Negative / Null Result ReportOpen accessMedicine
Xiaodong Wang, Jing He, Gouping Ding et al. · 2025 · Frontiers in Immunology
Immune checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 have achieved groundbreaking clinical success in multiple cancers; however, a large proportion of patients experience primary or acquired resistance. This review synthesizes the complex mechanisms underlying resistance to PD-1/CTLA-4 blockade and surveys emerging strategies to overcome them. Resistance arises from multifaceted interactions among tumor-intrinsic alterations (e.g., epigenetic silencing of antigen presentation machinery via EZH2/PRC2, oncogenic pathway-driven upregulation of PD-L1, genetic loss of IFNγ pathway componen
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ahmet Jeyhunov, Jong Dae Kim, Seong Mi Bae · 2025 · Sustainability
This paper explores the effect of board diversity on environmental, social, and governance (ESG) performance in Korean-listed firms using regression analysis. Our findings reveal that an increased board size significantly correlates with higher ESG scores when combined with other board diversity dimensions. The presence of female directors on boards was found to have a significant effect on environmental and social components of ESG performance. Age diversity exhibits a negative association with ESG scores, emphasizing potential disruptions from intergenerational differences. Foreign directors
View details →Negative / Null Result ReportOpen accessComputer Science
Emma Croxford, Yanjun Gao, Elliot First et al. · 2025 · npj Digital Medicine
Electronic Health Records (EHRs) contain vast clinical data that are difficult for providers to synthesize. Generative AI with Large Language Models (LLMs) can summarize records to reduce cognitive burden, but ensuring accuracy requires…
View details →Negative / Null Result ReportOpen accessEngineering
Jianghui Zheng, Guoliang Wang, Leiping Duan et al. · 2025 · Nature Nanotechnology
Abstract Triple‐junction solar cells theoretically outperform their double-junction and single‐junction counterparts in power conversion efficiency, yet practical perovskite–perovskite–silicon devices have fallen short of both theoretical limits and commercial targets. To address surface defects in the top perovskite junction, we introduce a piperazine-1,4-diium chloride treatment, which replaces less stable lithium fluoride. For interfacing the top and middle perovskite junctions, we optimize the size of gold nanoparticles deposited on atomic layer-deposited tin oxide for best ohmic contactin
View details →Failed Experiment ReportOpen accessMedicine
Robert E. Coleman, Ying Zhou, Danielle Jandial et al. · 2021 · Advances in Therapy
INTRODUCTION: D-CARE, an international, phase 3, randomized, double-blind, placebo-controlled study in women with early-stage breast cancer at high risk of disease recurrence, failed to meet its primary endpoint-improvement in bone…
View details →Negative / Null Result Report
A. Cazor, A. Schmidt, J. Shatrov et al. · 2022 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract Purpose The purpose of this study was to evaluate the clinical outcomes and survivorship at minimum 10‐year follow‐up of patients undergoing primary valgisation high tibial osteotomy (HTO) for medial osteoarthritis (OA), treated…
View details →Negative / Null Result ReportOpen accessNeuroscience
Lloyd Christopher Smith · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This paper forms part of Mirror Programme, Volume I: Observerhood. Mirror Mathematics II develops the formal threshold layer of the Mirror Mathematics arc. Building on Mirror Mathematics I, it asks when a self-model becomes observer-relevant rather than merely predictive, self-referential or descriptive. The paper introduces a minimal Mirror observer predicate grounded in self-model reliability, action-guidance, cost-sensitive repair and positive viability coupling under perturbation. The central condition is expressed through a salience functional measuring whether the expected viability bene
View details →Replication FailureOpen accessMedicine
Triin Kikas, Kristiina Rull, Robin N. Beaumont et al. · 2019 · Frontiers in Genetics
= 6830) did not replicate these findings. In summary, the study emphasizes the role of genetic variation in driving the transcriptome profile of the human placenta and the importance to explore further its functional implications.
View details →Negative / Null Result ReportOpen accessMedicine
Natalia Spasova, Desislava Somleva, Bozhidar Krastev et al. · 2024 · Folia Medica
Introduction : Trimethylamine-N-oxide (TMAO) is a metabolite produced by intestinal microbiota. It is well recognized as an independent risk marker for cardiovascular and renal diseases and mortality. Aim : The aim of the present study was…
View details →Negative / Null Result Report
Michael Hoppe, Alastair B. Ross, Cecilia Svelander et al. · 2018 · European Journal of Nutrition
Abstract Purpose To investigate the effects of eating wholegrain rye bread with high or low amounts of phytate on iron status in women under free-living conditions. Methods In this 12-week, randomized, parallel-design intervention study,…
View details →Negative / Null Result Report
Shiekh Marifatul Haq, Muhammad Waheed, Riyaz Ahmad et al. · 2023 · Biology
The distribution of large ungulates is more often negatively impacted by the changing climate, especially global warming and species with limited distributional zones. While developing conservation action plans for the threatened species…
View details →Negative / Null Result Report
Hunter Warwick, Carolyn Hutyra, Cary Politzer et al. · 2019 · Clinical Orthopaedics & Related Research
Abstract Background The generalizability of data derived from patient-reported outcome measures (PROMs) depends largely on the proportion of the relevant population that completes PROM surveys. However, PROM survey responses remain low,…
View details →Negative / Null Result Report
Thomas L. Delworth, William F. Cooke, Vaishali Naik et al. · 2022 · Proceedings of the National Academy of Sciences
The Mediterranean region has been identified as a climate hot spot, with models projecting a robust warming and rainfall decline in response to increasing greenhouse gases. The projected rainfall decline would have impacts on agriculture…
View details →Negative / Null Result Report
Vladimir Nikitović, Vesna Lukić · 2010 · International Migration
Abstract Serbia still hosts the largest number of forced migrants in Europe. The paper examines the impact of the refugee influx from newly formed states on the territory of the Socialist Federal Republic of Yugoslavia (SFRY) into Serbia…
View details →Negative / Null Result ReportOpen accessMedicine
Michelle Beam, Angela G. Spencer, Lauralee Fernandez et al. · 2018 · American Journal of Tropical Medicine and Hygiene
larvae (neurocysticercosis) is a leading cause of preventable epilepsy worldwide. Effective and sustainable strategies to control parasite transmission in rural endemic communities are needed to prevent the disease. Surveillance and…
View details →Negative / Null Result ReportOpen accessMedicine
Yue Yang, Dominic B. Rowe, Heather McCann et al. · 2023 · Neuropathology and Applied Neurobiology
AIMS: Although the orally available brain-penetrant copper compound CuATSM has demonstrated promising effects in SOD1-linked mouse models, the impact of CuATSM on disease pathology in patients with amyotrophic lateral sclerosis (ALS) remains unknown. METHODS: The present study set out to address this deficit by performing the first pilot comparative analysis of ALS pathology in patients that had been administered CuATSM and riluzole [N = 6 cases composed of ALS-TDP (n = 5) and ALS-SOD1 (n = 1)] versus riluzole only [N = 6 cases composed of ALS-TDP (n = 4) and ALS-SOD1 (n = 2)]. RESULTS: Our re
View details →Negative / Null Result ReportOpen accessSocial Sciences
Daniel Lee, Gwendolyn Gardiner, Erica Baranski et al. · 2020 · Journal of Personality
OBJECTIVE: The current study seeks to replicate and extend principal findings reported in The World at 7:00, a project that examined the psychological experience of situations in 20 countries. METHOD: Data were collected from participants…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Matthijs J. H. M. van der Loos, Philipp Koellinger, Patrick J. F. Groenen et al. · 2011 · Small Business Economics
Candidate gene studies of human behavior are gaining interest in economics and entrepreneurship research. Performing and interpreting these studies is not straightforward because the selection of candidates influences the interpretation of…
View details →Negative / Null Result ReportPsychology
Valeriia V. Vlasenko, Emma G. Rogers, Christian E. Waugh · 2021 · Cognition & Emotion
Although affect labelling has been widely reported to decrease negative emotions, it is less clear whether affect labelling also decreases positive emotions. In four studies, we explored how affect labelling (choosing the emotion that best…
View details →Negative / Null Result ReportOpen accessMedicine
Geovani de Oliveira Ribeiro, Antônio Charlys da Costa, Danielle Elise Gill et al. · 2021 · Scientific Reports
Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying principles of mammalian pathogenicity. Here we describe the genetic characterization of a novel putative
View details →Negative / Null Result ReportOpen accessMedicine
Steven J. Kiddle, Nicola Voyle, Richard J.B. Dobson · 2018 · Journal of Alzheimer s Disease
Ever since the discovery of APOEɛ4 around 25 years ago, researchers have been excited about the potential of a blood test for Alzheimer's disease (AD). Since then researchers have looked for genetic, protein, metabolite, and/or gene…
View details →Negative / Null Result ReportOpen accessMedicine
Kushala Abeysekera, James Orr, Paul Madley‐Dowd et al. · 2021 · The Lancet Regional Health - Europe
BACKGROUND: The importance of the maternal-infant dyad in the genesis of nonalcoholic fatty liver disease (NAFLD) is of increasing interest. The Avon Longitudinal Study of Parents and Children (ALSPAC) showed that at age 24, 1 in 5 had…
View details →Replication Failure
Brian Chin, Andrea Copeland, Lucas Gallo et al. · 2019 · Plastic & Reconstructive Surgery
Background: The fragility index has been proposed as a metric to evaluate the robustness of statistically significant findings in randomized controlled trials. It measures the number of events that a trial result relies on to maintain…
View details →Negative / Null Result ReportOpen accessMaterials Science
Kimberly M. Sogi, Zev J. Gartner, Mark A. Breidenbach et al. · 2013 · PLoS ONE
The genome of Mycobacterium tuberculosis (Mtb) encodes nine putative sulfatases, none of which have a known function or substrate. Here, we characterize Mtb's single putative type II sulfatase, Rv3406, as a non-heme iron (II) and α-ketoglutarate-dependent dioxygenase that catalyzes the oxidation and subsequent cleavage of alkyl sulfate esters. Rv3406 was identified based on its homology to the alkyl sulfatase AtsK from Pseudomonas putida. Using an in vitro biochemical assay, we confirmed that Rv3406 is a sulfatase with a preference for alkyl sulfate substrates similar to those processed by Ats
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Irina Travkina, Manuela Tvaronavičienė · 2015 · Journal of Entrepreneurship and Sustainability Issues
The research paper discusses the relationship between international trade, especially export, and the economic growth, presented by GDP, in Lithuania over the period of 2000-2015 years. The analysis is started by the historical review of possible types of relationships between exports and economic growth. Furthermore, the paper presents four theoretical propositions as export-led growth (1), growth-driven export (2), a feedback relationship (3) and simple contemporaneous relationship (4). This study examines the importance of the export-led growth hypothesis for Lithuania. The testing is based
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
John F. Krisko, Nurjahan Begum, Caroline E. Baker et al. · 2016 · Journal of Virology
UNLABELLED: The multifunctional HIV-1 accessory protein Vif counters the antiviral activities of APOBEC3G (A3G) and APOBEC3F (A3F), and some Vifs counter stable alleles of APOBEC3H (A3H). Studies in humanized mice have shown that HIV-1…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Neil D. Clarke, James R. Thomas, Marion Kagka et al. · 2016 · The Journal of Strength and Conditioning Research
Clarke, ND, Thomas, JR, Kagka, M, Ramsbottom, R, and Delextrat, A. No dose-response effect of carbohydrate mouth rinse concentration on 5-km running performance in recreational athletes. J Strength Cond Res 31(3): 715-720, 2017-Oral…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Rebecca Fisher, David R. Fox · 2023 · Environmental Toxicology and Chemistry
The no-effect concentration (NEC) is the preferred threshold metric for single-species toxicity tests applied to derive safe concentration thresholds for contaminants in the environment for use in species sensitivity distributions.…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Wei Hu · 2013 · Social Networking
Various networks exist in the world today including biological, social, information, and communication networks with the Internet as the largest network of all. One salient structural feature of these networks is the formation of groups or communities of vertices that tend to be more connected to each other within the same group than to those outside. Therefore, the detection of these communities is a topic of great interest and importance in many applications and different algorithms including label propagation have been developed for such purpose. Speaker-listener label propagation algorithm
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Benjamin L. Rambo‐Martin, Jennifer G. Mulle, David J. Cutler et al. · 2017 · G3 Genes Genomes Genetics
One in five people with Down syndrome (DS) are born with an atrioventricular septal defect (AVSD), an incidence 2000 times higher than in the euploid population. The genetic loci that contribute to this risk are poorly understood. In this study, we tested two hypotheses: (1) individuals with DS carrying chromosome 21 copy number variants (CNVs) that interrupt exons may be protected from AVSD, because these CNVs return AVSD susceptibility loci back to disomy, and (2) individuals with DS carrying chromosome 21 genes spanned by microduplications are at greater risk for AVSD because these microdup
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