Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A2A Receptor
Tasia Amelia; Jacobus P. D. van Veldhoven; Matteo Falsini; Rongfang Liu; Laura H. Heitman; Gerard J. P. van Westen; Elena Segala; Grégory Verdon · 2021 · Journal of Medicinal Chemistry
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction between the partial agonist, belonging to a class of dicyanopyridines, and amino…
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Metadata source: OpenAlex · DOI 10.1021/acs.jmedchem.0c01856