21,681 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Rong Zhang, Yize Li, Timothy J. Cowley et al. · 2015 · Journal of Virology
UNLABELLED: Mouse hepatitis virus (MHV) isolates JHM.WU and JHM.SD promote severe central nervous system disease. However, while JHM.WU replicates robustly and induces hepatitis, JHM.SD fails to replicate or induce pathology in the liver.…
View details →Anna Elisabet Olafsdottir, Daniel D. Reidpath, Subhash Pokhrel et al. · 2011 · BMC Public Health
BACKGROUND: The literature on health systems focuses largely on the performance of healthcare systems operationalised around indicators such as hospital beds, maternity care and immunisation coverage. A broader definition of health systems however, needs to include the wider determinants of health including, possibly, governance and its relationship to health and health equity. The aim of this study was to examine the relationship between health systems outcomes and equity, and governance as a part of a process to extend the range of indicators used to assess health systems performance. METHOD
View details →Timothy P. LaBranche, Alison M. Bendele, Brian C Omura et al. · 2016 · Annals of the Rheumatic Diseases
OBJECTIVE: To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. METHODS:…
View details →Kin Sibanda, Progress Hove-Sibanda, Herring Shava · 2018 · Acta Commercii
Orientation: Globally, the majority of Small and Medium-sized entities (SMEs) are resource constrained. As a result, not all SMEs are able to fully exploit the benefits associated with international trade as they face challenges when exporting their produce.Research purpose: This article presents an investigation into the impact of access to finance on firm performance and exporting behaviour of SMEs in Harare, Zimbabwe.Motivation for the study: The article stems from the observation that although there is a growing importance and contribution of SMEs worldwide, research has shown that only a
View details →Jonna Nilsson, Alexander V. Lebedev, Martin Lövdén · 2015 · Frontiers in Aging Neuroscience
Transcranial direct current stimulation (tDCS) has been put forward as a non-pharmacological alternative for alleviating cognitive decline in old age. Although results have shown some promise, little is known about the optimal stimulation parameters for modulation in the cognitive domain. In this study, the effects of tDCS over the dorsolateral prefrontal cortex (dlPFC) on working memory performance were investigated in thirty older adults. An N-back task assessed working memory before, during and after anodal tDCS at a current strength of 1 mA and 2 mA, in addition to sham stimulation. The st
View details →Karin Welén, Ebba Rosendal, Magnus Gisslén et al. · 2021 · European Urology
BACKGROUND: Men are more severely affected by COVID-19. Testosterone may influence SARS-CoV-2 infection and the immune response. OBJECTIVE: To clinically, epidemiologically, and experimentally evaluate the effect of antiandrogens on…
View details →Tomris Özben · 2014 · Current Topics in Medicinal Chemistry
Radiation and some chemotherapeutic agents used in conventional cancer treatment generate reactive oxygen species (ROS), and a high ROS level diminishes cellular antioxidant capacity and leads to apoptosis and cancer cell death.…
View details →Ashley L. Ruba, Andrew N. Meltzoff, Betty M. Repacholi · 2019 · Developmental Psychology
There is extensive disagreement as to whether preverbal infants have conceptual categories for different emotions (e.g., anger vs. disgust). In addition, few studies have examined whether infants have conceptual categories of emotions…
View details →Daniel M. Mazzaferro, Ari M. Wes, Sanjay Naran et al. · 2017 · Plastic & Reconstructive Surgery
BACKGROUND: The effects of orthognathic surgery go beyond objective cephalometric correction of facial and dental disproportion and malocclusion, respectively. The authors hypothesized that there is tangible improvement following surgery…
View details →Chia‐Hsuin Chang, Jou‐Wei Lin, Fu‐Chun Chiu et al. · 2014 · Circulation Arrhythmia and Electrophysiology
BACKGROUND: This study examined the effect of radiofrequency catheter ablation (RFA) on reducing morbidity and mortality among patients with atrial fibrillation (AF). METHODS AND RESULTS: A retrospective cohort of patients with AF without…
View details →Brett M. Kroncke, Amanda M. Duran, Jeffrey Mendenhall et al. · 2016 · Biochemistry
There is a compelling and growing need to accurately predict the impact of amino acid mutations on protein stability for problems in personalized medicine and other applications. Here the ability of 10 computational tools to accurately…
View details →Levent Dizdar, Georg Fluegen, Guus van Dalum et al. · 2019 · Molecular Oncology
The GILUPI CellCollector (CC) is a novel in vivo circulating tumor cell (CTC) detection device reported to overcome the limitations of small blood sample volumes. The aim of this prospective, blinded study was to evaluate the clinical application of the CC and to compare its performance to the CellSearch (CS) system in M0 and M1 colorectal cancer (CRC) patients. A total of 80 patients (31 M0, 49 M1) with CRC were enrolled. CTCs were simultaneously measured in the peripheral blood using CS and the CC, and the results of both assays were correlated to clinicopathological variables and overall su
View details →Chaolong Wang, Kari B Schroeder, Noah A Rosenberg · 2012 · Genetics
Abstract Allelic dropout is a commonly observed source of missing data in microsatellite genotypes, in which one or both allelic copies at a locus fail to be amplified by the polymerase chain reaction. Especially for samples with poor DNA…
View details →Philipp Brun, Thomas Kiørboe, Priscilla Licandro et al. · 2016 · Global Change Biology
Statistical species distribution models (SDMs) are increasingly used to project spatial relocations of marine taxa under future climate change scenarios. However, tests of their predictive skill in the real-world are rare. Here, we use…
View details →Alice Monzani, Anna Rapa, P Fonio et al. · 2011 · Journal of Pediatric Gastroenterology and Nutrition
OBJECTIVE: The aim of this study was to evaluate performance of serum antibodies against deamidated gliadin peptides (a-DGPs) in detecting compliance with gluten-free diet (GFD) in children with celiac disease (CD). PATIENTS AND METHODS:…
View details →Thilo Kunkel, Matthew Walker, Courtney Hodge · 2018 · European Sport Management Quarterly
Research question: Analogous to traditional brands, athlete (i.e. personal) brands require management and maintenance. While the use of athlete endorsers is an effective marketing strategy for companies wanting to increase visibility,…
View details →Manish R. Patel, Gerald S. Falchook, K Hamada et al. · 2021 · Cancer Medicine
Abstract Background Microsatellite‐stable (MSS) colorectal cancer (CRC) tends to be poorly immunogenic, with limited treatment options. In MSS CRC xenograft models, trifluridine/tipiracil (FTD/TPI) plus programed death 1 inhibitors resulted in synergistic antitumor activity and increased tumor immunogenicity. This phase 2 study evaluated FTD/TPI plus nivolumab in patients with MSS metastatic CRC. Methods This single‐arm, safety lead‐in study used a Simon's two‐stage design (enrolling 6 patients in the safety lead‐in, proceeding to stage 2 if ≥2 of the first 15 patients achieved a partial or co
View details →Tae Gun Shin, Youn‐Jung Kim, Seung Mok Ryoo et al. · 2019 · Journal of Clinical Medicine
Background: Intravenous vitamin C and thiamine administration may be a potential adjuvant therapy for septic shock. We aimed to investigate the impact of early vitamin C and thiamine administration in septic shock patients. Methods: This retrospective before-and-after cohort study used data extracted from the Korean Shock Society’s prospective septic shock registry. We compared 28-day and in-hospital mortality rates between patients treated with intravenous vitamin C (3 g/12 h or 1.5 g/6 h) and thiamine (200 mg/12 h) <6 h after shock recognition from July through December 2017 (n = 229) and
View details →Sriram Balusu, Bart De Strooper · 2024 · Acta Neuropathologica
Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully explains the extensive neuronal loss observed in AD brains. Recent evidence shows that necroptosis is abundant in AD, that necroptosis is closely linked to the appearance of Tau pathology, and that necroptosis markers accumulate in granulovacuolar neurodegeneration vesicles (GVD). We review here the neuron-specific activation of the granulovacuolar mediated neuronal-necroptosis pathway, the potential AD-relevant triggers upstream of this pathway, and the interaction of the necrosome with the endo-lysosomal p
View details →Charles Honoré, V. Atallah, Olivier Mir et al. · 2017 · PLoS ONE
BACKGROUND: Desmoplastic Small Round Cell Tumor (DSRCT) is a rare disease affecting predominantly children and young adults and for which the benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) after complete cytoreductive surgery (CCRS) remains unknown. METHODS: To identify patients with DSRCT without extraperitoneal metastases (EPM) who underwent CCRS between 1991 and 2015, a retrospective nation-wide survey was conducted by crossing the prospective and retrospective databases of the French Network for Rare Peritoneal Malignancies, French Reference Network in Sarcoma Pathology, Fren
View details →Christoph Röllig, Hubert Serve, Richard Noppeney et al. · 2021 · Leukemia
Early results of the randomized placebo-controlled SORAML trial showed that, in patients with newly diagnosed acute myeloid leukaemia (AML), sorafenib led to a significant improvement in event-free (EFS) and relapse-free survival (RFS). In order to describe second-line treatments and their implications on overall survival (OS), we performed a study after a median follow-up time of 78 months. Newly diagnosed fit AML patients aged ≤60 years received sorafenib (n = 134) or placebo (n = 133) in addition to standard chemotherapy and as maintenance treatment. The 5-year EFS was 41 versus 27% (HR 0.6
View details →Clark DuMontier, Hajime Uno, Tammy T. Hshieh et al. · 2021 · Haematologica
We conducted a randomized controlled trial in older adults with hematologic malignancies to determine the impact of geriatrician consultation embedded in our oncology clinic alongside standard care. From February 2015 to May 2018,…
View details →M. J. Ryan, Holly Morgan, Amedeo Chiribiri et al. · 2021 · European Heart Journal
Patients with ischaemic left ventricular dysfunction frequently undergo myocardial viability testing. The historical model presumes that those who have extensive areas of dysfunctional-yet-viable myocardium derive particular benefit from…
View details →Josep Tabernero, Paulo M. Hoff, Lin Shen et al. · 2022 · Gastric Cancer
BACKGROUND: Dual-targeted anti-HER2 therapy significantly improves outcomes in HER2-positive breast cancer and could be beneficial in other HER2-positive cancers. JACOB's end-of study analyses aimed to evaluate the long-term efficacy and safety of pertuzumab plus trastuzumab and chemotherapy for previously untreated HER2-positive metastatic gastric or gastroesophageal junction cancer. METHODS: Eligible patients were randomized 1:1 to pertuzumab/placebo plus trastuzumab and chemotherapy every 3 weeks. PRIMARY ENDPOINT: overall survival (OS). Secondary endpoints included progression-free surviva
View details →Kotaro Makino, Kosaku Kato, Keisuke Takano et al. · 2018 · Scientific Reports
Abstract With rapid advances occurring in terahertz (THz) radiation generation techniques, the interaction between matter and intense THz fields has become an important research topic. Among different types of THz radiation sources, the…
View details →Harald Zandler, Thomas Senftl, Kim André Vanselow · 2020 · Scientific Reports
Abstract Global environmental research requires long-term climate data. Yet, meteorological infrastructure is missing in the vast majority of the world’s protected areas. Therefore, gridded products are frequently used as the only…
View details →Marcelo Cajias, Franz Fuerst, Patrick McAllister et al. · 2014 · International Journal of Strategic Property Management
This paper investigates the relationship between corporate social and environmental performance and financial performance for a sample of publicly traded US real estate companies. Using the MSCI ESG (formerly KLD) database on seven…
View details →Adrienne L. Romer, Annchen R. Knodt, Maria L. Sison et al. · 2019 · Molecular Psychiatry
Transdiagnostic research has identified a general psychopathology factor-often called the 'p' factor-that accounts for shared variation across internalizing, externalizing, and thought disorders in diverse samples. It has been argued that the p factor may reflect dysfunctional thinking present in serious mental illness. In support of this, we previously used a theory-free, data-driven multimodal neuroimaging approach to find that higher p factor scores are associated with structural alterations within a cerebello-thalamo-cortical circuit (CTCC) and visual association cortex, both of which are
View details →Brit Mollenhauer, Frederick DuBois Bowman, Daniel Drake et al. · 2018 · Journal of Neurochemistry
Abstract α‐Synuclein is the major component of Lewy bodies and a candidate biomarker for neurodegenerative diseases in which Lewy bodies are common, including Parkinson's disease and dementia with Lewy bodies. A large body of literature suggests that these disorders are characterized by reduced concentrations of α‐synuclein in cerebrospinal fluid (CSF), with overlapping concentrations compared to healthy controls and variability across studies. Several reasons can account for this variability, including technical ones, such as inter‐assay and inter‐laboratory variation (reproducibility). We co
View details →Yonghui Zhang, Feng Cheng, Xueting Du et al. · 2016 · Oncotarget
// Yong-Hui Zhang 1 , Feng Cheng 1 , Xue-Ting Du 1 , Jin-Lai Gao 1 , Xiao-Lin Xiao 1 , Na Li 1 , Shan-Liang Li 1 and De-Li Dong 1 1 Department of Pharmacology (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, P.R.China Correspondence to: De-Li Dong, email: // Keywords : bone morphogenetic protein 11, growth differentiation factor 11, smad2/3, smad1/5/8,
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