Negative / Null Result ReportOpen accessMedicine
Aderibigbe AS · 2026 · Poultry science
Despite increasing attention to broiler welfare, there is still limited information comparing physiological stress responses between fast-growing (FG) and slow-growing (SG) genotypes under evolving production conditions. Investigating this…
View details →Replication FailureMedicine
Bao J, Uchiyama T, Kusunoki K et al. · 2026 · Life (Basel, Switzerland)
N -hydroxypipecolic acid (NHP) is a key mobile signal in systemic acquired resistance in plants, and its glycosylation has been proposed to regulate immune signaling. Previous studies have demonstrated that the UDP-glycosyltransferase…
View details →Failed Experiment ReportMedicine
Mathis S, Putzer G, Schnegg L et al. · 2026 · BMC anesthesiology
Background Intraoperative blood salvage (IBS) reduces exposure to allogeneic blood but is accompanied by concerns in oncologic surgery regarding the potential reinfusion of residual tumor cells and subsequent metastatic dissemination. The…
View details →Methods Dead-EndOpen accessMedicine
Aaby D, Sullivan JE, Carmona C et al. · 2026 · Archives of rehabilitation research and clinical translation
Objectives To quantify the Minimum Detectable Change (MDC) and the Minimal Clinically Important Difference (MCID) of the Box and Blocks Test (BBT) and Upper Extremity Fugl-Meyer Assessment (FMA-UE), and to determine whether there is a BBT…
View details →Abandoned Hypothesis
Qiu N, Allenmark F, Chen S et al. · 2026 · Preprint
Real-world distractors occur in environments whose states change at different rates. We asked whether such volatility alters early attentional gating or instead changes the criterion for committing to a response. Observers performed an…
View details →Replication FailureMedicine
Mansell J, Wang X, Jering KS et al. · 2026 · European journal of heart failure
Sex differences in transthyretin cardiac amyloidosis (ATTR-CM) are increasingly recognised; however, women are underrepresented in trials and sex-specific treatment effects remain incompletely understood. We evaluated sex differences in…
View details →Replication FailureOpen accessMedicine
Zhou Y, Zhong Z, Mo H et al. · 2026 · Research and practice in thrombosis and haemostasis
Background Platelet transfusion refractoriness (PTR) is a clinical challenge that can be classified into nonimmunologic and immunologic types, the latter resulting from both platelet alloimmunization and autoimmunity. Recent studies have…
View details →Replication FailureOpen accessMedicine
O'Connor LM, Singh A, Luallen RJ et al. · 2026 · microPublication biology
Vertically transmitted endosymbionts are microbes that live inside host cells and are transmitted between parent and offspring. Free-living nematodes interact with a wide variety of microbes but no vertically transmitted microbes have been…
View details →Negative / Null Result ReportOpen accessMedicine
Popiolek I, Hydzik P, Ciszowski K et al. · 2026 · Journal of clinical medicine
Background/Objectives: Alcohol-related liver disease (ALD) lacks widely adopted biomarkers that reflect disease activity and severity. High-mobility group box 1 (HMGB1), a damage-associated molecular pattern, has been implicated in ALD…
View details →Null DatasetMedicine
King DA, Altic N · 2026 · Health physics
Calculating scan minimum detectable concentration (MDC) values using the method in NUREG-1507 can be difficult, often requiring expert knowledge and expensive software. Because of this, many projects rely on example MDC values from…
View details →Negative / Null Result ReportOpen accessMedicine
Awadallah M, Singh A, Hale GL et al. · 2026 · Case reports in transplantation
Hepatitis E virus (HEV) infection is an increasingly recognized cause of acute and chronic hepatitis in immunosuppressed individuals, including solid organ transplant recipients. Although typically self-limited in immunocompetent hosts,…
View details →Negative / Null Result ReportMedicine
Yoon HJ, Kim GC, Nam SH · 2026 · Pathogens (Basel, Switzerland)
Background Oral candidiasis is an opportunistic infection caused by Candida albicans (C. albicans) , highlighting the need to evaluate candidate substances that ensure both antifungal efficacy and mucosal safety. This study aimed to assess…
View details →Negative / Null Result ReportMedicine
Carretero D, Giménez E, Pérez A et al. · 2026 · Enfermedades infecciosas y microbiologia clinica (English ed.)
Introduction Studies assessing SARS-CoV-2 antibodies and functional T-cell responses in hematological patients following receipt of a three-dose mRNA vaccine schedule have yielded conflicting results. Methods We conducted a retrospective…
View details →Negative / Null Result ReportMedicine
Chmielewska B, Marzec M, Szarejko I et al. · 2026 · Plant Science.
Root hairs, tubular extensions of the rhizodermal cells, facilitate nutrient uptake, yet their role in water acquisition remains debated and may be species- and soil-specific. To elucidate the genetic basis of root hair development and…
View details →Replication FailureMedicine
Friedman O, Maiershon D, Paniri Y et al. · 2026 · Plastic and reconstructive surgery
Background Hematoma remains a major complication following breast surgery. While tranexamic acid (TXA) efficacy is established in reduction mammaplasty, its utility across other breast procedures remains unclear. Methods This retrospective…
View details →Methods Dead-EndMedicine
Varol U, Kobylarz MD, López-Redondo M et al. · 2026 · Journal of clinical medicine
Background/Objectives : Shear wave elastography (SWE) may provide an objective method for quantifying piriformis muscle stiffness, but its clinical and research use requires evidence that the measurement procedure is reliable. This study…
View details →Failed Experiment ReportOpen accessMedicine
Mishra A, Abelman RO, Cunneely Q et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America
Antibody-drug conjugates (ADCs) target surface proteins on cancer cells, leading to internalization and delivery of a drug payload, thereby enhancing selectivity and minimizing toxicity. ADCs against TROP2 (Sacituzumab govitecan) or HER2…
View details →Negative / Null Result ReportMedicine
Lee HL, Choi SM, Cho SH et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives: Head trauma (HT) has been suggested as a risk factor for Parkinson's disease (PD), but its impact on the motor and non-motor manifestations remains unclear. We investigated whether patients with early PD and a…
View details →Negative / Null Result Report
Tripathy S, Crilley N, Morgan TK et al. · 2026 · Preprint
ABSTRACT Preterm birth before 28 weeks remains a leading cause of neonatal mortality and long-term morbidity. Intrauterine infection-driven chorioamnionitis is strongly associated with preterm labor, fetal inflammatory response syndrome,…
View details →Failed Experiment ReportMedicine
Rogachev VV, Goltyaev MV, Varlamova EG et al. · 2026 · Biochemical and biophysical research communications
This study presents a comparative evaluation of the behavioral and systemic effects of small (10 nm) and large (100 nm) tellurium nanoparticles (TeNPs) obtained by laser ablation in a chronic in vivo experiment on male BALB/c mice. TeNPs…
View details →Negative / Null Result ReportMedicine
Anand M, Kashyap R, Bhat P et al. · 2026 · BMC sports science, medicine & rehabilitation
Background Prolonged sedentary work is associated with hamstring tightness, reduced flexibility, and functional limitations among information technology (IT) professionals. Comparative evidence for static stretching and myofascial release…
View details →Negative / Null Result ReportOpen accessMedicine
Willems R, Cappelletti M, Schüre JR et al. · 2026 · Scientific reports
Messenger ribonucleic acid (mRNA)-based vaccines delivered via lipid nanoparticles (LNP) were pivotal in managing the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic. While mild systemic reactions are common after…
View details →Negative / Null Result Report
Khwanbua E, Lappe RR, Bierl AA et al. · 2026 · Preprint
Plant virus-based gRNA delivery systems offer a rapid alternative to stable transformation for CRISPR-mediated genome editing, but potyvirus-based platforms in Cas9-expressing plants are still underexplored. Here, we developed a turnip…
View details →Failed Experiment ReportMedicine
Wang Y, Chen Y, Wang K et al. · 2026 · Vaccines
Background/Objectives: Canine papillomavirus (CPV) is an important viral pathogen associated with papillomatosis in dogs, with canine papillomavirus type 1 (CPV1) and type 2 (CPV2) among the most prevalent and clinically relevant…
View details →Negative / Null Result ReportMedicine
Zaryczańska A, Sokołowska-Wojdyło M, Wilkowska A et al. · 2026 · Contact dermatitis
Background Chronic exposure to topical corticosteroids (TCS) in patients with atopic dermatitis (AD) may increase the risk of allergic contact dermatitis (ACD), which can mimic flares of the underlying disease and remain underrecognized.…
View details →Negative / Null Result ReportMedicine
Baneman E, Jacobs SE, Rana M et al. · 2026 · Clinical lymphoma, myeloma & leukemia
Background Cytomegalovirus (CMV) is an opportunistic pathogen that causes infection in certain immunocompromised hosts, but the risk of clinically significant CMV infection in patients with multiple myeloma (MM) is not well understood.…
View details →Negative / Null Result ReportMedicine
Srivastava A, Maienschein-Cline M, Pabalan A et al. · 2026 · Methods (San Diego, Calif.)
MicroRNAs (miRNAs) are promising biomarkers and therapeutic targets; however, reliable extracellular miRNA quantification by RT-qPCR depends on appropriate normalization, and no universal endogenous reference has been established. This…
View details →Negative / Null Result ReportOpen accessMedicine
Chen C, Qualls WA, Xue RD et al. · 2026 · Journal of economic entomology
The sterile insect technique (SIT) is increasingly used as an alternative or supplemental tool in the integrated mosquito management toolbox to protect human health worldwide. SIT programs targeting mosquitoes such as Aedes aegypti (L.)…
View details →Methods Dead-EndMedicine
Binda AC, Padula RS, Vianna de Andrade FPP et al. · 2026 · Journal of bodywork and movement therapies
Objectives The Reaching Performance Scale for Stroke (RPSS) is a clinically relevant tool to assess movement quality and compensatory strategies during reach-to-grasp tasks to a Close and Far targets. This study aimed to investigate the…
View details →Failed Experiment ReportMedicine
Gower JSE, Webster R, Westaway JAF et al. · 2026 · The Journal of infectious diseases
Background The zoonotic parasite Plasmodium knowlesi is an increasing cause of human malaria in Southeast Asia. We aimed to develop a P. knowlesi induced blood-stage malaria (IBSM) model to facilitate study of parasite biology, host…
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