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Browse the failure-mode index

21,216 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessNeuroscience

Real-time brain-machine interface in non-human primates achieves high-velocity prosthetic finger movements using a shallow feedforward neural network decoder

Matthew S. Willsey, Samuel R. Nason, Scott R. Ensel et al. · 2022 · Nature Communications

Despite the rapid progress and interest in brain-machine interfaces that restore motor function, the performance of prosthetic fingers and limbs has yet to mimic native function. The algorithm that converts brain signals to a control signal for the prosthetic device is one of the limitations in achieving rapid and realistic finger movements. To achieve more realistic finger movements, we developed a shallow feed-forward neural network to decode real-time two-degree-of-freedom finger movements in two adult male rhesus macaques. Using a two-step training method, a recalibrated feedback intention

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Population Genetic Analyses of the Fungal Pathogen Colletotrichum fructicola on Tea-Oil Trees in China

Li He, Guoying Zhou, Junang Liu et al. · 2016 · PLoS ONE

The filamentous fungus Colletotrichum fructicola is found in all five continents and is capable of causing severe diseases in a number of economically important plants such as avocado, fig, cocoa, pear, and tea-oil trees. However, almost nothing is known about its patterns of genetic variation and epidemiology on any of its host plant species. Here we analyzed 167 isolates of C. fructicola obtained from the leaves of tea-oil tree Camellia oleifera at 15 plantations in seven Chinese provinces. Multilocus sequence typing was conducted for all isolates based on DNA sequences at fragments of four

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Negative / Null Result ReportOpen accessMedicine

Discovery of a Unique Novel Clade of Mosquito-Associated Bunyaviruses

Marco Marklewitz, Florian Zirkel, Innocent B. Rwego et al. · 2013 · Journal of Virology

Bunyaviruses are the largest known family of RNA viruses, infecting vertebrates, insects, and plants. Here we isolated three novel bunyaviruses from mosquitoes sampled in Côte d'Ivoire, Ghana, and Uganda. The viruses define a highly…

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Negative / Null Result ReportOpen accessMedicine

DVT incidence and risk factors in critically ill patients with COVID-19

Shujing Chen, Dingyu Zhang, Tianqi Zheng et al. · 2020 · Journal of Thrombosis and Thrombolysis

Few data are available on the incidence of deep vein thrombosis (DVT) in critically ill COVID-19 with thrombosis prophylaxis. This study retrospectively included 88 patients in the ICU with critically ill COVID-19 at Jinyintan Hospital in Wuhan, China. All patients underwent compression ultrasonography for identifying DVT. Firth logistic regression was used to examine the association of DVT with sex, age, hypoalbuminemia, D-dimer, and SOFA score. The median (interquartile range [IQR]) age and SOFA score of 88 patients were 63 (55-71) years old and 5 (4-6), respectively. Despite all patients re

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Negative / Null Result ReportOpen accessNeuroscience

Glucagon‐like peptide‐1 receptor signalling reduces microvascular thrombosis, nitro‐oxidative stress and platelet activation in endotoxaemic mice

Sebastian Steven, Kerstin Jurk, Maximilian Kopp et al. · 2016 · British Journal of Pharmacology

Abstract Background and Purpose Excessive inflammation in sepsis causes microvascular thrombosis and thrombocytopenia associated with organ dysfunction and high mortality. The present studies aimed to investigate whether inhibition of…

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Negative / Null Result ReportDentistry

Peri‐implant evaluation of immediately loaded implants placed in esthetic zone in patients with diabetes mellitus type 2: a two‐year study

Antonio Aguilar‐Salvatierra, José Luis Calvo‐Guirado, Maximino González‐Jaranay et al. · 2015 · Clinical Oral Implants Research

OBJECTIVES: The aim of this study was to evaluate implant survival and primary stability parameters in patients with diabetes with different levels of glycosylated hemoglobin Alc (HbA1c) treated with immediate placement and…

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Negative / Null Result ReportBusiness, Management and Accounting

Impact of relational coordination on staff and patient outcomes in outpatient surgical clinics

Jody Hoffer Gittell, Caroline Logan, Jack L. Cronenwett et al. · 2018 · Health Care Management Review

BACKGROUND: Pressures are increasing for clinicians to provide high-quality, efficient care, leading to increased concerns about staff burnout. PURPOSE: This study asks whether staff well-being can be achieved in ways that are also…

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Negative / Null Result ReportMedicine

Ambrisentan for sarcoidosis associated pulmonary hypertension.

Marc A. Judson, Kristin B. Highland, Soon-Ho Kwon et al. · 2011 · PubMed

BACKGROUND: Sarcoidosis associated pulmonary hypertension (SAPH) is associated with significant morbidity and mortality. There is a paucity of information concerning therapy for this condition. METHODS: We performed a prospective,…

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Negative / Null Result ReportOpen accessComputer Science

External alternatives, job stress on job satisfaction and employee turnover intention

Ramlawati Ramlawati, Eva Trisnawati, Nurfatwa Andriani Yasin et al. · 2020 · Management Science Letters

The purpose of this study was to determine the alternative external influence and job stress on employee satisfaction and to determine the effects of the alternative external influence, job satisfaction job stress on Turnover Intention on employees of PT Bank Mandiri Regional X South Sulawesi. Respondents in this study were 100 people. The analysis model used to determine the effect between variables was a structural model with the Partial Least Square (PLS) approach. The results show that external alternatives had a significant effect on job satisfaction, stress had no significant effect on j

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Negative / Null Result ReportOpen accessMedicine

Partial Aortic Occlusion for Cerebral Perfusion Augmentation

Ashfaq Shuaib, Natan M. Bornstein, Hans‐Christoph Diener et al. · 2011 · Stroke

BACKGROUND AND PURPOSE: Fewer than 5% of patients with acute ischemic stroke are currently treated, and there is need for additional treatment options. A novel catheter treatment (NeuroFlo) that increases cerebral blood flow was tested to…

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Negative / Null Result ReportOpen accessNeuroscience

Transcorneal Electrical Stimulation for Patients With Retinitis Pigmentosa: A Prospective, Randomized, Sham-Controlled Follow-up Study Over 1 Year

Andreas Schatz, Johanna Pach, Mariya Gosheva et al. · 2017 · Investigative Ophthalmology & Visual Science

Purpose: After promising results of an exploratory study, this study was designed to assess the safety and efficacy of transcorneal electrical stimulation (TES) over 1 year in patients with retinitis pigmentosa (RP). Methods: We included 52 RP patients in this prospective, randomized, partially-masked study which was done in accordance with rules of good clinical practice. Transcorneal electrical stimulation by Okustim was applied monocularly for 30 minutes per week for 52 consecutive weeks. Patients were assigned randomly to the groups: sham, 150%, or 200% of individual electrical phosphene t

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Negative / Null Result ReportHealth Professions

The effects of pain neuroscience education and exercise on pain, muscle endurance, catastrophizing and anxiety in adolescents with chronic idiopathic neck pain: a school-based pilot, randomized and controlled study

Rosa Andias, Maritza Neto, Anabela G. Silva · 2018 · Physiotherapy Theory and Practice

PURPOSE: To compare the effectiveness of pain neuroscience education (PNE) and neck/shoulder exercises with no intervention in adolescents with chronic idiopathic neck pain (CINP). METHODS: Forty-three adolescents with CINP were randomly…

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Negative / Null Result ReportOpen accessPsychology

LGBQ-affirmative cognitive-behavioral therapy for young gay and bisexual men’s mental and sexual health: A three-arm randomized controlled trial.

John E. Pachankis, Audrey Harkness, Kaitlin R. Maciejewski et al. · 2022 · Journal of Consulting and Clinical Psychology

OBJECTIVE: Effective Skills to Empower Effective Men (ESTEEM) represents the first intervention to address the psychological pathways through which minority stress undermines young sexual minority men's (SMM's) mental and sexual health…

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Negative / Null Result ReportOpen accessImmunology and Microbiology

Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease

Danny Bruce, Heather E. Stefanski, Benjamin G. Vincent et al. · 2017 · Journal of Clinical Investigation

Acute graft-versus-host disease (aGVHD) is the most common complication for patients undergoing allogeneic stem cell transplantation. Despite extremely aggressive therapy targeting donor T cells, patients with grade III or greater aGVHD of…

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Negative / Null Result ReportOpen accessNursing

Benefits of Bifidobacterium breve M-16V Supplementation in Preterm Neonates - A Retrospective Cohort Study

Sanjay Patole, Shripada Rao, Anthony D. Keil et al. · 2016 · PLoS ONE

BACKGROUND: Systematic reviews of randomised controlled trials report that probiotics reduce the risk of necrotising enterocolitis (NEC) in preterm neonates. AIM: To determine whether routine probiotic supplementation (RPS) to preterm neonates would reduce the incidence of NEC. METHODS: The incidence of NEC ≥ Stage II and all-cause mortality was compared for an equal period of 24 months 'before' (Epoch 1) and 'after' (Epoch 2) RPS with Bifidobacterium breve M-16V in neonates <34 weeks. Multivariate logistic regression analysis was conducted to adjust for relevant confounders. RESULTS: A total

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Negative / Null Result ReportOpen accessMedicine

Low rates of antibiotic resistance and infectious mortality in a cohort of high-risk hematology patients: A single center, retrospective analysis of blood stream infection

Jason R. Conn, Elizabeth Catchpoole, Naomi Runnegar et al. · 2017 · PLoS ONE

Febrile neutropenia (FN) is a medical emergency and can represent a life-threatening complication for hematology patients treated with intensive chemotherapy regimens. In clinical practice, the diagnostic yield of blood cultures and other investigations which aim to identify a causative organism or site of infection is low. We have retrospectively examined all blood cultures collected in a "real world" cohort of patients receiving chemotherapy for acute leukemia and patients with aggressive lymphoma treated with Hyper-CVAD/MTX-cytarabine, at a single tertiary center over a five-year period. In

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Current Account ‘Core–Periphery Dualism’ in the EMU

Roberta De Santis, Tatiana Cesaroni · 2016 · World Economy

Abstract Current account ( CA ) dispersion within European Union ( EU ) Member States has been increasing progressively since the 1990s. Interestingly, the persistent deficits in many peripheral countries have not been accompanied by a…

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Negative / Null Result ReportOpen accessSocial Sciences

Foreign Aid and Government Legitimacy

Simone Dietrich, Matthew S. Winters · 2015 · Journal of Experimental Political Science

Abstract Branding of foreign aid may undermine government legitimacy in developing countries when citizens see social services being provided by external actors. We run a survey experiment on a sample of Indian respondents. All subjects…

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Negative / Null Result ReportOpen accessSocial Sciences

The effect of digital marketing and e-commerce on financial performance and business sustaina-bility of MSMEs during COVID-19 pandemic in Indonesia

Mas Intan Purba, Demak Claudia Yosephine Simanjutak, Yois Nelsari Malau et al. · 2021 · International Journal of Data and Network Science

The purpose of this study is to analyze the effects of digital marketing (DM), e-commerce (EC), business sustainability (BS) and financial performance (FP) of Micro, Small and Medium Enterprises (MSMEs) during Pandemic Covid19 in Indonesia. The relationships between digital marketing and business sustainability, e-commerce and business sustainability, digital marketing and financial performance, e-commerce and financial performance, financial performance and business sustainability are investigated. This research is quantitative research with a questionnaire approach. Data processing tools use

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Negative / Null Result ReportOpen accessMedicine

Evidence of advanced stage colorectal cancer with longer diagnostic intervals: a pooled analysis of seven primary care cohorts comprising 11 720 patients in five countries

Marie Louise Tørring, Peter Murchie, William Hamilton et al. · 2017 · British Journal of Cancer

BACKGROUND: The benefits from expedited diagnosis of symptomatic cancer are uncertain. We aimed to analyse the relationship between stage of colorectal cancer (CRC) and the primary and specialist care components of the diagnostic interval.…

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Negative / Null Result ReportOpen accessSocial Sciences

From the Lab to the Field: Cooperation among Fishermen

Jan Stoop, Charles Noussair, Daan van Soest · 2012 · Journal of Political Economy

We conduct a field experiment to measure cooperation among groups of recreational fishermen at a privately owned fishing facility. Group earnings are greater when group members catch fewer fish. Consistent with classical economic theory,…

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Negative / Null Result ReportOpen accessMedicine

Phase III Trial Adding Vincristine-Topotecan-Cyclophosphamide to the Initial Treatment of Patients With Nonmetastatic Ewing Sarcoma: A Children's Oncology Group Report

Patrick J. Leavey, Nadia N. Laack, Mark D. Krailo et al. · 2021 · Journal of Clinical Oncology

PURPOSE The primary aim of this phase III randomized trial was to test whether the addition of vincristine, topotecan, and cyclophosphamide (VTC) to interval compressed chemotherapy improved survival outcomes for patients with previously…

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