21,770 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Camon C, Kip E, Lord R et al. · 2026 · Preprint
Menopausal hormone therapy (MHT) is prescribed for climacteric symptoms including hot flushes and weight gain and contains estrogens such as 17 beta-estradiol (17βE2). However, estrogen receptor activation by MHT may increase reproductive…
View details →Kang A, Tian X, Mi Z et al. · 2026 · Environmental science & technology
Improving carbon productivity is essential for simultaneously achieving sustainable development goals and tackling climate change. While the Global Value Chains (GVCs) division enhances productive efficiency, its impact on carbon…
View details →Yamamoto Y, Takeuchi K, Tabe S et al. · 2026 · Preprint
Summary The specific contribution of tissue-resident macrophages (TRMs) to pancreatic ductal adenocarcinoma (PDAC) progression remains unclear. Here, we found that a high abundance of TRM-derived tumor-associated macrophages (TRM-TAMs) is…
View details →Rajan A, Prakash S, Singh D et al. · 2026 · Preprint
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by α-Synuclein (α-Syn) aggregation, dopaminergic neuronal loss, and chronic neuroinflammation. Chlorogenic acid (CA), a dietary polyphenol abundant in…
View details →Fulghum K, Hayir A, Ankeriasniemi R et al. · 2026 · Preprint
ABSTRACT Alzheimer’s disease and related tauopathies are escalating public health threats, particularly in the context of obesity and metabolic dysfunction, which accelerate cerebral glucose hypometabolism, tau pathology,…
View details →Xing L, Lu B, Zhu X et al. · 2026 · Inflammation and regeneration
Background Mesenchymal stromal cells (MSCs) possess therapeutic potential largely reliant on intact mitochondrial function to maintain reparative function. However, obesity compromises MSC metabolism and reparative capacity. MOTS-c, a…
View details →Zheng B · 2026 · Current molecular medicine
Background/objective Patients with renal artery stenosis (RAS) exhibit increased risk of cardiovascular death and all-cause death. Our previous finding showed that the presence of RAS is associated with poor coronary collateral development…
View details →Welles JE, Garifallou JP, Gonzalez MV et al. · 2026 · Preprint
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease for which the mechanisms linking lipid dysregulation to fibrosis remain poorly defined. Hepatic phosphatidylcholine (PC) content is reduced in MASH, but…
View details →Luda KM, Agerholm M, Sonne SB et al. · 2026 · Molecular metabolism
Background White adipose tissue (WAT) plays a central role in maintaining systemic metabolic homeostasis by buffering lipid flux throughout the body. Impairment of this lipid-buffering capacity is a hallmark of obesity and has also been…
View details →Ahlinder J, Waldmann P · 2026 · Preprint
Optimum contribution selection (OCS) balances genetic gain and inbreeding by optimizing parental contributions to the next generation, but current implementations rely on point estimates of breeding values that discard the uncertainty…
View details →Aguila L, Castillo R, Pérez-García F et al. · 2026 · Preprint
Haploid embryos constitute a valuable model for genetic and epigenetic studies; however, their developmental competence is reduced compared with diploid counterparts. This study evaluated whether supplementation of the culture medium with…
View details →Wang H, Kang L, Mu Y et al. · 2026 · Archives of animal nutrition
Light weaning body weight (LWBW) piglets exhibit inferior growth performance, and their energy requirement vary dynamically with increasing body weight. Although high-energy diets improve growth, they risk impairing liver health.…
View details →Walsh RW, Meledeo MA, Nicolson SE et al. · 2026 · Transfusion
Background Hypocalcemia is correlated with poor outcomes in trauma patients and is considered the fourth component in the "diamond of death" alongside acidosis, coagulopathy, and hypothermia. Study design and methods We characterized the…
View details →Pelletier M, Yang J, Joshi M et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Background Transforming Growth Factor Beta (TGFβ) plays a dual role in cancer, acting as a tumor suppressor early in disease but promoting progression and immune evasion when dysregulated. In pancreatic ductal adenocarcinoma (PDAC),…
View details →De S Ferreira JM, Rodrigues HP, Alba HDR et al. · 2026 · Animal : an international journal of animal bioscience
High-concentrate diets supplemented with rumen-protected fats are widely used in feedlot lamb systems to improve energy supply and performance; however, the metabolic efficacy of these lipid sources may depend on the availability of…
View details →Hanson M, Pitcher D · 2025 · Preprint
Understanding the behaviour and emotions of other people is predicated on accurately decoding nonverbal facial cues. In the current study, we investigated whether the ensemble encoding of these facial cues is processed differently between…
View details →· 2025 · Nephron
In the article "Immunosuppressant Agents as Add-On Therapy Failed to Improve the Outcome of Immunoglobulin A Nephropathy with Crescent Score C1" [Nephron. 2024;148:587-600; https://doi.org/10.1159/000534788] by Bi et al., the funding grant…
View details →Santos RdS, Gazzola MG, Figueira PM et al. · 2026 · Preprint
Abstract Background Despite rapid advances in large language models (LLMs), automated ICD-10 coding of real-world clinical narratives remains unreliable. A key challenge lies not only in model limitations, but in the intrinsic ambiguity of…
View details →Ngeve SM, Khoury AL, Long JM · 2026 · Journal of visualized experiments : JoVE
Vanishing Lung Syndrome (VLS) is a rare, severe form of bullous pulmonary disease characterized by giant bullae occupying more than 30% of the hemithorax, which can easily be misdiagnosed as a pneumothorax. While cigarette smoking is the…
View details →Stahl M, Zeidan AM · 2026 · Blood
Abstract Aside from allogeneic transplantation, the current standard-of-care approach for higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) remains monotherapy with a hypomethylating agent (HMA), including azacitidine, decitabine,…
View details →Matsushita H, Oba K, Kurono K et al. · 2026 · Shock (Augusta, Ga.)
Introduction In cardiogenic shock (CS), persistent microcirculatory impairment despite improved macrocirculatory parameters is associated with poor outcomes. Therapeutic strategies must therefore address both macro- and micro-circulation.…
View details →Florens N · 2026 · Nephrologie & therapeutique
Cardiovascular mortality among hemodialysis patients remains strikingly high—around 10% per year—despite substantial advances in dialysis technology and medical care. Historically, several strategies extrapolated from the general…
View details →Sekiguchi Y, Tsutsumi H, Kudo M et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy
84-year-old male was diagnosed with diffuse large B-cell lymphoma.He had Stage Ⅳ, performance status was 2, and 'high risk' according to the International Prognostic Index.He was started on Pola-R-mini-CHP.The day after completion of the 4…
View details →Al Hindawi MA, Omran NE, Mostafa MH et al. · 2026 · European journal of pharmacology
In metastatic melanoma with a BRAF V600 mutation, inhibitors of BRAF and MEK have improved survival. Resistance may be acquired through late genetic alterations that restore mitogen-activated protein kinase (MAPK) signaling. Resistance can…
View details →Chen H, Wang J, Fan C et al. · 2026 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Background and aim The benefit of combining linaclotide with polyethylene glycol (PEG) for improving bowel preparation quality and adenoma detection in patients at risk for inadequate bowel preparation remains uncertain. This study aimed…
View details →Xu K, Zhang R, Yuan Y et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Aims Gallbladder carcinoma (GBC) has a poor prognosis, with lymph node metastasis (LNM) being a key prognostic factor. Controversies remain regarding lymph node dissection (LND) utility and prognostic differences of direct (DGBC) vs.…
View details →Li A, Liu C, Xing R et al. · 2026 · Carbohydrate research
Phenol-sulfuric acid method, a classical approach for total sugar quantification, suffers from substantial variation in the colorimetric efficiency among different monosaccharides, which may result in significant measurement bias. In this…
View details →August D, Marsh N, Hall S et al. · 2026 · The Journal of perinatal & neonatal nursing
Purpose Implement and evaluate near-infrared (NIR) huddles for neonatal peripheral intravenous catheter (PIVC) insertion. Methods An implementation project investigated PIVC insertion attempts, site, inserter designation, dwell, and…
View details →Huang JQ, Xiao HM, Ma CX et al. · 2026 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
To compare survival outcomes and safety between concurrent chemoradiotherapy (CCRT) and CCRT with concurrent immune checkpoint inhibitor (ICI) in patients with locally advanced esophageal squamous cell carcinoma. This multicenter cohort…
View details →Moura RP, Mwema A, Bottemanne P et al. · 2026 · Journal of controlled release : official journal of the Controlled Release Society
Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting over 2.5 million people worldwide. Despite available therapies, no current treatment halts disease progression or specifically targets remyelination. Here, we…
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