e-ISSN: Pending

Browse the failure-mode index

21,294 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Comparison between drug-eluting bead transarterial chemoembolization versus conventional TACE in elderly patients with colorectal cancer liver metastases: a cohort study.

Tian L, Hu B, Song M et al. · 2026 · Frontiers in oncology

Background Drug-eluting bead (DEB) transarterial chemoembolization (TACE) possesses several advantages over conventional TACE (cTACE) such as higher intratumor drug concentration and lower systemic toxicity, which has been widely applied…

View details →
Negative / Null Result ReportMedicine

Boric acid Attenuates premature ovarian insufficiency by Modulating oxidative stress in a Cyclophosphamide-Induced rat model.

Ozcakar TG, Kender Erturk N, Onguncan O et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Aim This study aimed to investigate whether boric acid (BA) exerts potential protective effects against cyclophosphamide (CYC)-induced premature ovarian insufficiency (POI) in rats through modulation of oxidative stress and preservation of…

View details →
Negative / Null Result ReportMedicine

Effect of a goal-directed sedation nursing intervention bundle on comfort and compliance in children undergoing bronchoalveolar lavage under topical anesthesia with procedural sedation: a randomized controlled trial.

Luo X, Zhang H · 2026 · Frontiers in medicine

Objective To assess the impacts of goal-directed sedation nursing intervention on comfort and compliance in children undergoing bronchoalveolar lavage (BAL) under topical anesthesia with procedural sedation. Methods A total of 168 children…

View details →
Negative / Null Result ReportMedicine

Comparison of Dacryoendoscopy-Aided Silicone Tube Intubation and Endoscopic Dacryocystorhinostomy for Complete Nasolacrimal Duct Obstruction.

Yoon Y, Yoon JS, Ko J · 2026 · Korean journal of ophthalmology : KJO

Purpose To compare the surgical outcomes of dacryoendoscopy-aided silicone tube intubation (STI) and endoscopic dacryocystorhinostomy (endo-DCR) for complete nasolacrimal duct obstruction (NLDO), and to identify factors associated with…

View details →
Negative / Null Result ReportMedicine

Visual and refractive outcomes of small incision lenticule extraction planned with a VISULYZE-generated nomogram for myopia and astigmatism: a retrospective comparative study.

Lin Y, Wei X, Su H et al. · 2026 · BMC ophthalmology

Purpose Small-incision lenticule extraction (SMILE) is a widely used procedure for correcting myopia and myopic astigmatism. However, variability in refractive outcomes, particularly astigmatic correction, remains a concern. This study…

View details →
Negative / Null Result ReportMedicine

Fibular allograft augmentation shows potential benefits in treating medial column comminuted proximal humeral fractures with osteoporosis: a secondary analysis of a randomized controlled trial.

Chai Y, Shi T, Jiang H et al. · 2026 · Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology

Background Fibular allograft (FA) augmentation is proposed to address the lack of medial column support in plate-fixed proximal humeral fractures; however, the role of FA augmentation in these fractures remains inadequately elucidated. Our…

View details →
Negative / Null Result Report

Effect of Delayed Initiation of Mepolizumab on Exacto Scale Scores, Clinical Remission Separ-Remas Criteria, and Functional Outcomes in Uncontrolled Severe Asthma: A Real-World Study

León-Lloreda A, Muñoz-Sánchez B, Polonio-González M et al. · 2026 · Preprint

INTRODUCTION: Delayed initiation of mepolizumab may influence long-term disease control and the achievement of clinical and functional outcomes in patients with uncontrolled severe asthma (SUA), but no definitive conclusions have yet been…

View details →
Negative / Null Result ReportMedicine

Combined anterior cruciate ligament and anterolateral ligament reconstruction using an adjustable-loop device provides similar short-term clinical outcomes compared with isolated reconstruction.

Jaramillo Quiceno GA, Sarmiento Riveros PA, Arias Perez RD et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction/objectives Residual rotational laxity remains a relevant clinical concern after anterior cruciate ligament (ACL) reconstruction. Combined ACL and anterolateral ligament (ALL) reconstruction has been proposed to improve control…

View details →
Negative / Null Result ReportMedicine

Avoiding the Umbilical Incision in Obese Patients Undergoing Laparoscopic Cholecystectomy: A Retrospective Cohort Study of Wound-Related Outcomes.

Uesato Y, Inamine S · 2026 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Background The umbilical port is routinely used for camera insertion and specimen retrieval in laparoscopic cholecystectomy (LC). However, the umbilicus is anatomically vulnerable and may be associated with an increased risk of surgical…

View details →
Negative / Null Result ReportMedicine

Comparative Efficacy of Subcutaneous and Sublingual Allergen Immunotherapy for Grass Pollen-Induced Allergic Rhinoconjunctivitis: Pairwise and Adjusted Indirect Treatment Comparison of Standardized ALK Products.

Di Lorenzo G, Melluso M, Rodolico A et al. · 2026 · The journal of allergy and clinical immunology. In practice

Background Allergen immunotherapy (AIT) is the only disease-modifying treatment for grass pollen-induced allergic rhinoconjunctivitis (ARC). Three delivery routes-subcutaneous (SCIT), sublingual drops (SLIT-D), and sublingual tablets…

View details →
Negative / Null Result ReportMedicine

Documented Use of Piperacillin-Tazobactam and Increased 1-Month Mortality in Healthcare-Associated Intra-Abdominal Infections.

Baulier C, Zappella N, Grall N et al. · 2026 · Anaesthesia, critical care & pain medicine

Background Recent studies have increasingly questioned the efficacy and safety of piperacillin-tazobactam (TZP) in septic patients, particularly those with healthcare-associated intra-abdominal infections (hcIAI). This study assessed…

View details →
Negative / Null Result ReportMedicine

Evaluation of Structural and Functional Outcomes After the Application of an Initial Single Dose of Faricimab.

Ariza-Torrado IP, Groman-Lupa S, Martínez-Córdoba CJ et al. · 2026 · Journal of vitreoretinal diseases

Purpose: To evaluate functional and structural outcomes after application of a single intravitreal dose of faricimab in patients with chronic retinal diseases. Methods: In this observational, longitudinal, prospective study, best-corrected…

View details →
Negative / Null Result ReportMedicine

Olfactory function in patients with benign paroxysmal positional vertigo (BPPV): a cross-modal sensory analysis.

Tahsin S, Murat K, Gözde OK et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

OBJECTIVE: To investigate the potential interaction between the vestibular and olfactory systems by evaluating olfactory identification performance in patients with BPPV. METHODS: Fifty-two patients with BPPV and 50 age-matched healthy…

View details →
Negative / Null Result ReportMedicine

Postural Stability Changes During the 4 Phases of the Half Squat: Kinematics Profile of the Center of Pressure and Center of Mass in High-Performance Weightlifters-A Pilot Study.

Arrayales-Millán EM, Rodal M, González-Macías ME et al. · 2026 · Bioengineering (Basel, Switzerland)

This study investigated balance control during the half squat by analyzing the relationship between the center of mass (CoM) and the center of pressure (CoP) in five experienced male weightlifters performing segmented squats at five load…

View details →