Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Yukako Murakami, Saki Matsui, Akiko Kijima et al. · 2011 · Allergology International
We report a case of 7-year-old monozygotic twin patients with atopic dermatitis. The HLA haplotypes were HLA A2, A11, B27, B61, DR1, and DR4. Both serum IgE levels and cedar pollen radioallergosorbent test (RAST) scores were high in the twins (elder/younger sister: IgE: 5170/3980 IU/ml and Japansese cedar pollen: >100/64.0) in contrast to low mite and food RAST scores (Dermatophagoides Pterygonium; 0.59/0.4 and egg white 9.24/4.6). The patients showed positive immediate (20 min in both sisters) and delayed (24 hours in elder sister, 24, 48, 72 hours in younger sister) reactions to a scratch te
View details →Negative / Null Result ReportOpen accessMedicine (General)
Mercedes Navarro, Gonzalo Hijos, Carlos Sostres et al. · 2020 · Frontiers in Medicine
Introduction: The fecal immunochemical test (FIT) has been established as a cost-effective test in colon cancer screening programmes. This test could also be helpful in symptomatic patients prior to colonoscopy, but data about diagnostic performance, and accurate cut-off values for these patients are still scarce.Materials and Methods: Prospective study that included consecutive unselected patients with gastrointestinal symptoms referred for colonoscopy between November 2016 and June 2018. We performed a FIT (FOB Gold® test, cut-off 20 micrograms of Hb/gram of feces) prior to colonoscopy and d
View details →Negative / Null Result ReportOpen accessAnimal biochemistry
Zi-Hai Wei, Shu-Lin Liang, Feng-Fei Gu et al. · 2025 · Animal Nutriomics
One hundred and thirteen mid-lactation cows fed same diets and supplemented with 20 g/d rumen-protected methionine (RPM) for 8 weeks were used to investigate the individual responses of dairy cows to RPM in terms of lactation performance, amino acids (AA) metabolism, and milk metabolites. Among the cows, 10 cows exhibited positive responses (PR) and 10 cows showed limited responses (LR) in energy-corrected milk yield to RPM were used for further analysis. The lactation performance changed from gradual decline to steady increase in PR cows, while kept downward trend in LR cows following RPM sup
View details →Negative / Null Result ReportOpen accessPediatrics
Judy Ibrahim, Mohammad Alashqar, Shamma Al Zaabi et al. · 2021 · Case Reports in Pediatrics
Immune thrombocytopenia (ITP) is a disorder characterized by immune-mediated destruction of thrombocytes leading to peripheral blood platelet count of <100 × 10^9/L. Primary ITP is a terminology used in the absence of other causes or disorders that may be associated with thrombocytopenia, i.e., isolated thrombocytopenia. The term secondary ITP is used if such diseases coexist. We present here a case of a 14-year-old female diagnosed with immune thrombocytopenia. When her evaluation was not strongly supportive of primary ITP, she was screened and proved to have a concomitant Hashimoto thyroidit
View details →Negative / Null Result ReportOpen accessPhysiology
Ryan M. Corrick, Huiyin Tu, Dongze Zhang et al. · 2018 · Frontiers in Physiology
Extremity injuries with hemorrhage have been a significant cause of death in civilian medicine and on the battlefield. The use of a tourniquet as an intervention is necessary for treatment to an injured limb; however, the tourniquet and subsequent release results in serious acute ischemia-reperfusion (IR) injury in the skeletal muscle and neuromuscular junction (NMJ). Much evidence demonstrates that inflammation is an important factor to cause acute IR injury. To find effective therapeutic interventions for tourniquet-induced acute IR injuries, our current study investigated effect of dexameth
View details →Negative / Null Result ReportOpen accessMedicine
Kyung-Hee Cho, Seol-Hee Baek, Sung-Hee Kim et al. · 2024 · The Journal of Headache and Pain
Abstract Background Currently, there is a relative lack of detailed reports regarding clinical presentation and outcome of idiopathic intracranial hypertension in Asians. This study aims to describe the clinical features and treatment outcomes of Korean patients with idiopathic intracranial hypertension. Methods We prospectively recruited patients with idiopathic intracranial hypertension from one hospital and retrospectively analyzed the medical records of 11 hospitals in Korea. We collected data regarding preceding medical conditions or suspected medication exposure, headache phenotypes, oth
View details →Negative / Null Result ReportOpen accessPsychology
Liana eAmunts, Amit eYashar, Dominique eLamy · 2014 · Frontiers in Psychology
Visual search is considerably speeded when the target’s characteristics remain constant across successive selections. Here, we investigated whether such inter-trial priming increases the target’s attentional priority, by examining whether target repetition reduces search efficiency during serial search. As the study of inter-trial priming requires the target and distractors to exchange roles unpredictably, it has mostly been confined to singleton searches, which typically yield efficient search. We therefore resorted to two singleton searches known to yield relatively inefficient performance,
View details →Negative / Null Result ReportOpen accessMedicine
Irfan Afzal, Shakeel Imran, Talha Javed et al. · 2022 · PLoS ONE
Temperature is a key factor influencing plant growth and productivity, but its sudden rise can cause severe consequences on crop performances. Early sowing and application of growth promoting agents as a foliar spray can be a sustainable approach to cope with high temperature stress at grain filling stage of cereal crops. Therefore, a test was designed to explore the potential of different growth helping agents including sorghum water extract (SWE, 10 ml L-1), moringa leaf extract (MLE, 3%), hydrogen peroxide (H2O2, 2 μM), salicylic acid (SA, 50 mg L-1) and ascorbic acid (ASA, 50 mg L-1) as fo
View details →Negative / Null Result ReportOpen accessAnimal culture
Elisa Köhler Osmari, Ulysses Cecato, Francisco de Assis Fonseca de Macedo et al. · 2009 · Revista Brasileira de Zootecnia
Avaliaram-se os efeitos do fornecimento de volumosos suplementares sobre o consumo, a produção e a composição físico-química do leite de cabras F1 (Boer Saanen). Utilizaram-se 18 cabras distribuídas em três baias, recebendo como suplemento, à vontade, silagem de sorgo, silagem de milho ou feno de amoreira com controle diário do consumo de matéria seca. A média diária para produção semanal foi calculada reunindo-se dados leiteiros em três períodos pós-parto: 1 (34 a 40 dias/7 dias); 2 [(64 a 70 dias/7 dias) + (91 a 97 dias)/7 dias)]/2; e 3 (125 a 131 dias/7 dias) e a média pontual diária do per
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Masatake Kobayashi, Susan Stienen, Jozine M. terMaaten et al. · 2020 · ESC Heart Failure
Abstract Aims Activation of the renin–angiotensin–aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis. There are limited data on the associations of renin and aldosterone levels with clinical profiles, treatment response, and study outcomes in patients with HF. Methods and results We analysed 2,039 patients with available baseline renin and aldosterone levels in BIOSTAT‐CHF (a systems BIOlogy study to Tailored Treatment in Chronic Heart Failure). The primary outcome was the composite of all‐cause mortality or HF ho
View details →Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics
Maheswari S Mukherjee, Amber D Donnelly, Elizabeth R Lyden et al. · 2015 · Journal of Pathology Informatics
Background: Interest in developing more feasible and affordable applications of virtual microscopy in the field of cytology continues to grow. Aims: The aim of this study was to investigate the scanning parameters for the thyroid fine needle aspiration (FNA) cytology specimens. Subjects and Methods: A total of twelve glass slides from thyroid FNA cytology specimens were digitized at ×40 with 1 micron (μ) interval using seven focal plane (FP) levels (Group 1), five FP levels (Group 2), and three FP levels (Group 3) using iScan Coreo Au scanner (Ventana, AZ, USA) producing 36 virtual images (VI)
View details →Negative / Null Result ReportBusiness
Wuhu Yao, D. Gao, Pengfei Sheng · 2018 · Applied Economics Letters
ABSTRACT With respects to the low level of the healthcare expenditure, China has been experiencing a rapid growth of the education. This article is designed to test the education quantity and the education quality on the healthcare…
View details →Negative / Null Result ReportOpen accessAnimal culture
D.W. Liu, J.J. Zang, L. Liu et al. · 2014 · Czech Journal of Animal Science
Three experiments were conducted to compare raw corn, extruded corn, and dehulled-extruded corn in piglets' feeding. In Experiment (Exp.) 1, 8 barrows (19.9 ± 0.6 kg) were fed experimental diets containing one out of three corn samples and a rice-soybean meal basal diet in a double 4 × 4 Latin square design to determine the digestible energy (DE) and metabolizable energy (ME) in the corn samples using the difference method. The DE content in extruded (14.29 MJ/kg) and dehulled-extruded (14.42 MJ/kg) corn was greater (P < 0.05) than in raw corn (13.57 MJ/kg). In Exp. 2, 5 barrows (26.2 ± 1.3 kg
View details →Negative / Null Result ReportOpen accessAgriculture
Karin I. Köhl, Gedif Mulugeta Aneley, Manuela Haas et al. · 2021 · Agronomy
Potato is an important food crop with high water-use-efficiency but low drought tolerance. The bottleneck in drought tolerance breeding is phenotyping in managed field environments. Fundamental research on drought tolerance is predominantly done in container-based test systems in controlled environments. However, the portability of results from these systems to performance under field conditions is debated. Thus, we analyzed the effects of climate conditions, container size, starting material, and substrate on yield and drought tolerance assessment of potato genotypes compared to field trials.
View details →Negative / Null Result ReportOpen accessMedicine
Sonia Rekik, Hela Sahli, Khaoula Zouaoui et al. · 2022 · F1000Research
Background: Digital gangrene is a rare but serious complication of systemic lupus erythematosus (SLE). It occurs usually in middle-aged patients with longer disease duration. Case: Herein we report the case of a 56-year-old man (with no history suggestive of Raynaud’s phenomenon, diabetes mellitus, smoking, trauma, infection, or chemical exposure), who presented with SLE and digital gangrene was among the first signs. He presented with a one-month history of joint pain, hair loss, photosensitivity, mouth ulcers, malar rash, dyspnea, and digital pain. Physical examination revealed painful and d
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
M. Oksman, H. Iivonen, E. Hogyes et al. · 2006 · Neurobiology of Disease
The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3–4 months beginning at a young adult age (6 months). Hippocampal Aβ levels were determined with ELISA and plaque load by using immunocytochemistry. A typical Western diet with 40% saturated fatty acids and 1% of cholesterol increased, while diets supplemented with docosahexaenoic acid (DHA) decreased Aβ levels comp
View details →Negative / Null Result ReportOpen accessMedicine
Edward C. Y. Liew, Maureen Phelan, Keith L. McDougall · 2023 · Scientific Reports
Abstract Phytophthora cinnamomi is an oomycete found in the soil and capable of invading the roots of a wide range of host plants globally, potentially killing them and affecting the ecosystems they inhabit. This pathogen is often inadvertently dispersed in natural vegetation on the footwear of humans. A range of equipment is often provided or recommended to be carried for cleaning footwear in places where P. cinnamomi poses a threat to biodiversity. These are typically a brush for mechanically removing soil and/or a disinfectant for killing the pathogen. Despite their widespread use, to our k
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Talia Golan, Ravit Geva, Donald Richards et al. · 2018 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background Cachexia is a formidable clinical challenge in pancreatic cancer. We assessed LY2495655 (antimyostatin antibody) plus standard‐of‐care chemotherapy in pancreatic cancer using cachexia status as a stratifier. Methods In this randomized, phase 2 trial, patients with stage II–IV pancreatic cancer were randomized to 300 mg LY2495655, 100 mg LY2495655, or placebo, plus physician‐choice chemotherapy from a prespecified list of standard‐of‐care regimens for first and later lines of care. Investigational treatment was continued during second‐line treatment. The primary endpoint was
View details →Negative / Null Result ReportMedicine
Kute, Fujino, Centauri et al. · 2026 · Experimental and therapeutic medicine
Ultra-low anterior resection (ULAR) and total mesorectal excision (TME) are sphincter-preserving treatments for low rectal cancer. However, these techniques face challenges in patients with a narrow pelvis, particularly those with a high…
View details →Negative / Null Result ReportOpen accessMedicine
Cassandra M Wilkinson, Brittany A Fedor, Jasmine R Aziz et al. · 2019 · PLoS ONE
After intracerebral hemorrhage (ICH), brain edema commonly occurs and can cause death. Along with edema, there are significant alterations in the concentrations of key ions such as sodium, potassium, and chloride, which are essential to brain function. NKCC1, a cation-chloride cotransporter, is upregulated after brain damage, such as traumatic injury and ischemic stroke. NKCC1 brings sodium and chloride into the cell, possibly worsening ion dyshomeostasis. Bumetanide, a specific NKCC1 antagonist, blocks the transport of chloride into cells, and thus should attenuate the increases in chloride,
View details →Negative / Null Result ReportOpen accessPsychiatry
Nadine Farnes, Nadine Farnes, Henrik B. Jacobsen et al. · 2024 · Frontiers in Psychiatry
IntroductionDeep rTMS is an increasingly popular noninvasive brain stimulation technique which has shown promise for treating cognitive impairments. However, few studies have investigated the cognitive effects it could exert in patients with chronic peripheral neuropathic pain. Therefore, we aimed to assess the effects of deep rTMS on executive functioning in patients with peripheral neuropathic pain, in a randomized, double-blind crossover trial.MethodsIn total, 17 patients were randomly assigned to receive both active and sham deep H-coil rTMS targeting the primary motor cortex. Each treatme
View details →Negative / Null Result ReportOpen accessAnimal culture
Israel Lerma-Reyes, German D. Mendoza-Martínez, Rolado Rojo-Rubio et al. · 2018 · Asian-Australasian Journal of Animal Sciences
Objective This experiment was designed to evaluate the effect of supplementation with soybean or canola oil on milk production and the composition of long chain fatty acids as well as weight changes in the goats and their kids. Methods Thirty nine mulitparous crossed Alpine×Nubian goats (initial body weight [BW] 43.5±1.7 kg) from the day of parturition were assigned to the treatments: grazing control (n = 15); grazing plus 20 mL/goat/d of supplemental soybean oil (n = 12); and grazing plus 20 mL/goat/d of supplemental canola oil (n = 12) from November 26, 2014 to March 7, 2015. The planned con
View details →Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Yan Meng, Ming-xue Zhou, Chun-bo Wu et al. · 2023 · BMC Nephrology
Abstract Aim To determine whether continuous venovenous hemodiafiltration (CVVHDF) plus standard medical therapy (SMT) vs. SMT alone prevents rhabdomyolysis (RM)-induced acute kidney injury (AKI) and analyze the related health economics. Methods This retrospective cohort study involved 9 RM patients without AKI, coronary heart disease, or chronic kidney disease treated with CVVHDF plus SMT (CVVHDF + SMT group). Nine matched RM patients without AKI treated with SMT only served as controls (SMT group). Baseline characteristics, biochemical indexes, renal survival data, and health economic data w
View details →Negative / Null Result ReportOpen accessAnimal culture
P.P. Porto, E.O.S. Saliba, L.C. Gonçalves et al. · 2006 · Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Ensilaram-se três genótipos de girassol (M734, Rumbosol 91 e variedade V2000), enriquecidos no material original com: 0,5% de uréia (U); 0,5% de carbonato de cálcio (CC); 0,5% de uréia mais 0,5% de carbonato de cálcio (U+CC); inoculante bacteriano comercial (IB) comercial e sem aditivo que serviu como silagem testemunha (T). Foram utilizados silos de laboratório de PVC, abertos com 1, 3, 5, 7, 14, 28 e 56 dias de ensilados, sendo determinados fibra em detergente neutro (FDN), fibra em detergente ácido (FDA), lignina e digestibilidade in vitro da matéria seca (DIVMS). As silagens de Rumbosol 91
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
E. Lubinga, A.A. Maes, C.J.M. Jansen · 2016 · SAHARA-J
Most existent research on the effects of interpersonal discussions about health campaign messages is based on surveys. In this study, we analysed actual conversations about an HIV/AIDS poster to find out possible effects. Young South African women in 59 dyads (n = 118) participated in conversations about a deliberately puzzling HIV and AIDS poster that cautioned the target group to be faithful to one sexual partner. We measured their comprehension of the poster and beliefs about the message, before and after the conversations. Overall, actual comprehension (AC) was low, and we observed a large
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Maja Ivanovski, Miha Mrak, Anja Zupan Mežnar et al. · 2022 · Journal of Cardiovascular Development and Disease
Conduction system pacing (CSP) modalities, including His-bundle pacing (HBP) and left bundle branch pacing (LBBP), are increasingly used as alternatives to biventricular (BiV) pacing in heart failure (HF) patients scheduled for pace and ablate strategy. The aim of the study was to compare clinical outcomes of HF patients with refractory AF who received either BiV pacing or CSP in conjunction with atrio-ventricular node ablation (AVNA). Fifty consecutive patients (male 48%, age 70 years (IQR 9), left ventricular ejection fraction (LVEF) 39% (IQR 12)) were retrospectively analysed. Thirteen pati
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Shyamal Patel, Lucy Rose Howroyd, Helen Bucknall et al. · 2025 · CVIR Endovascular
Abstract Background Bronchial artery embolisation (BAE) is considered the most effective non-surgical technique for management of moderate-massive haemoptysis. Associated risks include neurological compromise such as stroke and spinal cord ischaemia. We aim to evaluate post-procedural outcomes and complication rates. Materials and methods A single-centre retrospective observational study was conducted for BAE cases performed between January 2002-June 2022 in a London teaching hospital. Data was collected from electronic medical records and Picture Archiving Communications System (PACS). Primar
View details →Negative / Null Result ReportOpen accessEnvironmental technology. Sanitary engineering
Igor Esau, Mikhail Tolstykh, Rostislav Fadeev et al. · 2018 · Environmental Research Letters
Systematic errors in forecast near-surface air temperature (SAT) still constitute a considerable problem for numerical weather prediction (NWP) at high latitudes. Numerous studies in the past have attempted to reduce this problem through recalibration of physical parameterization schemes and better approximation of the surface energy budget. The errors, however, remain despite notable improvements in the overall weather forecast performance. This study looks at the problem from a different perspective. It analyzes asymmetries in the SAT forecast errors. The study reveals a statistical pattern
View details →Replication FailureOpen accessMedicine
Hassan Rezvanian, Ali Kachuei, Ali Mirzapour · 2011 · مجله دانشکده پزشکی اصفهان
Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy. Methods: In this clinical trial study, after ethics committee approval, 65 Patients with type II diabetes mellitus were enrolled into a randomized simple sampling, prospective, double-blinded study. In the case group, was gave Milk thistle and control group was given placebo. We measured urine albumin/cratinine (A/C) ratio and eGFR before and after intervention. The gathered data were
View details →Replication FailureOpen accessDiseases of the endocrine glands. Clinical endocrinology
Quoc Huy Hoang, Hung Sy Ho, Huong Thuy Do et al. · 2021 · Reproductive Medicine and Biology
Abstract Purpose This study compared the therapeutic effects of transdermal testosterone gel (TTG) application at 4 and 6 weeks before controlled ovarian hyperstimulation (COH) in women with poor ovarian response (POR). Methods In this randomized control trial, infertile women with POR who underwent in vitro fertilization (IVF) were recruited and randomly classified into 4 week (n = 42) and 6 week (n = 38) TTG treatment groups and control group (n = 42). The primary outcome was total number of retrieved mature oocytes. The secondary outcomes were the biochemical pregnancy rate, clinical pregna
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