Lack of effect from genetic deletion of Hdac6 in a humanized mouse model of CMT2D.
Tadenev ALD; Hatton CL; Burgess RW · 2024 · Journal of the peripheral nervous system : JPNS
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background Inhibition of HDAC6 has been proposed as a broadly applicable therapeutic strategy for Charcot-Marie-Tooth disease (CMT). Inhibition of HDAC6 increases the acetylation of proteins important in axonal trafficking, such as…
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Metadata source: Europe PMC · DOI 10.1111/jns.12623