Negative / Null Result ReportMedicine
Stephan K, Stephens AN, Scully M et al. · 2024 · Accident; analysis and prevention
Background Globally, road traffic crashes are the leading cause of death for young adults. The P Drivers Project was a trial of a behavioural change program developed for, and targeted at, young Australian drivers in their initial months…
View details →Replication FailureOpen accessMedicine
Burgoyne K, Hargreaves S, Akhter N et al. · 2025 · JCPP advances
Background Parents play a key role in their child's early development but evidence that parental engagement strategies are effective is unclear. The current study evaluated a parent-delivered early language teaching programme that aimed to…
View details →Negative / Null Result ReportOpen accessMedicine
Hertler C, Lohmann J, Koulidiati J et al. · 2022 · European journal of public health
Abstract Background In 2020, about one in four women in Burkina Faso faced an unmet need for family planning (FP). Between 2013 and 2017, Burkina Faso implemented a performance-based financing (PBF) program to improve primary health care…
View details →Negative / Null Result ReportOpen accessMedicine
Howey C, McFetridge A, Luczak A · 2025 · International journal of molecular sciences
Epilepsy affects 50 to 70 million people worldwide and is characterized by recurring seizures that accelerate neurodegeneration; however, its mechanisms are still not well understood. It was proposed that epileptogenesis may be "hijacking"…
View details →Negative / Null Result ReportMedicine
Tadenev ALD, Hatton CL, Burgess RW · 2024 · Journal of the peripheral nervous system : JPNS
Background Inhibition of HDAC6 has been proposed as a broadly applicable therapeutic strategy for Charcot-Marie-Tooth disease (CMT). Inhibition of HDAC6 increases the acetylation of proteins important in axonal trafficking, such as…
View details →Negative / Null Result ReportOpen accessMedicine
· 2022 · Journal of the Endocrine Society
Abstract Metformin, a lipophilic biguanide inhibiting hepatic gluconeogenesis and improving peripheral utilization of glucose, is a well-established medication for the management of type 2 diabetes. Furthermore, metformin has been shown to…
View details →Negative / Null Result ReportMedicine
Leslie E, Gonzalez Bosc LV, Specht J et al. · 2024 · Medicine and science in sports and exercise
Purpose Chronic, high-altitude hypoxic exposure increases the risk of high-altitude pulmonary hypertension (PH). Emerging evidence shows maternal exercise may improve offspring resistance to disease throughout life. The purpose of this…
View details →Negative / Null Result ReportOpen accessMedicine
Contrada M, Pignolo L, Vatrano M et al. · 2024 · Brain sciences
Purpose Cognitive dysfunctions are still very common in the chronic phase of stroke when patients are discharged from neurorehabilitation centers. Even individuals who appear to have made a full clinical recovery may exhibit new…
View details →Negative / Null Result ReportOpen accessMedicine
Nieto-Felipe J, Macias-Diaz A, Alvarado S et al. · 2025 · Scientific reports
Store-operated Ca²⁺ entry (SOCE) is a major pathway for Ca²⁺ entry that regulates several cellular functions. SOCE remodeling mediated by changes in the expression and/or function of the Orai channels results in the reorganization of…
View details →Negative / Null Result ReportOpen accessMedicine
Bulgarella M, Reason A, Baty JW et al. · 2025 · Insects
Double-stranded RNA (dsRNA) biopesticides offer the potential for highly targeted pest control with minimal off-target impacts. Varroa mites ( Varroa destructor ) are an important pest of honey bees ( Apis mellifera ) that are primarily…
View details →Negative / Null Result ReportMedicine
Gunn D, Yeldho C, Hoad C et al. · 2024 · Neurogastroenterology and motility
Background Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti-diarrheal actions of ondansetron. Methods A…
View details →ProtocolOpen accessMedicine
Münzel T, Seidenstücker KC, Protzel C et al. · 2026 · ChemistryOpen
Selective inhibition of the transcription factor STAT5b is challenging owing to the high degree of similarity to the family member STAT5a. We recently reported catechol bisphosphates as selective inhibitors of STAT5b, with Stafib-2-CR as…
View details →Negative / Null Result ReportOpen accessMedicine
Mattar D, Cheewasopit W, Samir M et al. · 2023 · Reproduction & fertility
Kisspeptin, a hypothalamic neuropeptide encoded by the KISS1 gene, has a pivotal role in promoting GnRH secretion in mammals. Kisspeptin and its receptor (KISS1R) are also expressed in certain peripheral tissues including gonads,…
View details →Negative / Null Result ReportOpen accessMedicine
Ivanov YV, Ivanova AI, Kartashov AV et al. · 2026 · Biology
Manganese (Mn) is a crucial micronutrient for plants. The impaired function of the oxygen-evolving complex in Photosystem II (PSII) due to Mn deficiency is believed to result in the overproduction of reactive oxygen species and the…
View details →Negative / Null Result ReportOpen accessMedicine
Fondevila G, Fatmi H, Fernando P et al. · 2025 · Insects
The effects of Lys and Ile supplementation in a barley-based substrate on growth performance and nutrient deposition in Tenebrio molitor larvae were evaluated. Six trays per treatment containing sixty larvae were assigned to five…
View details →Negative / Null Result ReportMedicine
Boss M, Pels F, Kleinert J · 2023 · PsyCh journal
The purpose of this study was to analyze whether the social compensation of performance drops in a team setting depends on the relationship quality. Two experiments were conducted. Experiment 1: In a team-building condition, the…
View details →Negative / Null Result Report
Rivest D, Martin-Guay M · 2023 · Preprint
Well-designed temperate tree-based intercropping (TBI) systems can enhance soil nutrient cycling compared to conventional agricultural systems. To improve the TBI designs and their subsequent wide-scale adoption, greater understanding is…
View details →Negative / Null Result ReportOpen accessMedicine
Başeğmez M, Eryavuz A, Demirel HH · 2025 · Journal of biochemical and molecular toxicology
This study aims to determine the effect of orally administered vitamin C (Vit C) supplementation on physiological and histopathological changes in aged rats of different genders. A total of 28 Sprague-Dawley aged male and female rats were…
View details →Negative / Null Result Report
Ehinger BV, Bonasch H · 2023 · Preprint
Abstract 1 Some participants consistently show large, and others small activations in Electroencephalography (EEG) and other neuroimaging studies. Similarly, decoding accuracies in Brain-Computer-Interface (BCI) vary between subjects, in…
View details →Negative / Null Result ReportOpen accessMedicine
Scott MB, Kammermeier PJ · 2024 · Pharmaceuticals (Basel, Switzerland)
The gabapentenoids such as gabapentin (GP) and pregabalin are approved for the treatment of chronic pain, but their utility is limited by persistent side effects. These adverse effects result from GPs affecting many types of neurons and…
View details →Negative / Null Result ReportOpen accessMedicine
Choneva M, Delchev S, Hrischev P et al. · 2024 · International journal of molecular sciences
Diabetic cardiomyopathy is a major etiological factor in heart failure in diabetic patients, characterized by mitochondrial oxidative metabolism dysfunction, myocardial fibrosis, and marked glycogen elevation. The aim of the present study…
View details →Negative / Null Result ReportMedicine
Ebrahimi F, Kangari H, Akbarzadeh-Bagheban A et al. · 2025 · International journal of ophthalmology
Aim To evaluate the effects of polarized and non-polarized sunglasses on visual functions, including distance and near visual acuity, phoria, stereopsis and contrast sensitivity across five spatial frequencies (1.5, 3, 6, 12, 18…
View details →Negative / Null Result ReportOpen accessMedicine
Zeng X, Chen Y, Lin S et al. · 2026 · Frontiers in surgery
Purpose This study aimed to investigate the influence of previous percutaneous renal procedures on the outcome of ultrasound (US)-guided percutaneous nephrolithotomy (PCNL) in patients with upper urinary tract stones. Patients and methods…
View details →Negative / Null Result Report
Lartey NL, Nyarko ENY, Asare-Anane H et al. · 2023 · Preprint
ABSTRACT Background and aim The lack of standardization and scientific validation of the use of most plant extracts leads to toxicity problems. The stem bark extract of Annickia polycarpa has been shown to possess antioxidant,…
View details →Negative / Null Result ReportOpen accessMedicine
Kazmi S, Sanford E, Rammaha ZA et al. · 2025 · International journal of molecular sciences
Oral squamous cell carcinoma (OSCC) is marked by profound differences in survival between the localized and disseminated disease, estimated to result in a 70% and less than a 40% five-year survival rate with surgical and/or radiation…
View details →Negative / Null Result ReportMedicine
Dicker D, Tamir O, Lieberman-Segal G et al. · 2023 · The Israel Medical Association journal : IMAJ
Background In 2019, 1 mg subcutaneous semaglutide was registered for the treatment of diabetes in Israel. Recognition of its effect on weight has led to its use as a treatment for obesity. Objectives To explore physicians' pre-therapy…
View details →Negative / Null Result ReportOpen accessMedicine
Rolig AS, Ziglari T, McGee GH et al. · 2026 · Scientific reports
The tumor microenvironment (TME), which heavily influences immune checkpoint blockade (ICB) efficacy, is shaped by host-microbe interactions. Endogenous intratumoral bacteria have been implicated in efficacy of ICB, such as anti-PD-1…
View details →Negative / Null Result ReportOpen accessMedicine
Hauber MM, Nordahl O, Todisco V et al. · 2026 · PloS one
Many coregonine species have declined drastically across the Northern Hemisphere, including populations of Coregonus maraena (whitefish) in the Baltic Sea, and the mechanisms leading to these declines are not well investigated. An abrupt…
View details →Negative / Null Result ReportOpen accessMedicine
Marquis-Gravel G, Tong G, Dodd M et al. · 2025 · Journal of the Society for Cardiovascular Angiography & Interventions
Background Coronary artery bypass grafting (CABG) improves survival compared with optimal medical therapy (OMT) alone in patients with ischemic left ventricular systolic dysfunction (iLVSD), but percutaneous coronary intervention (PCI) did…
View details →Negative / Null Result ReportOpen accessMedicine
Shahid N, Kim CH, Jabilona KB et al. · 2026 · PloS one
Tyrosine kinase inhibitors (TKI) are often used in combination with other chemotherapeutic nucleoside/nucleobase analogues, such as gemcitabine and 6-mercaptopurine, in the treatment of various cancers. Past studies have shown that several…
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