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Browse the failure-mode index

21,742 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Replication FailureMedicine

UGT76B1 and 41 Additional Arabidopsis UDP-Glycosyltransferases Show No Detectable In Vitro Glycosylation Activity Toward <i>N</i>-Hydroxypipecolic Acid.

Bao J, Uchiyama T, Kusunoki K et al. · 2026 · Life (Basel, Switzerland)

N -hydroxypipecolic acid (NHP) is a key mobile signal in systemic acquired resistance in plants, and its glycosylation has been proposed to regulate immune signaling. Previous studies have demonstrated that the UDP-glycosyltransferase…

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Failed Experiment ReportMedicine

Evaluation of leukocyte depletion filters for the removal of EpCAM-positive tumor cells during oncologic intraoperative blood salvage using CATUVAB<sup>®</sup>: an exploratory feasibility study.

Mathis S, Putzer G, Schnegg L et al. · 2026 · BMC anesthesiology

Background Intraoperative blood salvage (IBS) reduces exposure to allogeneic blood but is accompanied by concerns in oncologic surgery regarding the potential reinfusion of residual tumor cells and subsequent metastatic dissemination. The…

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Methods Dead-EndOpen accessMedicine

Minimum Detectable Change and Minimal Clinically Important Difference for the Box and Block Test and Fugl-Meyer Assessment in Moderate to Severe Chronic Stroke.

Aaby D, Sullivan JE, Carmona C et al. · 2026 · Archives of rehabilitation research and clinical translation

Objectives To quantify the Minimum Detectable Change (MDC) and the Minimal Clinically Important Difference (MCID) of the Box and Blocks Test (BBT) and Upper Extremity Fugl-Meyer Assessment (FMA-UE), and to determine whether there is a BBT…

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Replication FailureOpen accessMedicine

Platelet desialylation, apoptosis, and T-lymphocyte-mediated immune dysregulation: unveiling the pathways of platelet clearance in platelet transfusion refractoriness.

Zhou Y, Zhong Z, Mo H et al. · 2026 · Research and practice in thrombosis and haemostasis

Background Platelet transfusion refractoriness (PTR) is a clinical challenge that can be classified into nonimmunologic and immunologic types, the latter resulting from both platelet alloimmunization and autoimmunity. Recent studies have…

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Replication FailureOpen accessMedicine

Searching for vertically transmitted endosymbionts in over 4,000 wild strains of three self-fertilizing <i>Caenorhabditis</i> species.

O'Connor LM, Singh A, Luallen RJ et al. · 2026 · microPublication biology

Vertically transmitted endosymbionts are microbes that live inside host cells and are transmitted between parent and offspring. Free-living nematodes interact with a wide variety of microbes but no vertically transmitted microbes have been…

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Negative / Null Result ReportOpen accessMedicine

Serum HMGB1 and Alcohol-Related Liver Disease.

Popiolek I, Hydzik P, Ciszowski K et al. · 2026 · Journal of clinical medicine

Background/Objectives: Alcohol-related liver disease (ALD) lacks widely adopted biomarkers that reflect disease activity and severity. High-mobility group box 1 (HMGB1), a damage-associated molecular pattern, has been implicated in ALD…

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Negative / Null Result ReportMedicine

In Vitro Evaluation of the Antifungal Activity and Cytotoxicity of <i>Sambucus williamsii</i> var. <i>coreana</i> Extract Against <i>Candida albicans</i> and HaCaT Cells.

Yoon HJ, Kim GC, Nam SH · 2026 · Pathogens (Basel, Switzerland)

Background Oral candidiasis is an opportunistic infection caused by Candida albicans (C. albicans) , highlighting the need to evaluate candidate substances that ensure both antifungal efficacy and mucosal safety. This study aimed to assess…

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Negative / Null Result ReportMedicine

SARS-CoV-2 spike-directed T cells and anti-receptor-binding-domain antibodies in hematological patients receiving three mRNA COVID-19 vaccine doses.

Carretero D, Giménez E, Pérez A et al. · 2026 · Enfermedades infecciosas y microbiologia clinica (English ed.)

Introduction Studies assessing SARS-CoV-2 antibodies and functional T-cell responses in hematological patients following receipt of a three-dose mRNA vaccine schedule have yielded conflicting results. Methods We conducted a retrospective…

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Methods Dead-EndMedicine

Reproducibility of a Shear Wave Elastography Procedure for Assessing the Piriformis Muscle Stiffness in a Sample of Healthy Young Adults Under Controlled Laboratory Conditions: An Intra- and Inter-Examiner Reliability Study.

Varol U, Kobylarz MD, López-Redondo M et al. · 2026 · Journal of clinical medicine

Background/Objectives : Shear wave elastography (SWE) may provide an objective method for quantifying piriformis muscle stiffness, but its clinical and research use requires evidence that the measurement procedure is reliable. This study…

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Failed Experiment ReportOpen accessMedicine

Dynamic monitoring of antibody drug conjugates targeting TROP2 or HER2 in breast cancer using circulating tumor cells.

Mishra A, Abelman RO, Cunneely Q et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America

Antibody-drug conjugates (ADCs) target surface proteins on cancer cells, leading to internalization and delivery of a drug payload, thereby enhancing selectivity and minimizing toxicity. ADCs against TROP2 (Sacituzumab govitecan) or HER2…

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Failed Experiment ReportMedicine

Comparative assessment of behavioral and systemic effects of small (10 nm) and large (100 nm) tellurium nanoparticles in a chronic mouse model.

Rogachev VV, Goltyaev MV, Varlamova EG et al. · 2026 · Biochemical and biophysical research communications

This study presents a comparative evaluation of the behavioral and systemic effects of small (10 nm) and large (100 nm) tellurium nanoparticles (TeNPs) obtained by laser ablation in a chronic in vivo experiment on male BALB/c mice. TeNPs…

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Negative / Null Result ReportMedicine

Short-term effects of static stretching versus myofascial release on hamstring tightness and lower extremity function in sedentary IT professionals: a randomized controlled trial.

Anand M, Kashyap R, Bhat P et al. · 2026 · BMC sports science, medicine & rehabilitation

Background Prolonged sedentary work is associated with hamstring tightness, reduced flexibility, and functional limitations among information technology (IT) professionals. Comparative evidence for static stretching and myofascial release…

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Negative / Null Result ReportOpen accessMedicine

Does mRNA-based COVID-19 vaccination in the subacute phase lead to microstructural brain changes? A prospective pilot MRI study using T1 relaxometry.

Willems R, Cappelletti M, Schüre JR et al. · 2026 · Scientific reports

Messenger ribonucleic acid (mRNA)-based vaccines delivered via lipid nanoparticles (LNP) were pivotal in managing the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic. While mild systemic reactions are common after…

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Negative / Null Result ReportOpen accessMedicine

X-rays and gamma rays do not differ in their effectiveness for sterilizing pupae and adults of the mosquito Aedes aegypti (Diptera: Culicidae).

Chen C, Qualls WA, Xue RD et al. · 2026 · Journal of economic entomology

The sterile insect technique (SIT) is increasingly used as an alternative or supplemental tool in the integrated mosquito management toolbox to protect human health worldwide. SIT programs targeting mosquitoes such as Aedes aegypti (L.)…

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Methods Dead-EndMedicine

Measurement error, minimal detectable change, and responsiveness of the Brazilian-Portuguese Reaching Performance Scale for Stroke under usual care conditions.

Binda AC, Padula RS, Vianna de Andrade FPP et al. · 2026 · Journal of bodywork and movement therapies

Objectives The Reaching Performance Scale for Stroke (RPSS) is a clinically relevant tool to assess movement quality and compensatory strategies during reach-to-grasp tasks to a Close and Far targets. This study aimed to investigate the…

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