Effect of liposome binding antisense oligonucleotide BP1003 on albumin-bound paclitaxel sensitivity in pancreatic cancer cells by inhibiting STAT3
FU Hua, ZHOU Guochao, CAI Rongmin, SONG Xin, YANG Dinghua · 2025 · Zhongguo aizheng zazhi
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Abstract
Background and purpose: The resistance of pancreatic cancer to albumin-bound paclitaxel affects the therapeutic effect and prognosis. Signal transducer and activator of transcription 3 (STAT3) is one of the important molecules regulating the chemotherapy sensitivity of cancer cells. The liposome BP1003 targeting the antisense oligonucleotide of STAT3 mRNA can inhibit the expression of STAT3 and increase the chemotherapy sensitivity. However, the effect of BP1003 on the sensitivity of pancreatic cancer cells to albumin-bound paclitaxel remains unclear. The purpose of this study was to investiga
Abstract by FU Hua, ZHOU Guochao, CAI Rongmin, SONG Xin, YANG Dinghua, Zhongguo aizheng zazhi (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.19401/j.cnki.1007-3639.2025.05.002