Antibody‐based methods for the measurement of α‐synuclein concentration in human cerebrospinal fluid – method comparison and round robin study
Brit Mollenhauer; Frederick DuBois Bowman; Daniel Drake; Jimmy Duong; Kaj Blennow; Omar M. A. El‐Agnaf; Leslie M. Shaw; Jennifer Masucci · 2018 · Journal of Neurochemistry
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract α‐Synuclein is the major component of Lewy bodies and a candidate biomarker for neurodegenerative diseases in which Lewy bodies are common, including Parkinson's disease and dementia with Lewy bodies. A large body of literature suggests that these disorders are characterized by reduced concentrations of α‐synuclein in cerebrospinal fluid (CSF), with overlapping concentrations compared to healthy controls and variability across studies. Several reasons can account for this variability, including technical ones, such as inter‐assay and inter‐laboratory variation (reproducibility). We co
Abstract by Brit Mollenhauer; Frederick DuBois Bowman; Daniel Drake; Jimmy Duong; Kaj Blennow; Omar M. A. El‐Agnaf; Leslie M. Shaw; Jennifer Masucci, Journal of Neurochemistry (2018) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1111/jnc.14569