Negative / Null Result Report
Ion RM, Hutanu A, Sala DT et al. · 2024 · Preprint
Abstract Background: Bariatric surgery plays an impotant role in immnological modulation by reducing levels of systemic inflammatory markers, such as interkleukin-6 and tumor necrosis factor alpha. The goal of this study is to establish…
View details →Negative / Null Result ReportOpen accessMedicine
Dong X, Liu Y, Chu X et al. · 2024 · CNS neuroscience & therapeutics
Background The ideal blood pressure (BP) target in patients who undergo endovascular thrombectomy (EVT) with successful reperfusion is uncertain. Observational studies show that elevated BP during this period is associated with a higher…
View details →Negative / Null Result ReportMedicine
Wilmshurst P, Pearson M, Walsh K et al. · 2026 · Diving and hyperbaric medicine
Introduction Transoesophageal echocardiography (TOE) is claimed to be the investigation of choice for detecting a persistent foramen ovale (PFO) with almost 100% diagnostic accuracy. If true, TOE would detect all large/clinically…
View details →Negative / Null Result ReportMedicine
Lalaurie CJ, Dalby PA, McDonnell T · 2026 · Scientific reports
Beta-2-Glycoprotein I (β2GPI) is the main autoantigenic target of antiphospholipid syndrome (APS). β2GPI can adopt a number of structures; an extended J-shape, an O-shape and a transitional S-shape. It has also been shown previously that…
View details →Negative / Null Result ReportMedicine
Schmidt M · 2026 · Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
Daily engagement games are widely used as motivational tools in applications ranging from language learning to medical licensing board preparations. In medical education, continuous engagement with basic science concepts has benefits for…
View details →Negative / Null Result Report
Demin K, Hwang JS, Che W et al. · 2026 · Preprint
Previous brain decoding studies indicate that an individual’s pain experience can be robustly predicted from distributed patterns of brain activity. Two brain decoders have notably been associated respectively with the nociceptive and…
View details →Negative / Null Result Report
Lee HJ, Bae Y, Woo JU et al. · 2026 · Preprint
Abstract Background Surgical success after the Maze procedure is conventionally defined as “freedom from atrial fibrillation (AF),” often grouping junctional rhythm (JR) with normal sinus rhythm (NSR). However, the specific hemodynamic…
View details →Negative / Null Result ReportMedicine
Park Y, Chae H, Yoon E et al. · 2026 · GeroScience
Gamma entrainment shows promise for Alzheimer's disease (AD) treatment in preclinical models, but human trials have yielded heterogeneous results. We hypothesized that the clinical efficacy of gamma entrainment depends on individual…
View details →Negative / Null Result Report
Isono S, Kajikawa K, Oseki Y et al. · 2025 · Preprint
Memory limitations have been assumed to be a major factor shaping human sentence comprehension, but characterizing memory-demanding structures in a broad-coverage and cross-linguistic manner has remained a challenge. A recent study…
View details →Negative / Null Result ReportMedicine
Yenidogan I, Tabori U, Das A · 2026 · Journal of neuro-oncology
Purpose Immune checkpoint inhibitors (ICI) have transformed cancer therapy but remain of limited efficacy in pediatric central nervous system tumors, which are characterized by low tumor mutational burden, sparse antigen presentation, and…
View details →Negative / Null Result ReportMedicine
Keselman B, Mazya MV, Strbian D et al. · 2026 · International journal of stroke : official journal of the International Stroke Society
Background Endovascular thrombectomy (EVT) is the standard of care for large-vessel occlusion stroke. Medium distal vessel occlusions (MDVO) account for 25-40% of acute ischemic stroke cases, but recanalization rates with intravenous…
View details →Failed Experiment ReportMedicine
Srivastava A, Renna HA, Hossain T et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background/Objectives : Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder. Current AD therapies offer minimal benefits and do not prevent or repair neuronal damage. More effective therapeutic approaches…
View details →Failed Experiment ReportMedicine
Ishikawa Y, Tanaka H, Kobayashi M et al. · 2026 · Japanese journal of clinical oncology
Background Fluorescence cystoscopy (FL) using 5-aminolevulinic acid (ALA) enhances the detection of urothelial carcinoma compared to white-light endoscopy (WL). The location of bladder tumors may affect the diagnostic performance of FL;…
View details →Negative / Null Result ReportMedicine
Yazdy GM, Workowski KA, Ghanem KG et al. · 2026 · American journal of obstetrics and gynecology
Bacterial vaginosis, the most common cause of vaginal complaints among reproductive-aged women, is highly recurrent and often challenging to treat. Whether bacterial vaginosis is sexually transmissible has long been questioned by patients,…
View details →Negative / Null Result ReportMedicine
Xue J, Ye J, Han P et al. · 2025 · The journal of gene medicine
Background Synovial mesenchymal stem cell-derived exosomes (SMSC-Exos) can regulate macrophage polarization and alleviate knee osteoarthritis (KOA). However, the underlying mechanisms remain unclear. This study explored the role of…
View details →Negative / Null Result ReportMedicine
Diener HC · 2025 · Brain : a journal of neurology
A number of neuropeptides, including pituitary adenylate cyclase-activating polypeptide (PACAP), play an important role in the pathophysiology of migraine. Infusions of PACAP in patients with migraine can provoke migraine attacks. A…
View details →Negative / Null Result ReportOpen accessMedicine
Park SK, Chung Y, Oh CM et al. · 2026 · Global heart
Background There have been inconsistent findings regarding the effects of high sodium intake on coronary artery disease (CAD). This study therefore aimed to investigate the relationship between sodium intake and the coronary artery calcium…
View details →Negative / Null Result ReportOpen accessMedicine
Ichimura Y, Niiyama S, Hirata A · 2026 · Case reports in dermatology
Introduction Basal cell carcinoma (BCC) is the most common skin cancer, with a rising incidence globally. We encountered a patient with the nonpigmented adenoid subtype of BCC. The nonpigmented subtype of BCC accounts for only a small…
View details →Replication FailureMedicine
Feng J, Yang C, Xie L et al. · 2026 · The Lancet. Neurology
Background Decompressive craniectomy has been widely evaluated across heterogeneous types of brain injury but its effect in patients with large acute epidural haematoma complicated by tentorial herniation remains unclear. We aimed to…
View details →Replication FailureMedicine
Nabid A, Carrier N, Vigneault É et al. · 2026 · International journal of radiation oncology, biology, physics
Purpose The impact of persistent hypogonadism post-androgen deprivation therapy (ADT) on overall survival (OS) of patients with prostate cancer (PCa) is poorly documented. We compared OS between patients who recovered testosterone and…
View details →Negative / Null Result Report
Spyropoulou N, Diamantopoulou S, Patrinos S et al. · 2025 · Preprint
OBJECTIVE: The purpose of this study was to examine and compare the clinical be-havior of indirect onlays/overlays made of lithium disilicate and composite resin and to investigate risk factors associated with restorations failures.…
View details →Negative / Null Result ReportOpen accessMedicine
Hayat F, Chiu S, Stuart A et al. · 2025 · Journal of gastrointestinal oncology
Background Tobacco smoking accounts for 22% of the pancreatic cancer burden in Australia. Smoking may increase therapy-related adverse effects and was associated with shorter survival in the previous analysis of all stages of pancreatic…
View details →Negative / Null Result ReportOpen accessMedicine
Dubin A · 2025 · Annals of intensive care
Background Fluids are a key component of shock resuscitation. Nevertheless, their microvascular effects are complex. In fluid responsive patients, fluids may increase tissue perfusion because of the increase in cardiac output. Since shock…
View details →Negative / Null Result ReportMedicine
Wregg JF, Hofer A, Gruber-Wackernagel A et al. · 2026 · Experimental dermatology
Water-filtered infrared-A (wIRA) has been proposed to enhance tissue perfusion and modulate fibrosis, but clinical evidence in morphea (localised scleroderma) is limited. We conducted a prospective, intra-individual pilot split-study in 10…
View details →Negative / Null Result Report
Cradeur A, Abshire M, Schichtel M et al. · 2025 · Preprint
Objectives: This prospective study aimed to assess noise levels in otolaryngology operating rooms (OR), explore noise variation across subspecialties, and examine the correlation between noise, verbal communication, and surgery complexity.…
View details →Negative / Null Result ReportMedicine
Acikgoz NB, Toplu-Hocaoglu A, Yildirim BA et al. · 2026 · Epilepsy research
Purpose The ketogenic diet has long been used in epilepsy treatment, particularly in drug-resistant cases, but its efficacy in idiopathic generalized epilepsy, including absence epilepsy, remains less studied. This study aimed to evaluate…
View details →Negative / Null Result Report
SAW YH, CHAI HI, YAHYA NA et al. · 2026 · Preprint
Abstract Background Energy drinks are widely consumed acidic beverages that may compromise the longevity of resin composite restorations. However, limited evidence exists regarding the use of swept-source optical coherence tomography…
View details →Negative / Null Result Report
Pettenuzzo T, Sella N, Zarantonello F et al. · 2026 · Preprint
Abstract Background. High-flow nasal cannula (HFNC) is a promising respiratory support modality that improves oxygenation, alveolar recruitment, and comfort while reducing dead space compared to conventional oxygen therapy. Recently, a…
View details →Negative / Null Result ReportMedicine
Dağlı E, Çapar ÖF, Sert S · 2026 · Scientific reports
This study examines the effects of freeze-thaw (F-T) cycles on the unconfined compressive strength (UCS) of untreated and stabilized soils using fly ash, lime, and lime-fly ash mixtures (30% FA, 5% L, and 30% FA + 5% L). Specimens were…
View details →Negative / Null Result ReportOpen accessMedicine
Ryou S, Jung Y, Kim DS et al. · 2026 · The Korean journal of internal medicine
Background/aims Few studies have compared modified endoscopic mucosal resection (EMR) techniques for small rectal neuroendocrine tumors (NETs). This study evaluated the clinical outcomes of ligation-assisted EMR (EMR-L) and precutting EMR…
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