Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Julie Clasen, Anders Fogh, Morten Kargo · 2018 · Journal of Dairy Science
Crossbreeding in dairy cattle has recently become of increased interest. However, farmers in Scandinavian countries are reluctant to implement crossbreeding in their herds, and one reason is the common opinion that only herds at a poor…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Melony J. Sellars, M Rao, SJ Arnold et al. · 2011 · Diseases of Aquatic Organisms
Gill-associated virus (GAV) is a nidovirus that commonly infects Penaeus monodon (black tiger shrimp) in eastern Australia, causing morbidity and mortalities in the acute stage of disease. Here we explored the possibility of inhibiting GAV…
View details →Negative / Null Result ReportOpen accessMedicine
Gonzague Jourdain, Sophie Le Cœur, Nicole Ngo‐Giang‐Huong et al. · 2013 · PLoS Medicine
BACKGROUND: Viral load (VL) is recommended for monitoring the response to highly active antiretroviral therapy (HAART) but is not routinely available in most low- and middle-income countries. The purpose of the study was to determine whether a CD4-based monitoring and switching strategy would provide a similar clinical outcome compared to the standard VL-based strategy in Thailand. METHODS AND FINDINGS: The Programs for HIV Prevention and Treatment (PHPT-3) non-inferiority randomized clinical trial compared a treatment switching strategy based on CD4-only (CD4) monitoring versus viral-load (VL
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michel Michaelides, Cagri G. Besirli, Yesa Yang et al. · 2024 · American Journal of Ophthalmology
PURPOSE: To assess the safety and efficacy of AAV5-hRKp.RPGR in participants with retinitis pigmentosa GTPase regulator (RPGR)-associated X-linked retinitis pigmentosa (XLRP). DESIGN: Open-label, phase 1/2 dose escalation/expansion study (ClinicalTrials.gov Identifier: NCT03252847). METHODS: vg/ml) was administered to the poorer-seeing eye (n = 10). Dose confirmation (intermediate dose) was carried out in 3 pediatric participants. In the dose expansion phase, 36 participants were randomized 1:1:1 to immediate (low or intermediate dose) or deferred (control) treatment. The primary outcome was s
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tasia Amelia, Jacobus P. D. van Veldhoven, Matteo Falsini et al. · 2021 · Journal of Medicinal Chemistry
receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction between the partial agonist, belonging to a class of dicyanopyridines, and amino…
View details →Negative / Null Result ReportOpen accessMedicine
Wilhelmina G. Melsen, Anne Marie G. A. de Smet, Jan Kluytmans et al. · 2011 · British journal of surgery
BACKGROUND: Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) are effective in improving survival in patients under intensive care. In this study possible differential effects in surgical and…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Thomas Lindebo Holm, Steen Seier Poulsen, Helle Markholst et al. · 2012 · International Journal of Inflammation
Animal models are important tools in the development of new drug candidates against the inflammatory bowel diseases (IBDs) Crohn's disease and ulcerative colitis. In order to increase the translational value of these models, it is important to increase knowledge relating to standard drugs. Using the SCID adoptive transfer colitis model, we have evaluated the effect of currently used IBD drugs and IBD drug candidates, that is, anti-TNF-α, TNFR-Fc, anti-IL-12p40, anti-IL-6, CTLA4-Ig, anti-α4β7 integrin, enrofloxacin/metronidazole, and cyclosporine. We found that anti-TNF-α, antibiotics, anti-IL-
View details →Negative / Null Result ReportOpen accessMedicine
Yuri Chaves Martins, Graziela Maria Zaniní, John A. Frangos et al. · 2012 · PLoS ONE
BACKGROUND: Low nitric oxide (NO) bioavailability plays a role in the pathogenesis of human as well as of experimental cerebral malaria (ECM) caused by Plasmodium berghei ANKA (PbA). ECM is partially prevented by administration of the NO-donor dipropylenetriamine NONOate (DPTA-NO) at high concentration (1 mg/mouse), which also induces major side effects such as a sharp drop in blood pressure. We asked whether alternative strategies to improve NO bioavailability with minor side effects would also be effective in preventing ECM. METHODOLOGY/PRINCIPAL FINDINGS: Mice were infected with PbA and pro
View details →Negative / Null Result ReportOpen accessMedicine
João Pedro Ferreira, Francisco Vasques‐Nóvoa, Diana Ferrão et al. · 2022 · Diabetes Care
OBJECTIVE: Patients with type 2 diabetes (T2D) have a high risk for developing heart failure (HF), which is associated with poor prognosis. Fenofibrate may reduce HF events through multiple mechanisms. We sought to study the effect of…
View details →Negative / Null Result ReportOpen accessMedicine
Michael Huang, Kenneth G. Lucas · 2010 · Sarcoma
Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, there has been little improvement in survival rates for patients with metastatic or recurrent ES. Herein we review the different current therapeutic approaches available, including the different upfront and salvage chemotherapy regimens, the role for stem cell transplantation, and potential use of immunotherapy.
View details →Negative / Null Result Report
Ann M. Mitchell, Lauren Terhorst · 2016 · Journal of the American Psychiatric Nurses Association
BACKGROUND: Although bereavement is not usually considered the type of stressor associated with posttraumatic stress disorder (PTSD), a risk factor often associated with poorer bereavement outcomes is when a death is sudden and unexpected.…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Michael P. Vandenbergh, Paul C Stern · 2026
Abstract Government laws and policies have produced substantial gains in environmental quality, but they have failed to achieve climate mitigation goals. Elinor Ostrom explored how resource users developed nongovernmental institutions to…
View details →Replication FailureOpen accessMedicine
Lena Hafrén, Elísabet Einarsdóttir, Erna Kentala et al. · 2015 · PLoS ONE
BACKGROUND: Predisposition to childhood otitis media (OM) has a strong genetic component, with polymorphisms in innate immunity genes suspected to contribute to risk. Studies on several genes have been conducted, but most associations have failed to replicate in independent cohorts. METHODS: We investigated 53 gene polymorphisms in a Finnish cohort of 624 cases and 778 controls. A positive association signal was followed up in a tagging approach and tested in an independent Finnish cohort of 205 cases, in a British cohort of 1269 trios, as well as in two cohorts from the United States (US); on
View details →Negative / Null Result ReportOpen accessMedicine
Junjie Ding, Nguyễn Thụy Thương Thương, Toi Van Pham et al. · 2020 · Clinical Pharmacology & Therapeutics
The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regimen did not improve survival or any other outcome. We therefore conducted a nested pharmacokinetic/pharmacodynamic study in 237 trial participants to define exposure-response relationships that might explain the trial results and improve future therapy. Rifampin 15 mg/kg increased plasma and cerebrospinal fluid (CSF) e
View details →Negative / Null Result ReportOpen accessComputer Science
Tarek Ali, Panos Kostakos, Saeid Sheikhi · 2026 · Telecom
Machine learning (ML) methods for network anomaly detection are emerging as effective proactive strategies in threat hunting, substantially reducing the time required for threat detection and response. However, the challenges in training and maintaining ML models, coupled with frequent false positives, diminish their acceptance and trustworthiness. In response, Explainable AI (XAI) techniques have been introduced to enable cybersecurity operations teams to assess alerts generated by AI systems more confidently. Despite these advancements, XAI tools have encountered limited acceptance from inci
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sara Zehtabcheh, Hamed Soleimani Samarkhazan, Marjan Asadi et al. · 2025 · Biomarker Research
Acute myeloid leukemia (AML) with KMT2A rearrangements (KMT2A-r) represents a highly aggressive and prognostically unfavorable subtype of leukemia, often resistant to standard treatments and associated with high relapse rates. KMT2A-r, found in 3-10% of adult AML cases, disrupt epigenetic regulation by forming chimeric proteins that activate oncogenic pathways like HOXA and MEIS1. These fusion proteins recruit cofactors such as Menin and DOT1L, driving leukemogenesis through abnormal histone methylation. Diagnosing KMT2A-r AML requires precision, with traditional methods like FISH and RT-PCR b
View details →Negative / Null Result ReportOpen accessMedicine
Ruben A. Mesa, Jean‐Jacques Kiladjian, Srđan Verstovšek et al. · 2013 · Haematologica
Prior to Janus kinase inhibitors, available therapies for myelofibrosis were generally supportive and did not improve survival. This analysis compares efficacy outcomes of patients with myelofibrosis in the control arms (placebo [n=154]…
View details →Negative / Null Result ReportOpen accessMedicine
Virve I. Enne, Susan Stirling, Julie Barber et al. · 2025 · Intensive Care Medicine
PURPOSE: INHALE investigated the impact of seeking pathogens by PCR on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia (HAP and VAP). METHODS: This pragmatic multicentre, open-label RCT…
View details →Negative / Null Result Report
Shoichi Kuramitsu, Hitoshi Matsuo, Tomohiro Shinozaki et al. · 2020 · Circulation: Cardiovascular Interventions
Background: The safety of fractional flow reserve (FFR)-based deferral of revascularization remains to be fully established in real-world practice. We sought to assess clinical outcomes after deferral of revascularization based on FFR.…
View details →Negative / Null Result Report
Nicole Sneath · 2010 · Neonatal Network
Background: Peripherally inserted central catheters (PICCs) are commonly used in NICUs. Although they have many benefits, they also have many potential complications. Confirming catheter tip position is essential to decreasing…
View details →Negative / Null Result ReportOpen accessNeuroscience
Timo Stein, Deema Awad, Surya Gayet et al. · 2018 · Journal of Experimental Psychology General
Visual stimuli with social-emotional relevance have been claimed to gain preferential access to awareness. For example, recent studies used the breaking continuous flash suppression paradigm (b-CFS) to show that faces that are perceived as less dominant and more trustworthy are prioritized for awareness. Here we asked whether these effects truly reflect differences in social-emotional meaning or whether they can be equally explained by differences in low-level stimulus properties. In Experiment 1, we successfully replicated dominance- and untrustworthiness-related slowing for upright faces. Ho
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Rania Magadmi, Judit Mészáros, Zoheir A. Damanhouri et al. · 2019 · Frontiers in Cellular Neuroscience
Neuroimmune interactions are important in the pathophysiology of many chronic inflammatory diseases, particularly those associated with alterations in sensory processing and pain. Mast cells and sensory neuron nerve endings are found in areas of the body exposed to the external environment; both are specialized to sense potential damage by injury or pathogens and signal to the immune system and nervous system respectively, to elicit protective responses. Cell adhesion molecule 1 (CADM1), also known as SynCAM1, has previously been identified as an adhesion molecule which may couple mast cells t
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Theocharis Ispoglou, D. A. O’Kelly, Athanasia Angelopoulou et al. · 2015 · The Journal of Strength and Conditioning Research
Mouth rinsing with carbohydrate (CHO) solutions during cycling time trials results in performance enhancements; however, most studies have used approximately 6% CHO solutions. Therefore, the purpose of this study was to compare the…
View details →Negative / Null Result Report
Camille Lique, Michael Steele · 2012 · Journal of Geophysical Research: Oceans
Recent mooring observations in the Arctic Basin suggest the existence of a seasonality of Atlantic Water (AW) temperature. Here the DRAKKAR global ocean/sea‐ice model is used to examine the seasonal cycle amplitude of AW temperature within…
View details →Negative / Null Result ReportPsychology
Shengquan Ye, Ting Kin Ng, Kin Hang Yim et al. · 2015 · Journal of Personality Assessment
This study aimed at validating the Curiosity and Exploration Inventory-II (CEI-II; Kashdan et al., 2009 ) in a Chinese context. A total of 294 Chinese first-year undergraduate students in Hong Kong completed the CEI-II and measures of…
View details →Negative / Null Result ReportHealth Professions
Richard D. Lennox, David A. Sharar, Eileen Schmitz et al. · 2010 · Journal of Workplace Behavioral Health
This article describes the development and validation of a five-item scale Workplace Outcome Suite designed as an open access instrument aimed at facilitating empirical research on Employee Assistance Program (EAP) interventions. The suite…
View details →Negative / Null Result ReportOpen accessNeuroscience
David D. Aguilar, Robert E. Strecker, Radhika Basheer et al. · 2019 · Journal of Neurophysiology
The type 5 metabotropic glutamate receptor (mGluR5) represents a novel therapeutic target for schizophrenia and other disorders. Schizophrenia is associated with progressive abnormalities in cortical oscillatory processes including reduced…
View details →Negative / Null Result ReportOpen accessNeuroscience
Logan A. Pendergrast, L Lundell, Amy M. Ehrlich et al. · 2023 · Proceedings of the National Academy of Sciences
The circadian clock is a cell-autonomous transcription–translation feedback mechanism that anticipates and adapts physiology and behavior to different phases of the day. A variety of factors including hormones, temperature, food-intake,…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sofia G. Seabra, Inês Fragata, Marta A. Antunes et al. · 2017 · Molecular Biology and Evolution
Experimental evolution is a powerful tool to understand the adaptive potential of populations under environmental change. Here, we study the importance of the historical genetic background in the outcome of evolution at the genome-wide level. Using the natural clinal variation of Drosophila subobscura, we sampled populations from two contrasting latitudes (Adraga, Portugal and Groningen, Netherlands) and introduced them in a new common environment in the laboratory. We characterized the genome-wide temporal changes underlying the evolutionary dynamics of these populations, which had previously
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Shobana Raghunath, Siba K. Samal, Subbiah Elankumaran · 2013 · Journal of Virology
Oncolytic virus (OV) therapies of cancer are based on the use of replication-competent, tumor-selective viruses with limited toxicity. Newcastle disease virus (NDV), an avian paramyxovirus, is a promising OV and is inherently tumor…
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