Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences
Silvia Tietz; Marcel Zwahlen; Neda Haghayegh Jahromi; Pascale Baden; Ivana Lazarević; Gaby Enzmann; Britta Engelhardt · 2016 · European Journal of Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis.…
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Metadata source: OpenAlex · DOI 10.1002/eji.201546272