Negative / Null Result Report
Irene Blanken, Niels van de Ven, Marcel Zeelenberg et al. · 2014 · Social Psychology
The present work includes three attempts to replicate the moral licensing effect by Sachdeva, Iliev, and Medin (2009) . The original authors found that writing about positive traits led to lower donations to charity and decreased…
View details →Negative / Null Result ReportOpen accessMedicine
C. Lennartz, John W. Pickering, Sarah Seiler-Mußler et al. · 2016 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Progression of CKD toward ESRD is heterogeneous. The Kidney Failure Risk Equation (KFRE) was developed to identify CKD patients at high risk of ESRD. We aimed to externally validate KFRE and to test whether the…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Laoise Renwick, Mary Lavelle, G. BRENNAN et al. · 2016 · International Journal of Mental Health Nursing
Workplace violence is a significant problem for health service personnel, with National Health Service (NHS) workers subject to 68 683 physical assaults between 2013 and 2014. Almost 70% of assaults occur in the mental health sector, and…
View details →Negative / Null Result ReportSocial Sciences
Haeseung Seo, Aiping Xiong, Dongwon Lee · 2019
Despite increased interests in the study of fake news, how to aid users' decision in handling suspicious or false information has not been well understood. To obtain a better understanding on the impact of warnings on individuals' fake…
View details →Negative / Null Result ReportOpen accessMedicine
Yi-Chieh Perng, Zhikang Qian, Anthony R. Fehr et al. · 2011 · Journal of Virology
In this study, we adopted a conditional protein genetic approach to characterize the role of the human cytomegalovirus (HCMV) gene UL79 during virus infection. We constructed ADddUL79, a recombinant HCMV in which the annotated UL79 open…
View details →Failed Experiment ReportOpen accessEngineering
Kaustav A. Gopinathan, Avanish Mishra, Baris R. Mutlu et al. · 2023 · Nature
Abstract Microfluidics have enabled notable advances in molecular biology 1,2 , synthetic chemistry 3,4 , diagnostics 5,6 and tissue engineering 7 . However, there has long been a critical need in the field to manipulate fluids and suspended matter with the precision, modularity and scalability of electronic circuits 8–10 . Just as the electronic transistor enabled unprecedented advances in the automatic control of electricity on an electronic chip, a microfluidic analogue to the transistor could enable improvements in the automatic control of reagents, droplets and single cells on a microflui
View details →Negative / Null Result ReportPsychology
Kasia Müldner, Rachel Lam, T. H. Michelene · 2013 · Journal of Educational Psychology
A promising instructional approach corresponds to learning by observing others learn (i.e., by watching tutorial dialogue between a tutor and tutee). However, more work is needed to understand this approach’s pedagogical utility. Thus, in…
View details →Negative / Null Result ReportOpen accessMedicine
Stefan Buettner, Bas Groot Koerkamp, Aslam Ejaz et al. · 2017 · Journal of Surgical Oncology
INTRODUCTION: While preoperative chemotherapy (pCT) is utilized in many intra-abdominal cancers, the use of pCT among patients with intrahepatic cholangiocarcinoma (ICC) remains ill defined. As such, the objective of the current study was…
View details →Negative / Null Result ReportMedicine
Paolo Capodaglio, Shirley A. De Souza, Cinzia Parisio et al. · 2012 · Disability and Rehabilitation
PURPOSE: The 6-Min Walking Test (6MWT) is widely used to measure the performance in various chronic conditions, such as in obese subjects. Reference equations for predicting distance walked during 6MWT specifically in adult obese subjects…
View details →Negative / Null Result Report
James Bailey, Anna Chorniy · 2015 · Contemporary Economic Policy
Many have argued that concerns over health insurance reduce labor market mobility in the United States, causing a “job lock” effect. We take advantage of the novel natural experiment created by the Affordable Care Act's dependent coverage…
View details →Negative / Null Result ReportOpen accessMedicine
Carolina Barroso, Pedro Carvalho, M.C. Nunes et al. · 2021 · Frontiers in Immunology
The current treatments applied in aquaculture to limit disease dissemination are mostly based on the use of antibiotics, either as prophylactic or therapeutic agents, with vaccines being available for a limited number of fish species and pathogens. Antimicrobial peptides are considered as promising novel substances to be used in aquaculture, due to their antimicrobial and immunomodulatory activities. Hepcidin, the major iron metabolism regulator, is found as a single gene in most mammals, but in certain fish species, including the European sea bass ( Dicentrarchus labrax ), two different hepci
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Henrique Lemos, Rong Ou, Caroline McCardle et al. · 2020 · Journal for ImmunoTherapy of Cancer
BACKGROUND: Activating the Stimulator of Interferon Genes (STING) adaptor incites antitumor immunity against immunogenic tumors in mice, prompting clinical trials to test STING activators. However, STING signaling in the tumor microenvironment (TME) during development of Lewis lung carcinoma (LLC) suppresses antitumor immunity to promote tumor growth. We hypothesized that local immune balance favoring suppression of antitumor immunity also attenuates antitumor responses following STING activation. The purpose of this study was to evaluate how STING activation impacts antitumor responses in mic
View details →Negative / Null Result ReportOpen accessMedicine
Yang Zhang, Chaoqiang Deng, Qiang Zheng et al. · 2023 · Journal of Thoracic Oncology
INTRODUCTION: We aimed to prospectively evaluate our previously proposed selective mediastinal lymph node (LN) dissection strategy for peripheral clinical T1N0 invasive NSCLC. METHODS: This is a multicenter, prospective clinical trial in…
View details →Negative / Null Result Report
Magali Petit, François Vézina · 2013 · Journal of Experimental Biology
Summary In small resident bird species living at northern latitudes, winter cold acclimatization is associated with an increase in pectoral muscle size and haematocrit level and this is thought to drive the seasonal increase in summit…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Andrés Baselga, Miguel B. Araújo · 2010 · Journal of Biogeography
Abstract Aim The aim of community‐level modelling is to improve the performance of species distributional models by taking patterns of co‐occurrence among species into account. Here, we test this expectation by examining how well three…
View details →Negative / Null Result ReportOpen accessMedicine
Harri Merisaari, Parisa Movahedi, Ileana Montoya Perez et al. · 2016 · Magnetic Resonance in Medicine
Purpose To evaluate different fitting methods for intravoxel incoherent motion (IVIM) imaging of prostate cancer in the terms of repeatability and Gleason score prediction. Methods Eighty‐one patients with histologically confirmed prostate…
View details →Negative / Null Result ReportMedicine
Fabrício Pereira, Alexandra Martini de Oliveira, Breno S. Diniz et al. · 2010 · Archives of Clinical Neuropsychology
The Direct Assessment of Functional Status-Revised (DAFS-R) is an instrument developed to objectively measure functional capacities required for independent living. The objective of this study was to translate and culturally adapt the…
View details →Negative / Null Result ReportOpen accessMedicine
J Kjaergaard, Carsten Bogh Juhl, Peter Lange et al. · 2020 · ERJ Open Research
OBJECTIVES: The aim of this study was to establish whether early pulmonary rehabilitation after severe exacerbation of chronic obstructive pulmonary disease (COPD) reduces mortality and hospital admissions, and increases physical…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Neil A. Hagen, Bernard Lapointe, May Ong-Lam et al. · 2011 · Current Oncology
BACKGROUND: Cancer pain is highly prevalent, and existing treatments are often insufficient to provide adequate relief. OBJECTIVES: We assessed the long-term safety and efficacy of subcutaneous tetrodotoxin treatment in reducing the intensity of chronic cancer-related pain. METHODS: In this multicentre open-label longitudinal trial, 30 μg tetrodotoxin was administered subcutaneously twice daily for 4 days in a heterogeneous cohort of patients with persistent pain despite opioids and other analgesics. "Responder" was defined as a mean reduction of 30% or more in pain intensity from baseline; an
View details →Negative / Null Result ReportOpen accessMedicine
Michael H. Roh, Vickie Y. Jo, Edward B. Stelow et al. · 2010 · American Journal of Clinical Pathology
A fine-needle aspiration sample composed exclusively of Hürthle cells is interpreted as "suspicious for a follicular neoplasm, Hürthle cell type" (SFNHCT). Because some nonneoplastic Hürthle cell proliferations in Hashimoto thyroiditis…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Alina Franzen, Timo Vogt, Tim Müller et al. · 2017 · Oncotarget
// Alina Franzen 1 , Timo J. Vogt 1 , Tim Müller 2 , Jörn Dietrich 1 , Andreas Schröck 1 , Carsten Golletz 2 , Peter Brossart 3 , Friedrich Bootz 1 , Jennifer Landsberg 4 , Glen Kristiansen 2 and Dimo Dietrich 1 1 Department of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany 2 Institute of Pathology, University Hospital Bonn, Bonn, Germany 3 Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany 4 Department of Dermatology, Bonn, University Hospital Bonn, Germany Correspondence to: Dimo Dietrich, email: dimo.di
View details →Negative / Null Result ReportMedicine
Benoît Tyl, Meriam Kabbaj, Sara M. Azzam et al. · 2011 · The Journal of Clinical Pharmacology
The effect of bilastine on cardiac repolarization was studied in 30 healthy participants during a multiple-dose, triple-dummy, crossover, thorough QT study that included 5 arms: placebo, active control (400 mg moxifloxacin), bilastine at…
View details →Negative / Null Result ReportOpen accessNeuroscience
Natalia Sánchez, Sungwoo Park, James M. Finley · 2017 · Scientific Reports
The theory that the sensorimotor system minimizes energetic cost during locomotion has long been supported by both computational models and empirical studies. However, it has yet to be determined if the behavior to which people converge when exposed to a novel perturbation during locomotion is also energetically optimal. We address this issue in the context of adaptation to walking on a split-belt treadmill, which can impose a left-right asymmetry in step lengths. In response to this asymmetry, participants gradually adjust their foot placement to adopt steps of equal length. Here, we characte
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Mohammad R. Jahan‐Parvar, Hassan Mohammadi · 2011 · The Journal of developing areas
We test the validity of the Dutch disease hypothesis by examining the relationship between real oil prices and real exchange rates in a sample of fourteen oil exporting countries. Autoregressive distributed lag (ARDL) bounds tests of…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Hlalefang Khobai, Nwabisa Kolisi, Clement Moyo et al. · 2020 · International Journal of Energy Economics and Policy
The importance of renewable energy consumption has grown to a large extent over the recent years. The benefits of renewable energy consumption ranging from improved environmental quality to higher economic growth are well documented. However, the impact of renewable energy consumption on unemployment has received relatively less attention. This study examines the relationship between renewable energy consumption and unemployment in South Africa over the period 1990-2014. The Autoregressive Distributed Lag (ARDL) model was employed to test the long-run and short-run impacts of renewable energy
View details →Negative / Null Result ReportOpen accessMedicine
Mona Ståhle‐Bäckdahl · 2026 · Acta Dermato Venereologica
The aim of the study was to investigate clinical aspects of pruritus in maintenance hemodialysis patients and to evaluate factors of putative pathogenic importance. 60-65% of the patients in a maintenance hemodialysis program during a…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Matthew R. Masters, Amr H. Mahmoud, Markus A. Lill · 2025 · Nature Communications
Co-folding models represent a major innovation in deep-learning-based protein-ligand structure prediction. The recent publications of RoseTTAFold All-Atom, AlphaFold3, and others have shown high-quality results on predicting the structures of proteins interacting with small-molecules, nucleic-acids, and other proteins. Despite these advanced capabilities and broad potential, the current study presents critical findings that question the adherence of these models to fundamental physical principles. Through adversarial examples based on established physical, chemical, and biological principles,
View details →Negative / Null Result Report
Megan Best, Phyllis Butow, Ian Olver · 2016 · Journal of Clinical Medicine
Background: Despite known health benefits of spiritual care and high patient interest in discussing spirituality with their physicians, the frequency of spiritual discussions in the medical consultation is low. We investigated spiritual…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Junpeng Wang, Xue Yubo, Minghao Liu · 2016
As the world's first completely decentralized digital payment system, the emergence of bitcoin represents a revolutionary phenomenon in financial markets. This paper mainly studies the fluctuations of bitcoin price and discusses weather…
View details →Negative / Null Result ReportOpen accessPsychology
Thomas Mangin, Nathalie André, Abdelrhani Benraïss et al. · 2021 · Psychology of sport and exercise
The ego-depletion effect refers to a temporary failure of self-control exertion after first performing an effortful task. This phenomenon has experienced a replication crisis in the past few years. In the present series of experiments, we…
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