin Yue et al. · 2025 · ACR Open Rheumatology
OBJECTIVE: This study aimed to report the safety of avacopan, an oral selective complement C5a receptor antagonist, using pooled data from clinical trials in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis…
View details →Negative / Null Result ReportOpen accessMedicine
Liangsuo Ma, Larry Keen, Joel L. Steinberg et al. · 2024 · NeuroImage
• Resting- state fMRI data were acquired from 34 healthy participants. • Effective connectivities (ECs) associated with HRV and heart rate were investigated. • Regression DCM and ICA were used to identify most relevant network nodes. • ECs…
View details →Negative / Null Result ReportOpen accessMedicine
Deborah Salvo, Inácio Crochemore-Silva, Andrea Wendt et al. · 2026 · Nature Medicine
With over 5 million attributed deaths per year, physical inactivity is a major global public health issue. Although the importance of physical activity is well recognized within the scope of obesity and cardiometabolic disease prevention…
View details →Negative / Null Result ReportOpen accessMaterials Science
Rong Guo, Qiuzheng Du, Yaping He et al. · 2026 · Nano-Micro Letters
Single-atom nanozymes (SAzymes) exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metal-carrier interactions, which have attracted significant attention in the biomedical field. However, stability issues may impede the clinical translation of SAzymes. This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields, including disease diagnosis (e.g., biosensors and diagnostic imaging), antitumor therapy (e.g., photothermal therapy, photodynamic therapy, sonodynamic therapy, and immunotherapy), antim
View details →Negative / Null Result ReportOpen accessArts and Humanities
Miya Williams Fayne, Stephanie Edgerly · 2025 · Mass Communication & Society
This study examines three forms of news avoidance (repertoire, self-identified, and topical) among Black Americans and the overlap between the different forms. We center African Americans, who are often ignored or stereotyped by mainstream…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Astrid Marinoni, John L. Voorheis · 2026 · Research Policy
The question of who gains from high-quality entrepreneurship is crucial to understanding whether investments in innovative startup firms produce socially beneficial outcomes. Although entrepreneurship is widely viewed as a central driver…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Aayush Saxena, Alex J. Cameron, Harley Katz et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT The ultraviolet (UV) continuum slope of galaxies, $\beta$, is a powerful diagnostic of the metallicity and ages of stars, nebular gas properties, dust content, and the escape of Lyman continuum (LyC) photons. In this study, we present $\beta$ measurements for 395 spectroscopically confirmed galaxies at $5 \lt z \lt 14.3$ selected primarily from JADES, using high-quality JWST (James Webb Space Telescope) NIRSpec/PRISM spectra. We find a median $\beta = -2.15$, finding a mild increase in blueness of $\beta$ with increasing redshift and fainter UV magnitudes. Interestingly, we find evide
View details →Negative / Null Result ReportOpen accessNeuroscience
Mariia Bocharova, Tom Borza, Leiv Otto Watne et al. · 2025 · Molecular Psychiatry
Late-life depression (LLD) has been linked to increased likelihood of dementia, although mechanisms responsible for this association remain largely unknown. One feature frequently observed in both LLD and dementia is elevated levels of plasma inflammatory markers. The present study aimed to compare the levels of 12 plasma inflammatory markers between older people with LLD and controls, and to explore whether these markers, along with clinical characteristics, can predict dementia in patients with LLD within 3 years of follow-up. Using multiple linear regression with stepwise adjustment, we com
View details →Negative / Null Result ReportOpen accessMedicine
Jeremy McGale, Harrison J. Howell, Arnaud Beddok et al. · 2024 · Pharmaceuticals
The integration of artificial intelligence (AI) and positron emission tomography (PET) imaging has the potential to become a powerful tool in drug discovery. This review aims to provide an overview of the current state of research and highlight the potential for this alliance to advance pharmaceutical innovation by accelerating the development and deployment of novel therapeutics. We previously performed a scoping review of three databases (Embase, MEDLINE, and CENTRAL), identifying 87 studies published between 2018 and 2022 relevant to medical imaging (e.g., CT, PET, MRI), immunotherapy, arti
View details →Negative / Null Result ReportOpen accessEngineering
Yue Zhao, Jiang Su, Zhengzhen An et al. · 2026 · Applied Sciences
Coal gangue is one of the most abundant solid wastes generated during coal mining. The use of coal gangue for underground backfilling is widely recognized as an effective approach to reducing waste accumulation and promoting sustainable utilization. To further investigate the bearing and deformation behavior of underground gangue filling materials, combined with the underground occurrence conditions of crushed gangue in goaf, a self-designed loading apparatus for crushed gangue was employed to perform lateral compression experiments on crushed gangue. The compaction deformation, fractal dimens
View details →Negative / Null Result ReportOpen accessPsychology
Mina Kian, Mingyu Zong, Katrin Fischer et al. · 2026 · Frontiers in Robotics and AI
Mental health is a significant healthcare challenge, and cognitive behavioral therapy (CBT) is a widely used therapeutic method for treating anxiety and depression. However, traditional CBT often requires access to trained clinicians and can be cost-prohibitive or logistically difficult for many individuals. To address these barriers, we developed a low-cost socially assistive robot (SAR) that uses a large language model (LLM) to guide the user through interactive at-home CBT exercises. In this exploratory study, 38 university students completed CBT exercises across a 15-day period using one o
View details →Negative / Null Result ReportOpen accessDecision Sciences
Yuan Ma, Wenchao Zhang, Chengxiang Ma et al. · 2025 · International Review of Economics & Finance
In an era defined by digital transformation, artificial intelligence (AI) has emerged as a critical driver of corporate competitiveness, yet the mechanisms through which it enhances innovation remain a key area of inquiry. This study…
View details →Negative / Null Result ReportOpen accessMedicine
Pan Min, Huike Chen, Kai Deng et al. · 2025 · Micromachines
The female reproductive system represents a highly complex regulatory network governing critical physiological functions, encompassing reproductive capacity and endocrine regulation that maintains female physiological homeostasis. The in vitro simulation system provides a novel tool for biomedical research and can be used as physiological and pathological models to study the female reproductive system. Recent advances in this technology have evolved from 2D and 3D printing to organ-on-a-chip (OOC) and microfluidic systems, which has emerged as a transformative platform for modeling the female
View details →Negative / Null Result ReportOpen accessNeuroscience
Shyanthony R. Synigal, Andrew J. Anderson, Edmund C. Lalor · 2026 · eNeuro
ABSTRACT The past few years have seen an increase in the use of encoding models to explain neural responses to natural speech. The goal of these models is to characterize how the human brain converts acoustic energy into distinct linguistic representations that enable everyday speech comprehension. For example, researchers have shown that electroencephalography (EEG) data can be modeled in terms of acoustic features of speech, such as its amplitude envelope or spectrogram, linguistic features such as phonemes and phoneme probability, and higher-level linguistic features like context-based word
View details →Negative / Null Result ReportOpen accessMedicine
Miao Cai, Taeyoung Choi, Yan Xie et al. · 2026 · BMJ
OBJECTIVES: To investigate whether initiation of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with both reduced risks of incident alcohol, cannabis, cocaine, nicotine, opioid, and other substance use disorders (SUDs) in…
View details →Negative / Null Result ReportOpen accessMedicine
Margareth C. Ozelo, Jane Mason, Amy L. Dunn et al. · 2025 · Journal of Thrombosis and Haemostasis
BACKGROUND: Valoctocogene roxaparvovec, an adeno-associated virus vector that transfers a human factor (F)VIII (FVIII) coding sequence to hepatocytes, provides bleeding protection for people with severe hemophilia A. OBJECTIVES: Determine…
View details →Negative / Null Result ReportOpen accessMedicine
Stefan Schreiber, Konrad Aden, Florian Tran et al. · 2025 · Gut
The clinical and molecular heterogeneity of IBD—both between patients and within the same individual over time—continues to pose a significant challenge to the implementation of truly personalised treatment strategies. Unlike oncology,…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Yuldoshboy Sobirov, Beruniy Artikov, Elbek Khodjaniyazov et al. · 2025 · Sustainability
This study examines the long-run relationship between carbon dioxide (CO2) emissions and key macroeconomic and sectoral drivers in ten ASEAN economies from 1995 to 2023. Employing Driscoll–Kraay standard errors, Prais–Winsten regression, heteroskedastic panel-corrected standard errors, Fully Modified Ordinary Least Squares (FMOLS), Dynamic Ordinary Least Squares (DOLS), and Canonical Cointegrating Regression (CCR) estimators, the analysis accounts for cross-sectional dependence, slope heterogeneity, and endogeneity. Results indicate that GDP exerts a more-than-unitary positive effect on emissi
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Yayaati Chachan, Jonathan J. Fortney, Kazumasa Ohno et al. · 2025 · The Astrophysical Journal
Abstract The rate at which giant planets accumulate solids and gas is a critical component of planet formation models, yet it is extremely challenging to predict from first principles. Characterizing the heavy element (everything other than hydrogen and helium) content of giant planets provides important clues about their provenance. Using thermal evolution models with an updated H–He equation of state and atmospheric boundary conditions that vary with envelope metallicity, we quantify the bulk heavy element content of 147 warm (<1000 K) giant planets with well-measured masses and radii, mo
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Fengqiu Adam Dong, Kaitlyn Shin, Casey Law et al. · 2025 · The Astrophysical Journal Letters
Abstract We report the discovery of CHIME J1634+44, a long-period radio transient (LPT) unique for two aspects: it is the first known LPT to emit fully circularly polarized radio bursts, and it is the first LPT with a significant spin-up. Given that high circular polarization (>90%) has been observed in FRB 20201124A and in some giant pulses of PSR B1937+21, we discuss the implications of the high circular polarization of CHIME J1634+44 and conclude its emission mechanism is likely to be “pulsar-like.” While CHIME J1634+44 has a pulse period of 841 s, its burst arrival patterns are indicati
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Alì Soltani, Parviz Azizi, Aliasghar Rahimioun et al. · 2025 · Journal of Urban Management
The escalating complexities of rapid urbanization necessitate a paradigm shift in urban form evaluation, moving beyond traditional horizontal analyses to incorporate the crucial dimension of vertical growth. This study pioneers a volumetric approach, integrating 3D and 2D spatial analyses, to dissect compactness, sprawl, and their underlying drivers across two contrasting metropolitan regions: the Tehran Metropolitan Region (TMR) and the Greater Sydney Region (GSR) over a 40-year period (1980s–2020s). Our findings reveal a striking dichotomy: TMR exhibits pronounced ‘vertical sprawl,’ characte
View details →Negative / Null Result ReportOpen accessSocial Sciences
Sumit Agarwal, Meghana Ayyagari, Yuxi Cheng et al. · 2026 · Management Science
This paper examines how infrastructure development affects stock market participation in India using trading data from more than 13 million individuals. Using the phased rollout of a national road construction program as a natural…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
T.C. Bruinjé, S.J. LeBlanc · 2025 · Animals
In the early postpartum period, dairy cows undergo significant adaptations in Ca and lipid metabolism, immune function, and inflammatory processes. Concurrent exposure to endotoxins from the uterus, gastrointestinal tract, or mammary gland increases the risk of disease and reproductive problems. Metabolic and inflammatory imbalances during this phase can have both immediate and long-term effects on reproductive health. Associations between metabolic disorders and reproductive outcomes are often confounded by immune activation and systemic inflammation. However, optimal markers, thresholds, and
View details →Replication FailureOpen accessMedicine
Xiaoyu Kang, Mingxing Xia, Jun Wang et al. · 2025 · Gut
BACKGROUND: Recent meta-analyses suggested diclofenac may be superior to indomethacin in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The aim of our study was to compare the efficacy of 100 mg…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Rasit Dinc, Nurittin Ardıç · 2026 · Cells
Exosomes and other extracellular vesicles (EVs) carry microRNAs, proteins, and lipids that reflect cardiovascular pathophysiology and can enable minimally invasive biomarker discovery. However, EV datasets are highly dimensional and heterogeneous, strongly influenced by pre-analytic variables and non-standardized isolation/characterization workflows, limiting reproducibility across studies. Artificial intelligence (AI), including machine learning (ML), deep learning (DL), and network-based approaches, can support EV biomarker development by integrating multi-omics profiles with clinical metada
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