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Browse the failure-mode index

21,742 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The influence of the Hunga Tonga-Hunga Ha'apai water vapor on ozone content in the Antarctic and Arctic stratospheric polar vortex in the winter 2023 and 2023–2024

Lukyanov AN, Vargin PN, Yushkov VA · 2025 · Atmospheric research

The eruption of the underwater volcano Hunga Tonga – Hunga Ha'apai (20.54° S, 178.3° W) on January 15, 2022, resulted in the first significant increase in the stratospheric water vapor content in the entire satellite observation era. This…

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Negative / Null Result ReportMedicine

Motivation-informed digital reminders were no more effective than standard reminders for trial task completion in a randomized Study Within A Trial (SWAT).

Ackermann DM, Medcalf E, Bracken K et al. · 2026 · Journal of clinical epidemiology

Objectives Digital reminders are widely used in clinical trials, but their design is rarely evidence-based. We evaluated the effectiveness of two types of digital reminders for trial task completion. Study design and setting This…

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Negative / Null Result ReportMedicine

Breastfeeding-injury link: are concerns warranted?

Jones PAT, Brockwell E, Hassan A et al. · 2025 · British journal of sports medicine

Objective Recreational and elite athletes report avoiding breastfeeding when returning to physical activity following childbirth due to a perceived increased risk of injury; yet, there are no empirical data to support this relationship. We…

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Negative / Null Result ReportMedicine

Cytomegalovirus DNAemia in the lower respiratory tract in nontransplant patients with hematologic malignancies.

Sadowska-Klasa A, Bełdzińska-Gądek K, Klein-Awerjanow K et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Cytomegalovirus (CMV) pneumonia is a serious complication in immunocompromised patients, but its role in non-transplant populations remains unclear. Methods We analyzed CMV DNA in bronchoalveolar lavage (BAL) samples from 100…

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Negative / Null Result ReportMedicine

Fine-Scale Variation in Optimal Clutch Size in a Blue Tit Population.

Garrido-Bautista J, Ortega Z, Pérez-Jiménez A et al. · 2025 · Ecological and evolutionary physiology

AbstractClutch size variation may be adaptive in bird populations if parents lay a clutch size that maximizes offspring recruitment. Brood size manipulation experiments allow for testing the optimization of clutch size by studying the…

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Negative / Null Result ReportMedicine

Pictures are not always worth a thousand words: Non-probative pictures did not increase the effectiveness of misinformation corrections.

Whitehead PS, Davis CP, Park JS et al. · 2025 · Journal of applied research in memory and cognition

Much research has focused on the language used for debunking false beliefs: communications should lead with facts, label misinformation as false, and reinforce true information. Pictures are used in debunking messages, but it remains…

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Negative / Null Result ReportMedicine

Evaluating Text Messaging Approaches to Promote Enrollment in Smoking Cessation Treatment Among Latino Adults: A Pragmatic Randomized Clinical Trial.

Cartujano-Barrera F, Catley D, Chávez-Iñiguez A et al. · 2026 · Chest

Background Little is known about the use of text messages to promote enrollment in smoking cessation treatment. Research question What is the impact of the number of outreach messages and monetary incentives on enrollment in smoking…

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Negative / Null Result ReportMedicine

Clinical efficacy and safety of long-term treatment, discontinuation, and extended dosing intervals of denosumab treatment for solid cancer bone metastasis: A retrospective study.

Mihara A, Iwanaga R, Muramatsu K et al. · 2025 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Background Metastatic bone tumors in solid cancer often induce excessive local bone resorption leading to skeletal related events (SRE) which may impact patients' quality of life and survival of the primary cancer. Denosumab, a bone…

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Negative / Null Result ReportMedicine

Development and testing of implementation strategies to increase the use of midline catheters in a paediatric intensive care unit.

Weber MD, Frankenberger W, Ullman AJ et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background Paediatric critically ill patients are at risk of harm from central venous catheter overuse. We applied an implementation science approach to promote appropriate use of midline catheters. The aim of this study was to evaluate…

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Negative / Null Result ReportOpen accessMedicine

First report of bilateral Bronchial Rheoplasty for treating chronic bronchitis performed in a single procedure.

Jensen K, Secher EL, Libermann RH et al. · 2025 · European clinical respiratory journal

Introduction The RheOx system delivers brief, high-voltage electrical pulses to the airway lining, promoting the regeneration of healthy tissue and reducing mucus production in COPD patients with chronic bronchitis. The procedure, called…

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Negative / Null Result ReportOpen accessMedicine

Extensive intraoperative peritoneal lavage (EIPL) for gastric cancer with positive peritoneal lavage and/or stamp cytology: An exploratory phase II study.

Tsujio G, Yashiro M, Miki Y et al. · 2026 · PloS one

Background Our group revealed that the combination of intra-operative stamp cytology and peritoneal lavage cytology (CY) improved the identification of individuals with high risk of peritoneal metastasis. In this exploratory Phase II…

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Negative / Null Result ReportMedicine

A Phase 1, Open-Label, Single Ascending Dose Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of ES-481 After Oral Administration in Healthy Volunteers.

Niecestro R, Foster EC, Millist L et al. · 2026 · European journal of drug metabolism and pharmacokinetics

Background and objectives ES-481 is a potent and selective antagonist of the transmembrane alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) receptor regulatory protein (TARP)-y8-dependent AMPA receptor being developed for…

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Negative / Null Result ReportMedicine

Human chorionic gonadotropin inhibits locomotion but not food intake independently of the area postrema and the nucleus tractus solitarius in female mice.

Anan M, Kagawa K, Okamatsu-Ogura Y et al. · 2026 · Physiology & behavior

The nausea and vomiting of pregnancy (NVP) affect many pregnant women's quality of life, and the underlying mechanisms are still unclear. Human chorionic gonadotropin (hCG) is suspected to be a factor in exacerbating NVP due to its…

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