Methotrexate in chronic-recurrent calcium pyrophosphate deposition disease: no significant effect in a randomized crossover trial
Axel Finckh; Geraldine M Mc Carthy; Anne Madigan; D Van Linthoudt; Marcel Weber; David Neto; G Rappoport; Sandra Blumhardt · 2014 · Arthritis Research & Therapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
INTRODUCTION: Calcium pyrophosphate deposition (CPPD) may cause severe arthropathy, major joint destruction and treatment options are limited. The aim of this study was to test the therapeutic efficacy of methotrexate (MTX) in chronic or recurrent CPPD arthropathy. METHODS: Patients with CPPD arthropathy were randomized to receive either weekly subcutaneous injections of 15 mg/week of MTX or placebo (PBO) for three months, in a double-blind, crossover randomized controlled trial. Inclusion criteria comprised definite CPPD disease, recurrent arthritis or persistent polyarthritis, and an insuffi
Abstract by Axel Finckh; Geraldine M Mc Carthy; Anne Madigan; D Van Linthoudt; Marcel Weber; David Neto; G Rappoport; Sandra Blumhardt, Arthritis Research & Therapy (2014) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s13075-014-0458-4