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WASTE Journal

Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Sitagliptin does not interfere with VEGF-A signaling in retinal endothelial cells in vitro.

Amthor L, Jaeckle A, Kampmeier J et al. · 2025 · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

Sitagliptin, an inhibitor of dipeptidyl peptidase-4 widely used in type 2 diabetes therapy, impairs the barrier formed by retinal endothelial cells (REC) during prolonged exposure. Because diabetic macular edema is treated with inhibitors…

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Negative / Null Result ReportMedicine

The effect of switching antipsychotics to aripiprazole versus paliperidone on weight/cardiometabolic parameters: 18-month follow-up findings from the European Long-acting Antipsychotics in Schizophrenia Trial (EULAST).

de Boer N, Vučko Z, Koster DI et al. · 2026 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

Antipsychotic-induced weight gain (AiWG) is a common, burdensome adverse effect. Switching to antipsychotics with lower metabolic risks, such as aripiprazole, is recommended, but long-term data is limited. Long-acting injectables (LAIs)…

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Negative / Null Result ReportMedicine

TNF-α antagonist alleviates muscular layer enlargement but does not prevent myenteric neuronal loss in the colon of streptozotocin-induced diabetic rats.

Sholikah TA, Septyaningtrias DE, Sumiwi YAA et al. · 2025 · Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

Background this study aimed to examine the impact of a TNF-α antagonist on markers of neuronal death, the total number of myenteric neurons, and the volume of each colonic layer in diabetic rats. Methods thirty male rats were divided into…

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Negative / Null Result ReportMedicine

Kaempferitrin modulates AMPK phosphorylation and PEPCK expression in the liver after a short-term high-fat, high-sucrose diet intervention in mice.

Garofolo IC, Santos PF, Silva MF et al. · 2026 · Nutrition and health

Background: Type 2 Diabetes Mellitus is a metabolic disease characterized by hyperglycemia and hyperinsulinemia, closely linked to obesity. According to the International Diabetes Federation, in 2021, almost 6.7 million adults aged 20-79…

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Negative / Null Result ReportMedicine

Relationship between inner hair cell synaptopathy and outer hair cell loss in two mouse models of accelerated age-related hearing loss.

Lankinen T, Leinonen S, Ikäheimo K et al. · 2025 · Neurobiology of aging

Hallmarks of sensorineural hearing loss are elevated hearing thresholds and defects in temporal auditory processing, the former being often caused by outer hair cell (OHC) damage, and the latter by the loss of synapses between inner hair…

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Negative / Null Result ReportMedicine

Should Ceramic-on-Ceramic or Ceramic-on-Polyethylene Bearings Be Preferred in Revision Total Hip Arthroplasty After Ceramic Head or Liner Fracture? A Retrospective Multicenter Case-Control Study of 33 Cases.

Oger R, Hulet C, Tripon M et al. · 2026 · Orthopaedics & traumatology, surgery & research : OTSR

Introduction Fracture of ceramic components in total hip arthroplasty (THA), although rare, remains a major concern. The optimal bearing choice in revision surgery following such fractures is still debated. Few studies have specifically…

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Negative / Null Result ReportMedicine

Oral Probiotic Containing <i>Streptococcus salivarius</i> K12 and <i>Lactobacillus brevis</i> CD2 for Preventing Bacterial Pneumonia in Severe COVID-19: Randomized Clinical Trial.

Lauxen JR, Callegari-Jacques SM, Mombelli AS et al. · 2025 · The journal of contemporary dental practice

Aims To assess the effect of dental application of oral probiotics containing Streptococcus salivarius K12 and Lactobacillus brevis CD2 on preventing secondary bacterial pneumonia in patients with severe COVID-19. Materials and methods In…

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Negative / Null Result ReportMedicine

Evaluating pressure injury and time of risk assessment for adults with hip fractures: A retrospective analysis.

Anderson P, Zhou H, Patton V et al. · 2025 · International journal of orthopaedic and trauma nursing

Background Pressure injuries are a worldwide concern for patients in the acute hospital setting. They are a common hospital-acquired complication and Australian national standards, state policies, and local procedures have been developed…

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Negative / Null Result ReportMedicine

In vitro mechanical stretch inhibits differentiation of mouse myoblast C2C12 cells without sustained eIF2α phosphorylation.

Mori K, Asahi T, Kataoka K et al. · 2025 · Biochemical and biophysical research communications

Mechanical stretch critically influences skeletal muscle physiology, yet its role in myoblast differentiation and the associated molecular mechanisms have not been fully clarified. This study investigated the effects of uniaxial cyclic…

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Negative / Null Result ReportMedicine

The mitochondrial-targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial-apoptotic but not necroptotic signalling during ovarian cancer.

Khajehzadehshoushtar S, Delfinis LJ, Rahman FA et al. · 2025 · The Journal of physiology

The degree to which mitochondrial-linked programmed cell death pathways contribute to skeletal muscle atrophy during cancer remains unknown. Here we combined a novel and robust mouse model of metastatic ovarian cancer with chronic…

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Negative / Null Result ReportOpen accessMedicine

Improvement of cardiac function by Ivabradine in a doxorubicin-induced cardiomyopathy murine model is associated with a normal renal angiotensin II type I receptor expression but not with a reduction in fibrosis.

Drumeva GO, Plane AF, Petrenyov DR et al. · 2026 · Cardio-oncology (London, England)

BACKGROUND: Ivabradine (IVAB) is an effective drug in patients with heart failure (HF). However, data in the context of chemotherapy-induced cardiomyopathy are limited. This study investigated the cardioprotective potential of IVAB in a…

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Negative / Null Result ReportOpen accessMedicine

Nephroprotective Effects of Wedelolactone against Snake Venom-Induced Acute Kidney Injury: Insights into Experimental Envenomation.

Romanelli MA, Nogueira-Souza PD, Gomes DS et al. · 2026 · ACS omega

Snakebite-induced acute kidney injury (sAKI) is a severe clinical complication associated with Bothrops envenomation that can lead to kidney failure. Alternative therapies are needed due to the limitations of antivenom, including variable…

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