Sitagliptin does not interfere with VEGF-A signaling in retinal endothelial cells in vitro.
Amthor L; Jaeckle A; Kampmeier J; Wolf A; Rehak M; Deissler H; Ziemssen F; Deissler HL · 2025 · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Sitagliptin, an inhibitor of dipeptidyl peptidase-4 widely used in type 2 diabetes therapy, impairs the barrier formed by retinal endothelial cells (REC) during prolonged exposure. Because diabetic macular edema is treated with inhibitors…
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Metadata source: Europe PMC · DOI 10.1055/a-2708-3562