Replication FailureOpen accessComputer Science
Tal Linzen, Yohei Oseki · 2018 · Glossa a journal of general linguistics
The reliability of acceptability judgments made by individual linguists has often been called into question. Recent large-scale replication studies conducted in response to this criticism have shown that the majority of published English acceptability judgments are robust. We make two observations about these replication studies. First, we raise the concern that English acceptability judgments may be more reliable than judgments in other languages. Second, we argue that it is unnecessary to replicate judgments that illustrate uncontroversial descriptive facts; rather, candidates for replicatio
View details →Negative / Null Result ReportOpen accessMedicine
Carolyn Tam, Deborah L. O’Connor, Gideon Koren · 2012 · Obstetrics and Gynecology International
There are increasing concerns that exposure to unmetabolized folic acid, which results from folic acid intakes that overwhelm the liver's metabolic capacity, may be associated with adverse effects. In this paper, we examined the folic acid status of women of reproductive age in relation to dietary intake and the effect of folic acid supplementation (1.1 mg or 5 mg). Plasma unmetabolized folic acid was not significantly correlated with folate intake estimated by food frequency questionnaire or biomarkers. The proportion of women with detectable levels of unmetabolized folic acid increased from
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Catherine E. Cottrell, Natalie Bir, Liz Varga et al. · 2011 · Autism Research
Structural and sequence variation have been described in several members of the contactin (CNTN) and contactin-associated protein (CNTNAP) gene families in association with neurodevelopmental disorders, including autism. Using array…
View details →Negative / Null Result ReportOpen accessMedicine
Nagla Abdel Karim, James Schuster, Ihab Eldessouki et al. · 2017 · Oncotarget
// Nagla Abdel Karim 1 , James Schuster 2 , Ihab Eldessouki 1 , Ola Gaber 1 , Tariq Namad 3 , Jiang Wang 4 , Changchun Xie 5 and John C. Morris 1 1 Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, OH 45219, USA 2 University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA 3 Military Hospital of Mohammed V, Department of Medical Oncology, Quartier Irfane, Rabat 10080, Morocco 4 UC Health University Hospital, Department of Pathology and Laboratory Medicine, Cincinnati, OH 45219, USA 5 Division of Biostatistics and Bioinformatics, Department of Environmental H
View details →Negative / Null Result ReportOpen accessMedicine
Mazen Hanna, W.H. Wilson Tang, Boon Wee Teo et al. · 2011 · Congestive Heart Failure
Compared with conventional diuretic (CD) therapy, ultrafiltration (UF) is associated with greater weight loss and fewer re-hospitalizations in patients admitted with decompensated heart failure (HF). Concerns have been raised regarding its…
View details →Negative / Null Result ReportOpen accessMedicine
J. Michael Jumper, Pravin U. Dugel, Sanford Chen et al. · 2018 · Clinical ophthalmology
PURPOSE: To evaluate the efficacy, safety, and injection frequency of vascular endothelial growth factor (VEGF) antagonists in the treatment of macular edema secondary to retinal vein occlusion (RVO) in clinical practice. PATIENTS AND…
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Rosendo Estrada, Guruprasad A. Giridharan, Mai-Dung Nguyen et al. · 2011 · Biomicrofluidics
Atherosclerotic lesions occur non-randomly at vascular niches in bends and bifurcations where fluid flow can be characterized as “disturbed” (low shear stress with both forward and retrograde flow). Endothelial cells (ECs) at these…
View details →Negative / Null Result Report
Irene Blanken, Niels van de Ven, Marcel Zeelenberg et al. · 2014 · Social Psychology
The present work includes three attempts to replicate the moral licensing effect by Sachdeva, Iliev, and Medin (2009) . The original authors found that writing about positive traits led to lower donations to charity and decreased…
View details →Negative / Null Result ReportOpen accessMedicine
C. Lennartz, John W. Pickering, Sarah Seiler-Mußler et al. · 2016 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Progression of CKD toward ESRD is heterogeneous. The Kidney Failure Risk Equation (KFRE) was developed to identify CKD patients at high risk of ESRD. We aimed to externally validate KFRE and to test whether the…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Laoise Renwick, Mary Lavelle, G. BRENNAN et al. · 2016 · International Journal of Mental Health Nursing
Workplace violence is a significant problem for health service personnel, with National Health Service (NHS) workers subject to 68 683 physical assaults between 2013 and 2014. Almost 70% of assaults occur in the mental health sector, and…
View details →Negative / Null Result ReportSocial Sciences
Haeseung Seo, Aiping Xiong, Dongwon Lee · 2019
Despite increased interests in the study of fake news, how to aid users' decision in handling suspicious or false information has not been well understood. To obtain a better understanding on the impact of warnings on individuals' fake…
View details →Negative / Null Result ReportOpen accessMedicine
Yi-Chieh Perng, Zhikang Qian, Anthony R. Fehr et al. · 2011 · Journal of Virology
In this study, we adopted a conditional protein genetic approach to characterize the role of the human cytomegalovirus (HCMV) gene UL79 during virus infection. We constructed ADddUL79, a recombinant HCMV in which the annotated UL79 open…
View details →Failed Experiment ReportOpen accessEngineering
Kaustav A. Gopinathan, Avanish Mishra, Baris R. Mutlu et al. · 2023 · Nature
Abstract Microfluidics have enabled notable advances in molecular biology 1,2 , synthetic chemistry 3,4 , diagnostics 5,6 and tissue engineering 7 . However, there has long been a critical need in the field to manipulate fluids and suspended matter with the precision, modularity and scalability of electronic circuits 8–10 . Just as the electronic transistor enabled unprecedented advances in the automatic control of electricity on an electronic chip, a microfluidic analogue to the transistor could enable improvements in the automatic control of reagents, droplets and single cells on a microflui
View details →Negative / Null Result ReportPsychology
Kasia Müldner, Rachel Lam, T. H. Michelene · 2013 · Journal of Educational Psychology
A promising instructional approach corresponds to learning by observing others learn (i.e., by watching tutorial dialogue between a tutor and tutee). However, more work is needed to understand this approach’s pedagogical utility. Thus, in…
View details →Negative / Null Result ReportOpen accessMedicine
Stefan Buettner, Bas Groot Koerkamp, Aslam Ejaz et al. · 2017 · Journal of Surgical Oncology
INTRODUCTION: While preoperative chemotherapy (pCT) is utilized in many intra-abdominal cancers, the use of pCT among patients with intrahepatic cholangiocarcinoma (ICC) remains ill defined. As such, the objective of the current study was…
View details →Negative / Null Result ReportMedicine
Paolo Capodaglio, Shirley A. De Souza, Cinzia Parisio et al. · 2012 · Disability and Rehabilitation
PURPOSE: The 6-Min Walking Test (6MWT) is widely used to measure the performance in various chronic conditions, such as in obese subjects. Reference equations for predicting distance walked during 6MWT specifically in adult obese subjects…
View details →Negative / Null Result Report
James Bailey, Anna Chorniy · 2015 · Contemporary Economic Policy
Many have argued that concerns over health insurance reduce labor market mobility in the United States, causing a “job lock” effect. We take advantage of the novel natural experiment created by the Affordable Care Act's dependent coverage…
View details →Negative / Null Result ReportOpen accessMedicine
Carolina Barroso, Pedro Carvalho, M.C. Nunes et al. · 2021 · Frontiers in Immunology
The current treatments applied in aquaculture to limit disease dissemination are mostly based on the use of antibiotics, either as prophylactic or therapeutic agents, with vaccines being available for a limited number of fish species and pathogens. Antimicrobial peptides are considered as promising novel substances to be used in aquaculture, due to their antimicrobial and immunomodulatory activities. Hepcidin, the major iron metabolism regulator, is found as a single gene in most mammals, but in certain fish species, including the European sea bass ( Dicentrarchus labrax ), two different hepci
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Henrique Lemos, Rong Ou, Caroline McCardle et al. · 2020 · Journal for ImmunoTherapy of Cancer
BACKGROUND: Activating the Stimulator of Interferon Genes (STING) adaptor incites antitumor immunity against immunogenic tumors in mice, prompting clinical trials to test STING activators. However, STING signaling in the tumor microenvironment (TME) during development of Lewis lung carcinoma (LLC) suppresses antitumor immunity to promote tumor growth. We hypothesized that local immune balance favoring suppression of antitumor immunity also attenuates antitumor responses following STING activation. The purpose of this study was to evaluate how STING activation impacts antitumor responses in mic
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Yang Zhang, Chaoqiang Deng, Qiang Zheng et al. · 2023 · Journal of Thoracic Oncology
INTRODUCTION: We aimed to prospectively evaluate our previously proposed selective mediastinal lymph node (LN) dissection strategy for peripheral clinical T1N0 invasive NSCLC. METHODS: This is a multicenter, prospective clinical trial in…
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Magali Petit, François Vézina · 2013 · Journal of Experimental Biology
Summary In small resident bird species living at northern latitudes, winter cold acclimatization is associated with an increase in pectoral muscle size and haematocrit level and this is thought to drive the seasonal increase in summit…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ziming Jiang, Haoxuan Zhang, Yibo Gao et al. · 2025 · Molecular Biomedicine
Multi-omics strategies, integrating genomics, transcriptomics, proteomics, and metabolomics, have revolutionized biomarker discovery and enabled novel applications in personalized oncology. Despite rapid technological developments, a comprehensive synthesis addressing integration strategies, analytical workflows, and translational applications has been lacking. This review presents a comprehensive framework of multi-omics integration, encompassing workflows, analytical techniques, and computational tools for both horizontal and vertical integration strategies, with particular emphasis on machi
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Mona Ståhle‐Bäckdahl · 2026 · Acta Dermato Venereologica
The aim of the study was to investigate clinical aspects of pruritus in maintenance hemodialysis patients and to evaluate factors of putative pathogenic importance. 60-65% of the patients in a maintenance hemodialysis program during a…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Andrés Baselga, Miguel B. Araújo · 2010 · Journal of Biogeography
Abstract Aim The aim of community‐level modelling is to improve the performance of species distributional models by taking patterns of co‐occurrence among species into account. Here, we test this expectation by examining how well three…
View details →Negative / Null Result ReportOpen accessMedicine
Harri Merisaari, Parisa Movahedi, Ileana Montoya Perez et al. · 2016 · Magnetic Resonance in Medicine
Purpose To evaluate different fitting methods for intravoxel incoherent motion (IVIM) imaging of prostate cancer in the terms of repeatability and Gleason score prediction. Methods Eighty‐one patients with histologically confirmed prostate…
View details →Negative / Null Result ReportMedicine
Fabrício Pereira, Alexandra Martini de Oliveira, Breno S. Diniz et al. · 2010 · Archives of Clinical Neuropsychology
The Direct Assessment of Functional Status-Revised (DAFS-R) is an instrument developed to objectively measure functional capacities required for independent living. The objective of this study was to translate and culturally adapt the…
View details →Negative / Null Result ReportOpen accessMedicine
J Kjaergaard, Carsten Bogh Juhl, Peter Lange et al. · 2020 · ERJ Open Research
OBJECTIVES: The aim of this study was to establish whether early pulmonary rehabilitation after severe exacerbation of chronic obstructive pulmonary disease (COPD) reduces mortality and hospital admissions, and increases physical…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Neil A. Hagen, Bernard Lapointe, May Ong-Lam et al. · 2011 · Current Oncology
BACKGROUND: Cancer pain is highly prevalent, and existing treatments are often insufficient to provide adequate relief. OBJECTIVES: We assessed the long-term safety and efficacy of subcutaneous tetrodotoxin treatment in reducing the intensity of chronic cancer-related pain. METHODS: In this multicentre open-label longitudinal trial, 30 μg tetrodotoxin was administered subcutaneously twice daily for 4 days in a heterogeneous cohort of patients with persistent pain despite opioids and other analgesics. "Responder" was defined as a mean reduction of 30% or more in pain intensity from baseline; an
View details →Negative / Null Result ReportOpen accessMedicine
Michael H. Roh, Vickie Y. Jo, Edward B. Stelow et al. · 2010 · American Journal of Clinical Pathology
A fine-needle aspiration sample composed exclusively of Hürthle cells is interpreted as "suspicious for a follicular neoplasm, Hürthle cell type" (SFNHCT). Because some nonneoplastic Hürthle cell proliferations in Hashimoto thyroiditis…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Alina Franzen, Timo Vogt, Tim Müller et al. · 2017 · Oncotarget
// Alina Franzen 1 , Timo J. Vogt 1 , Tim Müller 2 , Jörn Dietrich 1 , Andreas Schröck 1 , Carsten Golletz 2 , Peter Brossart 3 , Friedrich Bootz 1 , Jennifer Landsberg 4 , Glen Kristiansen 2 and Dimo Dietrich 1 1 Department of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany 2 Institute of Pathology, University Hospital Bonn, Bonn, Germany 3 Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany 4 Department of Dermatology, Bonn, University Hospital Bonn, Germany Correspondence to: Dimo Dietrich, email: dimo.di
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