Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anne J. M. R. Geijsen, Stefanie Brezina, Pekka Keski‐Rahkonen et al. · 2019 · International Journal of Cancer
Colorectal cancer is known to arise from multiple tumorigenic pathways; however, the underlying mechanisms remain not completely understood. Metabolomics is becoming an increasingly popular tool in assessing biological processes. Previous metabolomics research focusing on colorectal cancer is limited by sample size and did not replicate findings in independent study populations to verify robustness of reported findings. Here, we performed a ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) screening on EDTA plasma from 268 colorectal cancer
View details →Failed Experiment ReportOpen accessMedicine
Michael A. Castello, John D. Jeppson, Salvador Soriano · 2014 · BMC Neurology
BACKGROUND: High-profile Phase 3 clinical trials of bapineuzumab and solanezumab, antibodies targeted at amyloid-beta (Aβ) removal, have failed to meet their primary endpoints. Neither drug improves clinical outcomes in patients with late onset AD, joining a long list of unsuccessful attempts to treat AD with anti-amyloid therapies. DISCUSSION: These therapies are based on the assumption that Aβ accumulation is the primary pathogenic trigger of AD. Current evidence suggests that Aβ may actually accumulate as part of an adaptive response to long-term chronic brain stress stimuli that would make
View details →Replication FailureOpen accessDecision Sciences
Stephan Lewandowsky, Klaus Oberauer · 2020 · Nature Communications
There is a broad agreement that psychology is facing a replication crisis. Even some seemingly well-established findings have failed to replicate. Numerous causes of the crisis have been identified, such as underpowered studies, publication bias, imprecise theories, and inadequate statistical procedures. The replication crisis is real, but it is less clear how it should be resolved. Here we examine potential solutions by modeling a scientific community under various different replication regimes. In one regime, all findings are replicated before publication to guard against subsequent replicat
View details →Negative / Null Result ReportOpen accessMedicine
Konstantinos A. Toulis, Brian H Willis, Tom Marshall et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism
Context: Empagliflozin was found to decrease mortality in patients with type 2 diabetes mellitus (T2DM) and a prior cardiovascular disease (CVD) event. Objectives: To establish whether these benefits can be replicated in a real-world…
View details →Negative / Null Result ReportDentistry
Panagiotis A. Koromantzos, Konstantinos Makrilakis, Xanthippi Dereka et al. · 2011 · Journal of Periodontology
BACKGROUND: It is well accepted that glycemic control in patients with diabetes mellitus (DM) is affected by systemic inflammation and oxidative stress. The effect of periodontal therapy on these systemic factors may be related to…
View details →Negative / Null Result ReportMedicine
Oded Zmora, Khaled Madbouly, Hagit Tulchinsky et al. · 2010 · Diseases of the Colon & Rectum
PURPOSE: Urinary bladder drainage for several days after pelvic surgery is a common surgical practice, despite insufficient evidence supporting its routine use. The aim of this study was to prospectively evaluate the utility of urinary…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Joonho Suh, Yun‐Sil Lee · 2020 · Journal of Bone Metabolism
Myostatin, also known as growth differentiation factor 8 (GDF8), is a transforming growth factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly, loss-of-function mutations in myostatin result in a…
View details →ProtocolOpen accessMedicine
Eric Lim, Liz Darlison, John Edwards et al. · 2020 · BMJ Open
INTRODUCTION: Mesothelioma remains a lethal cancer. To date, systemic therapy with pemetrexed and a platinum drug remains the only licensed standard of care. As the median survival for patients with mesothelioma is 12.1 months, surgery is an important consideration to improve survival and/or quality of life. Currently, only two surgical trials have been performed which found that neither extensive (extra-pleural pneumonectomy) or limited (partial pleurectomy) surgery improved survival (although there was some evidence of improved quality of life). Therefore, clinicians are now looking to evalu
View details →Negative / Null Result ReportOpen accessMedicine
Mary Carmelle Philogene, Serena M. Bagnasco, Edward S. Kraus et al. · 2016 · Transplantation
BACKGROUND: This is a cross-sectional study designed to evaluate the histologic characteristics of graft injury in the presence of anti-angiotensin II type 1 receptor antibody (AT1R-Ab) and anti-endothelial cell antibody (AECA). METHODS:…
View details →Negative / Null Result ReportOpen accessMedicine
Sushmita Pamidi, Isabelle Marc, Gabrielle Simoneau et al. · 2016 · Thorax
OBJECTIVE: It is unclear whether objectively measured maternal sleep-disordered breathing (SDB) leads to poor fetal outcomes. In this study, we prospectively assessed whether polysomnography-based diagnosis of SDB in the third trimester is…
View details →Negative / Null Result ReportEnvironmental Science
Eric E. Knapp, J. Morgan Varner, Matt D. Busse et al. · 2011 · International Journal of Wildland Fire
Mechanical mastication converts shrub and small tree fuels into surface fuels, and this method is being widely used as a treatment to reduce fire hazard. The compactness of these fuelbeds is thought to moderate fire behaviour, but whether…
View details →Negative / Null Result ReportMedicine
Murat Gedikoğlu, Levent Oğuzkurt, Serkan Gür et al. · 2013 · Catheterization and Cardiovascular Interventions
OBJECTIVES: To compare the success and complication rates of ultrasound-guided or palpation-guided punctures of the common femoral artery in a prospective randomized study. BACKGROUND: Percutaneous femoral arterial access is sometimes…
View details →Negative / Null Result ReportMedicine
Jan Krhút, Vladimír Borovička, Karolína Bílková et al. · 2018 · Neurourology and Urodynamics
AIMS: To assess the efficacy and safety of mirabegron in the treatment of neurogenic detrusor overactivity. METHODS: This prospective, multicenter, randomized, double-blind, placebo-controlled study was conducted in three tertiary centers,…
View details →Negative / Null Result ReportOpen accessPsychology
Oren Contreras‐Rodríguez, Jesús Pujol, Iolanda Batalla et al. · 2013 · Social Cognitive and Affective Neuroscience
Psychopaths show a reduced ability to recognize emotion facial expressions, which may disturb the interpersonal relationship development and successful social adaptation. Behavioral hypotheses point toward an association between emotion…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Raquel Álvarez-Urdiola, David García, Yamir Moreno et al. · 2015 · EPJ Data Science
Recent grassroots movements have suggested that online social networks might play a key role in their organization, as adherents have a fast, many-to-many, communication channel to help coordinate their mobilization. The structure and dynamics of the networks constructed from the digital traces of protesters have been analyzed to some extent recently. However, less effort has been devoted to the analysis of the semantic content of messages exchanged during the protest. Using the data obtained from a microblogging service during the brewing and active phases of the 15M movement in Spain, we per
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jason Yao, Anna Pilko, Roy Wollman · 2016 · Molecular Systems Biology
The heterogeneity in mammalian cells signaling response is largely a result of pre-existing cell-to-cell variability. It is unknown whether cell-to-cell variability rises from biochemical stochastic fluctuations or distinct cellular states. Here, we utilize calcium response to adenosine trisphosphate as a model for investigating the structure of heterogeneity within a population of cells and analyze whether distinct cellular response states coexist. We use a functional definition of cellular state that is based on a mechanistic dynamical systems model of calcium signaling. Using Bayesian param
View details →Failed Experiment ReportOpen accessComputer Science
Xuhan Liu, Kai Ye, Herman van Vlijmen et al. · 2023 · Journal of Cheminformatics
Abstract Rational drug design often starts from specific scaffolds to which side chains/substituents are added or modified due to the large drug-like chemical space available to search for novel drug-like molecules. With the rapid growth of deep learning in drug discovery, a variety of effective approaches have been developed for de novo drug design. In previous work we proposed a method named DrugEx , which can be applied in polypharmacology based on multi-objective deep reinforcement learning. However, the previous version is trained under fixed objectives and does not allow users to input a
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
C. Schaefer, Mario Geiger, T. Kuntzer et al. · 2017 · Astronomy and Astrophysics
Context. Future large-scale surveys with high-resolution imaging will provide us with approximately 10 5 new strong galaxy-scale lenses. These strong-lensing systems will be contained in large data amounts, however, which are beyond the…
View details →Negative / Null Result ReportMedicine
Helena Brodská, J Valenta, Květa Pelinková et al. · 2017 · Clinical Chemistry and Laboratory Medicine (CCLM)
BACKGROUND: Inflammatory biomarkers may aid to distinguish between systemic inflammatory response syndrome (SIRS) vs. sepsis. We tested the hypotheses that (1) presepsin, a novel biomarker, can distinguish between SIRS and sepsis, and (2)…
View details →Negative / Null Result ReportSocial Sciences
Daniel Tinkelman, Daniel Neely · 2010 · Nonprofit and Voluntary Sector Quarterly
Several econometric issues arise in using nonprofit data. After controlling for unduly influential observations and heteroskedasticity, regression analysis performed on National Center for Charitable Statistics “digitized data” from 2001…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Shane Coffield, Casey Graff, Yang Chen et al. · 2019 · International Journal of Wildland Fire
Fires in boreal forests of Alaska are changing, threatening human health and ecosystems. Given expected increases in fire activity with climate warming, insight into the controls on fire size from the time of ignition is necessary. Such…
View details →Negative / Null Result ReportOpen accessMedicine
Patrick M. Honoré, Rita Jacobs, Inne Hendrickx et al. · 2015 · Annals of Intensive Care
Sepsis-induced acute kidney injury (SAKI) remains an important challenge in critical care medicine. We reviewed current available evidence on prevention and treatment of SAKI with focus on some recent advances and developments. Prevention of SAKI starts with early and ample fluid resuscitation preferentially with crystalloid solutions. Balanced crystalloids have no proven superior benefit. Renal function can be evaluated by measuring lactate clearance rate, renal Doppler, or central venous oxygenation monitoring. Assuring sufficiently high central venous oxygenation most optimally prevents SAK
View details →Negative / Null Result ReportOpen accessMedicine
Daqing Hong, Jeong Jin Min, Jeongwon Kim et al. · 2010 · Anaesthesia and Intensive Care
In several recent clinical trials on cardiac surgery patients, remote ischaemic preconditioning (RIPC) showed a powerful myocardial protective effect. However the effect of RIPC has not been studied in patients undergoing off-pump coronary…
View details →Negative / Null Result ReportPsychology
Hussam Jefee-Bahloul, Moustafa K. Moustafa, Fatma M. Shebl et al. · 2014 · Telemedicine Journal and e-Health
BACKGROUND: Given the scarcity of mental health resources available for refugees in areas of conflict, it is imperative to investigate interventions that would be accepted by the refugees. MATERIALS AND METHODS: In this study we surveyed…
View details →Negative / Null Result ReportMedicine
Margarida Corominas-Roso, Josep Antoni Ramos‐Quiroga, Marta Ribasés et al. · 2013 · The International Journal of Neuropsychopharmacology
It has been hypothesized that brain-derived neurotrophic factor (BDNF) is involved in the pathogenesis of attention-deficit hyperactivity disorder (ADHD), although experimental data regarding the contribution of BDNF gene polymorphisms to…
View details →Negative / Null Result ReportOpen accessHealth Professions
Isabelle Scholl, Levente Kriston, Jörg Dirmaier et al. · 2012 · Health Expectations
BACKGROUND: While there has been a clear move towards shared decision-making (SDM) in the last few years, the measurement of SDM-related constructs remains challenging. There has been a call for further psychometric testing of known…
View details →Negative / Null Result ReportOpen accessMedicine
Bernard F. Fuemmeler, Chongming Yang, Phil Costanzo et al. · 2012 · Health Psychology
OBJECTIVE: Parenting styles such as authoritarian, disengaged, or permissive are thought to be associated with greater adolescent obesity risk than an authoritative style. This study assessed the relationship between parenting styles and…
View details →Negative / Null Result ReportOpen accessMedicine
Christopher M. Jackson, Christina M. Kochel, Christopher J. Nirschl et al. · 2015 · Clinical Cancer Research
PURPOSE: Immune responses to antigens originating in the central nervous system (CNS) are generally attenuated, as collateral damage can have devastating consequences. The significance of this finding for the efficacy of tumor-targeted…
View details →Negative / Null Result ReportOpen accessMedicine
Boulos Nassar, Mary Vaughan‐Sarrazin, Lan Jiang et al. · 2014 · JAMA Internal Medicine
IMPORTANCE: Intensive care unit (ICU) telemedicine (TM) programs have been promoted as improving access to intensive care specialists and ultimately improving patient outcomes, but data on effectiveness are limited and conflicting.…
View details →Negative / Null Result ReportOpen accessMedicine
Michael Weller, Burt Nabors, Thierry Gorlia et al. · 2016 · Oncotarget
// Michael Weller 1 , Louis Burt Nabors 2 , Thierry Gorlia 3 , Henning Leske 4 , Elisabeth Rushing 4 , Pierre Bady 5, 6, 7 , Christine Hicking 8 , James Perry 9 , Yong-Kil Hong 10 , Patrick Roth 1 , Wolfgang Wick 11, 12 , Simon L. Goodman 8 , Monika E. Hegi 7 , Martin Picard 8 , Holger Moch 13 , Josef Straub 8 , Roger Stupp 14 1 Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland 2 University of Alabama at Birmingham, Birmingham, AL, USA 3 EORTC Data Centre, Brussels, Belgium 4 Institute of Neuropathology, University Hospital Zurich, Zurich, Switze
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