21,742 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Wu J, Li G, Pen J et al. · 2026 · Journal of environmental management
Saline-alkali grassland ecosystems are essential methane (CH 4 ) sinks, playing a significant role in global CH 4 budgets. However, our understanding of the CH 4 uptake potential in saline-alkali grasslands and its response to climate…
View details →Pirillo V, Barca F, Bruno D et al. · 2026 · Preprint
Insects offer promising opportunities for organic waste bioconversion; however, they cannot efficiently degrade synthetic polymers such as polyethylene terephthalate (PET). Here, we generated transgenic Drosophila melanogaster lines to…
View details →Fang YJ, Gonzalez K, Konecny F et al. · 2026 · American journal of physiology. Heart and circulatory physiology
Maternal exercise may influence long-term cardiovascular health in offspring, yet its effects on intrinsic myocardial performance and mitochondrial metabolism remain incompletely defined. We investigated whether maternal voluntary wheel…
View details →Nutter NA, Costa-Terryll A, Miller LM et al. · 2026 · Preprint
Streptococcus pneumoniae ( Spn ) asymptomatically colonizes the upper respiratory tract (URT), a niche from which it can transmit to another host or cause invasive disease in the same host. The in vivo transcriptional adaptations that Spn…
View details →Rajhansa S, Crump NT, Khoo HM et al. · 2026 · Experimental hematology
A major challenge in cancer therapeutics has been the identification of targets that are selectively toxic to cancer cells while displaying limited effects on healthy counterparts. Toxicities related to blood production from hematopoietic…
View details →Sawatpanich T, Innoi S, Chaiyamoon A et al. · 2026 · Life (Basel, Switzerland)
Morus alba L. fruit extract (MFE), which is rich in cyanidin 3-glucoside (C3G), demonstrates antioxidant properties and pharmacological effects, but its reproductive safety remains poorly understood. Polyphenols modulate steroidogenesis,…
View details →Jeremic M, Jovanovic-Tucovic M, Martinovic T et al. · 2026 · Neurotoxicology
The mechanistic target of rapamycin complex 2 (mTORC2), a key regulator of cellular metabolism, growth, and survival, remains poorly characterized in the context of dopaminergic neurotoxicity. In this study, we investigated the role of…
View details →Abdelmenam DS, Elshahawy WM, Ahmed RK · 2026 · Odontology
This study aimed to assess the effect of incorporating sodium fluoride (NaF) into an adhesive system on the microtensile bond strength of ceramic occlusal veneers. Eighty resin-dentin sticks (~ 1 mm 2 ) were obtained from 20 upper first…
View details →Nicholas M, Ianssen M, Costa D et al. · 2026 · Preprint
Abstract Purpose Psychosocial factors have been identified as risks for delayed recovery after work injuries but results from interventions for high-risk cases have been mixed. An earlier Australian study that matched care to assessed…
View details →Hajj-Boutros G, Faust A, Mastrandrea C et al. · 2026 · Experimental physiology
Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head-down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure…
View details →Cuadro R, Borrajo CI, Marino MA et al. · 2026 · European Journal of Agronomy.
Nitrogen (N) and phosphorus (P) deficiencies commonly limit plant growth in agroecosystems. While critical N concentration (Nc) dilution curves are widely used to assess the N status of crops and pastures, it remains unclear whether Nc…
View details →Zhao Y, Ma Y, Fan Y et al. · 2023 · Lung cancer (Amsterdam, Netherlands)
Purpose This study aimed to evaluate the efficacy and safety of cadonilimab (anti PD-1 and CTLA-4 bispecific antibody) in patients with previously treated metastatic non-small-cell lung cancer (NSCLC). Methods In this multicenter,…
View details →Karavia EA, Pittaras A, Andreopoulou O et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background/Objectives: Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), represents a growing global health burden closely linked to obesity, insulin…
View details →Limon D, Bokstein F, Blumenthal DT et al. · 2026 · Neuro-oncology advances
Background Tumor-treating fields (TTFields) have demonstrated efficacy in newly diagnosed glioblastoma (ndGBM) when combined with adjuvant temozolomide (TMZ). Preclinical studies suggest that TTFields enhance the therapeutic effect of…
View details →Gaebel L, Gerhardt T, Khamhoung A et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundClonal hematopoiesis (CH) increases with age and elevates the risk of numerous age-associated diseases. However, the association between CH and neurodegenerative diseases has remained unclear.ObjectiveWe tested the association…
View details →Zubareva OE, Melik-Kasumov TB, Sinyak DS et al. · 2026 · Neurochemistry international
Activation of peroxisome proliferator-activated receptor alpha (PPARα) suppresses neuroinflammation and may interrupt epileptogenesis. We tested whether early intervention with the PPARα agonist fenofibrate exerts disease-modifying effects…
View details →Prakash V, Barnes BG, Windorff CJ · 2026 · Communications chemistry
Uranium-nitrogen compounds (U x N y ) pose interesting structural and electronic questions. Understanding the formation and speciation of U x N y may provide insights in nitrogen fixation as well as the preparation of potential uranium…
View details →Lawrence AG, Murangi T, Chevalier A et al. · 2026 · Journal of thrombosis and haemostasis : JTH
Background Hemophilic arthropathy (HA) is a chronic joint disease caused by repeated joint bleeding in patients with hemophilia, leading to joint degeneration despite prophylactic treatment. The CX3CL1 (fractalkine)-CX3CR1 chemokine axis…
View details →Chiusaroli L, Chiusaroli L, Boustany M et al. · 2026 · The Pediatric infectious disease journal
Background Routine blood cultures (BCs) are frequently obtained in hospitalized children with suspected infection. Although bacterial pathogens are the primary concern, fungal infections remain a consideration in high-risk populations,…
View details →Lerma-Clavero A, Kopsida M, Arendt N et al. · 2026 · FEBS open bio
The unfolded protein response (UPR) plays an important role in tumor progression and cellular stress adaptation. In hepatocellular carcinoma (HCC), pharmacological inhibition of the protein kinase R-like endoplasmic reticulum kinase (PERK)…
View details →Dantas MCDS, Moreira SDNT, Pinto Júnior FEL · 2026 · Journal of cancer education : the official journal of the American Association for Cancer Education
Background Communication of difficult news is a core competency in oncology education. How accurately medical students self-assess their communication performance shapes formative learning and curriculum design. Purpose To examine…
View details →Butzlaff R, Christoph C, Puhl L et al. · 2026 · Journal of psychosomatic research
Background Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising non-pharmacological approach for postoperative pain management, but its interaction with childhood trauma (CT) remains unclear. This three-armed randomized…
View details →Enciso-Pablo Ó, Sierra-Ramírez F, Sotres-Bayón F · 2026 · Preprint
Abstract Rationale: Benzodiazepines are widely used to treat anxiety; however, their influence on defensive behavior when threats compete with rewards remains unclear. Objectives Here, we tested the effects of diazepam on reactive…
View details →Barris CT, Kress TC, Antonova G et al. · 2025 · American journal of physiology. Heart and circulatory physiology
The global rise in obesity parallels the increasing rates of hypertension and cardiovascular disease (CVD). These trends, and recent clinical and experimental data, have revealed that obesity abolishes the protection from CVD typically…
View details →Both A, Chevalier C, Connor MG et al. · 2026 · Preprint
Crosstalk between respiratory bacteria and human airway epithelial cells initiates cellular immunity, yet the molecular determinants of asymptomatic carriage versus inflammation remain incompletely understood. A key regulator of airway…
View details →Souza VKB, Ferreira DA, Arantes APR et al. · 2026 · Cell biochemistry and biophysics
Chronic neuroinflammation contributes to neuronal damage through oxidative stress and inflammatory mediators, highlighting the need for novel therapeutic strategies. This study evaluated the cytotoxicity and neuroprotective effects of…
View details →Litif C, Libster AM, Desfor S et al. · 2026 · Preprint
The Reln gene encodes the extracellular glycoprotein Reelin that regulates synaptic plasticity and activity-dependent gene expression with implications in several neuropsychiatric disorders, including substance use disorder. While reduced…
View details →Anwar S, Ebrahimi-Iranpour S, Huq S et al. · 2025 · Preprint
Lysosomes are organelles responsible for degrading unwanted extracellular material that cells internalize, or intracellular material targeted for disposal. Typically, lysosomes are globular in morphology. However, in activated macrophages…
View details →Shim HG, Fanning AS, Raymond JL · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience
It is increasingly recognized that learning and memory depend not only on changes in synaptic strength but also on experience-dependent modifications of intrinsic neuronal excitability. However, how these two forms of plasticity interact…
View details →Acton JP, Alsharif NS, Bond JW et al. · 2026 · European journal of applied physiology
Coenzyme Q10 (CoQ 10 ) is an integral component of the mitochondrial electron transfer system. Most studies have administered the oxidised form of CoQ 10 (ubiquinone) and observed no effects on mitochondrial respiratory function or…
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