Negative / Null Result ReportMedicine
Benoît Tyl, Meriam Kabbaj, Sara M. Azzam et al. · 2011 · The Journal of Clinical Pharmacology
The effect of bilastine on cardiac repolarization was studied in 30 healthy participants during a multiple-dose, triple-dummy, crossover, thorough QT study that included 5 arms: placebo, active control (400 mg moxifloxacin), bilastine at…
View details →Negative / Null Result ReportOpen accessNeuroscience
Natalia Sánchez, Sungwoo Park, James M. Finley · 2017 · Scientific Reports
The theory that the sensorimotor system minimizes energetic cost during locomotion has long been supported by both computational models and empirical studies. However, it has yet to be determined if the behavior to which people converge when exposed to a novel perturbation during locomotion is also energetically optimal. We address this issue in the context of adaptation to walking on a split-belt treadmill, which can impose a left-right asymmetry in step lengths. In response to this asymmetry, participants gradually adjust their foot placement to adopt steps of equal length. Here, we characte
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Mohammad R. Jahan‐Parvar, Hassan Mohammadi · 2011 · The Journal of developing areas
We test the validity of the Dutch disease hypothesis by examining the relationship between real oil prices and real exchange rates in a sample of fourteen oil exporting countries. Autoregressive distributed lag (ARDL) bounds tests of…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Hlalefang Khobai, Nwabisa Kolisi, Clement Moyo et al. · 2020 · International Journal of Energy Economics and Policy
The importance of renewable energy consumption has grown to a large extent over the recent years. The benefits of renewable energy consumption ranging from improved environmental quality to higher economic growth are well documented. However, the impact of renewable energy consumption on unemployment has received relatively less attention. This study examines the relationship between renewable energy consumption and unemployment in South Africa over the period 1990-2014. The Autoregressive Distributed Lag (ARDL) model was employed to test the long-run and short-run impacts of renewable energy
View details →Negative / Null Result Report
Megan Best, Phyllis Butow, Ian Olver · 2016 · Journal of Clinical Medicine
Background: Despite known health benefits of spiritual care and high patient interest in discussing spirituality with their physicians, the frequency of spiritual discussions in the medical consultation is low. We investigated spiritual…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Junpeng Wang, Xue Yubo, Minghao Liu · 2016
As the world's first completely decentralized digital payment system, the emergence of bitcoin represents a revolutionary phenomenon in financial markets. This paper mainly studies the fluctuations of bitcoin price and discusses weather…
View details →Negative / Null Result ReportOpen accessPsychology
Thomas Mangin, Nathalie André, Abdelrhani Benraïss et al. · 2021 · Psychology of sport and exercise
The ego-depletion effect refers to a temporary failure of self-control exertion after first performing an effortful task. This phenomenon has experienced a replication crisis in the past few years. In the present series of experiments, we…
View details →Negative / Null Result ReportOpen accessMedicine
Florian Thibord, Melissa V. Chan, Ming‐Huei Chen et al. · 2022 · Human Genetics and Genomics Advances
Host genetic variants influence the susceptibility and severity of several infectious diseases, and the discovery of genetic associations with coronavirus disease 2019 (COVID-19) phenotypes could help to develop new therapeutic strategies…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ying Shen, Mumtahena Rahman, Stephen Piccolo et al. · 2015 · Bioinformatics
MOTIVATION: Although gene-expression signature-based biomarkers are often developed for clinical diagnosis, many promising signatures fail to replicate during validation. One major challenge is that biological samples used to generate and…
View details →Negative / Null Result ReportMedicine
Lionel A. Marzette, Leon W. Herndon · 2011 · Ophthalmic surgery, lasers & imaging retina
BACKGROUND AND OBJECTIVE: To compare the success and complication rates of patients with glaucoma who had an Ex-PRESS mini glaucoma shunt device implantation (Optonol, Ltd., Neve Ilan, Israel) to those who had conventional trabeculectomy.…
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
T. Acciavatti, Matteo Lupi, Rita Santacroce et al. · 2017 · Human Psychopharmacology Clinical and Experimental
OBJECTIVE: Comorbidities between psychiatric diseases and use of traditional substances of abuse are common. Nevertheless, there are few data regarding the use of novel psychoactive substances (NPS) among psychiatric patients. Aim of this…
View details →Negative / Null Result ReportOpen accessMedicine
Cheng‐Yu Long, Kun‐Ling Lin, Chin-Ru Shen et al. · 2021 · Scientific Reports
The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wall where mid-urethra locates. Self-reported questionnaires were used to measure pre-treatment, 1 month and 6 months post-treatment symptom severity. Secondary outcomes of sexual function and treatment effect sorted by age were analyzed with valid statistical methods. A-PRP is effe
View details →Negative / Null Result ReportOpen accessSocial Sciences
Andrea L. Roberts, Kristen Lyall, Janet W. Rich‐Edwards et al. · 2015 · Autism
We sought to determine whether maternal (a) physical harm from intimate partner abuse during pregnancy or (b) sexual, emotional, or physical abuse before birth increased risk of autism spectrum disorder. We calculated risk ratios for…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jill M. Haenfler, Geena Skariah, Caitlin M. Rodriguez et al. · 2018 · Frontiers in Molecular Neuroscience
Fragile X Syndrome (FXS) is the most common inherited cause of intellectual disability and autism. It results from expansion of a CGG nucleotide repeat in the 5’ untranslated region of FMR1. Large expansions elicit repeat and promoter hyper-methylation, heterochromatin formation, FMR1 transcriptional silencing, and loss of the Fragile X protein, FMRP. Efforts aimed at correcting the sequelae resultant from FMRP loss have thus far proven insufficient, perhaps because of FMRP’s pleiotropic functions. As the repeats do not disrupt the FMRP coding sequence, reactivation of endogenous FMR1 gene exp
View details →Negative / Null Result ReportOpen accessMedicine
Vladimir Lazarević, A-S Hörstedt, Bertil Johansson et al. · 2014 · Blood Cancer Journal
The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively…
View details →Negative / Null Result ReportOpen accessNeuroscience
Mahmoud G. El Baassiri, Zachariah Raouf, Sarah Badin et al. · 2024 · Journal of Neuroinflammation
Traumatic brain injury (TBI) is a chronic and debilitating disease, associated with a high risk of psychiatric and neurodegenerative diseases. Despite significant advancements in improving outcomes, the lack of effective treatments underscore the urgent need for innovative therapeutic strategies. The brain-gut axis has emerged as a crucial bidirectional pathway connecting the brain and the gastrointestinal (GI) system through an intricate network of neuronal, hormonal, and immunological pathways. Four main pathways are primarily implicated in this crosstalk, including the systemic immune syste
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zahra Yazdanpour, Omid Tadjrobehkar, Motahareh Shahkhah · 2020 · BMC Microbiology
BACKGROUND: Antibiotic resistance is an increasing phenomenon in many bacterial pathogens including uropathogenic Escherichia coli. Hypothetical anti-virulent agents could be a solution, but first clear virulence associated gene-pool of antibiotic resistant isolates have to be determined. The aim of this study is to investigate the significant associations between genes encoding VFs with antibiotic resistance and phylogenetic groups in UPEC isolates. RESULTS: The majority of 248 UPEC isolates belonged to phylogenetic group B2 (67.3%). The maximum and minimum resistance was attributed to amoxic
View details →Negative / Null Result ReportOpen accessComputer Science
Xi Yang, Xing He, Hansi Zhang et al. · 2020 · JMIR Medical Informatics
BACKGROUND: Semantic textual similarity (STS) is one of the fundamental tasks in natural language processing (NLP). Many shared tasks and corpora for STS have been organized and curated in the general English domain; however, such resources are limited in the biomedical domain. In 2019, the National NLP Clinical Challenges (n2c2) challenge developed a comprehensive clinical STS dataset and organized a community effort to solicit state-of-the-art solutions for clinical STS. OBJECTIVE: This study presents our transformer-based clinical STS models developed during this challenge as well as new mo
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Juan Pablo Nani, Fernanda Marcondes de Rezende, Francisco Peñagaricano · 2019 · BMC Genomics
BACKGROUND: Fertility is among the most important economic traits in dairy cattle. Genomic prediction for cow fertility has received much attention in the last decade, while bull fertility has been largely overlooked. The goal of this study was to assess genomic prediction of dairy bull fertility using markers with large effect and functional annotation data. Sire conception rate (SCR) was used as a measure of service sire fertility. Dataset consisted of 11.5 k U.S. Holstein bulls with SCR records and about 300 k single nucleotide polymorphism (SNP) markers. The analyses included the use of bo
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Matthew R. Masters, Amr H. Mahmoud, Markus A. Lill · 2025 · Nature Communications
Co-folding models represent a major innovation in deep-learning-based protein-ligand structure prediction. The recent publications of RoseTTAFold All-Atom, AlphaFold3, and others have shown high-quality results on predicting the structures of proteins interacting with small-molecules, nucleic-acids, and other proteins. Despite these advanced capabilities and broad potential, the current study presents critical findings that question the adherence of these models to fundamental physical principles. Through adversarial examples based on established physical, chemical, and biological principles,
View details →Negative / Null Result ReportOpen accessMedicine
Nienke M. Siebelink, Susan M. Bögels, Anne Speckens et al. · 2021 · Journal of Child Psychology and Psychiatry
BACKGROUND: Family mindfulness-based intervention (MBI) for child attention-deficit/hyperactivity disorder (ADHD) targets child self-control, parenting and parental mental health, but its effectiveness is still unclear. METHODS: MindChamp…
View details →Negative / Null Result Report
Yongbo Wang, Xiang Gao, Pardis Pedram et al. · 2016 · Nutrients
Selenium (Se) is a trace element which plays an important role in adipocyte hypertrophy and adipogenesis. Some studies suggest that variations in serum Se may be associated with obesity. However, there are few studies examining the…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Katarzyna A. Cieslik, George E. Taffet, Jeffrey R. Crawford et al. · 2013 · Journal of Molecular and Cellular Cardiology
We have demonstrated that scar formation after myocardial infarction (MI) is associated with an endogenous pool of CD44(pos)CD45(neg) multipotential mesenchymal stem cells (MSC). MSC differentiate into fibroblasts secreting collagen that forms a scar and mature into myofibroblasts that express alpha smooth muscle actin (α-SMA) that stabilizes the scar. In the aging mouse, cardiac repair after MI is associated with impaired differentiation of MSC; MSC derived from the aged hearts form dysfunctional fibroblasts that deposit less collagen in response to transforming growth factor beta-1 (TGF-β1)
View details →Negative / Null Result ReportOpen accessMedicine
David Casadevall, Javier Gimeno, Sergi Clavé et al. · 2015 · Oncotarget
// David Casadevall 1, 6, * , Javier Gimeno 2, * , Sergi Clavé 3, 4, * , Álvaro Taus 1 , Lara Pijuan 2 , Miriam Arumí 1 , Marta Lorenzo 4 , Silvia Menéndez 4 , Israel Cañadas 4 , Joan Albanell 1, 4, 5 , Sergio Serrano 2 , Blanca Espinet 3, 4 , Marta Salido 3, 4 , Edurne Arriola 1, 4, # 1 Servei d’Oncologia Mèdica, Hospital del Mar, Barcelona, Spain 2 Servei de Patologia, Hospital del Mar, Barcelona, Spain 3 Laboratori de Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain 4 Cancer Research Program, IMIM (Hospita
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Xiao Fan, Wentao Han, Linhong Teng et al. · 2019 · New Phytologist
Brown algae have convergently evolved plant-like body plans and reproductive cycles, which in plants are controlled by differential DNA methylation. This contribution provides the first single-base methylome profiles of haploid gametophytes and diploid sporophytes of a multicellular alga. Although only c. 1.4% of cytosines in Saccharina japonica were methylated mainly at CHH sites and characterized by 5-methylcytosine (5mC), there were significant differences between life-cycle stages. DNA methyltransferase 2 (DNMT2), known to efficiently catalyze tRNA methylation, is assumed to methylate the
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Cristiano Xavier Lima, Danielle G. Souza, Flávio A. Amaral et al. · 2015 · PLoS ONE
INTRODUCTION: Toll-like receptors (TLRs) play an important role in the recognition of microbial products and in host defense against infection. However, the massive release of inflammatory mediators into the bloodstream following TLR activation following sepsis is thought to contribute to disease pathogenesis. METHODS: Here, we evaluated the effects of preventive or therapeutic administration of monoclonal antibodies (mAbs) targeting either TLR2 or TLR4 in a model of severe polymicrobial sepsis induced by cecal ligation and puncture in mice. RESULTS: Pre-treatment with anti-TLR2 or anti-TLR4 m
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Wenji Piao, Lisa W. Ru, Kurt H. Piepenbrink et al. · 2013 · Proceedings of the National Academy of Sciences
Toll/IL-1R resistance (TIR) domain-containing adapter-inducing IFN-β (TRIF) is a Toll-like receptor (TLR) adapter that mediates MyD88-independent induction of type I interferons through activation of IFN regulatory factor 3 and NFκB. We…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Claudio Toma, Amaia Hervás, Bàrbara Torrico et al. · 2012 · Psychiatric Genetics
Impairment of language abilities is a common feature in autistic individuals. Heterozygous mutations in the Forkhead Box P2 (FOXP2) gene lead to a severe spoken language disorder. Recently, several studies have pinpointed the involvement…
View details →Negative / Null Result ReportOpen accessMathematics
Lincoln Colling, Dénes Szűcs, Damiano De Marco et al. · 2020 · Advances in Methods and Practices in Psychological Science
The attentional spatial-numerical association of response codes (Att-SNARC) effect (Fischer, Castel, Dodd, & Pratt, 2003)—the finding that participants are quicker to detect left-side targets when the targets are preceded by small numbers and quicker to detect right-side targets when they are preceded by large numbers—has been used as evidence for embodied number representations and to support strong claims about the link between number and space (e.g., a mental number line). We attempted to replicate Experiment 2 of Fischer et al. by collecting data from 1,105 participants at 17 labs. Acr
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Batsirai Winmore Mazviona, T Sakahuhwa, M Dube · 2017 · RePEc: Research Papers in Economics
The study sought to examine factors affecting the performance of insurance companies in Zimbabwe. We utilized secondary data from twenty short-term insurance companies. The data was for the period from 2010 to 2014. We used factor analysis and multiple linear regression models to determine the factors affecting performance and identifying their impact. Our findings revealed that expense ratio, claims ratio and the size of a company significantly affect insurance companies’ performance negatively. Whilst leverage and liquidity affect performance positively. We recommend that insurance companies
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