21,216 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Wai‐Ping Yau, Allen A. Mitchell, Kueiyu Joshua Lin et al. · 2013 · American Journal of Epidemiology
Previous studies suggested that early pregnancy exposure to specific oral decongestants increases the risks of several birth defects. Using January 1993-January 2010 data from the Slone Epidemiology Center Birth Defects Study, we tested…
View details →Xiuli Zhang, S. Peter Goedegebuure, Michael Y. Chen et al. · 2024 · Genome Medicine
BACKGROUND: Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II epitopes and performed a phase 1 clinical trial in triple-negative breast cancer patients with persistent disease on surgical pathology following neoadjuvant chemotherapy, a patient population at high risk of disease recurrence. METHODS: Expressed somatic mutations were identified by tumor/normal exome sequencing and tumor RNA sequencing. The pVACtools sof
View details →Matthew J. Hirshberg, Corrina Frye, Cortland J. Dahl et al. · 2022 · Journal of Educational Psychology
s<.031 corrected except mindful action at follow-up). We found no evidence for elevated adverse events and the HMP was equally effective among participants with elevated baseline anxiety and depressive symptoms. These data suggest that the…
View details →Michael Minkov, Anneli Kaasa · 2020 · Cross Cultural & Strategic Management
Purpose Recent studies exposed serious issues with Hofstede's popular model of culture, especially his uncertainty avoidance (UA) and masculinity-femininity (MAS–FEM) dimensions. However those studies did not focus on work-related issues…
View details →Céline Carillier, Hélène Larroque, Christèle Robert-Granié · 2014 · Genetics Selection Evolution
BACKGROUND: All progeny-tested bucks from the two main French dairy goat breeds (Alpine and Saanen) were genotyped with the Illumina goat SNP50 BeadChip. The reference population consisted of 677 bucks and 148 selection candidates. With the two-step approach based on genomic best linear unbiased prediction (GBLUP), prediction accuracy of candidates did not outperform that of the parental average. We investigated a GBLUP method based on a single-step approach, with or without blending of the two breeds in the reference population. METHODS: Three models were used: (1) a multi-breed model, in whi
View details →Philippa Garety, Clementine Edwards, Hassan Jafari et al. · 2024 · Nature Medicine
Distressing voices are a core symptom of psychosis, for which existing treatments are currently suboptimal; as such, new effective treatments for distressing voices are needed. AVATAR therapy involves voice-hearers engaging in a series of facilitated dialogues with a digital embodiment of the distressing voice. This randomized phase 2/3 trial assesses the efficacy of two forms of AVATAR therapy, AVATAR-Brief (AV-BRF) and AVATAR-Extended (AV-EXT), both combined with treatment as usual (TAU) compared to TAU alone, and conducted an intention-to-treat analysis. We recruited 345 participants with p
View details →Imane Boutitah-Benyaich, Herena Eixarch, Javier Villacieros‐Álvarez et al. · 2025 · Signal Transduction and Targeted Therapy
Multiple sclerosis is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, axonal loss, and neuroinflammation, culminating in progressive neurological disability. Despite significant advances in understanding its immunopathogenesis, current immunotherapies remain limited in their ability to halt disease progression, making multiple sclerosis incurable and highlighting the critical need for novel therapeutic strategies. Antigen-specific immunotherapy represents a groundbreaking approach that aims to restore immune tolerance to myelin-derived antigens
View details →Oliver Hauser, Francesca Gino, Michael I. Norton · 2018 · Mind & Society
Nudges have become a popular tool for behaviour change; but, some interventions fail to replicate, even when the identical, previously successful intervention is used. One cause of this problem is that people default to using some of or all of the previously-successful existing nudges for any problem—the “kitchen sink” approach. We argue that the success of an intervention depends on understanding people’s current behaviour and beliefs to ensure that any nudge will actually “budge” them from their current beliefs. We introduce the Beliefs–Barriers–Context model, with three components: understa
View details →Arshad Khan, Lovepreet K. Mann, Ramesha Papanna et al. · 2017 · Scientific Reports
Human mesenchymal stem cells (MSCs) express scavenger receptors that internalize lipids, including oxidized low-density lipoprotein (oxLDL). We report that MSCs phagocytose Mycobacterium tuberculosis (Mtb) through two types of scavenger receptors (SRs; MARCO and SR-B1), as blockade of the receptors with antibodies or siRNA knockdown decreased the uptake of Mtb. MSCs also expressed mannose receptor (MR) that was found to endocytose rhodamine-labeled mannosylated BSA (rMBSA), though the receptor was not involved in the uptake of Mtb. Dil-oxLDL and rMBSA taken up into MSC endosomes colocalized wi
View details →Andrés Cárdenas, Sabrina Faleschini, Andrea P. Cortés Hidalgo et al. · 2019 · Clinical Epigenetics
BACKGROUND: Maternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, and depression with cord blood DNA methylation across the genome at birth and test for persistence of associations in early and mid-childhood blood DNA. METHODS: A discovery phase was conducted in Project Viva, a prospective pre-birth cohort study with external replication in an independent cohort, the Generation R Study. In Project Viva, pregnant women were recruited between 1999 and 2002 in East
View details →François Renoz, Christine Noël, Abdelmounaim Errachid et al. · 2015 · PLoS ONE
In addition to its obligatory symbiont Buchnera aphidicola, the pea aphid Acyrthosiphon pisum can harbor several facultative bacterial symbionts which can be mutualistic in the context of various ecological interactions. Belonging to a genus where many members have been described as pathogen in invertebrates, Serratia symbiotica is one of the most common facultative partners found in aphids. The recent discovery of strains able to grow outside their host allowed us to simulate environmental acquisition of symbiotic bacteria by aphids. Here, we performed an experiment to characterize the A. pis
View details →Fernando A. Monteiro, Т. Е. Перетолчина, Cristiano Lazoski et al. · 2013 · PLoS ONE
BACKGROUND: Triatoma dimidiata is among the main vectors of Chagas disease in Latin America. However, and despite important advances, there is no consensus about the taxonomic status of phenotypically divergent T. dimidiata populations, which in most recent papers are regarded as subspecies. METHODOLOGY AND FINDINGS: A total of 126 cyt b sequences (621 bp long) were produced for specimens from across the species range. Forty-seven selected specimens representing the main cyt b clades observed (after a preliminary phylogenetic analysis) were also sequenced for an ND4 fragment (554 bp long) and
View details →Tom Smeets, Peter van Ruitenbeek, Bart Hartogsveld et al. · 2018 · Brain and Cognition
Instrumental learning, i.e., learning that specific behaviors lead to desired outcomes, occurs through goal-directed and habit memory systems. Exposure to acute stress has been shown to result in less goal-directed control, thus rendering…
View details →Haudi Haudi, Erna Retno Rahadjeng, Ruby Santamoko et al. · 2021 · Uncertain Supply Chain Management
The aim of this research is to analyze the effects of e-Marketing, e-CRM and e-Marketing on e-Loyalty and company performance. The study is quantitative with a questionnaire approach. Data processing tools use the SmartPLS 3.3.3 software.…
View details →Trina Das, Jean‐Jacques Hoarau, Marie Christine Jaffar Bandjee et al. · 2014 · Journal of General Virology
Chikungunya virus (CHIKV) has recently affected millions of people in the Indian Ocean, with rare cases of encephalopathy and encephalitis occurring in neonates. In the study described herein, the capacity of mouse brain cells to control…
View details →Richard Stebbings, David Eastwood, Stephen Poole et al. · 2012 · Journal of Immunotoxicology
The failure of regulatory science to keep pace with and support the development of new biological medicines was very publically highlighted in March 2006 when the first-in-man Phase I clinical trial of the immunomodulatory CD28-specific…
View details →Sabina Eggert, Frauke Ostermeyer, Marcus Hasselhorn et al. · 2013 · Education Research International
The purpose of the present study was to examine the effects of cooperative training strategies to enhance students' socioscientific decision making as well as their metacognitive skills in the science classroom. Socioscientific decision making refers to both “describing socioscientific issues” as well as “developing and evaluating solutions” to socioscientific issues. We investigated two cooperative training strategies which differed with respect to embedded metacognitive instructions that were developed on the basis of the IMPROVE method. Participants were 360 senior high school students who
View details →Valarie Blue Bird Jernigan, Marianna S. Wetherill, Jordan Hearod et al. · 2017 · American Journal of Public Health
OBJECTIVES: To examine food insecurity and cardiovascular disease-related health outcomes among American Indians (AIs) in rural Oklahoma. METHODS: We surveyed a cross-sectional sample of 513 AI adults to assess food insecurity domains…
View details →Robert S. Schwartz, Stacia Merkel Kraus, Jonathan Schwartz et al. · 2014 · PubMed
BACKGROUND: Long-term marathon running improves many cardiovascular risk factors, and is presumed to protect against coronary artery plaque formation. This hypothesis, that long-term marathon running is protective against coronary…
View details →Haitao Xiao, Yong Sik Yoon, Seung‐Mo Hong et al. · 2013 · American Journal of Clinical Pathology
OBJECTIVES: To evaluate the association of microsatellite instability (MSI) with clinicopathologic features and oncologic outcomes in patients with poorly differentiated colorectal cancer (PD). METHODS: Study patients were divided into…
View details →Stavroula Stavrakaki, Kalliopi Megari, Mary H. Kosmidis et al. · 2012 · Journal of Clinical and Experimental Neuropsychology
We investigated working memory and verbal fluency in simultaneous interpreters, expecting to find enhanced working memory and semantic processing in interpreters relative to others fluent in a second language. The interpreters (n = 15)…
View details →Frank Schwarz, Didem Hazar, Kathrin Becker et al. · 2018 · Journal Of Clinical Periodontology
OBJECTIVES: To assess and compare the efficacy and safety of autogenous tooth roots (TR) and autogenous bone blocks (AB) for lateral alveolar ridge augmentation and two-stage implant placement. MATERIAL AND METHODS: A total of 30 patients…
View details →Marje Prank, Shawn C Kenaley, Gary C Bergstrom et al. · 2019 · Environmental Research Letters
Abstract Long range atmospheric transport is an important pathway for the spread of plant pathogens, such as rust fungi which can devastate cereal crop health and food security worldwide. In recent years, serious concern has been caused by…
View details →Steffen Klamt, Radhakrishnan Mahadevan, Oliver Hädicke · 2017 · Biotechnology Journal
Apart from product yield and titer, volumetric productivity is a key performance indicator for many biotechnological processes. Due to the inherent trade‐off between the production of biomass as catalyst and of the actual target product,…
View details →Byoung Geol Choi, Seung‐Woon Rha, Seong Gyu Yoon et al. · 2019 · Journal of the American Heart Association
Background Significant coronary artery disease has a well‐known association with long‐term adverse cardiovascular events. In this study, we aimed to evaluate its association with long‐term major adverse clinical events ( MACE ) up to 5…
View details →Goele Bossaert, Anke de Boer, Per Frostad et al. · 2015 · Irish Educational Studies
Yearly data are collected describing progress in inclusive education. Frequently used criteria are the percentages of students attending special schooling or percentages of students officially labelled as having special educational needs…
View details →Lydia K. Greene, Kathleen E. Grogan, Kendra Smyth et al. · 2016 · Royal Society Open Science
Animals communicating via scent often deposit composite signals that incorporate odorants from multiple sources; however, the function of mixing chemical signals remains understudied. We tested both a 'multiple-messages' and a 'fixative' hypothesis of composite olfactory signalling, which, respectively, posit that mixing scents functions to increase information content or prolong signal longevity. Our subjects-adult, male ring-tailed lemurs (Lemur catta)-have a complex scent-marking repertoire, involving volatile antebrachial (A) secretions, deposited pure or after being mixed with a squalene-
View details →Fabien Gaud, Baptiste Lepers, Jérémie Decouchant et al. · 2014 · Open Repository and Bibliography (University of Luxembourg)
Application virtual address space is divided into pages, each requiring a virtual-to-physical translation in the page table and the TLB. Large working sets, common among modern applications, necessitate a lot of translations, which…
View details →Katherine S. Ruth, Robin N. Beaumont, Jessica Tyrrell et al. · 2016 · Human Reproduction
STUDY QUESTION: How does a genetic variant in the FSHB promoter, known to alter FSH levels, impact female reproductive health? SUMMARY ANSWER: The T allele of the FSHB promoter polymorphism (rs10835638; c.-211G>T) results in longer menstrual cycles and later menopause and, while having detrimental effects on fertility, is protective against endometriosis. WHAT IS KNOWN ALREADY: The FSHB promoter polymorphism (rs10835638; c.-211G>T) affects levels of FSHB transcription and, as a result, circulating levels of FSH. FSH is required for normal fertility and genetic variants at the FSHB locus are as
View details →Wilson Sui, Justin T. Matulay, Maxwell B. James et al. · 2016 · Bladder Cancer
Introduction: Micropapillary bladder cancer (MPBC) is a variant histology of urothelial carcinoma (UC) that is associated with poor outcomes however given its rarity, little is known outside of institutional reports. We sought to use a…
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