Negative / Null Result ReportOpen accessMedicine (General)
Rui Ping Peng, Zi Qian Zhu, Hong Yi Shen et al. · 2022 · Frontiers in Medicine
ObjectiveThis study aimed to observe vascular and neuroretinal alterations in people with prediabetes [impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)] and normal glucose metabolism.MethodsA total of 21 patients with prediabetes (42 eyes) and 20 healthy controls (40 eyes) participated in our study. All patients underwent a complete eye examination [including fundus fluorescein angiography (FFA) and optical coherence tomography (OCT)] and a related general examination (complete biochemical analysis, routine blood tests, and glycosylated hemoglobin).ResultsOn FFA, no patients
View details →Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Alexandra Skovran, Mason Hinke, Shelly N. B. Sloan et al. · 2022 · Emergency and Critical Care Medicine
Abstract. Background. Sepsis is the leading cause of death in hospitalized patients and significant effort has been made to facilitate early diagnosis and management. However, aggressive treatment can have negative effects, especially in patients with unstable volume status, such as those with congestive heart failure. Methods. We used electronic medical records to perform a retrospective study looking at hospital outcomes in patients from Southwest Missouri who were admitted with sepsis and had a comorbid diagnosis of hypertensive heart failure. Our primary outcome was in-hospital mortality.
View details →Negative / Null Result ReportOpen accessDentistry
Utku Böcüoğlu, Esra Ateş Yıldırım, Selma Erdoğan Düzcü et al. · 2026 · BMC Oral Health
Abstract Objectives This in vitro study aimed to evaluate the effect of laser photobiomodulation on the structural integrity and degradation resistance of two types of platelet-rich fibrin membranes: Leukocyte- and Platelet-Rich Fibrin (L-PRF) and Titanium-Prepared Platelet-Rich Fibrin (T-PRF). Structural changes in the fibrin network were assessed using Scanning Electron Microscopy (SEM) and light microscopy. Materials and methods Our study was performed on 15 systemically healthy individuals and four L-PRF and four T-PRF membranes obtained from each individual, totaling 120 samples. L-PRF wa
View details →Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Zhu Guo-Pei, Lu Jiade, Xiong Xiao-Peng et al. · 2011 · Radiation Oncology
Abstract Background High-precision radiation therapy techniques such as IMRT or sterotactic radiosurgery, delivers more complex treatment fields than conventional techniques. The increased complexity causes longer dose delivery times for each fraction. The purpose of this work is to explore the radiobiologic effect of prolonged fraction delivery time on tumor response and survival in vivo. Methods 1-cm-diameter Lewis lung cancer tumors growing in the legs of C57BL mice were used. To evaluate effect of dose delivery prolongation, 18 Gy was divided into different subfractions. 48 mice were rando
View details →Negative / Null Result ReportOpen accessSurgery
Eiji Nomura, Takatoshi Seki, Kentaro Yatabe et al. · 2024 · World Journal of Surgical Oncology
Abstract Background Elderly gastric cancer patients (EGCPs) require treatment according to not just the stage of their cancer, but also to their general condition and organ function, and rather than full treatment, the appropriate amount of treatment is necessary. Methods A total of 425 patients who underwent gastrectomy for primary gastric cancer in our institution between April 2013 and March 2020 were classified by age into two groups: elderly patients (EP, age ≥ 80 years, n = 89); and younger patients (YP, age < 80 years, n = 336). The preoperative, intraoperative, and postoperative condit
View details →Negative / Null Result ReportOpen accessMedicine
Falcão MG, Suarez MA, Ferreira ACOP et al. · 2026 · Acta ortopedica brasileira
Objective To analyze the outcomes related to partial and total hip arthroplasties in elderly patients with femoral neck fractures at a hospital in the city of São Paulo. Material and methods We reviewed the medical records of patients…
View details →Negative / Null Result ReportOpen accessMedicine
Tryness Munyapa, Thokozani Mzumara, Grace Ogbonna et al. · 2023 · Health Science Reports
Abstract Background and Aim Goldman Applanation Tonometry (GAT), the gold standard of tonometry, is used without fluorescein in low‐resource settings. Nevertheless, corneal biomechanics differ among population groups. Purpose The aim of the study is to assess the relationship between GAT findings with and without fluorescein among glaucomatous and nonglaucomatous adults in Malawi. Methods This was a cross‐sectional quantitative study involving 22 glaucoma patients and 22 nonglaucoma patients at Mzuzu Central Hospital. We used a purposive sampling technique to select participants into the two g
View details →Negative / Null Result ReportOpen accessSpecialties of internal medicine
elham abdelsamiee, Fatma farahat, Ahmad Hamed · 2021 · Zagazig Journal of Forensic Medicine and Toxicology
Background: Sex identification of human skeleton is essential for bioarcheological and forensic studies. Determination of Sex is important to establish personal identity. Sex identification accurately depends on the presence of complete remains. Aim: This study aimed to estimate sex from measurements of sacrum and coccyx by computed tomography (CT) of Libyan population. Subjects and methods: A cross-sectional study was carried out in Radiological center of Aljala Hospital of Benghazi and Benghazi Medical Center, Libya on 120 subjects who were divided into 60 males and 60 females. Sex was deter
View details →Negative / Null Result ReportOpen accessMedicine
Esma Altan, Elife Barmak, Ebru Karaca Umay et al. · 2025 · Gazi Medical Journal
Objective: Spasmodic dysphonia (SD) is a neurological movement disorder involving the laryngeal muscles. There are three main types: adductor, abductor, and mixed type. Adductor type is the most common and mixed type is the rarest. Botox, the gold standard in treatment, is applied to the affected muscle group according to the type of SD. Dysphagia often occurs as a side effect of botulinum toxin injection treatment in spasmodic dystonia. Dysphagia may sometimes be seen secondary to SD. Methods: This study included 8 patients with adductor SD without dysphagia and 8 healthy subjects. The total
View details →Negative / Null Result ReportOpen accessOrthopedic surgery
Michał Maciejewski, Piotr Janusz, Michalina Dudkiewicz et al. · 2023 · Chirurgia Narządów Ruchu i Ortopedia Polska
Introduction. Radial neck fractures in children are rare and account for 1-3% of all childhood trauma. Severe displacement of the fracture can lead to a higher incidence of complications, such as limited range of motion (ROM), pain, instability, neurovascular trauma, premature physeal closure, cubitus valgus, radial head overgrowth, avascular necrosis and improper ossification. The treatment outcome depends on the injury type, treatment method and presence of complications.Aim. The purpose of the study was to assess the outcome of patients treated with elastic-stable intramedullary nailing (ES
View details →Negative / Null Result ReportOpen accessMedicine
Quamrun Nahar, Farhana Sultana, Anadil Alam et al. · 2014 · PLoS ONE
Background There has been no population-based study on human papillomavirus (HPV) prevalence or its genotypes in Bangladesh; a country eligible for GAVI funding for HPV vaccine. Methods We used baseline survey data of a prospective cohort study that was conducted in one urban and one rural area of Bangladesh. A total of 997 urban and 905 rural married women, aged 13 to 64 years, were enrolled in the baseline during July-December, 2011. Information was collected on socio-demographic characteristics and potential risk factors for HPV infection followed by gynecological examination and collection
View details →Negative / Null Result ReportOpen accessMedical technology
Mona Makita, Shinichi Kawamoto, Momoko Nagai-Tanima et al. · 2025 · Biomedical Engineering Advances
The ground reaction force (GRF) waveform during countermovement jumps (CMJs) is considered to reflect neuromuscular coordination strategies; yet the biomechanical mechanisms distinguishing unimodal from bimodal patterns remain unclear. This study investigated the influence of countermovement depth and velocity on GRF waveform shape and examined their relationship with joint moments and work. Twenty-six healthy young women (age: 22.1 ± 1.1 years; height: 160.8 ± 4.0 cm; body weight: 53.5 ± 5.6 kg) performed CMJs, and GRF waveforms were categorised as unimodal and bimodal patterns. Jump-related
View details →Negative / Null Result ReportOpen accessMedicine
Tuantuan Li, Jing Xu, Yong Gao et al. · 2023 · European Journal of Medical Research
Abstract Objective To investigate the clinical significance and value of peripheral blood T lymphocyte subset in patients with asymptomatic novel coronavirus variant strains infection (OMICRON). Methods A retrospective analysis of 281 patients with asymptomatic OMICRON infection who were admitted and isolated to the Fuyang Second People's Hospital from March to April 2022 was conducted. With 32 normal people as the control group, T lymphocytes of the two groups (CD3 + T, CD3 + CD4 + T, CD3 + CD8 + T) were analyzed and the differences between the two groups were analyzed. CD4 + T lymphocytes be
View details →Negative / Null Result ReportOpen accessMaterials of engineering and construction. Mechanics of materials
Lihui ZHANG, Shuo XIE, Mingfa LUO et al. · 2024 · Jin'gangshi yu moliao moju gongcheng
Objectives: Bone tissue grinding is one of the common and basic applications in orthopedic surgery clinics. The grinding process is energy-intensive and generates a lot of grinding heat. The accumulation of this heat may cause thermal damage to biological tissues. This paper presents experimental research to investigate the bone-grinding heat and the cooling method. Methods: The combined influence of nozzle position and feed direction on the cooling effect of bone grinding under cryogenic spray cooling conditions is experimentally investigated. A bone grinding platform with three-dimensional m
View details →Negative / Null Result ReportOpen accessMedicine
Darpan I. Patel, Kira Abuchowski, Bilal Sheikh et al. · 2019 · European Journal of Translational Myology
The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04).
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Ju Chen, Faming Zhao, Faming Zhao et al. · 2023 · Frontiers in Pharmacology
Background and Purpose: The aim of this study was to explore the effect of half a year of evolocumab plus moderate-intensity statin treatment on carotid intraplaque neovascularization (IPN) and blood lipid levels.Methods: A total of 31 patients with 33 carotid plaques who received evolocumab plus statin treatment were included. Blood lipid levels, B-mode ultrasound and contrast-enhanced ultrasonography (CEUS) at baseline and after half a year of evolocumab plus statin therapy were collected. The area under the curve (AUC) reflected the total amount of acoustic developer entering the plaque or
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Rafigheh Ghiasi, Mustafa Mohammadi, Javad Ashrafi Helan et al. · 2015 · Journal of Cardiovascular and Thoracic Research
Introduction: The previous studies have suggested that alteration in oxidative stress and antioxidant defense depends on various factors, such as mode, intensity, frequency and duration of exercise. In this study, we compared the effects of two various durations of resistance exercise (1 month and 4 month) on oxidative stress and antioxidant status in cardiac tissue. Methods: Thirty Wistar male rats divided into 3 groups: control (sedentary), exercise-1 (regular exercise for 1 month) and exercise-2 group (regular exercise for 4 months). After the final to the experiment, the rats were anesthet
View details →Negative / Null Result ReportOpen accessDentistry
Mirian de Waele Souchois Marsillac, Alberto Carlos Botazzo Delbem, Ricardo de Sousa Vieira · 2016 · Brazilian Journal of Oral Sciences
A cross-sectional microhardness (CSMH) test was carried out in human dental enamel exposed to a demineralizing solution in order to evaluate two different times of indentation in sound tissue and artificially induced caries. Twenty caries-free extracted human molars had one of their smooth surfaces sectioned and the enamel surface was isolated with nail polish except for an area of 6 mm2 . These specimens were submitted to artificially induced enamel caries on a lactate buffer containing 0.1 ppm fluoride (F) during 28 days. All specimens were bisected to create groups A and B in which CSMH tes
View details →Negative / Null Result ReportOpen accessMedicine
Jingjing Zhou, Shanshan Wu, Xiaojing Wu et al. · 2023 · PLoS ONE
The cultural landscape in traditional settlements is an important historical and cultural resource created by human beings in the process of historical evolution, and is an important resource for the development of traditional settlement tourism. This paper selected 21 representative traditional settlements for research using online comments from tourists as data and content analytical methods including high-frequency vocabulary, semantic networks and emotional attitudes to explore the public perspective on the connotations of cultural landscape features in traditional settlements. There are f
View details →Negative / Null Result ReportOpen accessDentistry
M. A. Adedigba, O. O. Ojo, E. O. Ogunbodede et al. · 2008 · Nigerian Dental Journal
Objective: To determine the coping ability of people living with HIV/AIDS (PLWHA) across demographic variations of gender, duration of living with HIV infection, marital status and living arrangements either with the family or alone. Method: The research design adopted in this study was descriptive survey. The population consisted of all PLWHA in Nigeria. The sample comprised of 117 PLWHA attending clinic regularly at General Hospital Ilesa, Osun State, Nigeria. The subjects had all been exposed to voluntary counselling and testing (VCT). Only those who consented participated in the study. A s
View details →Negative / Null Result ReportOpen accessSurgery
Eric R. Bain, Bistees George, Syed H. Jafri et al. · 2024 · Journal of Cardiothoracic Surgery
Abstract Background Patients with severe aortic stenosis (AS) and left ventricular (LV) dysfunction demonstrate improvement in left ventricular injection fraction (LVEF) after aortic valve replacement (AVR). The timing and magnitude of recovery in patients with very low LVEF (≤ 25%) in surgical or transcatheter AVR is not well studied. Objective Determine clinical outcomes following transcatheter aortic valve replacement (TAVR) and surgical aortic valve repair (SAVR) in the subset of patients with severely reduced EF ≤ 25%. Methods Single-center, retrospective study with primary endpoint of LV
View details →Negative / Null Result ReportOpen accessPsychology
Sime Nkemeni Darrin, Hong Hao, Cheng Long et al. · 2026 · Frontiers in Psychology
IntroductionThis study investigates the cognitive effects of long term (years of practice) Tai Chi practice, revealing mixed outcomes for executive functions. This study equally addresses the gap in research regarding the long term effects of Tai Chi, emphasizing its influence on the executive functions of young adults.MethodsUsing the BRIEFA scale and tasks like the Flanker task, More Odd Shift Task, and Nback tasks, significant differences emerged between Tai Chi students and nonstudents.ResultsIn the results, Tai Chi students demonstrated superior inhibitory control and working memory compa
View details →Negative / Null Result ReportOpen accessAnesthesiology
Volkan Hancı, Şule Özbilgin, Seda Özbal et al. · Revista Brasileira de Anestesiologia
Abstract Background: Intra-arterial injection of medications may cause acute and severe ischemia and result in morbidity and mortality. There is no information in the literature evaluating the arterial endothelial effects of sugammadex and dexmedetomidine. The hypothesis of our study is that sugammadex and dexmedetomidine will cause histological changes in arterial endothelial structure when administered intra-arterially. Methods: Rabbits were randomly divided into 4 groups. Group Control (n = 7); no intervention performed. Group Catheter (n = 7); a cannula inserted in the central artery of th
View details →Negative / Null Result ReportOpen accessDentistry
Priscilla Coutinho ROMUALDO, Thaís Rodrigues GUERRA, Fábio Lourenço ROMANO et al. · Journal of Applied Oral Science
Abstract Bacterial endotoxin (LPS) adhesion to orthodontic brackets is a known contributing factor to inflammation of the adjacent gingival tissues. Objective The aim of this study was to assess whether LPS adheres to orthodontic adhesive systems, comparing two commercial brands. Material and Methods Forty specimens were fabricated from Transbond XT and Light Bond composite and bonding agent components (n=10/component), then contaminated by immersion in a bacterial endotoxin solution. Contaminated and non-contaminated acrylic resin samples were used as positive and negative control groups, res
View details →Negative / Null Result ReportOpen accessMedicine (General)
Olivia Anna Mair, Maren Himmler, Suna Brunnemer et al. · 2022 · Medicina
Background and Objectives : Although urogenital injuries are common in severely injured patients, their diagnosis is often delayed. Predicting genitourinary injuries (GUI), especially in the immediate stages post injury, remains a challenge. This study aims to evaluate and determine positive predictive factors for the presence of GUI in polytrauma patients. Subsequently, these factors shall be used to develop an easy-to-use scoring system, deployable directly in the emergency setting. Materials and Methods : This study evaluates all severely injured patients with an Injury Severity Score (ISS)
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Anqi Wang, Anqi Wang, Xuan Meng et al. · 2024 · Frontiers in Neurology
ObjectiveTo determine the efficacy of mechanical thrombectomy combined with prolonged mild hypothermia compared with conventional treatment in managing acute middle cerebral artery occlusion, and to explore whether extending the duration of hypothermia can improve neurological function.MethodFrom 2018 to June 2023, a retrospective analysis was conducted on 45 patients with acute middle cerebral artery occlusion treated at the NICU of Suzhou Kowloon Hospital, affiliated with Shanghai Jiao Tong University School of Medicine. After thrombectomy, patients were admitted to the neurological intensiv
View details →Negative / Null Result ReportOpen accessAnimal culture
Alberto Luiz Freire de Andrade Júnior, Patrícia Costa da Silva, Emerson Moreira de Aguiar et al. · 2012 · Revista Brasileira de Parasitologia Veterinária
Coccidiosis is a serious obstacle to sheep production, which is becoming a limiting factor, especially with regard to lamb production. However, there are few studies on this parasite in the State of Rio Grande do Norte. The aim of this study was to evaluate the action of decoquinate, added to mineral salt, for controlling Eimeria infection in lambs, and to identify which species are infecting sheep in the eastern region of the state. This study was carried out from August 2009 to January 2010, and used 76 animals. These were divided into two treatment groups: one with common mineral salt, and
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Akif Albayrak, Baris Ozkul, Mehmet Bulent Balioglu et al. · 2016 · Journal of Craniovertebral Junction and Spine
Study Design: Retrospective cohort study. Purpose: Facet joints are considered a common source of chronic low-back pain. To determine whether pathogens related to the facet joint arthritis have any effect on treatment failure. Materials and Methods: Facet joint injection was applied to 94 patients treated at our hospital between 2011 and 2012 (mean age 59.5 years; 80 women and 14 men). For the purpose of analysis, the patients were divided into two groups. Patients who only had facet hypertrophy were placed in group A (47 patients, 41 women and 6 men, mean age 55.3 years) and patients who had
View details →Negative / Null Result ReportOpen accessGynecology and obstetrics
Tom Marcelissen, Tanja Hüsch, Tiago Antunes-Lopes et al. · 2022 · Clinical and Experimental Obstetrics & Gynecology
Objectives: Minimally invasive sling procedures for the treatment of stress urinary incontinence has gained a topic of great interest for the last decades. However, postoperative storage symptoms after sling implantation or conventional surgical techniques are one of the most distressing complications which can significantly impair quality of life. The current review aims to focus on the development of storage symptoms after surgical treatment in comparison of different surgical techniques. Mechanism: A narrative review has been performed to identify literature reporting the incidence of stora
View details →Negative / Null Result ReportOpen accessMedicine (General)
Jae-Ik Lee, Dong-Hyun Kim, Hyun-Jin Yoo et al. · 2021 · Diagnostics
This study aimed to validate the accuracy and prediction performance of machine learning (ML), deep learning (DL), and logistic regression methods in the treatment of medial meniscus posterior root tears (MMPRT). From July 2003 to May 2018, 640 patients diagnosed with MMPRT were included. First, the affecting factors for the surgery were evaluated using statistical analysis. Second, AI technology was introduced using X-ray and MRI. Finally, the accuracy and prediction performance were compared between ML&DL and logistic regression methods. Affecting factors of the logistic regression method co
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