Impacts of ketogenic diet intervention on cardiometabolic outcomes in obese, dysglycemic mice
Cassandra A. A. Locatelli; My-Anh Nguyen; Nadya M. Morrow; Elena Cameron; Natasha A. Trzaskalski; Ilka Lorenzen-Schmidt; Arianne Morissette; Erin E. Mulvihill · 2026 · Cardiovascular Diabetology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background The ketogenic diet (KD) is widely recognized for its potential benefits in individuals with type 2 diabetes, but findings from both human and animal studies remain inconsistent. Type 2 diabetes is often comorbid with liver steatosis and atherosclerosis which are characterized by inflammation and dysregulated lipid metabolism. Moreover, whereas KD has shown mixed, sometimes detrimental, effects on circulating cholesterol levels in humans, it is currently unclear the whole-body balance of risk and benefit across hepatic, atherosclerotic, and pancreatic effects. Methods We use
Abstract by Cassandra A. A. Locatelli; My-Anh Nguyen; Nadya M. Morrow; Elena Cameron; Natasha A. Trzaskalski; Ilka Lorenzen-Schmidt; Arianne Morissette; Erin E. Mulvihill, Cardiovascular Diabetology (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12933-025-03046-3