21,681 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Eric Rassin, Anita Eerland, Ilse Kuijpers · 2010 · Journal of Investigative Psychology and Offender Profiling
Abstract People involved in criminal proceedings (e.g. police officers, district attorneys, judges, and jury members) may run the risk of developing confirmation bias, or tunnel vision. That is, these parties may readily become convinced…
View details →Ira J. Dunkel, François Doz, Nicholas K. Foreman et al. · 2023 · Neuro-Oncology
BACKGROUND: Therapeutic options are limited in pediatric CNS malignancies. CheckMate 908 (NCT03130959) is an open-label, sequential-arm, phase 1b/2 study investigating nivolumab (NIVO) and NIVO + ipilimumab (IPI) in pediatric patients with…
View details →Arshad Husain Rahmani, Mohammad A. Alzohairy, Ali Yousif Babiker et al. · 2012 · PubMed
A high frequency of mutations at the PTEN locus has been noticed in carcinoma of oral. However, the role of PTEN alternations and its association with outcome variables in the genesis of oral carcinoma is not understood fully. The purpose…
View details →Paul B. Perrin, Andrew J. Johnston, Bruce Vogel et al. · 2010 · The Journal of Rehabilitation Research and Development
This study developed and implemented the Transition Assistance Program (TAP) for stroke caregivers. The program is composed of (1) skill development, (2) education, and (3) supportive problem solving. Sixty-one dyads (n = 122)…
View details →Charles R. Dunlop, Yann Wallez, Timothy Isaac Johnson et al. · 2020 · British Journal of Cancer
BACKGROUND: Personalised medicine strategies may improve outcomes in pancreatic ductal adenocarcinoma (PDAC), but validation of predictive biomarkers is required. Having developed a clinical trial to assess the ATR inhibitor, AZD6738, in combination with gemcitabine (ATRi/gem), we investigated ATM loss as a predictive biomarker of response to ATRi/gem in PDAC. METHODS: Through kinase inhibition, siRNA depletion and CRISPR knockout of ATM, we assessed how ATM targeting affected the sensitivity of PDAC cells to ATRi/gem. Using flow cytometry, immunofluorescence and immunoblotting, we investigate
View details →Yoshiyuki Suzuki, Katsuyuki Shirai, Kuniyuki Oka et al. · 2010 · Journal of Radiation Research
phosphorylated-Akt (pAkt) plays an important role in tumorigenesis through promotion of cell survival by inhibiting apoptosis and mediating cell proliferation. Higher expression of pAkt has been reported to be associated with an…
View details →Ilker Uçkay, Benjamin Kressmann, Sarah Malacarne et al. · 2018 · BMC Infectious Diseases
BACKGROUND: An adjunctive topical therapy with gentamicin-sponges to systemic antibiotic therapy might improve the healing of infected diabetic foot ulcers (DFUI). METHODS: Single-center, investigator-blinded pilot study, randomizing (1:1) the gentamicin-sponge with systemic antibiotic versus systemic antibiotics alone for patients with DFUI. RESULTS: We included 88 DFUI episodes with 43 patients in the gentamicin-sponge arm and 45 in the control arm. Overall, 64 (64/88; 73%) witnessed total clinical cure, 13 (15%) significant improvement, and 46 (52%) showed total eradication of all pathogens
View details →Shuming Jiao, Yang Gao, Jun Feng et al. · 2020 · Optics Express
Deep learning has been extensively applied in many optical imaging problems in recent years. Despite the success, the limitations and drawbacks of deep learning in optical imaging have been seldom investigated. In this work, we show that…
View details →Adrian S. Sabau, Adrian Bejan, D.L. Brownell et al. · 2020 · Applied Thermal Engineering
A novel heat exchanger architecture was investigated, in which each fluid pathway transitions through the heat exchanger from tube-flow to shell-flow, or from shell-flow to tube-flow. The heat exchangers (HX) consisted of two plenums…
View details →Basheer A. Elubid, Tao Huang, Ekhlas H. Ahmed et al. · 2019 · International Journal of Environmental Research and Public Health
The observation of groundwater quality elements is essential for understanding the classification and distribution of drinking water. Geographic Information System (GIS) and remote sensing (RS), are intensive tools for the performance and analysis of spatial datum associated with groundwater sources control. In this study, groundwater quality parameters were observed in three different aquifers including: sandstone, alluvium and basalt. These aquifers are the primary source of national drinking water and partly for agricultural activity in El Faw, El Raha (Fw-Rh), El Qalabat and El Quresha (Qa
View details →Shannon Rhodes, Janet S. Sinsheimer, Yvette Bordelon et al. · 2010 · Annals of Human Genetics
In the investigation of disease aetiology, the genome-wide association study (GWAS) provides a hypothesis-free investigation of the broader human genome and, as with all scientific investigations, replication is essential to validate any…
View details →Jong‐Min Kim, Soo-Heon Hong, Jong‐Min Kim et al. · 2014 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: The aim of this study was to determine (1) variations in the shape of the proximal, middle, and distal femur in a series of Korean patients who had undergone total knee arthroplasty (TKA), (2) the preoperative relationship between…
View details →Axel Finckh, Geraldine M Mc Carthy, Anne Madigan et al. · 2014 · Arthritis Research & Therapy
INTRODUCTION: Calcium pyrophosphate deposition (CPPD) may cause severe arthropathy, major joint destruction and treatment options are limited. The aim of this study was to test the therapeutic efficacy of methotrexate (MTX) in chronic or recurrent CPPD arthropathy. METHODS: Patients with CPPD arthropathy were randomized to receive either weekly subcutaneous injections of 15 mg/week of MTX or placebo (PBO) for three months, in a double-blind, crossover randomized controlled trial. Inclusion criteria comprised definite CPPD disease, recurrent arthritis or persistent polyarthritis, and an insuffi
View details →Joyce O’Shaughnessy, Hartmut Koeppen, Yuanyuan Xiao et al. · 2015 · Clinical Cancer Research
PURPOSE: We conducted a randomized phase III study to determine whether patients with early breast cancer would benefit from the addition of capecitabine (X) to a standard regimen of doxorubicin (A) plus cyclophosphamide (C) followed by…
View details →Manoeli Lupatini, Afnan Khalil Ahmad Suleiman, Rodrigo Josemar Seminoti Jacques et al. · 2013 · PLoS ONE
The Pampa biome is considered one of the main hotspots of the world's biodiversity and it is estimated that half of its original vegetation was removed and converted to agricultural land and tree plantations. Although an increasing amount of knowledge is being assembled regarding the response of soil bacterial communities to land use change, to the associated plant community and to soil properties, our understanding about how these interactions affect the microbial community from the Brazilian Pampa is still poor and incomplete. In this study, we hypothesized that the same soil type from the s
View details →Alban de Lavenne, Vazken Andréassian, Guillaume Thirel et al. · 2019 · Water Resources Research
Abstract In semidistributed hydrological modeling, sequential calibration usually refers to the calibration of a model by considering not only the flows observed at the outlet of a catchment but also the different gauging points inside the…
View details →Ariel Kalil, Kathleen M. Ziol‐Guest, Jodie Levin Epstein · 2010 · Journal of Marriage and the Family
This article replicated and extended Harriet Presser's (2000) investigation of the linkages between nonstandard work and marital instability. We reexplored this question using data from a sample of 2,893 newlywed couples from the National…
View details →Gyrd Skraaning, Greg A. Jamieson · 2019 · Human Factors The Journal of the Human Factors and Ergonomics Society
OBJECTIVE: Test the automation transparency design principle using a full-scope nuclear power plant simulator. BACKGROUND: Automation transparency is a long-held human factors design principle espousing that the responsibilities,…
View details →Paul Dagum, Donald Leo Elbert, Laurent Giovangrandi et al. · 2026 · Nature Communications
ABSTRACT Poor sleep is implicated in the development of Alzheimer’s disease (AD) pathology and cognitive impairment. Dysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and AD, and in…
View details →Jorming Goh, Elizabeth A. Kirk, Shu Xian Lee et al. · 2026 · PubMed
Regular exercise and physical activity provide many health benefits and are encouraged by medical professionals for the primary prevention of and adjuvant treatment of breast cancer Current consensus in the discipline of exercise oncology…
View details →Darryl Falzarano, David Safronetz, Joseph Prescott et al. · 2015 · Emerging infectious diseases
The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.
View details →Adrian Abac, I. Abouelfettouh, F. Acernese et al. · 2026 · The Astrophysical Journal Letters
Abstract Version 4.0 of the Gravitational-Wave Transient Catalog (GWTC-4.0) adds new candidates detected by the LIGO, Virgo, and KAGRA observatories through the first part of the fourth observing run (O4a: 2023 May 24 15:00:00 to 2024 January 16 16:00:00 UTC) and a preceding engineering run. In these new data, we find 128 compact binary coalescence candidates that are identified by at least one of our search algorithms with a probability of astrophysical origin p astro ≥ 0.5 and that are not vetoed during event validation. We also provide detailed source property measurements for 86 of these t
View details →Céline Teney, Perrine Devleeshouwer, Laurie Hanquinet · 2013 · Ethnicities
Ethnic disparities in educational aspirations and choices are important to comprehend ethnic education inequality. Based on a mixed-method approach (3121 questionnaires and 40 interviews of pupils), this article investigates ethnic…
View details →Muhammad Shahbaz, Mehmet Balcılar, Mantu Kumar Mahalik et al. · 2021 · International Journal of Finance & Economics
Abstract By using quarterly data over the period 1970Q1‐2017Q4, this paper examines the dynamic causal relationship between globalization and energy consumption by using rolling and recursive rolling Granger causality methods. This study…
View details →Prasit Kumar Sahoo, Anima Bose, Prasenjit Mal · 2015 · European Journal of Organic Chemistry
Abstract We report here an understanding of systems chemistry on small molecules through covalent mechanochemistry. As a proof‐of‐concept, the multicomponent Biginelli reaction by subcomponent synthesis was considered as a model system.…
View details →David Rozado · 2024 · PLoS ONE
I report here a comprehensive analysis about the political preferences embedded in Large Language Models (LLMs). Namely, I administer 11 political orientation tests, designed to identify the political preferences of the test taker, to 24 state-of-the-art conversational LLMs, both closed and open source. When probed with questions/statements with political connotations, most conversational LLMs tend to generate responses that are diagnosed by most political test instruments as manifesting preferences for left-of-center viewpoints. This does not appear to be the case for five additional base (i.
View details →Michael Devitt, Nicolas Porot · 2018 · Cognitive Science
Experiments on theories of reference have mostly tested referential intuitions. We think that experiments should rather be testing linguistic usage. Substantive Aim (I): to test classical description theories of proper names against usage…
View details →John P Grogan, Demitra Tsivos, Laura Smith et al. · 2017 · eLife
Emerging evidence suggests that dopamine may modulate learning and memory with important implications for understanding the neurobiology of memory and future therapeutic targeting. An influential hypothesis posits that dopamine biases reinforcement learning. More recent data also suggest an influence during both consolidation and retrieval. Eighteen Parkinson's disease patients learned through feedback ON or OFF medication, with memory tested 24 hr later ON or OFF medication (4 conditions, within-subjects design with matched healthy control group). Patients OFF medication during learning decre
View details →Alexander C. Wilson, Dorothy Bishop · 2018 · PeerJ
BACKGROUND: It has been suggested that failure to establish cerebral lateralisation may be related to developmental language disorder (DLD). There has been weak support for any link with handedness, but more consistent reports of associations with functional brain lateralisation for language. The consistency of lateralisation across different functions may also be important. We aimed to replicate previous findings of an association between DLD and reduced laterality on a quantitative measure of hand preference (reaching across the midline) and on language laterality assessed using functional t
View details →Caroline Cormier, Bruno Voisard · 2018 · Frontiers in ICT
The flipped classroom as a form of active pedagogy in post-secondary chemistry has been developed during the last 10 years and has been gaining popularity with instructors and students ever since. In the current paradigm in STEM (science, technology, engineering and mathematics) education, it is widely recognized that active learning has significant positive effects on students’ grades. Post-secondary organic chemistry is a difficult course for students and the traditional way of teaching does not foster students’ active involvement. Implementation of active pedagogy could increase students’ a
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