Negative / Null Result ReportOpen accessMedicine
Antonella Ferro, Michela Campora, A. Caldara et al. · 2024 · Journal of Clinical Medicine
Estrogen receptor (ER)-positive breast cancer (BC) is the most common BC subtype. Endocrine therapy (ET) targeting ER signaling still remains the mainstay treatment option for hormone receptor (HR)-positive BC either in the early or in advanced setting, including different strategies, such as the suppression of estrogen production or directly blocking the ER pathway through SERMs—selective estrogen receptor modulators—or SERDs—selective estrogen receptor degraders. Nevertheless, the development of de novo or acquired endocrine resistance still remains challenging for oncologists. The use of no
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Annalisa Petrelli, Sabrina Rizzolio, Filippo Pietrantonio et al. · 2023 · Cancer Research
Despite negative results of clinical trials conducted on the overall population of patients with gastric cancer, PARP inhibitor (PARPi) therapeutic strategy still might represent a window of opportunity for a subpopulation of patients with…
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Haiming Liu, Jiaohua Luo, Bobby Guillory et al. · 2020 · Oncotarget
// Haiming Liu 1 , 2 , * , Jiaohua Luo 3 , 4 , * , Bobby Guillory 3 , Ji-an Chen 3 , 5 , Pu Zang 3 , 6 , Jordan K. Yoeli 3 , Yamileth Hernandez 3 , Ian (In-gi) Lee 1 , 2 , Barbara Anderson 1 , 2 , Mackenzie Storie 1 , 2 , Alison Tewnion 1 and Jose M. Garcia 1 , 2 , 3 1 Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA 2 Gerontology and Geriatric Medicine, University of Washington Department of Medicine, Seattle, WA, USA 3 Division of Endocrinology, Diabetes and Metabolism, MCL, Center for Translational Research on Inflammatory
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Maarten Korrel, Sanne Lof, Jony van Hilst et al. · 2020 · Annals of Surgical Oncology
BACKGROUND: Surgical factors, including resection of Gerota's fascia, R0-resection, and lymph node yield, may be associated with survival after distal pancreatectomy (DP) for pancreatic ductal adenocarcinoma (PDAC), but evidence from large multicenter studies is lacking. This study aimed to identify predictors for overall survival after DP for PDAC, especially those related to surgical technique. PATIENTS AND METHODS: Data from an international retrospective cohort including patients from 11 European countries and the USA who underwent DP for PDAC (2007-2015) were analyzed. Cox proportional ha
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Vandana Chaturvedi, Nora Lakes, Minh H. Tran et al. · 2021 · Blood
Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory disorder in which numerous cytokines are elevated, though interferon-γ (IFN-γ) is central to disease pathogenesis and a key therapeutic target. Experimental and early clinical…
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Ronak G Gandhi, Camille N Kotton · 2022 · Therapeutics and Clinical Risk Management
Purpose of Review: Cytomegalovirus (CMV) infections are a common complication in solid organ (SOT) and hematopoietic stem cell transplant (HSCT) recipients, leading to increased morbidity and mortality. Currently available treatment…
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Aldina Mešić, Emahlea Jackson, Mathias Lalika et al. · 2022 · PLOS Global Public Health
The interferon (IFN) system is a potent line of defense against viral infections. IFN-based agents already tested may be of use in COVID-19 or future viral respiratory outbreaks. Here we review the comparative efficacy, safety/tolerability, and future potential of IFN-based therapeutics. We reviewed human studies in which IFN or IFN pathway-interacting agents were used for viral respiratory infections. We identified 977 articles, of which 194 were included for full-text review. Of these, we deemed 35 articles to be relevant. The use of IFN-based agents for pre-exposure prophylaxis (n = 19) and
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Michelle Xiao, Joseph Donahue, Marc R. Safran et al. · 2020 · Arthroscopy The Journal of Arthroscopic and Related Surgery
Purpose To discern differences between the PearlDiver and MarketScan databases with regards to patient demographics, costs, reoperations, and complication rates for isolated meniscectomy. Methods We queried the PearlDiver Humana Patient…
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Amie Fairs, Kristof Strijkers · 2021 · PLOS ONE
The closure of cognitive psychology labs around the world due to the COVID-19 pandemic has prevented in-person testing. This has caused a particular challenge for speech production researchers, as before the pandemic there were no studies…
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Kazuyuki Uehara, Takashi Sasayama, Daisuke Miyawaki et al. · 2012 · Radiation Oncology
BACKGROUND: The purpose of the present study was to analyze the recurrence pattern of high-grade glioma treated with a multimodal treatment approach and to evaluate whether the MIB-1 labeling index (LI) could be a useful marker for predicting the pattern of failure in glioblastoma (GB). METHODS AND MATERIALS: We evaluated histologically confirmed 131 patients with either anaplastic astrocytoma (AA) or GB. A median dose was 60 Gy. Concomitant and adjuvant chemotherapy were administered to 111 patients. MIB-1 LI was assessed by immunohistochemistry. Recurrence patterns were categorized according
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Berna Harmse, Herculina S. Kruger · 2011 · PubMed
Low-grade systemic inflammation is emerging as a component of the metabolic syndrome. The purpose of this study was to assess the association between serum C-reactive protein (CRP), physical activity and body composition in 193 black children aged 13 to 18 years from a South African township. Demographic information and anthropometric measurements were taken, and fasting blood samples were analysed for high-sensitivity serum CRP. Body fat was measured by air displacement plethysmography. There was a trend towards higher serum CRP in the boys with a higher percentage body fat. After multiple re
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Marina A Pak, Dmitry N Ivankov · 2022 · Bioinformatics
Abstract Motivation Prediction of protein stability change upon mutation (ΔΔG) is crucial for facilitating protein engineering and understanding of protein folding principles. Robust prediction of protein folding free energy change…
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Sheeva Bhattarai, Tore Framstad, Jens Peter Nielsen · 2019 · Acta Veterinaria Scandinavica
Abstract Background Anemia characterized by low hemoglobin concentration (HbC) is common in indoor housed pregnant sows. Iron is essential for hemoglobin synthesis and a number of metabolic processes including DNA synthesis and regulation…
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Mylène Potier, Gilles Fromentin, Aurélie Lesdema et al. · 2010 · British Journal of Nutrition
Whether protein is the macronutrient with the strongest satiety effect remains a matter of debate because of the diversity of study designs employed. The aim of the present study was to compare the effect of different liquid preloads made…
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John Guenther, Samuel Osborne · 2020 · The Australian Journal of Indigenous Education
Abstract Over the 10 years of ‘Closing the Gap’, several interventions designed to improve outcomes for Aboriginal and Torres Strait Islander students have been trialled. In 2014 the Australian Government announced the ‘Flexible Literacy…
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Anne Watson, Leon A. Barmuta · 2011 · Marine and Freshwater Research
The loss of connectivity in intermittent streams can limit aquatic-invertebrate access to food resources, with different resources available in individual pools. Although leaf litter was abundant in the Macquarie River in Tasmania, stable…
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Michał Borys, Beata Potręć-Studzińska, Marcin Wiech et al. · 2019 · Anaesthesiology Intensive Therapy
Background Sparse data exist on the prevalence and severity of chronic postsurgical pain (CPSP) following cesarean section. Our study aimed to compare the effectiveness of transversus abdominis plane (TAP) block and…
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Miled El Hajji · 2018 · International Journal of Biomathematics
In this paper, I consider two species feeding on limiting substrate in a chemostat taking into account some possible effects of each species on the other one. System of differential equations is proposed as model of these effects with…
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Benjamin Udoka Nwosu, Layana Al-Halbouni, Sadichchha Parajuli et al. · 2021 · Frontiers in Endocrinology
Importance There is no consensus on the impact of the 2020 COVID-19 pandemic lockdown on glycemic control in children and adolescents with type 1 diabetes (T1D) in the US. Aim To determine the impact of the pandemic lockdown of March 15th…
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Vasilios A. Raoulis, Aristidis Zibis, Maria Dimitra Chiotelli et al. · 2021 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract Purpose The purpose of this study was to compare the maximum load to failure and stiffness of three medial patella‐femoral ligament (MPFL) reconstruction techniques: (i) suture anchor fixation (SA), (ii) interference screw…
View details →Negative / Null Result ReportOpen accessHealth Professions
Osea Giuntella, Johannes König, Luca Stella · 2025 · Scientific Reports
This study explores the relationship between artificial intelligence (AI) and workers' well-being and health using longitudinal survey data from Germany (2000-2020). Using a measure of occupational exposure to AI, we explore an event study…
View details →Negative / Null Result ReportOpen accessEngineering
Poundoss Chellamuthu, Kirubaveni Savarimuthu, M. Gulam Nabi Alsath et al. · 2026 · Scientific Reports
Chronic Obstructive Pulmonary Disease (COPD) is a progressively debilitating and life-threatening respiratory condition that has long been attributed to exposure to airborne toxic substances like carbon monoxide (CO), a reliable biomarker…
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Hayato Omori, Yutaka Tanizawa, Rie Makuuchi et al. · 2018 · World Journal of Surgery
BACKGROUND: The REGATTA trial showed that gastrectomy followed by chemotherapy for advanced gastric cancer with a single non-curable factor did not improve survival outcomes in comparison with chemotherapy alone. Chemotherapy is therefore…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Carmella Evans‐Molina, Richard A. Oram · 2025 · Diabetes Obesity and Metabolism
Type 1 diabetes (T1D) has been historically regarded as a childhood-onset disease; however, recent epidemiological data indicate that adult-onset T1D accounts for a substantial proportion of cases worldwide. There is evidence that…
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P. Gamborg Nielsen, S Madsen, L. Strömberg · 2026 · Acta Dermato Venereologica
The effects of a hydrocolloid dressing (Comfeel Ulcus) on the physical environment of chronic leg ulcers in 58 consecutive out-patients were investigated. Patients were subdivided into two groups of which Group 1 included 31 (53.4%) and…
View details →Negative / Null Result ReportOpen accessComputer Science
Bismark Nyaaba Akanzire, Matthew Nyaaba, Macharious Nabang · 2025 · Journal of Digital Educational Technology
This rapid study explores teacher educators’ perceptions of generative artificial intelligence (GenAI) in teacher education, conducted through a descriptive survey involving 55 teacher educators from two colleges of education in Ghana. A convenience sampling technique was adopted for data collection, and a data analysis using <i>exploratory factor analysis</i> was used to identify primary factors shaping perceptions and preparedness of GenAI integration. Key findings reveal a generally positive perception among the teacher educators, who recognize GenAI’s potential to support acade
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Noriyuki Otsuki, Yuichiro Nakatsu, Toru Kubota et al. · 2013 · PLoS ONE
Canine distemper virus (CDV) becomes able to use human receptors through a single amino acid substitution in the H protein. In addition, CDV strains possessing an intact C protein replicate well in human epithelial H358 cells. The present study showed that CDV strain 007Lm, which was isolated from lymph node tissue of a dog with distemper, failed to replicate in H358 cells, although it possessed an intact C protein. Sequence analyses suggested that a cysteine-to-tyrosine substitution at position 267 of the V protein caused this growth defect. Analyses using H358 cells constitutively expressing
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Michelle Curran, John P. Campbell, Mark T. Drayson et al. · 2026 · PubMed
Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that targets and destroys insulin-secreting pancreatic beta cells. Beta cell specific T cells are highly differentiated and show evidence of previous antigen exposure.…
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Bruce Cree, Joseph R. Berger, Benjamin Greenberg · 2025 · CNS Drugs
B-cell depletion with CD20-targeted agents is commonly used for treatment of multiple sclerosis (MS), other autoimmune diseases, and certain hematologic malignancies. Initial apparent success with rituximab in MS and neuromyelitis optica…
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Osama Sobhi Moaket, Sarah Eyad Obaid, Fawaz Eyad Obaid et al. · 2025 · International Journal of Molecular Sciences
Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and depression, are marked by progressive neuronal dysfunction and loss, yet current treatments remain largely symptomatic with limited disease-modifying efficacy. Glucagon-like peptide-1 (GLP-1), an incretin hormone traditionally associated with metabolic regulation, has emerged as a promising neuroprotective agent. Its receptor, GLP-1R, is expressed in key brain regions implicated in cognition, emotion, and motor control, including the hippocampus, frontal cortex, and substantia nigra. GLP-1R a
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