ClpP-deletion impairs the virulence of Legionella pneumophila and the optimal translocation of effector proteins
Beibei Zhao; Xianghui Li; Yonglun Zeng; Yongjun Lu · 2016 · BMC Microbiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: The opportunistic bacterial pathogen Legionella pneumophila uses substrate effectors of Dot/Icm type IVB secretion system (T4BSS) to accomplish survival and replication in amoebae cells and mammalian alveolar macrophages. During the conversion between its highly resistant, infectious dormant form and vigorously growing, uninfectious replicative form, L. pneumophila utilizes a complicated regulatory network in which proteolysis may play a significant role. As a highly conserved core protease, ClpP is involved in various cellular processes as well as virulence in bacteria, and has be
Abstract by Beibei Zhao; Xianghui Li; Yonglun Zeng; Yongjun Lu, BMC Microbiology (2016) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12866-016-0790-8