Negative / Null Result ReportOpen accessMedicine
Fukunaga N, Takanishi T, Wakami T et al. · 2026 · Circulation reports
Background The impact of emergency surgery for acute type A aortic dissection (ATAAD) on renal function in patients with autosomal dominant polycystic kidney disease (ADPKD) remains unclear. Methods and results The renal function of 4…
View details →Failed Experiment Report
Bradley A, Gmiro Y, Stoakes A et al. · 2026 · Preprint
Concerns about the impact of social media on young adult mental health persists despite weak and inconclusive empirical evidence. This study aimed to replicate a highly-cited study showing improved well-being after limiting time on social…
View details →Replication FailureMedicine
Nguyen TT, Kanemoto Y, Sawada T et al. · 2026 · Bioscience, biotechnology, and biochemistry
Vitamin D (VD) and Wnt signaling both play important roles in bone metabolism and are targeted in osteoporosis therapy. Combination treatment with VD derivatives and anti-sclerostin antibodies that activate Wnt signaling improves clinical…
View details →Replication Failure
Gama de Matos D, de Santana JL, Aidar FJ et al. · 2026 · Preprint
Background: Frailty is a multifactorial condition that significantly impacts older adults' health and independence, which can be mitigated through training. This study examined the effects of a 12-week progressive strength training (PST)…
View details →Replication FailureMedicine
Yang Y, Zeng L, Ren R et al. · 2026 · Veterinary sciences
Dental calculus is a highly prevalent oral condition in dogs and is widely recognized as an important risk factor for gingival inflammation and periodontal disease. Effective strategies for its prevention and treatment remain limited,…
View details →Replication Failure
Leonov G, Malvina A, Kosyura S et al. · 2026 · Preprint
Background Obesity is a modifiable risk factor for osteoarthritis and may contribute to pain, functional impairment, inflammation, and cartilage degradation. Resveratrol has potential anti-inflammatory and chondroprotective effects, but…
View details →Negative / Null Result Report
Aguiar PV, Paul BT · 2026 · Preprint
Older adults with age-related hearing loss (OAHL) are more strongly influenced by vision during audiovisual perception tasks compared to typical-hearing old adults, suggesting a greater weighting of visual input in the former group. This…
View details →Failed Experiment ReportMedicine
Toshida K, Sugitani Y, Itoh S et al. · 2026 · Surgery today
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. Machine learning (ML) may enable the noninvasive prediction of histopathological features using clinical and imaging data. This study evaluated the utility of…
View details →Negative / Null Result ReportMedicine
Brandon AS, Murphy BS, Nam Y et al. · 2026 · The American journal of cardiology
Peripheral arterial disease (PAD) has many established risk factors, but social determinants of health (SDoH) are increasingly recognized as a cardiovascular disease risk factor. The multi-ethnic study of atherosclerosis (MESA) cohort was…
View details →Negative / Null Result ReportMedicine
Arnaoutis G, Vallas G, Toubekis AG et al. · 2026 · International journal of sport nutrition and exercise metabolism
Beetroot juice (BRJ) has been proposed as an ergogenic aid due to its high nitrate content, yet evidence from field-based studies in elite swimmers remains limited. This study investigated the acute effects of concentrated BRJ ingestion on…
View details →Negative / Null Result ReportMedicine
Ayaz SN, Kucuk M, Yanık Nalbantoğlu D et al. · 2025 · Odontology
We evaluated the effect of supplementary instrumentation on the removal of gutta-percha and compared the efficacy of three file systems with different metallurgical properties via micro-computed tomography (micro-CT). Forty-two moderately…
View details →Negative / Null Result ReportMedicine
Moghadam H, Sourinejad I, Kalbassi MR et al. · 2026 · Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
Widely recognized for its translational relevance, the zebrafish (Danio rerio) is a validated model for evaluating antihyperglycemic agents. Nanocapsulation technologies have been proposed to enhance the bioefficacy of natural compounds…
View details →Negative / Null Result Report
Micca L, Albouy G, King BR et al. · 2026 · Preprint
Motor memory retention is impaired in Parkinson’s disease (PD), affecting long-term rehabilitation outcomes. It appears that NREM sleep could be beneficial for consolidation processes in PD, and could be leveraged with non-invasive sleep…
View details →Negative / Null Result Report
Robin N, Bonnin T, Rienzo FD et al. · 2026 · Preprint
Abstract Pre-serve preparatory movements including imagery and air movements are commonly observed in tennis players during both training and competition. The present study (ACTES URp54-2025-05) compared the effects of pre-performance…
View details →Negative / Null Result ReportMedicine
Mayer S, Wegehaupt FJ, Hamza B · 2026 · BMC oral health
Objectives This in-vitro study compared the protective effects of a 5000-ppm fluoride dentifrice with an anti-erosive 1450-ppm formulation containing stannous chloride and chitosan under erosive, abrasive, and erosive/abrasive conditions.…
View details →Negative / Null Result Report
Chew KH, Michael MC, Ghani NRNA · 2026 · Preprint
Abstract Objectives To investigate the influence of different coronal restorative strategies on the fracture resistance and failure patterns of endodontically treated maxillary incisors following thermomechanical aging. Materials and…
View details →Negative / Null Result ReportMedicine
Sinha P, Chatterjee P, Kathiresan P et al. · 2026 · Journal of the American Geriatrics Society
Objective To evaluate the efficacy of adjunct probiotic supplementation (Lactobacillus helveticus and Bifidobacterium longum) alongside standard care compared to placebo in older adults with moderate unipolar depression. Methods A…
View details →Negative / Null Result ReportMedicine
Pontet Y, Aguirrezábal P, Pintos J et al. · 2026 · Journal of clinical gastroenterology
Background In adults, the diagnosis of celiac disease (CeD) relies on the presence of disease-specific antibodies and the confirmation of duodenal atrophy. This study aimed to develop a diagnostic model to predict duodenal atrophy in…
View details →Negative / Null Result ReportMedicine
Tanabe H, Watanabe D, Agawa M et al. · 2026 · Biochemical and biophysical research communications
Objectives Intestinal fibrosis is a severe complication of Crohn's disease (CD). While ADAMDEC1 has been identified as a marker for specific fibroblast subsets, its functional role in fibrogenesis remains unclear. This study aimed to…
View details →Negative / Null Result ReportMedicine
Souza AF, Fraga MAA, Correr AB et al. · 2026 · Dental materials : official publication of the Academy of Dental Materials
Objectives To evaluate the effects of incorporating the antibacterial monomer dimethylaminohexadecyl methacrylate (DMAHDM; 2.5% and 5% wt%) and amorphous calcium phosphate nanoparticles (NACP; 2 wt%) on the antibacterial activity,…
View details →Negative / Null Result Report
Duymaz I, Engeser M, Kaiser D · 2026 · Preprint
Multivariate analyses of M/EEG data are typically performed on neural responses time-locked to discrete stimulus onsets. Such designs usually reveal high decoding performance during the initial transient response (0-500 ms), which…
View details →Negative / Null Result Report
Varghese C, Sosa C, Maique J et al. · 2026 · Preprint
Abstract Plant-based cheese alternatives (PBCAs) are considered sustainable substitutes for dairy-based cheese (DB); however, their consumer acceptance remains limited, particularly in dairy-dominant cultural contexts such as Uruguay,…
View details →Negative / Null Result ReportMedicine
Johannesdottir F, Aspelund T, Mahar S et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Current fracture risk assessment does not directly include fall probability, despite the fact that most hip fractures resulting from falls. Additionally, the role of trochanteric soft tissue thickness (TST) in hip fracture risk remains…
View details →Negative / Null Result ReportMedicine
López-Cruz R, Ragazzo-Sánchez JA, Calderón-Santoyo M · 2026 · Archives of microbiology
In this study, mango fruit trees cv. Kent (Mangifera indica L.) grown in Nayarit, Mexico, during the 2024 and 2025 seasons were preharvest-treated with four applications of microencapsulated Meyerozyma guilliermondii LMA-Cp01 (0.4 g L⁻¹),…
View details →Negative / Null Result Report
Lima LC, Caetano D, Pinto L et al. · 2026 · Preprint
Abstract The global burden of bone fractures is projected to double by 2050, and this trend is driven by an aging population, higher incidence of car accidents, cancer-related bone damage, and osteoporosis, which compromises bone…
View details →Negative / Null Result ReportMedicine
Kharazmi K, Saroughi M, Khoshniat MT et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
Lead exposure is linked to various adverse effects on human health, including toxicity to multiple organs such as the kidneys, liver, and reproductive system. Lead induces its toxic effects through complex pathways, including mitochondrial…
View details →Negative / Null Result ReportMedicine
Riesenbach IC, Tsomik G, Chiasson M et al. · 2026 · Aquaculture.
Insects, such as black soldier flies (BSF), have garnered attention in the aquaculture industry as a sustainable protein and lipid alternative to fishmeal and fish oil. However, research is lacking on which components of BSF improve fish…
View details →Negative / Null Result Report
Salinas-Marcos J, Cruz-Luis J, Aguirre L · 2025 · Preprint
The “algarrobo”, Neltuma pallida is a key tree species in the seasonally dry tropical forests in Equatorial Pacific South America, currently at risk. Its regeneration depends on endozoochorous seed dispersal, in which seeds are ingested…
View details →Negative / Null Result ReportMedicine
Nakajima K, Ishida Y, Miura D et al. · 2026 · Odontology
This study investigated the effects of air abrasion with different abrasive particles on the surface roughness and bond strength of resin-based luting agents to enamel and dentin, including dentin surfaces treated with immediate dentin…
View details →Negative / Null Result Report
Fleming HA, Whines A, Whelehan P et al. · 2025 · Preprint
Central to survival is our ability to learn that the sensory properties of food are associated with metabolic interoceptive signals (e.g., changing blood glucose). These signals influence cognition and brain activity, shaping the hedonic…
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