Biomarker analysis from patients with metastatic PDAC treated with TGFβ antibody, NIS793, plus abraxane+gemcitabine vs. abraxane+gemcitabine alone in a phase II, open label, randomized study.
Pelletier M; Yang J; Joshi M; Grauel A; Abecunas C; Altzerinakou MA; Zhou Z; Zhu X · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background Transforming Growth Factor Beta (TGFβ) plays a dual role in cancer, acting as a tumor suppressor early in disease but promoting progression and immune evasion when dysregulated. In pancreatic ductal adenocarcinoma (PDAC),…
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Metadata source: Europe PMC · DOI 10.1158/1078-0432.ccr-26-0805