21,770 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Hamilton WL, Moore J, Patel P et al. · 2026 · Preprint
Introduction: Invasive fungal infections (IFI) are an important cause of morbidity and mortality in haemato-oncology (haem-onc) patients with neutropenia, requiring rapid and accurate diagnosis. Gap Statement With widespread use of…
View details →De Gregorio DA, Castro DC · 2026 · Preprint
The mu opioid receptor system has long been recognized for its role in regulating ingestive behaviors and food palatability. However, beyond their robust expression in the brain, opioid receptors are also found throughout the body,…
View details →Wojciechowska M, Rodzeń W · 2026 · Preprint
Background: /Objectives: The present study aimed to examine the relationship between Dark Triad personality traits (narcissism, psychopathy, and machiavellianism) and conspiratorial thinking. Additionally, it sought to investigate whether…
View details →Jorgensen E, Modahl L, Noll A et al. · 2026 · The Journal of the Acoustical Society of America
This study investigated how hearing loss and hearing aid use affect environmental sound ratings in laboratory and real-world contexts using the soundscape framework. Forty-four participants (17 normal hearing, 14 with unaided hearing loss,…
View details →Parrish BP, McCool BA · 2026 · Neuropharmacology
Acute ethanol modulates an incredibly diverse number of neurotransmitter receptors and intracellular pathways. Presynaptic modulation by acute ethanol has been identified at some GABAergic synapses; but descriptions of acute ethanol…
View details →Strandberg E, Vikmoen O, Svindland KV et al. · 2026 · European journal of sport science
To evaluate whether strength training during chemotherapy alters (1) serum cytokines and (2) skeletal muscle autophagy- and heat-shock-related proteins in women with breast cancer. Exploratory analyses assessed associations between changes…
View details →Fortugno P, Foti F, Caparra P et al. · 2026 · Preprint
Bergamot-derived products have gained increasing interest as dietary supplements in small animal nutrition, due to their potential to improve meat quality, and provide functional bioactive compounds. This paper investigated the effects of…
View details →García-Mendoza A, González-Hernández M, Vega-Manriquez DX et al. · 2026 · Veterinary sciences
This study investigated the associations among dam lactation number, passive immunity transfer, internal parasite burden, and weaning performance in female calves. Early consumption of high-quality colostrum is critical for effective…
View details →Uenishi R, Kawata R, Manabe T et al. · 2026 · Preprint
Neuroinflammation is a central driver of tauopathy, yet the precise chemokines that orchestrate the inflammatory microenvironment remain elusive. Here, we report C-X-C motif chemokine ligand 10 (CXCL10) is markedly upregulated in the…
View details →Dachille GP, Zuanna AD, Paiella M et al. · 2026 · Preprint
Abstract We quantify how the employment expansion accompanying Italy’s post-pandemic recovery mitigated the distributional consequences of the contemporaneous surge in prices, which disproportionately affected households at the bottom of…
View details →Cárdenas SA · 2026 · Preprint
Objective(s): Strategic overcharging involves threatening disproportionately harsh punishment to widen the differential between the potential sentence if convicted at trial (PTS) and the plea sentence. Though larger discounts increase plea…
View details →Enciso-Pablo Ó, Sierra-Ramírez F, Sotres-Bayon F · 2026 · Psychopharmacology
Rationale Benzodiazepines are widely used to treat anxiety; however, their influence on defensive behavior when threats compete with rewards remains unclear. Objectives Here, we tested the effects of diazepam on reactive avoidance (no…
View details →Ben-Chetrit E, Zilberstein Z, Levin PD · 2026 · Preprint
Abstract Background Obtaining blood cultures at IV insertion is common practice, but is probably associated with greater contamination. Whether use of first-aliquot-diversion (diversion) reduces contamination in this context is not clear.…
View details →Jiang Y, Zanganeh M, Waugh N et al. · 2026 · Gastrointestinal endoscopy
Background and aims Endoscopy units are increasingly being encouraged to consider replacing multiple-use (MU) endoscopes with single-use (SU) endoscopes, largely due to reduction in cross-infection. While evidence suggests comparable…
View details →Rajhansa S, Crump NT, Khoo HM et al. · 2026 · Experimental hematology
A major challenge in cancer therapeutics has been the identification of targets that are selectively toxic to cancer cells while displaying limited effects on healthy counterparts. Toxicities related to blood production from hematopoietic…
View details →Sawatpanich T, Innoi S, Chaiyamoon A et al. · 2026 · Life (Basel, Switzerland)
Morus alba L. fruit extract (MFE), which is rich in cyanidin 3-glucoside (C3G), demonstrates antioxidant properties and pharmacological effects, but its reproductive safety remains poorly understood. Polyphenols modulate steroidogenesis,…
View details →Jeremic M, Jovanovic-Tucovic M, Martinovic T et al. · 2026 · Neurotoxicology
The mechanistic target of rapamycin complex 2 (mTORC2), a key regulator of cellular metabolism, growth, and survival, remains poorly characterized in the context of dopaminergic neurotoxicity. In this study, we investigated the role of…
View details →Abdelmenam DS, Elshahawy WM, Ahmed RK · 2026 · Odontology
This study aimed to assess the effect of incorporating sodium fluoride (NaF) into an adhesive system on the microtensile bond strength of ceramic occlusal veneers. Eighty resin-dentin sticks (~ 1 mm 2 ) were obtained from 20 upper first…
View details →Nicholas M, Ianssen M, Costa D et al. · 2026 · Preprint
Abstract Purpose Psychosocial factors have been identified as risks for delayed recovery after work injuries but results from interventions for high-risk cases have been mixed. An earlier Australian study that matched care to assessed…
View details →Hajj-Boutros G, Faust A, Mastrandrea C et al. · 2026 · Experimental physiology
Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head-down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure…
View details →Cuadro R, Borrajo CI, Marino MA et al. · 2026 · European Journal of Agronomy.
Nitrogen (N) and phosphorus (P) deficiencies commonly limit plant growth in agroecosystems. While critical N concentration (Nc) dilution curves are widely used to assess the N status of crops and pastures, it remains unclear whether Nc…
View details →Zhao Y, Ma Y, Fan Y et al. · 2023 · Lung cancer (Amsterdam, Netherlands)
Purpose This study aimed to evaluate the efficacy and safety of cadonilimab (anti PD-1 and CTLA-4 bispecific antibody) in patients with previously treated metastatic non-small-cell lung cancer (NSCLC). Methods In this multicenter,…
View details →Karavia EA, Pittaras A, Andreopoulou O et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background/Objectives: Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), represents a growing global health burden closely linked to obesity, insulin…
View details →Limon D, Bokstein F, Blumenthal DT et al. · 2026 · Neuro-oncology advances
Background Tumor-treating fields (TTFields) have demonstrated efficacy in newly diagnosed glioblastoma (ndGBM) when combined with adjuvant temozolomide (TMZ). Preclinical studies suggest that TTFields enhance the therapeutic effect of…
View details →Gaebel L, Gerhardt T, Khamhoung A et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundClonal hematopoiesis (CH) increases with age and elevates the risk of numerous age-associated diseases. However, the association between CH and neurodegenerative diseases has remained unclear.ObjectiveWe tested the association…
View details →Zubareva OE, Melik-Kasumov TB, Sinyak DS et al. · 2026 · Neurochemistry international
Activation of peroxisome proliferator-activated receptor alpha (PPARα) suppresses neuroinflammation and may interrupt epileptogenesis. We tested whether early intervention with the PPARα agonist fenofibrate exerts disease-modifying effects…
View details →Prakash V, Barnes BG, Windorff CJ · 2026 · Communications chemistry
Uranium-nitrogen compounds (U x N y ) pose interesting structural and electronic questions. Understanding the formation and speciation of U x N y may provide insights in nitrogen fixation as well as the preparation of potential uranium…
View details →Lawrence AG, Murangi T, Chevalier A et al. · 2026 · Journal of thrombosis and haemostasis : JTH
Background Hemophilic arthropathy (HA) is a chronic joint disease caused by repeated joint bleeding in patients with hemophilia, leading to joint degeneration despite prophylactic treatment. The CX3CL1 (fractalkine)-CX3CR1 chemokine axis…
View details →Chiusaroli L, Chiusaroli L, Boustany M et al. · 2026 · The Pediatric infectious disease journal
Background Routine blood cultures (BCs) are frequently obtained in hospitalized children with suspected infection. Although bacterial pathogens are the primary concern, fungal infections remain a consideration in high-risk populations,…
View details →Lerma-Clavero A, Kopsida M, Arendt N et al. · 2026 · FEBS open bio
The unfolded protein response (UPR) plays an important role in tumor progression and cellular stress adaptation. In hepatocellular carcinoma (HCC), pharmacological inhibition of the protein kinase R-like endoplasmic reticulum kinase (PERK)…
View details →