Effect of evolocumab on the progression of intraplaque neovascularization of the carotid based on contrast-enhanced ultrasonography (EPIC study): A prospective single-arm, open-label study
Ju Chen; Faming Zhao; Faming Zhao; Chengbin Lei; Tianjun Qi; Xin Xue; Yuan Meng; Wenzhong Zhang · 2023 · Frontiers in Pharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background and Purpose: The aim of this study was to explore the effect of half a year of evolocumab plus moderate-intensity statin treatment on carotid intraplaque neovascularization (IPN) and blood lipid levels.Methods: A total of 31 patients with 33 carotid plaques who received evolocumab plus statin treatment were included. Blood lipid levels, B-mode ultrasound and contrast-enhanced ultrasonography (CEUS) at baseline and after half a year of evolocumab plus statin therapy were collected. The area under the curve (AUC) reflected the total amount of acoustic developer entering the plaque or
Abstract by Ju Chen; Faming Zhao; Faming Zhao; Chengbin Lei; Tianjun Qi; Xin Xue; Yuan Meng; Wenzhong Zhang, Frontiers in Pharmacology (2023) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fphar.2022.999224