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Browse the failure-mode index

21,294 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Outcomes of a Foundational Sciences Daily Engagement Game in Medical Education.

Schmidt M · 2026 · Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

Daily engagement games are widely used as motivational tools in applications ranging from language learning to medical licensing board preparations. In medical education, continuous engagement with basic science concepts has benefits for…

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Negative / Null Result ReportMedicine

Immune checkpoint inhibitors in pediatric central nervous system tumors: biology, clinical experience, and translational pathways to precision immunotherapy.

Yenidogan I, Tabori U, Das A · 2026 · Journal of neuro-oncology

Purpose Immune checkpoint inhibitors (ICI) have transformed cancer therapy but remain of limited efficacy in pediatric central nervous system tumors, which are characterized by low tumor mutational burden, sparse antigen presentation, and…

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Negative / Null Result ReportMedicine

Endovascular thrombectomy in addition to intravenous thrombolysis versus intravenous thrombolysis alone in medium distal vessel occlusions: Results from the SITS International Stroke Treatment Register.

Keselman B, Mazya MV, Strbian D et al. · 2026 · International journal of stroke : official journal of the International Stroke Society

Background Endovascular thrombectomy (EVT) is the standard of care for large-vessel occlusion stroke. Medium distal vessel occlusions (MDVO) account for 25-40% of acute ischemic stroke cases, but recanalization rates with intravenous…

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Failed Experiment ReportMedicine

Bladder region-specific analysis of the diagnostic performance of oral 5-aminolevulinic acid fluorescence cystoscopy in non-muscle-invasive bladder cancer.

Ishikawa Y, Tanaka H, Kobayashi M et al. · 2026 · Japanese journal of clinical oncology

Background Fluorescence cystoscopy (FL) using 5-aminolevulinic acid (ALA) enhances the detection of urothelial carcinoma compared to white-light endoscopy (WL). The location of bladder tumors may affect the diagnostic performance of FL;…

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Negative / Null Result ReportMedicine

Male partner treatment and the potential sexual transmission of bacterial vaginosis: considerations for patient counseling and clinical application in the United States.

Yazdy GM, Workowski KA, Ghanem KG et al. · 2026 · American journal of obstetrics and gynecology

Bacterial vaginosis, the most common cause of vaginal complaints among reproductive-aged women, is highly recurrent and often challenging to treat. Whether bacterial vaginosis is sexually transmissible has long been questioned by patients,…

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Negative / Null Result ReportMedicine

PACAP and migraine.

Diener HC · 2025 · Brain : a journal of neurology

A number of neuropeptides, including pituitary adenylate cyclase-activating polypeptide (PACAP), play an important role in the pathophysiology of migraine. Infusions of PACAP in patients with migraine can provoke migraine attacks. A…

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Negative / Null Result ReportOpen accessMedicine

Nonpigmented Adenoid Subtype of Basal Cell Carcinoma: A Case Report.

Ichimura Y, Niiyama S, Hirata A · 2026 · Case reports in dermatology

Introduction Basal cell carcinoma (BCC) is the most common skin cancer, with a rising incidence globally. We encountered a patient with the nonpigmented adenoid subtype of BCC. The nonpigmented subtype of BCC accounts for only a small…

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Replication FailureMedicine

Safety and efficacy of decompressive craniectomy versus standard craniotomy for large acute epidural haematoma with tentorial herniation in China (PREDICT-AEDH): a nationwide, multicentre, open-label, parallel-group, randomised controlled trial.

Feng J, Yang C, Xie L et al. · 2026 · The Lancet. Neurology

Background Decompressive craniectomy has been widely evaluated across heterogeneous types of brain injury but its effect in patients with large acute epidural haematoma complicated by tentorial herniation remains unclear. We aimed to…

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Replication FailureMedicine

Impact of Persistent Hypogonadism on Overall Survival After Androgen Deprivation Therapy in Localized Prostate Cancer Patients: Long-Term Prospective Data.

Nabid A, Carrier N, Vigneault É et al. · 2026 · International journal of radiation oncology, biology, physics

Purpose The impact of persistent hypogonadism post-androgen deprivation therapy (ADT) on overall survival (OS) of patients with prostate cancer (PCa) is poorly documented. We compared OS between patients who recovered testosterone and…

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Negative / Null Result ReportOpen accessMedicine

Effects of current smoking on treatment outcomes in metastatic and locally advanced pancreatic carcinoma: a retrospective cohort study using the international PURPLE pancreas cancer registry.

Hayat F, Chiu S, Stuart A et al. · 2025 · Journal of gastrointestinal oncology

Background Tobacco smoking accounts for 22% of the pancreatic cancer burden in Australia. Smoking may increase therapy-related adverse effects and was associated with shorter survival in the previous analysis of all stages of pancreatic…

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Negative / Null Result Report

Noise Levels and Their Association with Surgical Complexity and Communication in Otolaryngology Sub-specialty Operating Rooms: A Prospective, Single Institution Study

Cradeur A, Abshire M, Schichtel M et al. · 2025 · Preprint

Objectives: This prospective study aimed to assess noise levels in otolaryngology operating rooms (OR), explore noise variation across subspecialties, and examine the correlation between noise, verbal communication, and surgery complexity.…

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Negative / Null Result ReportOpen accessMedicine

Comparison between ligation-assisted and precutting endoscopic mucosal resection for small rectal neuroendocrine tumors: a CHASID study.

Ryou S, Jung Y, Kim DS et al. · 2026 · The Korean journal of internal medicine

Background/aims Few studies have compared modified endoscopic mucosal resection (EMR) techniques for small rectal neuroendocrine tumors (NETs). This study evaluated the clinical outcomes of ligation-assisted EMR (EMR-L) and precutting EMR…

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