Negative / Null Result ReportOpen accessMedicine
Rinaldi V, Ridolfi F, Finotello R et al. · 2026 · Veterinary medicine and science
Hypertrophic osteopathy (HO) is a paraneoplastic or parainflammatory syndrome characterised by painful periosteal new bone formation and soft tissue swelling, most commonly associated with thoracic neoplasia. The pathogenesis of HO remains…
View details →Negative / Null Result ReportMedicine
Mano N, Mori K, Kuwabara T et al. · 2026 · Annals of biomedical engineering
Purpose Diverse gait patterns in individuals with stroke require personalized rehabilitation to improve paretic propulsion (Pp), which reflects gait function. However, the gait characteristics associated with Pp have not been fully…
View details →Negative / Null Result ReportOpen accessMedicine
Jaime-Jorge S, García-Ael C, Azanza G et al. · 2026 · European journal of investigation in health, psychology and education
This paper analyses associations between psychological health at work and life satisfaction among employees. Specifically, it investigates the association between work stress and emotional exhaustion and explores whether connectedness to…
View details →Replication Failure
Allfelt A, Bendahl PO, Alkner S et al. · 2026 · Preprint
Abstract Background Invasive lobular carcinoma (ILC) is a risk factor for positive margins after breast-conserving surgery (BCS). This retrospective observational study examined whether the presence of residual cancer cells in re-excision…
View details →Negative / Null Result ReportMedicine
Lu B, Wang P, Hu J et al. · 2026 · Environmental pollution (Barking, Essex : 1987)
Wetland interfaces regulate greenhouse-gas exchange and carbon retention, yet contaminant exposure may disrupt the relationship between these two processes. Whether aqueous perfluorooctane sulfonate (PFOS), a persistent aquatic…
View details →Negative / Null Result ReportMedicine
Shioiri H, Takahashi T, Matsumoto T · 2026 · International orthopaedics
Purpose To investigate factors associated with achieving both postoperative knee flexion range of motion (ROM) ≥ 125° and Numerical Rating Scale (NRS) pain score ≤ 1 at one year after posterior cruciate-retaining total knee arthroplasty…
View details →Negative / Null Result ReportMedicine
Liu S, Tan Y, Zang L · 2026 · Healthcare (Basel, Switzerland)
Background/Objectives: Climate change worry is an emerging concern in youth mental health, but little is known about how it is associated with positive psychological functioning among university students. This study examined whether…
View details →Negative / Null Result ReportMedicine
Turgut H, Özdemir R, Memişoğlu F · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Purpose This study aimed to characterize pathogen distribution and antimicrobial resistance patterns of gram-negative bloodstream infections in a tertiary neonatal intensive care unit and to determine which factors were associated with…
View details →Negative / Null Result ReportMedicine
Hsu LI, Chen JW, Hsu HW et al. · 2026 · Anesthesiology
Background Tranexamic acid (TXA) reduces perioperative blood loss, but comparative effectiveness and safety across administration routes remain uncertain. The authors evaluated topical, IV, and oral TXA in unilateral total hip and knee…
View details →Negative / Null Result ReportMedicine
Miyake H, Onishi A, Tsuji H et al. · 2026 · Modern rheumatology
To identify factors associated with flare after glucocorticoid (GC) reduction in systemic lupus erythematosus (SLE) and determine whether belimumab influences this risk. Using the ANSWER-SLE cohort, this retrospective multicentre study…
View details →Negative / Null Result ReportMedicine
Deconne TM, Suerken CK, Lipford ME et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundArterial stiffness is an emerging risk factor for Alzheimer's disease (AD) and related dementias (ADRD) and is assessed by measuring pulse wave velocity (PWV). Recent mathematical modeling has allowed for the delineation of…
View details →Negative / Null Result ReportMedicine
Grębska P, Fedorczak A, Pytrus T et al. · 2026 · Nutrients
Background/Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication, restricted and repetitive behaviors, and sensory processing abnormalities, including food…
View details →Replication FailureMedicine
Alija B, Bolas T, Vithiananthan S · 2026 · The Journal of surgical research
Introduction Over one million hernia repairs are performed annually in the United States, with more than 20 million worldwide. Although randomized trials support watchful waiting in select cases, delayed repair can lead to strangulation,…
View details →Negative / Null Result ReportMedicine
Tuddenham S, Brotman RM, Handa VL · 2026 · Urogynecology (Philadelphia, Pa.)
Importance Approximately 60% of adult women experience at least 1 urinary tract infection, and more than 25% experience multiple recurrences. If persistent bacterial reservoirs in the urinary tract contribute to the high incidence of…
View details →Negative / Null Result ReportMedicine
Pengpid S, Peltzer K, Hajek A · 2026 · Australasian journal on ageing
Objectives The aim of this study was to assess the longitudinal association between transitioning to adult caregiving, grandparent childcare and mental health outcomes (depressive symptoms, life satisfaction and cognitive functioning) and…
View details →Negative / Null Result ReportOpen accessMedicine
Theophil M, Lyimo AA, Ambikile JS · 2026 · PloS one
Background Chronic Kidney Disease (CKD) is a significant global health challenge, particularly among people living with HIV (PLHIV) on antiretroviral therapy (ART). The combined effects of HIV infection, long-term ART exposure, and other…
View details →Replication FailureMedicine
Aarhus M, Netteland DF, Tverdal C et al. · 2026 · Acta neurochirurgica
Purpose Traumatic brain injury (TBI) in patients ≥ 80 years poses major clinical challenges, with limited evidence to guide neurosurgical decision-making. We evaluated mortality, functional outcomes, and prognostic factors in patients…
View details →Replication FailureMedicine
Fisayo T, Evans C, Mutasa K et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Cytomegalovirus (CMV) co-infection is associated with mortality in adults with HIV, but whether CMV is associated with mortality in children with HIV remains uncertain. Methods In 498 children (median age 6.3 years,…
View details →Negative / Null Result ReportMedicine
Mayo AK, Beaudoin JJ, Woodhead JL et al. · 2026 · Clinical pharmacology and therapeutics
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving…
View details →Negative / Null Result ReportOpen accessMedicine
Frey L, Grunwald S, Ruckes C et al. · 2026 · European urology open science
Background and objective Metastatic testicular germ cell tumors (mTGCTs) are treated with combination chemotherapy (Cx) containing bleomycin (BEP [bleomycin, etoposide, and cisplatin]). Bleomycin-induced pulmonary toxicity (BPT) is a…
View details →Negative / Null Result ReportMedicine
Liang D, Tong Y, Li F et al. · 2026 · Cerebrovascular diseases (Basel, Switzerland)
Introduction General anesthesia (GA) with endotracheal intubation is standard during endovascular treatment (EVT) for acute ischemic stroke (AIS), but the optimal timing for post-procedural extubation remains unclear. Methods In this…
View details →Failed Experiment ReportMedicine
Radha S, Arends M, Kislinger G et al. · 2026 · PLoS biology
Rapid information processing in complex organisms depends on myelin, which consists of a multilamellar membrane that tightly adheres to the axonal surface along the internode and at paranodal loops, where specialized adhesion proteins…
View details →Negative / Null Result ReportMedicine
Mirda D, Hao J, Dungan M et al. · 2026 · Cancers
Background : Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC), and colorectal surveillance has been shown to reduce death from CRC in this high-risk population. This study aimed to examine adherence to…
View details →Negative / Null Result ReportMedicine
Ito K, Fujii M, Oba Y et al. · 2026 · International orthopaedics
Purpose To determine changes in low back pain (LBP) after total hip arthroplasty (THA), identify preoperative factors associated with residual LBP and LBP improvement, and clarify the association between residual LBP and patient-reported…
View details →Negative / Null Result Report
Hamasaki H, Taxiarchi V · 2026 · Preprint
Aims Sarcopenia and sarcopenic obesity are associated with increased risks of cardiovascular (CV) disease and mortality. This study examined the associations of body composition and daily physical activity with mortality, CV events and…
View details →Negative / Null Result ReportMedicine
Cunningham PM, Hayes JE · 2026 · Appetite
Widespread nutrition advice instructs consumers to drink water with meals to increase fullness and reduce energy intake. However, recent data indicates greater water intake is associated with more food intake at a meal, not less. Switching…
View details →Negative / Null Result ReportMedicine
Charoenrat B, Sungkarat S, Phirawatthakul C et al. · 2026 · BMC geriatrics
Background Neck pain is associated with altered postural and gait performance in older adults. Smartphone use may further challenge postural and gait control due to additional cognitive and motor demands. This study aimed to investigate…
View details →Negative / Null Result ReportMedicine
Ediz E, Küçükdağ HN, Özel MA · 2026 · Scientific reports
Although high fructose consumption is known to be associated with metabolic disorders, specific intake thresholds and consumption patterns related to hepatic steatosis have not been fully defined. This study aimed to quantify daily…
View details →Negative / Null Result ReportMedicine
Millarch AS, Schøning J, Hjulmand VG et al. · 2026 · The journal of trauma and acute care surgery
Background Opioids have a well-known capacity to induce long-term dependency with related increased morbidity and mortality. Usage patterns following traumatic injury are, however, not well studied. We investigated long-term opioid usage…
View details →Negative / Null Result ReportMedicine
Melcer T, Robinson MI, Jurick S et al. · 2026 · The journal of trauma and acute care surgery
Background Limited longitudinal research has been conducted on health outcomes during the first 15 years after combat-related lower limb amputation. Methods This retrospective analysis of Departments of Defense and Veterans Affairs health…
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