Negative / Null Result ReportOpen accessNeuroscience
David J. Caldwell, Jeneva A. Cronin, Jing Wu et al. · 2019 · Scientific Reports
Direct cortical stimulation (DCS) of primary somatosensory cortex (S1) could help restore sensation and provide task-relevant feedback in a neuroprosthesis. However, the psychophysics of S1 DCS is poorly studied, including any comparison to cutaneous haptic stimulation. We compare the response times to DCS of human hand somatosensory cortex through electrocorticographic grids with response times to haptic stimuli delivered to the hand in four subjects. We found that subjects respond significantly slower to S1 DCS than to natural, haptic stimuli for a range of DCS train durations. Median respon
View details →Negative / Null Result ReportMedicine
Emilie Sundqvist, Peter Sundström, Magdalena Lindén et al. · 2012 · Neurology
BACKGROUND: Epstein-Barr virus infection, smoking, HLA-A*02, and DRB1*15 have all been proposed as risk factors for multiple sclerosis (MS). In 2010, Simon et al. described an interaction on the multiplicative scale between EBNA1…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ullrich K. H. Ecker, Brandon K. N. Sze, Matthew Andreotta · 2021 · Philosophical Transactions of the Royal Society B Biological Sciences
Misinformation often has a continuing effect on people's reasoning despite clear correction. One factor assumed to affect post-correction reliance on misinformation is worldview-driven motivated reasoning. For example, a recent study with an Australian undergraduate sample found that when politically situated misinformation was retracted, political partisanship influenced the effectiveness of the retraction. This worldview effect was asymmetrical, that is, particularly pronounced in politically conservative participants. However, the evidence regarding such worldview effects (and their symmetr
View details →Negative / Null Result ReportEngineering
Narayana Raju, Shriniwas Arkatkar, Gaurang Joshi · 2019 · Journal of Intelligent Transportation Systems
This research work is focused on modeling vehicle following behavior under mixed traffic conditions. Vehicle-following behavior can be potentially utilized in building real-time drivers’ assistance systems or identifying collision escaping…
View details →Negative / Null Result Report
Johannes Claßen, Stefan Pischinger, Sascha Krysmon et al. · 2020 · International Journal of Engine Research
The progression of emission legislation has intensified the efforts of the automotive industry to develop improved exhaust gas after-treatment systems. The requirement to fulfill Euro 6d-TEMP in real-world driving scenarios, the already…
View details →Negative / Null Result ReportImmunology and Microbiology
Jennifer Kyle, Cameron Casey, Kelly G. Stratton et al. · 2016 · Rapid Communications in Mass Spectrometry
RATIONALE: The use of dried blood spots (DBS) has many advantages over traditional plasma and serum samples such as the smaller blood volume required, storage at room temperature, and ability to sample in remote locations. However,…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Roberta Amoriello, Maria Chernigovskaya, Victor Greiff et al. · 2021 · EBioMedicine
BACKGROUND: T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Although several studies recently investigated the T-cell receptor…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Almut Balleer · 2012 · Quantitative Economics
Can the standard search-and-matching labor market model replicate the business cycle fluctuations of the job finding rate and the unemployment rate? In the model, these fluctuations are driven by movements in productivity. This paper…
View details →Negative / Null Result ReportMathematics
Arthur J. Baroody, Michael D. Eiland, David J. Purpura et al. · 2013 · American Educational Research Journal
In a 9-month training experiment, 64 first graders with a risk factor were randomly assigned to computer-assisted structured discovery of the add-1 rule (e.g., the sum of 7 + 1 is the number after “seven” when we count), unstructured…
View details →Negative / Null Result ReportOpen accessMedicine
Ruby Yu, Grace Leung, Jean Woo · 2021 · International Journal of Environmental Research and Public Health
(1) Objective: This study examined the effects of a combined intervention of Brainastic computerized cognitive training (CCT) preceded by physical exercise (PE) for improving frailty status and cognitive function in older adults. (2) Methods: Older adults aged 50 years or older attending elderly centers, without frailty/history of cognitive impairment, were randomly allocated into either a 12-week (i) multi-domain CCT + PE (n = 117), (ii) two-domain CCT + PE (n = 116) or (iii) video watching + PE (i.e., control, n = 114). Brainastic is an online application for cognitive training through video
View details →Negative / Null Result Report
Ariana L. Smith, Alan J. Wein · 2011 · BJU International
OBJECTIVE • To evaluate the statistical and clinical efficacy of the pharmacological treatments of nocturia using non‐antidiuretic agents. PATIENTS AND METHODS • A literature review of treatments of nocturia specifically addressing the…
View details →Negative / Null Result ReportPsychology
Margaret‐Anne Mackintosh, James Niehaus, Casey T. Taft et al. · 2017 · Military Medicine
OBJECTIVE: Anger is a symptom of post-traumatic stress disorder (PTSD) associated with a range of clinical and functional impairments, and may be especially prevalent among veterans with PTSD. Effective anger management therapies exist but…
View details →Negative / Null Result ReportEnvironmental Science
Di Tian, Christopher J. Martinez, W. D. Graham et al. · 2014 · Journal of Climate
Abstract This study compared two types of approaches to downscale seasonal precipitation (P) and 2-m air temperature (T2M) forecasts from the North American Multimodel Ensemble (NMME) over the states of Alabama, Georgia, and Florida in the…
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Ali Aminian, Mohammad Jamal, Toms Augustin et al. · 2015 · Diabetes Technology & Therapeutics
The metabolic profile of patients after a failed surgical weight loss procedure is unknown. Long-term clinical outcomes of 31 obese diabetes patients with post–bariatric surgery excess weight loss of ≤25% were assessed. At a median…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Julie Clasen, Anders Fogh, Morten Kargo · 2018 · Journal of Dairy Science
Crossbreeding in dairy cattle has recently become of increased interest. However, farmers in Scandinavian countries are reluctant to implement crossbreeding in their herds, and one reason is the common opinion that only herds at a poor…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Melony J. Sellars, M Rao, SJ Arnold et al. · 2011 · Diseases of Aquatic Organisms
Gill-associated virus (GAV) is a nidovirus that commonly infects Penaeus monodon (black tiger shrimp) in eastern Australia, causing morbidity and mortalities in the acute stage of disease. Here we explored the possibility of inhibiting GAV…
View details →Negative / Null Result ReportOpen accessMedicine
Gonzague Jourdain, Sophie Le Cœur, Nicole Ngo‐Giang‐Huong et al. · 2013 · PLoS Medicine
BACKGROUND: Viral load (VL) is recommended for monitoring the response to highly active antiretroviral therapy (HAART) but is not routinely available in most low- and middle-income countries. The purpose of the study was to determine whether a CD4-based monitoring and switching strategy would provide a similar clinical outcome compared to the standard VL-based strategy in Thailand. METHODS AND FINDINGS: The Programs for HIV Prevention and Treatment (PHPT-3) non-inferiority randomized clinical trial compared a treatment switching strategy based on CD4-only (CD4) monitoring versus viral-load (VL
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michel Michaelides, Cagri G. Besirli, Yesa Yang et al. · 2024 · American Journal of Ophthalmology
PURPOSE: To assess the safety and efficacy of AAV5-hRKp.RPGR in participants with retinitis pigmentosa GTPase regulator (RPGR)-associated X-linked retinitis pigmentosa (XLRP). DESIGN: Open-label, phase 1/2 dose escalation/expansion study (ClinicalTrials.gov Identifier: NCT03252847). METHODS: vg/ml) was administered to the poorer-seeing eye (n = 10). Dose confirmation (intermediate dose) was carried out in 3 pediatric participants. In the dose expansion phase, 36 participants were randomized 1:1:1 to immediate (low or intermediate dose) or deferred (control) treatment. The primary outcome was s
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tasia Amelia, Jacobus P. D. van Veldhoven, Matteo Falsini et al. · 2021 · Journal of Medicinal Chemistry
receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction between the partial agonist, belonging to a class of dicyanopyridines, and amino…
View details →Negative / Null Result ReportOpen accessMedicine
Wilhelmina G. Melsen, Anne Marie G. A. de Smet, Jan Kluytmans et al. · 2011 · British journal of surgery
BACKGROUND: Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) are effective in improving survival in patients under intensive care. In this study possible differential effects in surgical and…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Thomas Lindebo Holm, Steen Seier Poulsen, Helle Markholst et al. · 2012 · International Journal of Inflammation
Animal models are important tools in the development of new drug candidates against the inflammatory bowel diseases (IBDs) Crohn's disease and ulcerative colitis. In order to increase the translational value of these models, it is important to increase knowledge relating to standard drugs. Using the SCID adoptive transfer colitis model, we have evaluated the effect of currently used IBD drugs and IBD drug candidates, that is, anti-TNF-α, TNFR-Fc, anti-IL-12p40, anti-IL-6, CTLA4-Ig, anti-α4β7 integrin, enrofloxacin/metronidazole, and cyclosporine. We found that anti-TNF-α, antibiotics, anti-IL-
View details →Negative / Null Result ReportOpen accessMedicine
Yuri Chaves Martins, Graziela Maria Zaniní, John A. Frangos et al. · 2012 · PLoS ONE
BACKGROUND: Low nitric oxide (NO) bioavailability plays a role in the pathogenesis of human as well as of experimental cerebral malaria (ECM) caused by Plasmodium berghei ANKA (PbA). ECM is partially prevented by administration of the NO-donor dipropylenetriamine NONOate (DPTA-NO) at high concentration (1 mg/mouse), which also induces major side effects such as a sharp drop in blood pressure. We asked whether alternative strategies to improve NO bioavailability with minor side effects would also be effective in preventing ECM. METHODOLOGY/PRINCIPAL FINDINGS: Mice were infected with PbA and pro
View details →Negative / Null Result ReportOpen accessMedicine
João Pedro Ferreira, Francisco Vasques‐Nóvoa, Diana Ferrão et al. · 2022 · Diabetes Care
OBJECTIVE: Patients with type 2 diabetes (T2D) have a high risk for developing heart failure (HF), which is associated with poor prognosis. Fenofibrate may reduce HF events through multiple mechanisms. We sought to study the effect of…
View details →Negative / Null Result ReportOpen accessMedicine
Michael Huang, Kenneth G. Lucas · 2010 · Sarcoma
Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, there has been little improvement in survival rates for patients with metastatic or recurrent ES. Herein we review the different current therapeutic approaches available, including the different upfront and salvage chemotherapy regimens, the role for stem cell transplantation, and potential use of immunotherapy.
View details →Negative / Null Result Report
Ann M. Mitchell, Lauren Terhorst · 2016 · Journal of the American Psychiatric Nurses Association
BACKGROUND: Although bereavement is not usually considered the type of stressor associated with posttraumatic stress disorder (PTSD), a risk factor often associated with poorer bereavement outcomes is when a death is sudden and unexpected.…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Michael P. Vandenbergh, Paul C Stern · 2026
Abstract Government laws and policies have produced substantial gains in environmental quality, but they have failed to achieve climate mitigation goals. Elinor Ostrom explored how resource users developed nongovernmental institutions to…
View details →Replication FailureOpen accessMedicine
Lena Hafrén, Elísabet Einarsdóttir, Erna Kentala et al. · 2015 · PLoS ONE
BACKGROUND: Predisposition to childhood otitis media (OM) has a strong genetic component, with polymorphisms in innate immunity genes suspected to contribute to risk. Studies on several genes have been conducted, but most associations have failed to replicate in independent cohorts. METHODS: We investigated 53 gene polymorphisms in a Finnish cohort of 624 cases and 778 controls. A positive association signal was followed up in a tagging approach and tested in an independent Finnish cohort of 205 cases, in a British cohort of 1269 trios, as well as in two cohorts from the United States (US); on
View details →Negative / Null Result ReportOpen accessMedicine
Junjie Ding, Nguyễn Thụy Thương Thương, Toi Van Pham et al. · 2020 · Clinical Pharmacology & Therapeutics
The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regimen did not improve survival or any other outcome. We therefore conducted a nested pharmacokinetic/pharmacodynamic study in 237 trial participants to define exposure-response relationships that might explain the trial results and improve future therapy. Rifampin 15 mg/kg increased plasma and cerebrospinal fluid (CSF) e
View details →Negative / Null Result ReportOpen accessComputer Science
Tarek Ali, Panos Kostakos, Saeid Sheikhi · 2026 · Telecom
Machine learning (ML) methods for network anomaly detection are emerging as effective proactive strategies in threat hunting, substantially reducing the time required for threat detection and response. However, the challenges in training and maintaining ML models, coupled with frequent false positives, diminish their acceptance and trustworthiness. In response, Explainable AI (XAI) techniques have been introduced to enable cybersecurity operations teams to assess alerts generated by AI systems more confidently. Despite these advancements, XAI tools have encountered limited acceptance from inci
View details →Negative / Null Result ReportOpen accessMedicine
Ali Azarbarzin, Daniel Vena, Neda Esmaeili et al. · 2025 · European Heart Journal
BACKGROUND AND AIMS: Randomized trials of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in patients with cardiovascular disease have not detected reduced risk of major adverse cardiovascular and…
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