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Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Progression-Free Survival with PARP Inhibitors According to Clinical Risk in Patients with Ovarian Cancer: An Indirect Comparison Using Reconstructed Data.

Gasperoni L, Del Bono L, Farolfi A et al. · 2026 · Oncology research

Background: Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are established maintenance treatments in ovarian cancer, but comparative efficacy across genetic profiles and relapse risk categories remains unclear. The aim of this…

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Negative / Null Result ReportMedicine

Gynecomastia: Etiological Analysis Beyond Hormonal Imbalance.

Kim JH, Song M, Lee K et al. · 2026 · Life (Basel, Switzerland)

Background: Gynecomastia is a benign enlargement of the male breast with multiple causes. This retrospective study evaluated whether serum estradiol (E2), testosterone (T), or the E2/T ratio differed between patients and controls, while…

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Negative / Null Result ReportMedicine

Regional Fascial Plane Blocks and Early Postoperative Complications in Reduction Mammaplasty: A Retrospective Cohort Study.

Derebaşınlıoğlu H, Avcı O, Çelik M et al. · 2026 · Aesthetic plastic surgery

Background Regional fascial plane blocks are widely used in breast surgery for postoperative analgesia. While analgesic benefits are established, their impact on early complications after reduction mammaplasty remains unclear. Objective To…

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Negative / Null Result ReportOpen accessMedicine

Thyroid Function Tests and Serum Amylase Levels in Chronic Kidney Disease: A Cross-Sectional Study Correlating Biochemical Changes With Disease Severity at a Tertiary Care Centre in India.

Sharma P, Samaria A, Tak H et al. · 2026 · Cureus

Background Chronic kidney disease (CKD) represents a major and growing health concern in both global and Indian populations. In addition to progressive renal dysfunction, CKD is frequently accompanied by metabolic and endocrine…

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Negative / Null Result ReportMedicine

Aqueous Humor Angiotensin-Converting Enzyme and TGF-β1 Levels in Proliferative Vitreoretinopathy: A Prospective Clinical Study.

Koçak N, Özdemir A, Esenkaya M et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose To evaluate plasma and aqueous humor angiotensin-converting enzyme (ACE) and transforming growth factor-β1 (TGFβ1) levels in patients with proliferative vitreoretinopathy (PVR) secondary to rhegmatogenous retinal detachment (RRD).…

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Negative / Null Result ReportMedicine

Cardiac Computed Tomography-Guided Procedural Planning for Percutaneous Mitral Paravalvular Leak Closure: Impact on Crossing Time.

Vella C, Romano V, Ricchetti G et al. · 2026 · The Canadian journal of cardiology

Mitral paravalvular leaks (PVLs) are a recognized complication of prosthetic valve implantation and may cause heart failure or hemolysis, often requiring percutaneous closure in patients at high surgical risk. Although transesophageal…

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Negative / Null Result ReportMedicine

A community-based exercise intervention to reduce functional risk factors for injury among stroke survivors in South Korea: a pilot randomized controlled trial.

Kang D, Eun SD, Park J · 2026 · Scientific reports

Stroke survivors living in the community often experience persistent impairments in muscle strength, balance, mobility, and cardiorespiratory fitness after hospital discharge, which increase vulnerability during daily activities. This…

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Negative / Null Result ReportMedicine

Real-world predictors of severe chemotherapy-induced neutropenia in non-Hodgkin lymphoma: Evaluation of biosimilar and reference rituximab.

Andriyanto DB, Syafhan NF, Nurhayati F · 2026 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

BackgroundThe adoption of rituximab biosimilars offers a cost-effective alternative for treating Non-Hodgkin Lymphoma (NHL). However, real-world safety data regarding severe hematological toxicities in the Indonesian clinical setting…

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Negative / Null Result ReportMedicine

Three-year results of a prospective, controlled clinical study evaluating treatment of intra-bony defects with PRF or EMD- a randomized control trial.

Dőri F, Németh F, Arweiler N et al. · 2026 · BMC oral health

Background Periodontal regenerative surgery is a well-established treatment modality for intrabony periodontal defects. Enamel matrix derivative (EMD) is one of the most extensively documented biologic agents, whereas platelet-rich fibrin…

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