21,300 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Stahl M, Zeidan AM · 2026 · Blood
Abstract Aside from allogeneic transplantation, the current standard-of-care approach for higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) remains monotherapy with a hypomethylating agent (HMA), including azacitidine, decitabine,…
View details →Matsushita H, Oba K, Kurono K et al. · 2026 · Shock (Augusta, Ga.)
Introduction In cardiogenic shock (CS), persistent microcirculatory impairment despite improved macrocirculatory parameters is associated with poor outcomes. Therapeutic strategies must therefore address both macro- and micro-circulation.…
View details →Florens N · 2026 · Nephrologie & therapeutique
Cardiovascular mortality among hemodialysis patients remains strikingly high—around 10% per year—despite substantial advances in dialysis technology and medical care. Historically, several strategies extrapolated from the general…
View details →Sekiguchi Y, Tsutsumi H, Kudo M et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy
84-year-old male was diagnosed with diffuse large B-cell lymphoma.He had Stage Ⅳ, performance status was 2, and 'high risk' according to the International Prognostic Index.He was started on Pola-R-mini-CHP.The day after completion of the 4…
View details →Al Hindawi MA, Omran NE, Mostafa MH et al. · 2026 · European journal of pharmacology
In metastatic melanoma with a BRAF V600 mutation, inhibitors of BRAF and MEK have improved survival. Resistance may be acquired through late genetic alterations that restore mitogen-activated protein kinase (MAPK) signaling. Resistance can…
View details →Chen H, Wang J, Fan C et al. · 2026 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Background and aim The benefit of combining linaclotide with polyethylene glycol (PEG) for improving bowel preparation quality and adenoma detection in patients at risk for inadequate bowel preparation remains uncertain. This study aimed…
View details →Xu K, Zhang R, Yuan Y et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Aims Gallbladder carcinoma (GBC) has a poor prognosis, with lymph node metastasis (LNM) being a key prognostic factor. Controversies remain regarding lymph node dissection (LND) utility and prognostic differences of direct (DGBC) vs.…
View details →Li A, Liu C, Xing R et al. · 2026 · Carbohydrate research
Phenol-sulfuric acid method, a classical approach for total sugar quantification, suffers from substantial variation in the colorimetric efficiency among different monosaccharides, which may result in significant measurement bias. In this…
View details →August D, Marsh N, Hall S et al. · 2026 · The Journal of perinatal & neonatal nursing
Purpose Implement and evaluate near-infrared (NIR) huddles for neonatal peripheral intravenous catheter (PIVC) insertion. Methods An implementation project investigated PIVC insertion attempts, site, inserter designation, dwell, and…
View details →Huang JQ, Xiao HM, Ma CX et al. · 2026 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
To compare survival outcomes and safety between concurrent chemoradiotherapy (CCRT) and CCRT with concurrent immune checkpoint inhibitor (ICI) in patients with locally advanced esophageal squamous cell carcinoma. This multicenter cohort…
View details →Moura RP, Mwema A, Bottemanne P et al. · 2026 · Journal of controlled release : official journal of the Controlled Release Society
Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting over 2.5 million people worldwide. Despite available therapies, no current treatment halts disease progression or specifically targets remyelination. Here, we…
View details →Wu F, Wu R, Chen L et al. · 2026 · New biotechnology
Enhancing enzyme thermostability is crucial for industrial applications requiring robust performance under extreme conditions. Structure-based protein design models excel at improving thermal stability but often compromise enzymatic…
View details →Liu X, Wang Y, Medina AA et al. · 2026 · Pharmacological research
Gut-liver axis disturbance is the unifying pathogenesis of cholestatic liver diseases. The purpose of this study was to explore the underlying mechanisms of the probiotic Lactobacillus amylovorus (LA) and its secreted extracellular…
View details →Sohal P, Gupta K, Kaushal S et al. · 2025 · Preprint
ABSTRACT Objective Acute isoniazid toxicity causes refractory seizures due to pyridoxine deficiency-mediated gamma-aminobutyric acid depletion. While pyridoxine is the established antidote, its limited availability in emergency settings…
View details →Huchthausen C, Shi M, Sousa GL et al. · 2025 · Preprint
Abstract Radiomics-based machine learning models have the potential to detect lung cancer at inception from CT scans and transform patient outcomes. Low malignancy rates in early-development pulmonary nodules (PNs) and variable image…
View details →Timimi S · 2025 · Child and adolescent mental health
Because definitions of mental disorder are inescapably subjective, they can be continuously expanded in response to commercial, guild and social interests and pressures. In this article, I argue that this has resulted in young people…
View details →Moncheaux A, Guimond A, Spiegelhalter C et al. · 2025 · Preprint
ABSTRACT Background Mutations in CAV3 , encoding caveolin-3, cause caveolinopathies, rare genetic disorders affecting both skeletal and cardiac muscle. Caveolin-3 contributes to T-tubule formation and excitation-contraction coupling. BIN1…
View details →Fujii T, Nogami Y, Seo T · 2026 · BMJ open
Objectives Cognitive behavioural therapy (CBT) is recommended as a first-line treatment for depression and anxiety disorders, but its utilisation under Japan's national health insurance remains poorly understood. This study aimed to…
View details →Ead AS, Wirkus J, Machuca J et al. · 2026 · The Journal of nutrition
Background Pancreatic ductal adenocarcinoma is a deadly cancer linked to obesity. Adipose tissue contributes to tumor progression by promoting inflammation and supplying lipids and cytokines that support cancer growth. Although omega-6…
View details →Mudupula Vemula SS, Adhikari S, Motkur S et al. · 2026 · Cureus
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ dysfunction, with high untreated mortality that can…
View details →Alpat SE, Kaya B, Nakkaş HG et al. · 2026 · Burns : journal of the International Society for Burn Injuries
Objective Despite notable advancements in burn care, morbidity and mortality remain high, with progressive tissue loss typically occurring in the first 48 h post-injury. While microneedling and topical retinyl palmitate are recognized for…
View details →A. Hietanen, K. Kajantie, M. Laine et al. · 2008 · arXiv
We update Monte Carlo simulations of the three-dimensional SU(3) + adjoint Higgs theory, by extrapolating carefully to the infinite volume and continuum limits, in order to estimate the contribution of the infrared modes to the pressure of hot QCD. The sum of infrared contributions beyond the known 4-loop order turns out to be a smooth function, of a reasonable magnitude and specific sign. Unfortunately, adding this function to the known 4-loop terms does not improve the match to four-dimensional lattice data, in spite of the fact that other quantities, such as correlation lengths, spatial str
View details →Yunxiao Zhang, Nan Huo, Liang Cui et al. · 2022 · arXiv
In classical coherence theory, coherence time is typically related to the bandwidth of the optical field. Narrowing the bandwidth will result in the lengthening of the coherence time. This will erase temporal distinguishability of photons due to time delay in pulsed photon interference. However, this is changed in an SU(1,1)-type quantum interferometer where quantum entanglement is involved. In this paper, we investigate how the temporal coherence of the fields in a pulse-pumped SU(1,1) interferometer changes with the bandwidth of optical filtering. We find that, because of the quantum entangl
View details →Lei Wang, Ee-Peng Lim · 2024 · arXiv
Large language models (LLMs) have shown excellent performance on various NLP tasks. To use LLMs as strong sequential recommenders, we explore the in-context learning approach to sequential recommendation. We investigate the effects of instruction format, task consistency, demonstration selection, and number of demonstrations. As increasing the number of demonstrations in ICL does not improve accuracy despite using a long prompt, we propose a novel method called LLMSRec-Syn that incorporates multiple demonstration users into one aggregated demonstration. Our experiments on three recommendation
View details →Maximilian Spliethöver, Jonas Klaff, Hendrik Heuer · 2019 · arXiv
Attention mechanisms have seen some success for natural language processing downstream tasks in recent years and generated new State-of-the-Art results. A thorough evaluation of the attention mechanism for the task of Argumentation Mining is missing, though. With this paper, we report a comparative evaluation of attention layers in combination with a bidirectional long short-term memory network, which is the current state-of-the-art approach to the unit segmentation task. We also compare sentence-level contextualized word embeddings to pre-generated ones. Our findings suggest that for this tas
View details →Yuval Kirstain, Patrick Lewis, Sebastian Riedel et al. · 2021 · arXiv
We investigate the dynamics of increasing the number of model parameters versus the number of labeled examples across a wide variety of tasks. Our exploration reveals that while scaling parameters consistently yields performance improvements, the contribution of additional examples highly depends on the task's format. Specifically, in open question answering tasks, enlarging the training set does not improve performance. In contrast, classification, extractive question answering, and multiple choice tasks benefit so much from additional examples that collecting a few hundred examples is often
View details →Nicolas Burq, Nicolas Camps, Mickaël Latocca et al. · 2024 · arXiv
We consider the Wick ordered cubic Schrödinger equation (NLS) posed on the two-dimensional sphere, with initial data distributed according to a Gaussian measure. We show that the second Picard iteration does not improve the regularity of the initial data in the scale of the classical Sobolev spaces. This is in sharp contrast with the Wick ordered NLS on the two-dimensional tori, a model for which we know from the work of Bourgain that the second Picard iteration gains one half derivative. Our proof relies on identifying a singular part of the nonlinearity. We show that this singular part is re
View details →Örs Legeza, Florian Gebhard, Jörg Rissler · 2005 · arXiv
For the one-dimensional Hubbard model subject to periodic boundary conditions we construct a unitary transformation between basis states so that open boundary conditions apply for the transformed Hamiltonian. Despite the fact that the one-particle and two-particle interaction matrices link nearest and next-nearest neighbors only, the performance of the density-matrix renormalization group method for the transformed Hamiltonian does not improve. Some of the new interactions act as independent quantum channels which generate the same level of entanglement as periodic boundary conditions in the o
View details →Pierre Boullier · 1996 · arXiv
In this paper we present a new parsing algorithm for linear indexed grammars (LIGs) in the same spirit as the one described in (Vijay-Shanker and Weir, 1993) for tree adjoining grammars. For a LIG $L$ and an input string $x$ of length $n$, we build a non ambiguous context-free grammar whose sentences are all (and exclusively) valid derivation sequences in $L$ which lead to $x$. We show that this grammar can be built in ${\cal O}(n^6)$ time and that individual parses can be extracted in linear time with the size of the extracted parse tree. Though this ${\cal O}(n^6)$ upper bound does not impro
View details →Ryoutaro Watanabe · 2017 · arXiv
We study possible new physics (NP) effects on $B_c \to J/ψτ\barν$, which has been recently measured at LHCb as the ratio of $R_{J/ψ} = \mathcal B(B_c \to J/ψτ\barν)/\mathcal B(B_c \to J/ψμ\barν)$. Combining it with the long-standing $R_{D^{(*)}}$ measurements, in which the discrepancy with the prediction of the standard model is present, we find possible solutions to the anomaly by several NP types. Then, we see that adding the $R_{J/ψ}$ measurement does not improve NP fit to data, but the NP scenarios still give better $χ^2$ than the SM. We also investigate indirect NP constraints from the li
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