The CCTG PA.7 phase II trial of gemcitabine and nab-paclitaxel with or without durvalumab and tremelimumab as initial therapy in metastatic pancreatic ductal adenocarcinoma
Daniel J. Renouf; Jonathan M. Loree; Jennifer J. Knox; James T. Topham; Petr Kavan; Derek J. Jonker; Stephen Welch; Félix Couture · 2022 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Immunotherapy-based monotherapy treatment in metastatic pancreatic ductal adenocarcinoma (mPDAC) has shown limited benefit outside of the mismatch repair deficiency setting, while safety and efficacy of combining dual-checkpoint inhibitor immunotherapy with chemotherapy remains uncertain. Here, we present results from the CCTG PA.7 study (NCT02879318), a randomized phase II trial comparing gemcitabine and nab-paclitaxel with and without immune checkpoint inhibitors durvalumab and tremelimumab in 180 patients with mPDAC. The primary endpoint was overall survival. Secondary endpoints included pr
Abstract by Daniel J. Renouf; Jonathan M. Loree; Jennifer J. Knox; James T. Topham; Petr Kavan; Derek J. Jonker; Stephen Welch; Félix Couture, Nature Communications (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-022-32591-8