Negative / Null Result ReportOpen accessMedicine· cited by 73

Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood

Andrés Cárdenas; Sabrina Faleschini; Andrea P. Cortés Hidalgo; Sheryl L. Rifas‐Shiman; Andrea Baccarelli; Dawn L. DeMeo; Augusto A. Litonjua; Alexander Neumann · 2019 · Clinical Epigenetics

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

BACKGROUND: Maternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, and depression with cord blood DNA methylation across the genome at birth and test for persistence of associations in early and mid-childhood blood DNA. METHODS: A discovery phase was conducted in Project Viva, a prospective pre-birth cohort study with external replication in an independent cohort, the Generation R Study. In Project Viva, pregnant women were recruited between 1999 and 2002 in East

Abstract by Andrés Cárdenas; Sabrina Faleschini; Andrea P. Cortés Hidalgo; Sheryl L. Rifas‐Shiman; Andrea Baccarelli; Dawn L. DeMeo; Augusto A. Litonjua; Alexander Neumann, Clinical Epigenetics (2019) — licensed CC BY 4.0.

Read the full paper (open access)