Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
FU Hua, ZHOU Guochao, CAI Rongmin, SONG Xin, YANG Dinghua · 2025 · Zhongguo aizheng zazhi
Background and purpose: The resistance of pancreatic cancer to albumin-bound paclitaxel affects the therapeutic effect and prognosis. Signal transducer and activator of transcription 3 (STAT3) is one of the important molecules regulating the chemotherapy sensitivity of cancer cells. The liposome BP1003 targeting the antisense oligonucleotide of STAT3 mRNA can inhibit the expression of STAT3 and increase the chemotherapy sensitivity. However, the effect of BP1003 on the sensitivity of pancreatic cancer cells to albumin-bound paclitaxel remains unclear. The purpose of this study was to investiga
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Bo Yang, Zhi Biao Nan, Yan Zhong Li · 2025 · Frontiers in Veterinary Science
IntroductionStanding milkvetch (Astragalus adsurgens) is widely distributed in the wild in Eurasia and North America and has been bred for cultivated forage in China. Yellow stunt and root rot disease caused by Alternaria gansuense is the primary disease of standing milkvetch. A. gansuense promotes the production of swainsonine in the plant. This study aimed to determine the safety of standing milkvetch that is infected with A. gansuense as forage for animals.MethodsTwo-week-old specific pathogen-free (SPF) male white mice were fed a commercial mouse feed (CMF), healthy plant feed (HPF) and di
View details →Negative / Null Result ReportOpen accessMedicine
Ning Li, Jincai Huang, Yanghe Feng · 2020 · PLoS ONE
Background Cognitive ability refers to the ability to receive, process, store, and extract information. It is the most important psychological condition for people to successfully complete activities. Previous studies have shown that the design of the human-computer interface of the command and control system cannot exceed the cognitive ability of the operator of the command and control system, and it must match the cognitive ability of the operator in order to reduce the mental load intensity, and improve the accuracy, timeliness and work efficiency. However, previous researchers in the field
View details →Negative / Null Result ReportOpen accessSports
Atefe Eftekhari, Jalal Dehghanizade · 2022 · رشد و یادگیری حرکتی ورزشی
The aim of this study was to investigate the effect of self-movement on distance perception. The method of the present study is quasi-experimental. The statistical population of the present study was the students of Urmia University who were randomly selected as a sample of 60 students who were eligible to participate in the study and were randomly divided into three groups of 20 people including static group, dynamic group with treadmill speed 4 Km/h and the dynamic group were divided at a speed of 8 km/h. The test of walking blindfolded in a straight line to a previously observed target was
View details →Negative / Null Result ReportOpen accessMedicine
Zhongwei Yu, Chenhui Zhao, Anqing Yang et al. · 2025 · Scientific Reports
Abstract To investigate the correlation between serum sex hormone levels and clear cell renal cell carcinoma(ccRCC). The clinical data of male patients diagnosed with ccRCC and with simple renal cysts in our hospital from 2017 to 2023 were collected. The basic clinical data and serum sex hormone levels, including luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol(E2), prolactin (PRL), progesterone(P), and testosterone (T), were compared between patients with ccRCC and patients with simple renal cysts. A total of 56 male patients with ccRCC and 82 male patients with simple
View details →Negative / Null Result ReportOpen accessMedical technology
Jian Zhang, Guohai Sun, Lei Zhang et al. · 2025 · Journal of Medical Ultrasound
Background: This study aimed to investigate the effects of combining an ilioinguinal/iliohypogastric nerve block with an ultrasound-guided quadratus lumborum block during inguinal surgery in older patients. Methods: Between December 2020 and June 2023, 300 elderly patients who underwent inguinal surgery at our institution were randomly divided into an observation group (n = 150) and a control group (n = 150). The observation group received ultrasound-guided quadratus lumborum block in addition to ilioinguinal/iliohypogastric nerve block, whereas the control group received only ultrasound-guide
View details →Negative / Null Result ReportOpen accessEconomic theory. Demography
Kitti Dióssy · 2024 · Köz-gazdaság
Hungarian Életünk és mindennapjaink egyre nagyobb részére van befolyása a mesterséges intelligenciának (MI). A munkaerőpiacon már jelenlévő Y és Z generáció motivációja és attitűdje hatással van hosszú távon a vállalatok versenyképességére. Az MI előnyeinek felismerése mellett annak alkalmazása és az esetleges hátrányaihoz való alkalmazkodás is jelentős feladat. Kutatásomban arra fókuszálok, hogy feltárjam a fiatal közgazdászok gondolkodásmódját az MI-vel kapcsolatban, anonim kérdőívek segítségével (147 magyar, 105 amerikai válaszadó). Ennek érdekében amerikai (fejlett gazdaság és élen járó az
View details →Negative / Null Result ReportOpen accessAgriculture
B. Falahatkar email ; H. Abdi; N. Mahmoudi · 2012 · Majallah-i ̒Ilmī-i Shīlāt-i Īrān
Considering the effects of dietary nucleotides on growth and metabolism, this study was conducted to determine the effect of different levels of this nutrient on the sources of the body needed energy, and growth performance of common carp. Fish with average (±SD) weight of 7.5±0.2g were fed to five levels of dietary nucleotides containing 0, 0.1, 0.2, 0.3 and 0.4 percent for 8 weeks. Fish were fed 5 times daily according the satiation. After 56 days, the results showed that the level 0.2% nucleotide had the highest growth rate in terms of weight and length, but other parameters such as body
View details →Negative / Null Result ReportOpen accessDentistry
Marieta Bujak, Ivan Brakus, Ratka Borić · 2023 · Acta Stomatologica Croatica
Objectives: The primary aim was to compare the amount of bone height change that occurs around the tooth and the implant when having tooth-implant-supported prosthetic restorations versus bone height change that appears around implants in only implant-supported prosthetic restorations. The secondary aim was to examine the influence of various factors such as the number of teeth involved in the construction, their endodontic treatment, number of implants, the type of implantology construction, the jaw in which the construction is located, the condition of the opposite jaw, gender, age, and work
View details →Negative / Null Result ReportOpen accessBiology (General)
Dewi Sekarsari, Viskasari P. Kalanjati, Abdulloh Machin et al. · 2020 · Majalah Biomorfologi
Background: Various risk factors of epilepsy in children had been reported although differences were found amongst regions. Objective: To identify the profile of epilepsy patients and previous febrile seizure history in children aged 0-17 years at Pediatric Ward, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2017. Materials and Methods: This was a cross-sectional retrospective study, using secondary data from medical records of epilepsy patients with febrile seizure history in children aged 0-17 years old at Pediatric Ward, Dr. Soetomo General Academic Hospital, Surabaya, Indo
View details →Negative / Null Result ReportOpen accessNursing
YE Yuquan (叶玉泉) · 2021 · 中西医结合护理
Objective To observe the effect of external application with Traditional Chinese Medicine in prevention of postoperative fever (＞38 ℃) in patient undergoing surgery for obstructive sleep apnea-hypopnea syndrome. Methods Totally 118 patients undergoing bilateral tonsillectomy/adenoidectomy were randomly divided into the study group and the control group, with 59 cases in each group. All patients received routine care after surgery, and those in the study group were given external application with Traditional Chinese Medicine. The incidence of postoperative fever (＞38 ℃) was compared between two
View details →Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Min GUO, Jianmin LI, Jianhui LIU et al. · 2023 · Zhongguo shuxue zazhi
Objective To investigate the preparation quality and clinical application effect of pooled platelets with leukocytes reduced. Methods The quality and clinical effect of the buffy-coated method prepared pooled platelets leukocytes reduced (experimental group, n=40) and apheresis platelets leukocytes reduced (control group, n=40) were compared. Results The platelet volume (mL), platelet count (×1011), red blood cell contamination (×108) and residual white blood cell (×106) of the experimental group and control group were 278.90±7.92 vs 276.52±8.01, 2.66±0.09 vs 2.66±0.83, 0.54±0.42 vs 0.83±0.84,
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Seyed Mostafa Shiryazdi, Mohammad Dehestani, Mohammad forat yazdi et al. · 2015 · Journal of Community Health Research
Introduction: As a glycoprotein, Plasma Prostate-Specific Antigen (PSA) is mainly produced by prostate epithelial cells and is used as a major diagnostic tool for prostate cancer. A group of researchers relate the elevated number of estrogen receptors in breast cancer samples to the over-production of PSA in this type of cancer. Therefore, the present study aimed to determine the participants' plasma PSA level as a new biomarker for the primary diagnosis of breast cancer. Methods: Employing a historical cohort design, this study was conducted on 95 patients suffering from breast masses. The pa
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Tatik Hernawati, Suherni Susilowati, Tri Wahyu Suprayogi et al. · 2024 · Ovozoa: Journal of Animal Reproduction
One of the many efforts to increase the quality of livestock genetics is through artificial insemination (AI). Other than increasing it, AI can be conducted to preserve semen. A successful AI is determined by seminal quality, therefore, a method to preserve semen for a longer storage time is needed. The method used is adding an extender that fulfills prerequisites for a semen extender such as coconut water combined with egg yolk citrate extender. Coconut water is rich in carbohydrates, protein, vitamins, and antioxidants while egg yolk contains lecithin. This study aims to find out the Pote bu
View details →Negative / Null Result ReportOpen accessMedicine
Ryo Obata, Yasuo Yanagi · 2014 · PLoS ONE
Purpose It has not been clarified whether early age-related macular degeneration (AMD) is associated with cone photoreceptor distribution. We used adaptive optics fundus camera to examine cone photoreceptors in the macular area of aged patients and quantitatively analyzed its relationship between the presence of early AMD and cone distribution. Methods Sixty cases aged 50 or older were studied. The eyes were examined with funduscopy and spectral-domain optical coherence tomography to exclude the eyes with any abnormalities at two sites of measurement, 2° superior and 5° temporal to the fovea.
View details →Negative / Null Result ReportOpen accessAgriculture
M. Amerian, S. E. Hashemi Garmdareh, A. Karami · 2020 · علوم آب و خاک
Today, one of the biggest challenges facing the world is the lack of water, especially in the agricultural sector. In this research, we investigated the effects of irrigation method and deficit irrigation with the urban refined effluent on biomass, grain yield, yield components and water use efficiency in single grain crosses 704 maize. This research was carried out in a randomized complete block design with two irrigation systems (furrow irrigation (F) and drip irrigation (T)) and three levels of deficit irrigation treatments of 100 (D1), 75 (D2) and 55 (D3) percent of water requirements in t
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Diego Raimondo, Antonio Raffone, Antonio Raffone et al. · 2022 · Frontiers in Oncology
Data about the oncological outcomes in women with borderline ovarian tumor (BOT) undergoing uterine-sparing surgery without ovarian preservation are poor. We aimed to assess the oncological outcomes in women with BOT undergoing uterine-sparing surgery without ovarian preservation. A multi-center observational retrospective cohort study was performed including all consecutive postmenopausal patients who underwent surgical treatment for BOT at three tertiary level referral centers for gynecologic oncology from January 2005 to December 2016. Patients were divided into two groups for comparisons:
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Chanchal Katariya, Arvina Rajasekar · 2022 · Journal of Advanced Pharmaceutical Technology & Research
Microsurgery is a minimally invasive procedure that uses a surgical microscope, specially designed equipment, and suture materials. Even though this equipment and expertise of numerous surgeries are required to meet patient esthetic reckoning, doctors must be ready to invest time and effort into becoming familiar with novel surgical methods and devices. The ambition of this case series is to compare conventional macro surgery and microsurgery in terms of clinical approach. This study included four cases, two flap surgery, and two root coverage. Clinical parameters for root coverage, increase i
View details →Negative / Null Result ReportOpen accessScience (General)
Akeem Dauda Babatunde, Hafsah Maiazara Adamu, Hauwau Abubakar Salele · 2023 · UMYU Scientifica Journal
The study was conducted over a period of fifty-six (56) days to investigate the effects of different colours of culture tanks on the water quality, growth, and feed utilization of Nile tilapia (Oreochromis niloticus) juveniles. O. niloticus of mean body weight of 8.5g were stocked and fed twice daily with a commercial diet containing 42% crude protein. The experiment had four treatments based on tank colours; white, green, black and blue coloured tanks. Some water quality indices were assessed once in a week while the fish were weighed at the end of the experiment to compute the performance in
View details →Negative / Null Result ReportOpen accessAnimal culture
Cut Nila Thasmi, Nuzul Asmilia, Elfi Satria Suryani et al. · 2022 · Jurnal Kedokteran Hewan
This study aims to analyze the effect of administering Malacca leaves (Phyllanthus emblica) extract on the sperm quality of mice. This leaf extract was administered orally using gavage method once daily for 21 days. There were four treatment groups: the control group (P0) received distilled water while the first (P1), second (P2), and third (P3) treatment groups received 300 mg, 600 mg, and 1200 mg of Malacca leaf ethanol extract/kg body weight, respectively. Each groups consisted of four mice and was evaluated for sperrm motility, viability, morphology, and concentration. The results showed t
View details →Negative / Null Result ReportOpen accessAnimal culture
Jing-ping GAO, Jia-ning SUN, Xian-hua LI et al. · 2021 · Siliao yanjiu
The experiment was to study the effect of the combination of glucose oxidase (GOD) and Lactobacillus on growth performance and immune function of broilers. A total of 1 200 one-day-old AA broilers were randomly divided into four groups: group Ⅰ (control group), group Ⅱ, group Ⅲ and group Ⅳ. The control group was free to drink water, group Ⅱ was added 0.1% GOD in the drinking water of each chicken daily, and group Ⅲ was added 1.5×10 5 CFU/g Lactobacillus preparation in the drinking water of each chicken daily. In test group Ⅳ, 0.1% GOD and 1.5×10 5 CFU/g Lactobacillus were added to each chicken
View details →Negative / Null Result ReportOpen accessDentistry
Ganesh RamKumar Rajapandi, Ahila Singaravel Chidambaranathan, MuthuKumar Balasubramanium · 2025 · Biomaterial Investigations in Dentistry
Introduction: Debonding of silicone prostheses from metal substructures is a frequently reported complication in prosthodontics. Polyether ether ketone (PEEK) has emerged as a promising alternative framework material owing to its favourable biomechanical properties; however, its limited bond strength to silicone remains a concern. The present study aimed to evaluate the shear bond strength between PEEK and maxillofacial silicone following laser etching of PEEK and subsequent accelerated ageing. Materials and methods: According to ISO 10477:2020, 128 PEEK specimens were fabricated using Compute
View details →Negative / Null Result ReportOpen accessScience
Hans IJzerman, Jaap J. A. Denissen · 2019 · Royal Society Open Science
We report a replication and extension of a finding from Studies 1 and 2 of Van Lange et al.'s influential paper (Van Lange et al. 1997 J. Pers. Soc. Psychol. 73, 733–746. (doi:10.1037/0022-3514.73.4.733)), which showed an association between Social Value Orientation (SVO) and attachment security. We report a close replication but with measures of attachment that are considered superior in comparison to measures used by Van Lange et al., due to subsequent psychometric improvements. Psychometric analyses indeed showed that our attachment measures were reliable and valid, demonstrating theoretica
View details →Negative / Null Result ReportOpen accessMedicine
Mojtaba Khazaei, Fatemeh Saadati Pour, Masoud Ghiasian et al. · 2024 · مجله علوم پزشکی فیض (پیوسته)
Background and Aim: Edaravone is known for its efficacy in inhibiting free radical formation, activating microglia, and promoting neurogenesis and neuroprotection following acute ischemic stroke. This clinical trial aimed to investigate the effects of Edaravone on clinical symptoms and oxidative stress factors in patients with acute ischemic stroke. Methods: In this clinical trial, fifty-two patients diagnosed with acute ischemic stroke were randomly assigned to receive either Edaravone (120 mg daily up to 3 doses intravenously) or a placebo in addition to standard treatment. Stroke severity w
View details →Negative / Null Result ReportOpen accessMedicine (General)
Seoyoung Wy, Seoyoung Wy, Young Kook Kim et al. · 2022 · Frontiers in Medicine
PurposeTo compare the clinical outcomes of maximum tolerated medical therapy (MTMT) in patients with penetrating keratoplasty (PKP) with those of Ahmed glaucoma valve (AGV) implantation.MethodsThe medical records were retrospectively reviewed in patients who had undergone PKP for bullous keratopathy and were treated with MTMT or AGV implantation for the management of glaucoma. A total of 18 bullous keratopathic patients were investigated between January 2010 and February 2017: 9 patients treated with MTMT and 9 patients treated with AGV implantation. Non-corrected visual acuity (NCVA), intraoc
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Andra DEGAN, Ruxandra TUDOR, Ruxandra COSTEA et al. · 2019 · Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine
General anesthesia produces different degrees of central nervous depression and changes in the peripheral circulation, therefore affecting the patient’s thermoregulatory mechanism. Moreover, the lack of proper, specially designed equipment for magnetic resonance imaging (MRI) environment monitoring can represent a challenge for the anesthetist. We examined the temperature variations correlated with different anesthetic protocols in dogs that underwent general anesthesia in order to evaluate changes in rectal and distal extremities temperature, before and after anesthesia. This study was conduc
View details →Negative / Null Result ReportOpen accessMedicine (General)
Martins MJ, Martins CPMO, Castro-Alves LJ et al. · 2018 · Journal of Pain Research
Marcelo J Martins,1 Caroline Paiva Matos Oliveira Martins,2 Lucas J Castro-Alves,3 Gabriel Nascimento Jesus,4 Guilherme Oliveira Campos,5 Breno Barbosa Cerqueira Sacramento,4 Leonardo Ferrari Borges,6 Carlos Augusto Bastos Mello,6 Rodrigo Leal Alves,5 Norma Sueli Pinheiro Módolo7 1Department of Anesthesiology, São Paulo State University (UNESP), São Paulo, Brazil; 2Department of Anesthesiology at Federal University of Bahia, Bahia, Brazil; 3Department of Anesthesiology, Santo Antonio Hospital, Salvador, Bahia, Brazil; 4Department of Anesthesia, Bahia University of Medicine
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Xingtao Ge, Xinghua Ge, Chen Wang et al. · 2022 · BMC Musculoskeletal Disorders
Abstract Background A safe and effective technique for anterolateral portal placement in elbow arthroscopy is significant. We compared the outcomes of patients who underwent elbow arthroscopy using different ultrasound-assisted techniques. Methods From May 2016 to June 2021 a retrospective analysis on all patients who underwent elbow arthroscopy in our department was performed. Patients were separated into three groups: non-ultrasound; preoperative ultrasound; and intraoperative ultrasound. The minimum follow-up period was 1 year. Nerve injuries, visual analog scale (VAS), Mayo elbow-performan
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Maryam Sharifi, Shahrbanoo Oryan, Alireza Komaki et al. · 2023 · IBRO Neuroscience Reports
There is growing evidence that the hippocampus comprises diverse neural circuits that exhibit longitudinal variation in their properties, however, the intermediate region of the hippocampus has received comparatively little attention. Therefore, this study was designed to compared short- and long-term synaptic plasticity between the dorsal and intermediate regions of the hippocampus in normal and PTZ-kindled rats. Short-term plasticity was assessed by measuring the ratio of field excitatory postsynaptic potentials’ (fEPSPs) slope in response to paired-pulse stimulation at three different inter
View details →Negative / Null Result ReportOpen accessAgriculture
Preetaman Bajwa, Rupinder Saini, Sukhbir Singh et al. · 2025 · Agrosystems, Geosciences & Environment
Abstract Industrial hemp is receiving attention for its numerous benefits, particularly in the fiber industry. Weed competition is a primary concern for hemp cultivation, causing reduced yields and inferior‐quality fiber. However, little is known about herbicide application in hemp since a limited range of herbicides are available for hemp production. During 2023, this study evaluated the effect of different post‐emergence herbicides applied at early and late growth stages to optimize weed suppression and minimize crop injury in hemp under semiarid conditions. A randomized complete block desig
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