21,222 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Bruce A. Rayton, Zeynep Y. Yalabik, Andriana Rapti · 2019 · Journal of Managerial Psychology
Purpose The purpose of this paper is to explore the relationship between fit (organization and job) perceptions and work engagement (WE). Design/methodology/approach The authors deployed a two-wave survey among 377 clerical employees of…
View details →Eleni Karakike, Brendon P. Scicluna, Maria Roumpoutsou et al. · 2022 · Critical Care
BACKGROUND: Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves 28-day mortality among patients with sepsis, respiratory and multiple organ dysfunction syndrome. METHODS: We conducted a multicenter, randomized, clinical trial in patients with sepsis. Participants with ratio of partial oxygen pressure to fraction of inspired oxygen less than 200 and more than 3 SOFA points from systems other than the respiratory function were enrolled betw
View details →Andreas Nolte, Nico W. Funk, Latha Mukunda et al. · 2013 · PLoS ONE
The mechanisms of insect odor transduction are still controversial. Insect odorant receptors (ORs) are 7TM receptors with inverted membrane topology. They colocalize with a conserved coreceptor (Orco) with chaperone and ion channel function. Some studies suggest that insects employ exclusively ionotropic odor transduction via OR-Orco heteromers. Other studies provide evidence for different metabotropic odor transduction cascades, which employ second messenger-gated ion channel families for odor transduction. The hawkmoth Manduca sexta is an established model organism for studies of insect olfa
View details →Ryosuke Omori, Yukihiko Nakata, Heidi L. Tessmer et al. · 2015 · Scientific Reports
Until the early 1990 s, incidences of Mycoplasma pneumoniae (MP) infection showed three to five year epidemic cycles in multiple countries, however, the mechanism for the MP epidemic cycle has not been understood. Here, we investigate the determinant of periodicity in MP incidence by employing a mathematical model describing MP transmission dynamics. Three candidates for the determinant of periodicity were evaluated: school-term forcing, minor variance in the duration of immunity, and epidemiological interference between MP serotypes. We find that minor variation in the duration of immunity at
View details →José de León, Paula Mallory, Lorraine Maw et al. · 2011 · Annals of Clinical Psychiatry
BACKGROUND: In 2 Spanish case-control studies, low cholesterol levels in males were consistently associated with suicide attempts. METHODS: This US study tried to replicate the association between low cholesterol levels and suicide…
View details →Denise Y. Geiskkovitch, Raquel Thiessen, James E. Young et al. · 2019
Robots that interact with children are becoming more common in places such as child care and hospital environments. While such robots may mistakenly provide nonsensical information, or have mechanical malfunctions, we know little of how…
View details →Anne Line Engsbro, Christen Rune Stensvold, Henrik Nielsen et al. · 2012 · American Journal of Tropical Medicine and Hygiene
The role of Dientamoeba fragilis in irritable bowel syndrome (IBS) is incompletely known. We aimed to investigate whether eradication of D. fragilis alleviates symptoms in IBS. Twenty-five D. fragilis-positive IBS patients were treated…
View details →Mohammad W. Marashdeh, Baker Ababneh, O. M. Lemine et al. · 2019 · Results in Physics
In this study, iron oxide (γ-Fe2O3) nanoparticles (IONs) were successfully synthesized using sol-gel method, and characterized by XRD and VSM. The potential application of the differently sized IONs (22 nm and 30 nm) as magnetic resonance…
View details →Vijay Gondaliya, Govind Dhinaiya · 2017 · Zenodo (CERN European Organization for Nuclear Research)
Every investor and investment planner talk about risk tolerance and what people think is appropriate because there’s so much more to risk tolerance than what you can capture. Defining and understanding risk are important challenges for…
View details →Ann L. Griffen, Zachary A. Thompson, Clifford J. Beall et al. · 2019 · Scientific Reports
Persons infected with HIV are particularly vulnerable to a variety of oral microbial diseases. Although various study designs and detection approaches have been used to compare the oral microbiota of HIV-negative and HIV-positive persons, both with and without highly active antiretroviral therapy (HAART), methods have varied, and results have not been consistent or conclusive. The purpose of the present study was to compare the oral bacterial community composition in HIV-positive persons under HAART to an HIV-negative group using 16S rRNA gene sequence analysis. Extensive clinical data was col
View details →Carmen Kivistik, Jan Knobloch, Kairi Käiro et al. · 2020 · Frontiers in Microbiology
Differences in salinity are boundaries that act as barriers for the dispersal of most aquatic organisms. This creates distinctive biota in freshwater and brackish water (mesohaline) environments. To test how saline boundaries influence the diversity and composition of host-associated microbiota, we analyzed the microbiome within the digestive tract of Theodoxus fluviatilis, an organism able to cross the freshwater and mesohaline boundary. Alpha-diversity measures of the microbiome in freshwater and brackish water were not significantly different. However, the composition of the bacterial commu
View details →Lisa L. Lacher, Mark C. Lewis · 2015
The use of online videos and flipped classrooms is a natural fit for many CS courses, especially in the introductory sequence, and the use of these techniques is growing. However, the benefits of these techniques depend heavily on student…
View details →Rachel Hayes, Daniel Titheradge, Kate Allen et al. · 2019 · British Journal of Educational Psychology
BACKGROUND: Teaching is a stressful occupation with poor retention. The Incredible Years® Teacher Classroom Management (TCM) programme is a training programme that research has demonstrated may be an effective intervention for improving…
View details →Jane Farmer, Mary Currie, Jeff Hyman et al. · 2011 · Scottish Medical Journal
Physician assistants (PAs) have medical training and work supervised by a doctor. In 2006-2008 the Scottish Government piloted use of USA-trained PAs. The aim of the paper is to evaluate the impact and contribution made by PAs to…
View details →Tory A. Eisenlohr‐Moul, Susan S. Girdler, Jacqueline L. Johnson et al. · 2017 · Depression and Anxiety
BACKGROUND: Although traditionally dosed combined oral contraceptives (COCs) (21 days of active pills, 7 days of inactive pills) have not been demonstrated as superior to placebo for the treatment of premenstrual dysphoria (PMD), some…
View details →Rolf Ulrich, Jeff Miller · 2020 · eLife
This article examines why many studies fail to replicate statistically significant published results. We address this issue within a general statistical framework that also allows us to include various questionable research practices (QRPs) that are thought to reduce replicability. The analyses indicate that the base rate of true effects is the major factor that determines the replication rate of scientific results. Specifically, for purely statistical reasons, replicability is low in research domains where true effects are rare (e.g., search for effective drugs in pharmacology). This point is
View details →David J. Caldwell, Jeneva A. Cronin, Jing Wu et al. · 2019 · Scientific Reports
Direct cortical stimulation (DCS) of primary somatosensory cortex (S1) could help restore sensation and provide task-relevant feedback in a neuroprosthesis. However, the psychophysics of S1 DCS is poorly studied, including any comparison to cutaneous haptic stimulation. We compare the response times to DCS of human hand somatosensory cortex through electrocorticographic grids with response times to haptic stimuli delivered to the hand in four subjects. We found that subjects respond significantly slower to S1 DCS than to natural, haptic stimuli for a range of DCS train durations. Median respon
View details →Emilie Sundqvist, Peter Sundström, Magdalena Lindén et al. · 2012 · Neurology
BACKGROUND: Epstein-Barr virus infection, smoking, HLA-A*02, and DRB1*15 have all been proposed as risk factors for multiple sclerosis (MS). In 2010, Simon et al. described an interaction on the multiplicative scale between EBNA1…
View details →Ullrich K. H. Ecker, Brandon K. N. Sze, Matthew Andreotta · 2021 · Philosophical Transactions of the Royal Society B Biological Sciences
Misinformation often has a continuing effect on people's reasoning despite clear correction. One factor assumed to affect post-correction reliance on misinformation is worldview-driven motivated reasoning. For example, a recent study with an Australian undergraduate sample found that when politically situated misinformation was retracted, political partisanship influenced the effectiveness of the retraction. This worldview effect was asymmetrical, that is, particularly pronounced in politically conservative participants. However, the evidence regarding such worldview effects (and their symmetr
View details →Narayana Raju, Shriniwas Arkatkar, Gaurang Joshi · 2019 · Journal of Intelligent Transportation Systems
This research work is focused on modeling vehicle following behavior under mixed traffic conditions. Vehicle-following behavior can be potentially utilized in building real-time drivers’ assistance systems or identifying collision escaping…
View details →Johannes Claßen, Stefan Pischinger, Sascha Krysmon et al. · 2020 · International Journal of Engine Research
The progression of emission legislation has intensified the efforts of the automotive industry to develop improved exhaust gas after-treatment systems. The requirement to fulfill Euro 6d-TEMP in real-world driving scenarios, the already…
View details →Jennifer Kyle, Cameron Casey, Kelly G. Stratton et al. · 2016 · Rapid Communications in Mass Spectrometry
RATIONALE: The use of dried blood spots (DBS) has many advantages over traditional plasma and serum samples such as the smaller blood volume required, storage at room temperature, and ability to sample in remote locations. However,…
View details →Roberta Amoriello, Maria Chernigovskaya, Victor Greiff et al. · 2021 · EBioMedicine
BACKGROUND: T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Although several studies recently investigated the T-cell receptor…
View details →Almut Balleer · 2012 · Quantitative Economics
Can the standard search-and-matching labor market model replicate the business cycle fluctuations of the job finding rate and the unemployment rate? In the model, these fluctuations are driven by movements in productivity. This paper…
View details →Arthur J. Baroody, Michael D. Eiland, David J. Purpura et al. · 2013 · American Educational Research Journal
In a 9-month training experiment, 64 first graders with a risk factor were randomly assigned to computer-assisted structured discovery of the add-1 rule (e.g., the sum of 7 + 1 is the number after “seven” when we count), unstructured…
View details →Ruby Yu, Grace Leung, Jean Woo · 2021 · International Journal of Environmental Research and Public Health
(1) Objective: This study examined the effects of a combined intervention of Brainastic computerized cognitive training (CCT) preceded by physical exercise (PE) for improving frailty status and cognitive function in older adults. (2) Methods: Older adults aged 50 years or older attending elderly centers, without frailty/history of cognitive impairment, were randomly allocated into either a 12-week (i) multi-domain CCT + PE (n = 117), (ii) two-domain CCT + PE (n = 116) or (iii) video watching + PE (i.e., control, n = 114). Brainastic is an online application for cognitive training through video
View details →Ariana L. Smith, Alan J. Wein · 2011 · BJU International
OBJECTIVE • To evaluate the statistical and clinical efficacy of the pharmacological treatments of nocturia using non‐antidiuretic agents. PATIENTS AND METHODS • A literature review of treatments of nocturia specifically addressing the…
View details →Margaret‐Anne Mackintosh, James Niehaus, Casey T. Taft et al. · 2017 · Military Medicine
OBJECTIVE: Anger is a symptom of post-traumatic stress disorder (PTSD) associated with a range of clinical and functional impairments, and may be especially prevalent among veterans with PTSD. Effective anger management therapies exist but…
View details →Di Tian, Christopher J. Martinez, W. D. Graham et al. · 2014 · Journal of Climate
Abstract This study compared two types of approaches to downscale seasonal precipitation (P) and 2-m air temperature (T2M) forecasts from the North American Multimodel Ensemble (NMME) over the states of Alabama, Georgia, and Florida in the…
View details →Ali Aminian, Mohammad Jamal, Toms Augustin et al. · 2015 · Diabetes Technology & Therapeutics
The metabolic profile of patients after a failed surgical weight loss procedure is unknown. Long-term clinical outcomes of 31 obese diabetes patients with post–bariatric surgery excess weight loss of ≤25% were assessed. At a median…
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