LY2495655, an antimyostatin antibody, in pancreatic cancer: a randomized, phase 2 trial
Talia Golan; Ravit Geva; Donald Richards; Srinivasan Madhusudan; Boris Kin Lin; Haofei Tiffany Wang; Richard A. Walgren; Salomon M. Stemmer · 2018 · Journal of Cachexia, Sarcopenia and Muscle
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Cachexia is a formidable clinical challenge in pancreatic cancer. We assessed LY2495655 (antimyostatin antibody) plus standard‐of‐care chemotherapy in pancreatic cancer using cachexia status as a stratifier. Methods In this randomized, phase 2 trial, patients with stage II–IV pancreatic cancer were randomized to 300 mg LY2495655, 100 mg LY2495655, or placebo, plus physician‐choice chemotherapy from a prespecified list of standard‐of‐care regimens for first and later lines of care. Investigational treatment was continued during second‐line treatment. The primary endpoint was
Abstract by Talia Golan; Ravit Geva; Donald Richards; Srinivasan Madhusudan; Boris Kin Lin; Haofei Tiffany Wang; Richard A. Walgren; Salomon M. Stemmer, Journal of Cachexia, Sarcopenia and Muscle (2018) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1002/jcsm.12331