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21,742 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessVeterinary medicine

Evaluation of primary wound healing and potential complications after perioperative infiltration with lidocaine without adrenaline in surgical incisions in dogs and cats

Erica Anna Gumpert Herlofson, Francesca Tavola, Karolina Siri Engdahl et al. · 2023 · Acta Veterinaria Scandinavica

Abstract Background Pre-emptive local analgesia with the use of lidocaine is practised increasingly in veterinary medicine as part of applied multimodal analgesia, despite its controversial impact on wound healing. The purpose of this prospective, randomised, double-blinded, placebo-controlled clinical study was to evaluate if preoperative subcutaneous infiltration of lidocaine has a negative impact on primary wound healing of surgical incisions. Fifty-two companion animals (3 cats and 49 dogs) were enrolled in the study. The inclusion criteria were as follows: American Society of Anaesthesiol

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Negative / Null Result ReportOpen accessAgriculture

Assessment of beet leaf yellowing virus tolerance based on leaf yellowing in sugar beet

Yosuke Kuroda, Kazuyuki Okazaki, Kenji Takashino et al. · 2025 · Agrosystems, Geosciences & Environment

Abstract Sugar beet (Beta vulgaris) production in Japan faces major challenges from virus yellows (VY), caused by beet leaf yellowing virus (BLYV) and transmitted by aphids. Outbreaks have reduced sugar yields, and breeding for tolerant varieties has not been conducted in Japan. This study marks the first step toward developing VY‐tolerant varieties by testing three hypotheses: (1) leaf yellowing can be induced by artificial inoculation, (2) tolerance varies among breeding materials, and (3) differences in tolerance to yellowing disease can be evaluated. From 2017 to 2020, four sugar beet mate

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Negative / Null Result ReportOpen accessTherapeutics. Pharmacology

Population Pharmacokinetics and Exposure–Response Analysis of Serplulimab in Small Cell Lung Cancer Patients

Kun Wang, Yuanyuan Shen, Chen Hu et al. · 2025 · Clinical and Translational Science

ABSTRACT While PD‐L1 antibodies have demonstrated efficacy in small cell lung cancer, the therapeutic benefits remain limited. To address this unmet medical need, serplulimab was developed as an innovative monoclonal antibody targeting PD‐1. This study evaluated the pharmacokinetic (PK) properties of serplulimab and their relationship with efficacy and safety in patients with extensive‐stage small cell lung cancer (ES‐SCLC), using population pharmacokinetics (PopPK) and exposure–response (E–R) analysis to inform dose selection. Data from 1144 patients across eight Phase I–III clinical trials s

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Negative / Null Result ReportOpen accessScience (General)

Clinical significance of serum lactate and lactate dehydrogenase levels for disease severity and clinical outcomes in patients with colorectal cancer admitted to the intensive care unit

Xin Wang, Chen Li, Ming Li et al. · 2024 · Heliyon

Objective: Serum lactate (LA) and lactate dehydrogenase (LDH) levels have a major impact on the clinical treatment of malignant tumors and critically ill patients. Nevertheless, the assessment of disease severity in oncology patients admitted to the intensive care unit (ICU) remains incomplete when considering the serum LA and LDH levels. This study aimed to investigate the significance of serum LDH and LA levels in assessing disease severity and predicting clinical outcomes in patients with colorectal cancer (CRC) admitted to the ICU. Methods: This retrospective study included patients with C

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Negative / Null Result ReportOpen accessMedicine

LIPID PROFILES IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA ON L-ASPARAGINASE THERAPY

Janan G. Hasan · 2010 · The Medical Journal of Basrah University

ABSTRACT Background: Abnormal blood lipid profiles have been associated with many malignant diseases especially in children with acute lymphoblastic leukemia on L-asparaginase therapy Objective: To investigate the frequency and clinical significance of altered lipid profiles in children with Acute lymphoblastic leukemia (ALL) on L-asparaginase therapy Patients and Methods: A prospective study was carried out between February 2008 till January 2009 on a total of 50 patients with recently diagnosed and non-treated acute lymphoblastic leukemia who were admitted to pediatric oncology unit at Basra

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Negative / Null Result ReportOpen accessBiology (General)

Increased Circulating H3 Histone in Response to Repeated Bouts of Exercise Does Not Associate with Parallel Alterations of Cell-Free DNA

Robert Stawski, Konrad Walczak, Ewelina Perdas et al. · 2021 · Biology

Numerous studies have shown that cf nDNA significantly rises in stress caused by exercise. However, during nuclear decondensation, released DNA is followed by histones. Histones are also a common disease marker. After PAD4 mediated hypercitrullination extracellular H3Cit exhibits high toxicity contributing to tissue damage which, in cases of systemic inflammation, may lead to multiorgan failure and finally to death. We tested whether circulating histones rise in response to strenuous exercise. Eleven average-trained men performed three treadmill exercise tests to exhaustion at speed correspond

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Negative / Null Result ReportOpen accessPsychiatry

C-reactive protein levels and cognitive functions in patients with bipolar disorder

O. Elleuch, M. Maalej, W. Guidara et al. · 2023 · European Psychiatry

Introduction The pathophysiology of bipolar disorder (BD) is complex and remains uncertain to this day. Several hypotheses have been suggested, including the involvement of inflammatory mechanisms in its pathogenesis and in eventual cognitive impairment. C-reactive protein (CRP) is one of the most commonly used inflammatory markers. High-sensitivity CRP (hs- CRP) is a more sensitive marker. Objectives We aimed to examine hs-CRP levels in patients with BD, and to investigate its relationship with cognitive functions. Methods We conducted a cross-sectional study between June 2016 and July 2018 o

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Negative / Null Result ReportOpen accessMedicine

GSDM gene polymorphisms regulate the IgE level in asthmatic patients.

Amer Imraish, Tuqa Abu-Thiab, Tareq Alhindi et al. · 2022 · PLoS ONE

Background Gasdermin A (GSDMA) and gasdermin B (GSDMB) have been associated with childhood and adult asthma in many populations including the Jordanian population. It is also known that IgE plays a crucial role in various allergic disorders, such elevated levels of total serum IgE were detected in asthma and allergic rhinitis. IgE immunoglobulin is responsible for the release of numerous inflammatory mediators, such as histamine and prostaglandins, from mast cells in asthmatic patients. Objective In this study, single nucleotide polymorphisms of GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C

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Negative / Null Result ReportOpen accessGeophysics. Cosmic physics

Magnesian clay minerals and their influence on pores in the first member of Middle Permian Maokou Formation, southern Sichuan Basin

Liyu ZHANG, Donghua YOU, Rong LI et al. · 2025 · Shiyou shiyan dizhi

In recent years, multiple wells in the Sichuan Basin have produced industrial gas from the marlstone/marl-bearing limestone strata in the first member of the Middle Permian Maokou Formation (Mao 1), demonstrating promising exploration potential. Previous studies have suggested that the marlstone/marl-bearing limestone in Mao 1 exhibits self-generation and self-storage characteristics, forming low-porosity, low-permeability fracture-porosity type tight carbonate reservoirs with diverse storage spaces. Notably, diagenetic shrinkage pores and fractures formed during the transformation of sepiolit

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Negative / Null Result ReportOpen accessImmunologic diseases. Allergy

Comprehensive 18F-FDG PET-based radiomics in elevating the pathological response to neoadjuvant immunochemotherapy for resectable stage III non-small-cell lung cancer: A pilot study

Yingpu Cui, Yingpu Cui, Yaobin Lin et al. · 2022 · Frontiers in Immunology

PurposeTo develop a comprehensive PET radiomics model to predict the pathological response after neoadjuvant toripalimab with chemotherapy in resectable stage III non-small-cell lung cancer (NSCLC) patients.MethodsStage III NSCLC patients who received three cycles of neoadjuvant toripalimab with chemotherapy and underwent 18F-FDG PET/CT were enrolled. Baseline 18F-FDG PET/CT was performed before treatment, and preoperative 18F-FDG PET/CT was performed three weeks after the completion of neoadjuvant treatment. Surgical resection was performed 4–5 weeks after the completion of neoadjuvant treatm

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Negative / Null Result ReportOpen accessMedicine

Correlation Between Exercise Frequency and Menstrual Cycle Characteristics in Perimenopausal Women Aged 45–50 Years

Ni Luh Kadek Alit Arsani, Luh Ari Arini, Luh Yenny Armayanti et al. · 2026 · Althea Medical Journal

Background: During perimenopause, declining estrogen levels often lead to altered menstrual patterns and other age-related health concerns. Consequently, the role of physical activity warrants closer examination. This study investigated the correlation between exercise frequency and menstrual cycle characteristics in premenopausal women Methods: A cross-sectional observational study was conducted in Singaraja City, Indonesia, from July to October 2024. A total of 150 premenopausal women aged 45–50 years were recruited through random sampling. Exercise frequency was measured using the World Hea

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Negative / Null Result ReportOpen accessVeterinary medicine

The incidence and trends of proteinuria, azotemia and hypertension in cats receiving toceranib phosphate

Kimberly Williams, Valerie MacDonald-Dickinson, Arata Matsuyama · 2024 · Journal of Feline Medicine and Surgery

Objectives This retrospective study aimed to determine the incidence and trends of proteinuria, elevations in serum creatinine and urea, and systolic blood pressure in cats undergoing treatment with toceranib. Methods In total, 32 cats treated with toceranib for malignancies were analyzed. Cats were included if urinalysis and urine protein:creatinine ratio (UPC) measurements were available at 28 days (T1) and 56 days (T2) after starting the treatment. Cats with concurrent lower urinary tract disease, including urinary tract malignancy, were excluded. Friedman’s ANOVA compared variables between

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Negative / Null Result ReportOpen accessMedicine

Characteristics of atmospheric dustfall fluxes and particle size in an open pit coal mining area and surrounding areas

Yayuan Deng, Hongxuan Wu, Tingning Zhao et al. · 2025 · Scientific Reports

Abstract Atmospheric dustfall is solid air pollutant, which is mainly influenced by local sources, so it has a major impact on the local environment and the health of local residents. The objective of this study was to investigate the distribution characteristics of dustfall fluxes and particle size, and the meteorological factors affected them. Atmospheric dustfall was collected in an open-pit coal mining area and surrounding areas in the arid desert area of Northwest China from March to December 2018. Dustfall fluxes was measured, particle size was measured by using graphical methods and gra

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Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system

The role of suction drainage in the management of peri-operative bleeding in Total and Unicomcompartmental knee arthroplasty: a retrospective comparative study

Nicola Manta, Laura Mangiavini, Cristiana Balbino et al. · 2021 · BMC Musculoskeletal Disorders

Abstract Background Suction drainage is commonly applied after total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) to reduce hematoma, swelling and to favor surgical wound healing. However, its efficacy remains controversial; thus, the purpose of this study is to evaluate drainage efficiency in the management of postoperative bleeding in TKA and UKA. Methods The cohort comprised 134 clinical records of patients affected by knee osteoarthritis (OA) who underwent either TKA or UKA. All the patients were subdivided into 2 groups: the first one with drainage and the second o

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Negative / Null Result ReportOpen accessVeterinary medicine

Exploring the relationship between calcitonin, ionized calcium, and bone turnover in cats with and without naturally occurring hypercalcemia

Evangelia Maniaki, Carmen Pineda, Angie Hibbert et al. · 2024 · Frontiers in Veterinary Science

ObjectivesThis case-control study aimed to evaluate calcitonin response in naturally occurring hypercalcemia in cats and assess the relationships between calcitonin and ionized calcium (iCa) and examine relationships between calcitonin, iCa and bone turnover.MethodsHypercalcemic cats (persistently increased iCa concentration [>1.40 mmol/l]) were identified retrospectively via a medical database search; additional hypercalcemic and normocalcemic cats were recruited prospectively. Data regarding routine biochemical and urine testing, diagnostic imaging and additional blood testing were obtained.

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Negative / Null Result ReportOpen accessMedicine

Effect of baseline characteristics on mortality in the SURVIVE trial on the effect of levosimendan vs dobutamine in acute heart failure: Sub-analysis of the Finnish patients.

M. Kivikko, P. Pollesello, Tuukka Tarvasmäki et al. · 2016 · International Journal of Cardiology

BACKGROUND In the SURVIVE trial, including 1327 acute heart failure patients, no statistically significant difference between levosimendan and dobutamine in the 180-day all-cause mortality was seen. Country-specific differences in outcome…

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Negative / Null Result ReportOpen accessMedicine

Grading angiogenesis in oral squamous cell carcinoma: a histomorphometric study.

V. Wadhwan, Preeti Sharma, Chitrapriya Saxena et al. · 2015 · Indian Journal of Dental Research

CONTEXT Like normal tissues, tumors require an adequate supply of oxygen, metabolites and an effective way to remove waste products. This is achieved by angiogenesis, which is defined as the process by which new blood vessels are produced…

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Negative / Null Result ReportOpen access

Microscale Dynamics of Larval Fish Assemblages in the Straits of Malacca Nearshore Coincided with Lunar Phases

Ali Md. Yeakub, Fatimah Md. Yusoff, Natrah Fatin Mohd. Ikhsan et al. · 2023 · Pertanika Journal of Tropical Agricultural Science

Marine fish larvae are an integral part of the marine environment because their abundance can become an ecological indicator. The abundance is dependent on the environmental variations that include but are not limited to lunar phases and…

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Negative / Null Result ReportOpen accessMedicine

Successful weight loss maintenance in relation to method of weight loss

Angela Marinilli Pinto, A. A. Gorin, Hollie A Raynor et al. · 2008 · Obesity

This study examined the relation between method of weight loss and long‐term maintenance among successful weight losers enrolled in a weight‐loss maintenance trial. Participants were 186 adults (mean age = 51.6 ± 10.7 years, mean BMI =…

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Negative / Null Result ReportMedicine

Comparative Pathologic Analysis of Breast Cancers Classified as HER2/neu-Amplified by FISH Using a Standard HER2/CEP17 Dual Probe and an Alternative Chromosome 17 Control Probe

Somaye Y. Zare, Leo I. Lin, Abrar Alghamdi et al. · 2018 · American Journal of Surgical Pathology

At our institution, breast cancer cases that generate an equivocal HER2/neu (HER2) result by fluorescence in situ hybridization (FISH) using the dual HER2/chromosome enumeration probe (CEP17) are reflexed to an assay that utilizes an…

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Negative / Null Result ReportMedicine

Accuracy comparison of 3D printed tooth-supported implant surgical guides: A prospective observational clinical study.

A. Rezaei, Farnoush Fotovat, Ali Heidari et al. · 2026 · The Journal of prosthetic dentistry (Print)

STATEMENT OF PROBLEM Implant-supported prostheses provide a reliable method of replacing missing teeth. To avoid complications, their accurate placement is critical. Advances in static computer-aided implant surgery (sCAIS), which uses…

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Negative / Null Result ReportMedicine

Impact of Moderate‐Intensity Multicomponent Training on Cardiometabolic Health‐Related Outcomes in Older Adults With Overweight and Obesity: A 9‐Month Quasi‐Experimental Single‐Arm Pretest‐Posttest Study

Enzo Berbery, Vitor de Salles Painelli, Paulo Vitor Suto Aizava et al. · 2026 · Australasian Journal on Ageing

ABSTRACT Objective The aim of this study was to investigate the effects of a moderate‐intensity multicomponent training (MCT) program on body composition, physical function, glycaemic control and lipid profiles in overweight and obese…

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Negative / Null Result ReportOpen accessMedicine

Perbandingan Pemberian Informasi Verbal dengan Presentasi Video Terhadap Pengetahuan Prosedur Anestesi Umum pada Pasien yang Akan Menjalani Operasi di RSUP DR Hasan Sadikin Bandung

Yodi Suryo Arnanto, Ruli Herman Sitanggang, Nurita Dian Kestriani Saragi Sitio · 2018 · Jurnal Anestesi Perioperatif

Informasi mengenai indikasi, tujuan, prosedur, risiko, manfaat, dan alternatif tindakan anestesi yang akan dilakukan harus disampaikan kepada pasien. Pemberian informasi dilakukan secara verbal atau lisan pada saat proses persetujuan…

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