Monocyte matrix metalloproteinase production in Type 2 diabetes and controls – a cross sectional study
Davies Isabel R; Gavrilovic Jelena; Baugh Mark D; Hughes David A; Sampson Mike J · 2003 · Cardiovascular Diabetology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Coronary plaque rupture may result from localised over expression of matrix metalloproteinases (MMPs) within the plaque by infiltrating monocyte – macrophages. As MMP expression can be promoted by the modified lipoproteins, oxidative stress and hyperglycaemia that characterises Type 2 diabetes, we hypothesised that peripheral monocytes in these patients, exposed to these factors in vivo, would demonstrate increased MMP production compared to controls. Methods We examined peripheral venous monocyte expression of MMP and tissue inhibitor of metalloproteinase-1 (TIMP-1) in 18
Abstract by Davies Isabel R; Gavrilovic Jelena; Baugh Mark D; Hughes David A; Sampson Mike J, Cardiovascular Diabetology (2003) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/1475-2840-2-3