Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jantina Toxopeus, Vladimı́r Košťál, Brent J. Sinclair · 2019 · Proceedings of the Royal Society B Biological Sciences
Freeze tolerance, the ability to survive internal ice formation, facilitates survival of some insects in cold habitats. Low-molecular-weight cryoprotectants such as sugars, polyols and amino acids are hypothesized to facilitate freeze…
View details →Negative / Null Result ReportMedicine
Bahaa Aba Alkhail · 2015 · Medical Teacher
INTRODUCTION: A near-peer-assisted learning term (NPAL) is "a trainee one or more years senior to another trainee". The current study is aiming to determine the pattern of NPAL activities, to compare its effect on student's course…
View details →Negative / Null Result ReportOpen accessMedicine
Young-Hyo Ryu, Yong-Hee Kim, Jin‐Young Lee et al. · 2013 · PLoS ONE
Non-thermal plasma at atmospheric pressure has been actively applied to sterilization. However, its efficiency for inactivating microorganisms often varies depending on microbial species and environments surrounding the microorganisms. We investigated the influence of environmental factors (surrounding media) on the efficiency of microbial inactivation by plasma using an eukaryotic model microbe, Saccharomyces cerevisiae, to elucidate the mechanisms for differential efficiency of sterilization by plasma. Yeast cells treated with plasma in water showed the most severe damage in viability and ce
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Bria M. Coates, Kelly L. Staricha, Nandini Ravindran et al. · 2017 · Frontiers in Immunology
Influenza A virus (IAV) is a significant cause of life-threatening lower respiratory tract infections in children. Antiviral therapy is the mainstay of treatment, but its effectiveness in this age group has been questioned. In addition, damage inflicted on the lungs by the immune response to the virus may be as important to the development of severe lung injury during IAV infection as the cytotoxic effects of the virus itself. A crucial step in the immune response to IAV is activation of the NOD-like receptor protein 3 (NLRP3) inflammasome and the subsequent secretion of the inflammatory cytok
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Eli Ben‐Chetrit, Avraham Ben‐Chetrit, Yackov Berkun et al. · 2010 · Arthritis Care & Research
OBJECTIVE: To evaluate the outcome of pregnancies in women with familial Mediterranean fever (FMF) who are taking colchicine, and to reconsider the justification for amniocentesis in these women. METHODS: The outcome of 179 pregnancies in…
View details →Negative / Null Result ReportMedicine
Yasin Çınar, Abdullah Kürşat Cingü, Fatih Mehmet Türkçü et al. · 2013 · Cutaneous and Ocular Toxicology
PURPOSE: To compare outcomes of accelerated and conventional corneal cross-linking (CXL) for progressive keratoconus (KC). MATERIALS AND METHODS: Patients were divided into two groups as the accelerated CXL group and the conventional CXL…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Il‐Kang Na, Matthew Buckland, Carlo Agostini et al. · 2019 · European Journal Of Haematology
OBJECTIVE: Despite long-standing safe and effective use of immunoglobulin replacement therapy (IgRT) in primary immunodeficiency, clinical data on IgRT in patients with secondary immunodeficiency (SID) due to B-cell lymphoproliferative…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
T. Dassopoulos, Marla C. Dubinsky, J. L. Bentsen et al. · 2013 · Alimentary Pharmacology & Therapeutics
BACKGROUND: Azathioprine (AZA), a pro-drug metabolised to the active metabolites 6-tioguanine nucleotides (6TGN), is a steroid-sparing therapy for Crohn's disease (CD). AIM: To investigate whether AZA therapy is optimised by individualised…
View details →Negative / Null Result ReportNeuroscience
Gonzalo Garcia Guerra, Charlene M.T. Robertson, Gwen Y. Alton et al. · 2011 · Pediatric Anesthesia
OBJECTIVES/AIM: To determine whether sedation/analgesia drugs used before, during, and after infant cardiac surgery are associated with neurodevelopmental outcome. BACKGROUND: Animal models suggest detrimental effects of anesthetic drugs…
View details →Negative / Null Result ReportComputer Science
Başak Alper, Tobias Höllerer, JoAnn Kuchera-Morin et al. · 2011 · IEEE Transactions on Visualization and Computer Graphics
In this paper we present a new technique and prototype graph visualization system, stereoscopic highlighting, to help answer accessibility and adjacency queries when interacting with a node-link diagram. Our technique utilizes stereoscopic…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
J. Castro, Andrés Gómez, Bryan A. White et al. · 2016 · Journal of Dairy Science
The objective of this work was to assess the effects of age and gastrointestinal location (rumen vs. colon) on bacterial community diversity and composition, as well as short-chain fatty acid profiles of preruminant male Holstein calves on…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Michael A. Litzow, Mary E. Hunsicker · 2016 · Ecosphere
Abstract Early warning signals ( EWS ) might dramatically improve our ability to manage nonlinear ecological change. However, the degree to which theoretical EWS predictions are supported in empirical systems remains unclear. The goal of this study is to make recommendations for identifying the types of ecological transitions that are expected to show EWS . We conducted a review and meta‐analysis of published studies and comparative analysis of eight northeast Pacific Ocean time series to illustrate the importance of testing for nonlinearity in empirical EWS studies. We found that published st
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Lu (Lucy) Yan, Jianping Peng, Yong Tan · 2015 · Information Systems Research
Social networks have been shown to affect health. Because online social networking makes it easier for individuals to interact with experientially similar others in regard to health issues and to exchange social support, there has been an…
View details →Negative / Null Result ReportOpen accessMedicine
Maya Williams, Sandra V. Mayer, William L. Johnson et al. · 2014 · American Journal of Tropical Medicine and Hygiene
During 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in Loreto after almost 8 years.…
View details →Negative / Null Result ReportOpen accessNeuroscience
Frieder M. Paulus, Johannes Bedenbender, Sören Krach et al. · 2013 · Human Brain Mapping
BACKGROUND: Genome-wide association studies have identified the rs1006737 single nucleotide polymorphism (SNP) in the CACNA1C gene as a susceptibility locus for schizophrenia and bipolar disorder. On the neural systems level this…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Husam Rjoub, Mehmet Ağa, Ahmad Abu Alrub et al. · 2017 · Economies
The recognition of Foreign Direct Investment (FDI) as a source of funding to foster economic development in both developed and developing countries has been in ascendancy. The prime purpose of this study is to empirically investigate the determinants of FDI for the “landlocked countries” in Sub-Saharan Africa over the period 1995–2013. By employing panel data analysis, the result of the study revealed that domestic investment, trade (openness), human capital, political constraint, natural resource endowment and the market size (with the GDP growth as proxy) as having positive impact on determi
View details →Negative / Null Result ReportOpen accessDecision Sciences
Sujin Pyo, Jaewook Lee, Mincheol Cha et al. · 2017 · PLoS ONE
The prediction of the trends of stocks and index prices is one of the important issues to market participants. Investors have set trading or fiscal strategies based on the trends, and considerable research in various academic fields has been studied to forecast financial markets. This study predicts the trends of the Korea Composite Stock Price Index 200 (KOSPI 200) prices using nonparametric machine learning models: artificial neural network, support vector machines with polynomial and radial basis function kernels. In addition, this study states controversial issues and tests hypotheses abou
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Nancy McCarthy, Talip Kilic, Josh Brubaker et al. · 2021 · Environment and Development Economics
Abstract Climate change is predicted to increase the frequency of extreme weather events, increasing the vulnerability of smallholder farmers dependent on rain-fed agriculture. We evaluate the extent to which farmers in Malawi suffer crop production losses due to extreme weather, and whether sustainable land management (SLM) practices help shield crop production losses from extreme events. We use a three period panel dataset where widespread floods and droughts occurred in separate periods, offering a unique opportunity to evaluate impacts using data collected immediately following these event
View details →Failed Experiment ReportOpen accessEnvironmental Science
Tetsu K. Tokunaga, Jiamin Wan, Jongwon Jung et al. · 2013 · Water Resources Research
In geologic carbon sequestration, reliable predictions of CO 2 storage require understanding the capillary behavior of supercritical (sc) CO 2 . Given the limited availability of measurements of the capillary pressure ( P c ) dependence on…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Brent B. Hughes, M. D. Levey, Monique C. Fountain et al. · 2015 · Proceedings of the National Academy of Sciences
Coastal ecosystems provide numerous important ecological services, including maintenance of biodiversity and nursery grounds for many fish species of ecological and economic importance. However, human population growth has led to increased…
View details →Negative / Null Result Report
Christina Brock, Christian Stevns Hansen, Jesper Karmisholt et al. · 2019 · British Journal of Clinical Pharmacology
Aims Type 1 diabetes can be complicated with neuropathy that involves immune‐mediated and inflammatory pathways. Glucagon‐like peptide‐1 receptor agonists such as liraglutide, have shown anti‐inflammatory properties, and thus we…
View details →Negative / Null Result ReportOpen accessMedicine
Yoshimi Kubota, Hiroyasu Iso, Chigusa Date et al. · 2011 · Stroke
BACKGROUND AND PURPOSE: Only a few reports have dealt with the association of antioxidant vitamin intakes with mortality or morbidity from cardiovascular disease in Asia. We investigated the relation of dietary vitamins A, E, and C intake…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Nicholas F. Evageliou, Michelle Haber, Annette Vu et al. · 2016 · Clinical Cancer Research
PURPOSE: Deregulated MYC drives oncogenesis in many tissues yet direct pharmacologic inhibition has proven difficult. MYC coordinately regulates polyamine homeostasis as these essential cations support MYC functions, and drugs that…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Albert B. Phillimore, Sandra Stålhandske, R. Smithers et al. · 2012 · The American Naturalist
Phenology affects the abiotic and biotic conditions that an organism encounters and, consequently, its fitness. For populations of high-latitude species, spring phenology often occurs earlier in warmer years and regions. Here we apply a…
View details →Negative / Null Result ReportOpen accessMedicine
Katherine Andrinopoulos, Gretchen Clum, Debra A. Murphy et al. · 2011 · AIDS Education and Prevention
In this study HIV health-related quality of life (HIV-HRQOL) is examined among 179 behaviorally infected adolescent and young adult women. Modifiable psychosocial variables including depression, stigma, social support, and illness…
View details →Negative / Null Result ReportOpen accessMedicine
Catherine Townsend, Julie Laffy, Bryan Wu et al. · 2016 · Frontiers in Immunology
Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain complementarity-determining region (CDR)-H3 region. In this paper, we set out to investigate the physicochemical and structural differences between human kappa and lambda light chain CDR regions. We constructed a dataset containing over 29,000 light chain variable region sequences from IgM-transcribing, newly f
View details →Negative / Null Result ReportOpen accessMedicine
Marcos Hortes Nisihara Chagas, José Alexandre S. Crippa, Antônio Waldo Zuardi et al. · 2013 · Journal of Psychopharmacology
UNLABELLED: Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle. OBJECTIVE: The objective of this paper is to assess the effects on sleep of acute…
View details →Negative / Null Result ReportOpen accessMedicine
Davide Castagno, Mark C. Petrie, Brian Claggett et al. · 2012 · European Heart Journal
AIMS: The importance of heart rate in the pathophysiology of heart failure with reduced LVEF has recently attracted attention. In particular, the findings of the Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial…
View details →Negative / Null Result ReportOpen accessMedicine
Selma Kronsteiner-Gicevic, Audrey J. Gaskins, Teresa T. Fung et al. · 2018 · PLoS ONE
BACKGROUND: Dietary diversity scores (DDS) are considered as metrics for monitoring the implementation of the UN's Sustainable Development Goals, but they need to be rigorously evaluated. OBJECTIVE: To examine two DDS, the Food Groups Index (FGI), and the Minimum Dietary Diversity-Women (MDD-W), alongside two dietary quality scores, the Alternate Healthy Eating Index (AHEI-2010) and the Prime Diet Quality Score (PDQS), with risks of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDPs). DESIGN: The analysis included 21,312 (GDM) and 19,917 (HDPs) singleton births r
View details →Negative / Null Result ReportOpen accessMaterials Science
Mathilde Hunault, T. Leguay, Xavier Thomas et al. · 2010 · Haematologica
BACKGROUND: The prognosis of acute lymphoblastic leukemia in the elderly is poor. The GRAALL-SA1 phase II, randomized trial compared the efficacy and toxicity of pegylated liposomal doxorubicin versus continuous-infusion doxorubicin in…
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