Dexamethasone Protects Against Tourniquet-Induced Acute Ischemia-Reperfusion Injury in Mouse Hindlimb
Ryan M. Corrick; Huiyin Tu; Dongze Zhang; Aaron N. Barksdale; Robert L. Muelleman; Michael C. Wadman; Yu-Long Li · 2018 · Frontiers in Physiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Extremity injuries with hemorrhage have been a significant cause of death in civilian medicine and on the battlefield. The use of a tourniquet as an intervention is necessary for treatment to an injured limb; however, the tourniquet and subsequent release results in serious acute ischemia-reperfusion (IR) injury in the skeletal muscle and neuromuscular junction (NMJ). Much evidence demonstrates that inflammation is an important factor to cause acute IR injury. To find effective therapeutic interventions for tourniquet-induced acute IR injuries, our current study investigated effect of dexameth
Abstract by Ryan M. Corrick; Huiyin Tu; Dongze Zhang; Aaron N. Barksdale; Robert L. Muelleman; Michael C. Wadman; Yu-Long Li, Frontiers in Physiology (2018) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fphys.2018.00244